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1. 发明申请

WO2004023974A2 APPARATUS AND METHOD FOR NON-INVASIVE MEASUREMENT OF BLOOD CONSTITUENTS 审中-公开
标题翻译：用于血液成分非侵入性测量的装置和方法
公开(公告)号：WO2004023974A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/028230
申请日：2003-09-08
申请人： EURO-CELTIQUE, S.A. , CIURCZAK, Emil , RITCHIE, Gary
发明人： CIURCZAK, Emil , RITCHIE, Gary
IPC分类号： A61B
CPC分类号： G01J3/12 , A61B5/0022 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14551 , G01J3/021 , G01J3/0229 , G01J3/0232 , G01J3/0254 , G01J3/0256 , G01J3/0264 , G01J3/08 , G01J3/1256 , G01J3/18 , G01J3/26 , G01J2003/1226 , G01J2003/1243 , G01N21/359 , G01N21/474 , G01N2021/1744 , G01N2021/4757 , G01N2201/0221 , G01N2201/065 , G01N2201/1293 , G01N2201/1296 , G06F19/00 , G16H40/67
摘要： A system for predicting blood constituent values in a patient includes a remote wireless noninvasive spectral device, the remote wireless non-invasive spectral device generating a spectral scan of a body part of the patient. Also included are a remote invasive device and a central processing device. The remote invasive device generates a constituent value for the patient, while the central processing device predicts a blood constituent value for the patient based upon the spectral scan and the constituent value.
摘要翻译：用于预测患者中血液成分值的系统包括远程无线非侵入性光谱设备，所述远程无线非侵入光谱设备产生患者身体部位的光谱扫描。还包括远程侵入性装置和中央处理装置。远程入侵设备生成患者的构成值，而中央处理设备基于光谱扫描和构成值预测患者的血液成分值。

2. 发明申请

WO2003094679A2 SPECTROSCOPIC ANALYZER FOR BLENDER 审中-公开
标题翻译：荧光分析仪
公开(公告)号：WO2003094679A2
公开(公告)日：2003-11-20
申请号：PCT/US2003/013373
申请日：2003-04-30
申请人： EURO-CELTIQUE, S.A. , GEHRLEIN, Lane , CIURCZAK, Emil , RITCHIE, Gary
发明人： GEHRLEIN, Lane , CIURCZAK, Emil , RITCHIE, Gary
IPC分类号： A47J
CPC分类号： B01F9/04 , B01F3/02 , B01F9/005 , B01F15/00207
摘要： A blending apparatus comprises a. blender including a container having a wall, the wall including a window. The container rotates about an axis of rotation. A wireless spectrometer is mounted to the container and operates through the window, in a direction that does not intersect the axis of rotation, for obtaining a set of spectroscopic data regarding the product during an operation of the blender. In addition, a method for assaying a blended product in a blender includes mounting a wireless spectrometer to the container, rotating the container about its axis of rotation so as to blend the product; operating the wireless spectrometer through a window in the container, in a direction that does not intersect the axis of rotation, to obtain spectroscopic data regarding the product during the blending, and determining a homogeneity of the product from the spectroscopic data.
摘要翻译：混合装置包括a。搅拌器包括具有壁的容器，所述壁包括窗口。容器围绕旋转轴线旋转。将无线光谱仪安装到容器上，并且在与旋转轴线不相交的方向上通过窗口操作，以在搅拌器的操作期间获得关于产品的一组光谱数据。此外，用于在混合器中测定混合产品的方法包括将无线光谱仪安装到容器上，使容器围绕其旋转轴线旋转以便混合产品; 通过容器中的窗口沿不与旋转轴线相交的方向操作无线光谱仪，以获得关于混合期间产品的光谱数据，以及根据光谱数据确定产品的均匀性。

3. 发明申请

WO2003094679A3 SPECTROSCOPIC ANALYZER FOR BLENDER 审中-公开
公开(公告)号：WO2003094679A3
公开(公告)日：2003-11-20
申请号：PCT/US2003/013373
申请日：2003-04-30
申请人： EURO-CELTIQUE, S.A. , GEHRLEIN, Lane , CIURCZAK, Emil , RITCHIE, Gary
发明人： GEHRLEIN, Lane , CIURCZAK, Emil , RITCHIE, Gary
IPC分类号： G01J3/42
摘要： A blending apparatus (1) comprises a. blender (10) including a container (19) having a wall, the wall including a window (12). The container (19) rotates about an axis of rotation (15). A wireless spectrometer (21) is mounted to the container (19) and operates through the window (12), in a direction that does not intersect the axis of rotation (15), for obtaining a set of spectroscopic data regarding the product during an operation of the blender (10). In addition, a method for assaying a blended product in a blender (10) includes mounting a wireless spectrometer (21) to the container (19), rotating the container (19) about its axis of rotation (15) so as to blend the product; operating the wireless spectrometer (21) through a window (19) in the container, in a direction that does not intersect the axis of rotation (15), to obtain spectroscopic data regarding the product during the blending, and determining a homogeneity of the product from the spectroscopic data.

4. 发明申请

WO2003087740A1 METHOD AND APPARATUS FOR DETERMINING THE HOMOGENEITY OF A GRANULATION DURING TABLETING 审中-公开
标题翻译：用于测定碾米期间造粒的均匀性的方法和装置
公开(公告)号：WO2003087740A1
公开(公告)日：2003-10-23
申请号：PCT/US2003/010441
申请日：2003-04-03
申请人： EURO-CELTIQUE, S.A. , GEHRLEIN, Lane , CIURCZAK, Emil , RITCHIE, Gary , BYNUM, Kevin, C.
发明人： GEHRLEIN, Lane , CIURCZAK, Emil , RITCHIE, Gary , BYNUM, Kevin, C.
IPC分类号： G01J3/42
CPC分类号： G01N21/85 , B30B11/08 , B30B15/304 , G01N21/3563 , G01N2021/0118 , G01N2021/8592
摘要： An apparatus for detecting the homogeneity of a pharmaceutical mixture has a hopper (10) for containing a mixture of two or more pharmaceutical components and that is situated within a production line of preparation of a pharmaceutical dosage form. A spectroscope (20) is mounted to the hopper (10) for measuring spectroscopic characteristics of the mixture, and a processing device (32) that is not physically coupled to the spectroscope analyzes the spectroscopic characteristics of the mixture and derives information regarding the homogeneity of the mixture. The spectroscope wirelessly sends the spectroscopic characteristics to the processing device (32), which derives information regarding the homogeneity of the mixture. The wireless transmission of the spectroscopic characteristics can be done through infrared radiation or near infrared radiation, and the spectroscopic characteristics can be converted to digital signals prior to being transmitted.
摘要翻译：用于检测药物混合物的均匀性的装置具有用于容纳两种或更多种药物组分的混合物的料斗（10），其位于药物剂型制备的生产线内。将分光镜（20）安装到料斗（10）上，用于测量混合物的光谱特性，并且不物理耦合到分光镜的处理装置（32）分析混合物的光谱特性，并得出关于混合物的均匀性的信息混合物。分光器将光谱特性无线发送到处理装置（32），该处理装置（32）导出关于混合物的均匀性的信息。光谱特性的无线传输可以通过红外辐射或近红外辐射进行，并且光谱特性可以在传输之前转换为数字信号。

5. 发明公开

EP1536730A2 APPARATUS AND METHOD FOR NON-INVASIVE MEASUREMENT OF BLOOD CONSTITUENTS 审中-公开
标题翻译：装置和方法血液成分的非侵入式测量
公开(公告)号：EP1536730A2
公开(公告)日：2005-06-08
申请号：EP03795673.7
申请日：2003-09-08
申请人： Euro-Celtique, S.A.
发明人： CIURCZAK, Emil , RITCHIE, Gary
IPC分类号： A61B5/00
CPC分类号： G01J3/12 , A61B5/0022 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14551 , G01J3/021 , G01J3/0229 , G01J3/0232 , G01J3/0254 , G01J3/0256 , G01J3/0264 , G01J3/08 , G01J3/1256 , G01J3/18 , G01J3/26 , G01J2003/1226 , G01J2003/1243 , G01N21/359 , G01N21/474 , G01N2021/1744 , G01N2021/4757 , G01N2201/0221 , G01N2201/065 , G01N2201/1293 , G01N2201/1296 , G06F19/00 , G16H40/67
摘要： A system for predicting blood constituent values in a patient includes a remote wireless non-invasive spectral device, the remote wireless non-invasive spectral device generating a spectral scan of a body part of the patient. Also included are a remote invasive device and a central processing device. The remote invasive device generates a constituent value for the patient, while the central processing device predicts a blood constituent value for the patient based upon the spectral scan and the constituent value.

6. 发明公开

EP1509753A2 SPECTROSCOPIC ANALYZER FOR BLENDER 审中-公开
标题翻译：光谱分析仪将调音台
公开(公告)号：EP1509753A2
公开(公告)日：2005-03-02
申请号：EP03721948.2
申请日：2003-04-30
申请人： Euro-Celtique, S.A.
发明人： GEHRLEIN, Lane , CIURCZAK, Emil , RITCHIE, Gary
IPC分类号： G01J3/42
CPC分类号： B01F9/04 , B01F3/02 , B01F9/005 , B01F15/00207
摘要： A blending apparatus (1) comprises a. blender (10) including a container (19) having a wall, the wall including a window (12). The container (19) rotates about an axis of rotation (15). A wireless spectrometer (21) is mounted to the container (19) and operates through the window (12), in a direction that does not intersect the axis of rotation (15), for obtaining a set of spectroscopic data regarding the product during an operation of the blender (10). In addition, a method for assaying a blended product in a blender (10) includes mounting a wireless spectrometer (21) to the container (19), rotating the container (19) about its axis of rotation (15) so as to blend the product; operating the wireless spectrometer (21) through a window (19) in the container, in a direction that does not intersect the axis of rotation (15), to obtain spectroscopic data regarding the product during the blending, and determining a homogeneity of the product from the spectroscopic data.

7. 发明公开

EP1315953A1 AUTOMATED SYSTEM AND METHOD FOR SPECTROSCOPIC ANALYSIS 审中-公开
标题翻译：自动系统和方法的光谱分析
公开(公告)号：EP1315953A1
公开(公告)日：2003-06-04
申请号：EP01965883.0
申请日：2001-08-10
申请人： Euro-Celtique, S.A.
发明人： MARK, Howard , CIURCZAK, Emil , RITCHIE, Gary
IPC分类号： G01J3/28
CPC分类号： G01J3/28 , A61B5/14532 , G01J3/0264 , G01J2003/2866 , G01N21/274 , G01N21/31
摘要： An automated method for modeling spectral data includes accessing a set of spectral data, corresponding to each of a plurality of samples, each set having associated therewith at least one independently measured constituent value (201).Data transforms are applied to the set of spectral data to generate, for each sample, a set of transformed and untransformed spectral data, which with its associated constituent values, is divided into a calibration sub-set (231) and a validation sub-set (232). One or more of a partial least squares, principal component regression, neural net, or a multiple linear regression analysis is applied to the calibration data sub-sets to obtain corresponding modeling equations for predicting the target substance amount in a sample. The modeling equation with the best correlation between the spectral data in the validation sub-set and the corresponding constituent values in the validation sub-set is identified, preferably as a function of the SEE and SEP.

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