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    • 2. 发明申请
    • Porphyromonas gingivalis 1435/1449 LPS as an immune modulator
    • 牙龈卟啉单胞菌1435/1449 LPS作为免疫调节剂
    • US20070134170A1
    • 2007-06-14
    • US11301542
    • 2005-12-13
    • Richard DarveauRobert ReifeKeith Knutson
    • Richard DarveauRobert ReifeKeith Knutson
    • A61K8/96A61K39/02
    • A61K39/39A61K2039/55572
    • A preparation containing lipopolysaccharide (LPS) of Porphyromonas gingivalis having a molecular negative mass ion of 1435 or 1449 is used as an immune system modulator to redirect a host's immune system against an antigen of interest. The 1435/1449 LPS preparation can be isolated from P. gingivalis or prepared as a derivative or mimetic thereof. The immunomodulating preparations of P. gingivalis 1435/1449 can be used as a vaccine adjuvant, and can be used to stimulate an immune response against a selected antigen associated with a disease of interest, such an antigen associated with a tumor, infectious disease, autoimmune disease, MHC antigen, or to modulate asthma or other inflammatory conditions.
    • 使用含有分子负质量离子为1435或1449的牙龈卟啉单胞菌的脂多糖(LPS)的制剂作为免疫系统调节剂,以将宿主的免疫系统与目的抗原重定向。 1435/1449 LPS制剂可从牙龈卟啉单胞菌分离或制备为衍生物或模拟物。 牙龈卟啉单胞菌1435/1449的免疫调节制剂可用作疫苗佐剂,并且可用于刺激针对与感兴趣疾病相关的选定抗原的免疫应答,例如与肿瘤相关的抗原,感染性疾病,自身免疫 疾病,MHC抗原,或调节哮喘或其他炎性病症。
    • 4. 发明授权
    • Porphyromonas gingivalis 1435/1449 LPS as an immune modulator
    • 牙龈卟啉单胞菌1435/1449 LPS作为免疫调节剂
    • US07622128B2
    • 2009-11-24
    • US11301542
    • 2005-12-13
    • Richard P. DarveauRobert ReifeKeith Knutson
    • Richard P. DarveauRobert ReifeKeith Knutson
    • A61K45/00A61K47/00A61K49/00
    • A61K39/39A61K2039/55572
    • A preparation containing lipopolysaccharide (LPS) of Porphyromonas gingivalis having a molecular negative mass ion of 1435 or 1449 is used as an immune system modulator to redirect a host's immune system against an antigen of interest. The 1435/1449 LPS preparation can be isolated from P. gingivalis or prepared as a derivative or mimetic thereof. The immunomodulating preparations of P. gingivalis 1435/1449 can be used as a vaccine adjuvant, and can be used to stimulate an immune response against a selected antigen associated with a disease of interest, such an antigen associated with a tumor, infectious disease, autoimmune disease, MHC antigen, or to modulate asthma or other inflammatory conditions.
    • 使用含有分子负质量离子为1435或1449的牙龈卟啉单胞菌的脂多糖(LPS)的制剂作为免疫系统调节剂,以将宿主的免疫系统重定向于目的抗原。 1435/1449 LPS制剂可从牙龈卟啉单胞菌分离或制备为衍生物或模拟物。 牙龈卟啉单胞菌1435/1449的免疫调节制剂可用作疫苗佐剂,并且可用于刺激针对与感兴趣疾病相关的选定抗原的免疫应答,例如与肿瘤相关的抗原,感染性疾病,自身免疫 疾病,MHC抗原,或调节哮喘或其他炎性病症。