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1. 发明授权

US09580708B2 Multimeric oligonucleotides compounds 有权
标题翻译：多聚寡核苷酸化合物
公开(公告)号：US09580708B2
公开(公告)日：2017-02-28
申请号：US14344523
申请日：2012-09-14
申请人： Eugen Uhlmann , Markus Weber , Romesh Subramanian , Thomas Dino Rockel , Arthur M. Krieg
发明人： Eugen Uhlmann , Markus Weber , Romesh Subramanian , Thomas Dino Rockel , Arthur M. Krieg
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/113 , C12N2310/315 , C12N2310/3231 , C12N2310/341 , C12N2310/346 , C12N2310/51 , C12N2310/52
摘要： The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided.
摘要翻译：本公开提供了包含两个或多个靶特异性寡核苷酸（例如反义寡核苷酸（ASO））的多聚寡核苷酸化合物，其各自对切割具有抗性，并通过可切割连接子连接在一起。特别地，两种或更多种连接的靶特异性寡核苷酸，各自到不同的靶标，允许同时抑制多种基因的表达水平，同时显示出有利的药代动力学和药效学性质。还提供了制备和使用所述化合物的方法。

2. 发明申请

US20150299695A1 MULTIMERIC OLIGONUCLEOTIDES COMPOUNDS 有权
标题翻译：多元寡核苷酸化合物
公开(公告)号：US20150299695A1
公开(公告)日：2015-10-22
申请号：US14344523
申请日：2012-09-14
申请人： Eugen Uhlmann , Markus Weber , Romesh Subramanian , Thomas Dino Rockel , Arthur M. Krieg
发明人： Eugen Uhlmann , Markus Weber , Romesh Subramanian , Thomas Dino Rockel , Arthur M. Krieg
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/113 , C12N2310/315 , C12N2310/3231 , C12N2310/341 , C12N2310/346 , C12N2310/51 , C12N2310/52
摘要： The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided.
摘要翻译：本公开提供了包含两个或多个靶特异性寡核苷酸（例如反义寡核苷酸（ASO））的多聚寡核苷酸化合物，其各自对切割具有抗性，并通过可切割连接子连接在一起。特别地，两种或更多种连接的靶特异性寡核苷酸，各自到不同的靶标，允许同时抑制多种基因的表达水平，同时显示出有利的药代动力学和药效学性质。还提供了制备和使用所述化合物的方法。

3. 发明申请

US20110098456A1 IMMUNE STIMULATORY OLIGONUCLEOTIDE ANALOGS CONTAINING MODIFIED SUGAR MOIETIES 有权
标题翻译：含有改性糖酵母的免疫刺激寡核苷酸模拟物
公开(公告)号：US20110098456A1
公开(公告)日：2011-04-28
申请号：US12681800
申请日：2008-09-09
申请人： Eugen Uhlmann , Harald Debelak , Marion Jurk , Markus Weber
发明人： Eugen Uhlmann , Harald Debelak , Marion Jurk , Markus Weber
IPC分类号： C07H21/04 , C07H21/02
CPC分类号： A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/32 , C12N2310/322
摘要： The invention relates to oligonucleotides including at least one FANA substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
摘要翻译：本发明涉及包含至少一种FANA取代的核苷酸类似物和嘧啶 - 嘌呤二核苷酸的寡核苷酸。本发明还涉及药物组合物及其使用方法。

4. 发明授权

US09186399B2 Immune stimulatory oligonucleotide analogs containing modified sugar moieties 有权
标题翻译：含有修饰的糖部分的免疫刺激性寡核苷酸类似物
公开(公告)号：US09186399B2
公开(公告)日：2015-11-17
申请号：US12681800
申请日：2008-09-29
申请人： Eugen Uhlmann , Harald Debelak , Marion Jurk , Markus Weber
发明人： Eugen Uhlmann , Harald Debelak , Marion Jurk , Markus Weber
IPC分类号： A61K39/39 , A61K39/00 , C12N15/117
CPC分类号： A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/32 , C12N2310/322
摘要： The invention relates to oligonucleotides including at least one FANA substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
摘要翻译：本发明涉及包含至少一种FANA取代的核苷酸类似物和嘧啶 - 嘌呤二核苷酸的寡核苷酸。本发明还涉及药物组合物及其使用方法。

5. 发明授权

US09155571B2 Minimally invasive interspinous process spacer implants and methods 有权
标题翻译：微创棘突间隔植入物和方法
公开(公告)号：US09155571B2
公开(公告)日：2015-10-13
申请号：US12940125
申请日：2010-11-05
申请人： Daniel Thommen , Markus Weber , Jacques Teisen , Markus Kraft , Florian Kaufmann , Markus Hunziker , Felix Aschmann , Stefan Saladin , Martin Oswald , Roman Randegger
发明人： Daniel Thommen , Markus Weber , Jacques Teisen , Markus Kraft , Florian Kaufmann , Markus Hunziker , Felix Aschmann , Stefan Saladin , Martin Oswald , Roman Randegger
IPC分类号： A61F2/44 , A61B17/70 , A61B19/00 , A61B17/00
CPC分类号： A61B17/7065 , A61B17/7076 , A61B90/39 , A61B2017/00292 , A61B2017/00557 , A61B2017/00867
摘要： An interspinous process spacer for implantation in an interspinous space between a superior spinous process and an inferior spinous process includes a balloon-like body, a first deployable protrusion and a second deployable protrusion. The body has a distal end, a proximal end and a longitudinal axis extending between the proximal and distal ends. The spacer is arrangeable in an unexpanded configuration and an expanded configuration. The first deployable protrusion is mounted proximate the proximal end and the second deployable protrusion is mounted proximate the distal end. The first and second deployable protrusions are oriented generally parallel to the longitudinal axis in the unexpanded configuration and generally perpendicular to the longitudinal axis in the expanded configuration.
摘要翻译：用于植入在上棘突和下棘之间棘突间的棘突间间隔件包括球状体，第一展开突起和第二展开突起。主体具有在近端和远端之间延伸的远端，近端和纵向轴线。间隔件可布置在未膨胀构型和扩展构型中。第一可展开的突起被安装在近端附近，并且第二可展开突起被安装在远端附近。第一和第二可展开突起在未膨胀构造中大体上平行于纵向轴线定向并且在扩展构型中大致垂直于纵向轴线定向。

6. 发明授权

US09045743B2 Stabilization of thermolysin in aqueous solution 有权
标题翻译：溶菌酶在水溶液中的稳定化
公开(公告)号：US09045743B2
公开(公告)日：2015-06-02
申请号：US13488824
申请日：2012-06-05
申请人： Werner Hoelke , Johann-Peter Thalhofer , Antje Liehre , Markus Weber
发明人： Werner Hoelke , Johann-Peter Thalhofer , Antje Liehre , Markus Weber
IPC分类号： C12N9/54 , C12N9/96
CPC分类号： C12N9/54 , C12N9/96 , C12Y304/24027
摘要： The present invention deals with the proteolytic enzyme thermolysin which tends to be unstable in aqueous solution. The invention provides methods and compositions to enhance the stability of dissolved thermolysin in aqueous solution. Thermolysin, crude thermolysin or a lyophilizate containing thermolysin and one or more salts, is contacted with an aqueous buffer with a low salt concentration and a first solution is formed. Subsequently, a further salt in solid form is added and dissociated, thereby forming a second solution comprising thermolysin in a stabilized form.
摘要翻译：本发明涉及在水溶液中趋于不稳定的蛋白水解酶嗜热溶菌酶。本发明提供了增加溶解的嗜热溶菌酶在水溶液中的稳定性的方法和组合物。将嗜热菌蛋白酶，粗嗜热菌蛋白酶或含有嗜热菌蛋白酶和一种或多种盐的冻干物与低盐浓度的水性缓冲液接触，形成第一溶液。随后，加入固体形式的另外的盐并解离，由此形成稳定形式的包含嗜热菌蛋白酶的第二溶液。

7. 发明授权

US08841481B2 Use of foam bodies in oxidation reactors for preparing unsaturated aldehydes or carboxylic acids 有权
标题翻译：在氧化反应器中使用泡沫体制备不饱和醛或羧酸
公开(公告)号：US08841481B2
公开(公告)日：2014-09-23
申请号：US13060599
申请日：2009-07-29
申请人： Horst-Werner Zanthoff , Nicole Brausch , Franz-Felix Kuppinger , Jorg Sauer , Andreas Sabbagh , Dennis Fruhling , Markus Weber , Oliver Becker
发明人： Horst-Werner Zanthoff , Nicole Brausch , Franz-Felix Kuppinger , Jorg Sauer , Andreas Sabbagh , Dennis Fruhling , Markus Weber , Oliver Becker
IPC分类号： C07C45/35 , C07C57/04 , B01J37/02 , C07C5/333 , C07C51/25 , B01J23/00 , B01J19/24 , B01J35/04 , B01J8/06 , B01J23/888
CPC分类号： B01J8/067 , B01J19/249 , B01J23/002 , B01J23/8885 , B01J35/04 , B01J37/0219 , B01J37/0225 , B01J2208/00221 , B01J2208/025 , B01J2219/00006 , B01J2219/0004 , B01J2219/2453 , B01J2219/2479 , B01J2219/2481 , B01J2523/00 , C07C5/333 , C07C45/35 , C07C51/252 , Y02P20/52 , C07C11/06 , C07C47/22 , C07C57/04 , B01J2523/17 , B01J2523/55 , B01J2523/68 , B01J2523/69
摘要： The present invention relates to a process for preparing unsaturated aldehydes or unsaturated carboxylic acids by heterogeneous catalytic gas phase oxidation of unsaturated or saturated hydrocarbons, comprising the process steps of: i) providing a gas mixture comprising a saturated hydrocarbon and catalytically dehydrogenating the saturated hydrocarbon in the gas phase to obtain a gas mixture comprising an unsaturated hydrocarbon in a dehydrogenation reactor having a dehydrogenation catalyst material; or ii) providing a gas mixture comprising oxygen and an unsaturated hydrocarbon; iii) catalytically oxidizing the unsaturated hydrocarbon obtained in process step i) or provided in process step ii) in the gas phase to obtain a gas mixture comprising an unsaturated aldehyde in a first oxidation reactor having a first oxidation catalyst material; wherein at least one of the reactors selected from the dehydrogenation reactor, the first oxidation reactor and the second oxidation reactor comprises at least one foam body.
摘要翻译：本发明涉及通过不饱和烃或饱和烃的非均相催化气相氧化制备不饱和醛或不饱和羧酸的方法，包括以下工艺步骤：i）提供包含饱和烃的气体混合物并将饱和烃催化脱氢在具有脱氢催化剂材料的脱氢反应器中获得包含不饱和烃的气体混合物; 或ii）提供包含氧和不饱和烃的气体混合物; iii）在工艺步骤i）中获得或在工艺步骤ii）中提供的不饱和烃催化氧化以在具有第一氧化催化剂材料的第一氧化反应器中获得包含不饱和醛的气体混合物; 其中选自脱氢反应器，第一氧化反应器和第二氧化反应器的反应器中的至少一个包括至少一个泡沫体。

8. 发明授权

US08614164B2 Iron- and copper-comprising heterogeneous catalyst and process for preparing olefins by reacting carbon monoxide with hydrogen 失效
标题翻译：含铁和铜的非均相催化剂和通过一氧化碳与氢气反应制备烯烃的方法
公开(公告)号：US08614164B2
公开(公告)日：2013-12-24
申请号：US12939281
申请日：2010-11-04
申请人： Jochen Steiner , Kerem Bay , Vera Werner , Jürgen Amann , Stefan Bunzel , Claudia Moβbacher , Joachim Müller , Ekkehard Schwab , Markus Weber
发明人： Jochen Steiner , Kerem Bay , Vera Werner , Jürgen Amann , Stefan Bunzel , Claudia Moβbacher , Joachim Müller , Ekkehard Schwab , Markus Weber
IPC分类号： B01J23/58 , C07C27/00 , B01J23/70 , B01J23/72 , B01J23/74
CPC分类号： B01J23/745 , B01J23/002 , B01J23/005 , B01J23/72 , B01J23/78 , B01J35/023 , B01J37/0201 , B01J37/086 , B01J37/14 , B01J37/18 , B01J2523/00 , C07C1/044 , C07C2523/04 , C07C2523/72 , C07C2523/745 , C07C2523/885 , C10G2/332 , C10G2400/20 , C07C11/02 , B01J2523/17 , B01J2523/842
摘要： Iron- and copper-containing heterogeneous catalyst, and a process for producing it, including the following steps: thermal decomposition of gaseous iron pentacarbonyl to give carbonyl iron powder having spherical primary particles; treatment of carbonyl iron powder with hydrogen, resulting in the metallic spherical primary particles at least partly agglomerating; surface oxidation of the iron particles to form iron oxide; contacting the particles with an aqueous solution of a copper compound; drying in the presence of oxygen and subsequent calcination in the absence of oxygen, resulting in oxygen-comprising copper compounds on the particles; and finally reaction of these with the iron oxide to form a mixed oxide of the formula CuxFe3-xO4, where 0
摘要翻译：含铁和铜的非均相催化剂及其制备方法，包括以下步骤：将五羰基气态铁热分解，得到具有球形初级颗粒的羰基铁粉; 用氢气处理羰基铁粉末，导致金属球形初级颗粒至少部分凝聚; 铁颗粒的表面氧化形成氧化铁; 使所述颗粒与铜化合物的水溶液接触; 在氧气存在下干燥，随后在不存在氧气下进行煅烧，导致颗粒上含氧的铜化合物; 最后使它们与氧化铁反应形成式CuxFe3-xO4的混合氧化物，其中0

9. 发明授权

US08549610B2 Network-based security services for managed internet service 有权
标题翻译：用于托管互联网服务的基于网络的安全服务
公开(公告)号：US08549610B2
公开(公告)日：2013-10-01
申请号：US12636286
申请日：2009-12-11
申请人： Christopher O'Brien , Joseph Blanda, Jr. , William Rehrmann , Markus Weber
发明人： Christopher O'Brien , Joseph Blanda, Jr. , William Rehrmann , Markus Weber
IPC分类号： H04L29/06
CPC分类号： H04L45/00 , H04L63/0227
摘要： Data traffic is routed from a customer edge (CE) router to an Ethernet services router via a generic routing encapsulation (GRE) tunnel. Upon routing the data traffic from the CE router to the Ethernet services router, the data traffic is routed from the Ethernet services router to an aggregation switch. Upon routing the data traffic from the Ethernet services router to the aggregation switch, the data traffic is routed from the aggregation switch to a service switch through a security module, the security module configured to filter the data traffic. The filtered data traffic is routed from the service switch to the Ethernet services router. Upon routing the filtered data traffic from the service switch to the Ethernet services router, the filtered data traffic is routed from the Ethernet services router to a provider edge (PE) router.
摘要翻译：数据流量通过通用路由封装（GRE）隧道从客户端（CE）路由器路由到以太网服务路由器。在将数据流量从CE路由器路由到以太网服务路由器时，数据流量从以太网服务路由器路由到聚合交换机。在将数据流量从以太网服务路由器路由到聚合交换机时，数据流量通过安全模块从聚合交换机路由到业务交换机，安全模块被配置为过滤数据流量。经过过滤的数据流量从服务交换机路由到以太网服务路由器。将经过过滤的数据流量从业务交换机路由到以太网业务路由器后，过滤的数据流量将从以太网业务路由器路由到提供商边缘（PE）路由器。

10. 发明授权

US08420879B2 Process for workup of a stream comprising butene and/or butadiene 有权
标题翻译：用于后处理包含丁烯和/或丁二烯的流的方法
公开(公告)号：US08420879B2
公开(公告)日：2013-04-16
申请号：US13411080
申请日：2012-03-02
申请人： Albena Kostova , Regina Benfer , Jochen Götz , Alireza Rezai , Aristides Morillo , Gerhard Olbert , Peter Pfab , Grigorios Kolios , Markus Weber , Alexander Weck
发明人： Albena Kostova , Regina Benfer , Jochen Götz , Alireza Rezai , Aristides Morillo , Gerhard Olbert , Peter Pfab , Grigorios Kolios , Markus Weber , Alexander Weck
IPC分类号： C07C7/08
CPC分类号： C07C7/04 , C07C7/08 , C07C7/11 , C07C11/08 , C07C11/167
摘要： The invention relates to a process for workup of a stream (1) comprising butene and/or butadiene, butane, hydrogen and/or nitrogen and carbon dioxide, comprising: (a) absorption of stream (1) with a mixture (5) comprising 80 to 97% by weight of N-methylpyrrolidone and 3 to 20% by weight of water to obtain a stream (9) comprising N-methylpyrrolidone, water, butene and/or butadiene, butane, and optionally carbon dioxide, and a stream (7) comprising hydrogen and/or nitrogen and butane, (b) extractive distillation of stream (9) with a stream (13) comprising 80 to 97% by weight of N-methylpyrrolidone and 3 to 20% by weight of water to separate the stream (9) into a stream (17) comprising N-methylpyrrolidone, water, butene and/or butadiene, and a stream (15) comprising essentially butane, and optionally carbon dioxide, (c) distillation of stream (17) into a stream (23) comprising essentially N-methylpyrrolidone and water, and a stream (21) comprising butene and/or butadiene.
摘要翻译：本发明涉及一种用于后处理包含丁烯和/或丁二烯，丁烷，氢气和/或氮气和二氧化碳的物流（1）的方法，其包括：（a）通过混合物（5）吸收料流（1） 80至97重量％的N-甲基吡咯烷酮和3至20重量％的水，以获得包含N-甲基吡咯烷酮，水，丁烯和/或丁二烯，丁烷和任选的二氧化碳的流（9）和流 7）包含氢和/或氮和丁烷，（b）用包含80至97重量％的N-甲基吡咯烷酮和3至20重量％的水的料流（13）萃取蒸馏料流（9）以分离（9）进入包含N-甲基吡咯烷酮，水，丁烯和/或丁二烯的物流（17）和基本上包含丁烷和任选的二氧化碳的物流（15），（c）将物流（17）蒸馏成流（23）和包含丁烯和/或丁二烯的物流（21）。

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