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1. 发明授权

US06997863B2 Thermotherapy via targeted delivery of nanoscale magnetic particles 失效
公开(公告)号：US06997863B2
公开(公告)日：2006-02-14
申请号：US10200082
申请日：2002-07-19
申请人： Erik S. Handy , Robert Ivkov , Diane Ellis-Busby , Allan Foreman , Susan J. Braunhut , Douglas U. Gwost , Blair Ardman
发明人： Erik S. Handy , Robert Ivkov , Diane Ellis-Busby , Allan Foreman , Susan J. Braunhut , Douglas U. Gwost , Blair Ardman
IPC分类号： A61N2/00
CPC分类号： A61N1/406 , A61N2/02 , Y10S977/904
摘要： Disclosed are therapeutic methods for the treatment of disease material involving administration of a thermotherapeutic magnetic composition, which contains single-domain magnetic particles attached to a target-specific ligand, to a patient and application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. Also disclosed are methods of administering the thermotherapeutic magnetic material composition. The thermotherapeutic methods may be used where the predetermined target is associated with diseases, such as cancer, diseases of the immune system, and pathogen-borne diseases, and undesirable targets, such as toxins, reactions associated with organ transplants, hormone-related diseases, and non-cancerous diseased cells or tissue.

2. 发明授权

US07074175B2 Thermotherapy via targeted delivery of nanoscale magnetic particles 失效
公开(公告)号：US07074175B2
公开(公告)日：2006-07-11
申请号：US10176950
申请日：2002-06-18
申请人： Erik Schroeder Handy , Robert Ivkov , Diane Ellis-Busby , Allan Foreman
发明人： Erik Schroeder Handy , Robert Ivkov , Diane Ellis-Busby , Allan Foreman
IPC分类号： A61N2/00
CPC分类号： A61N1/406 , A61N2/02 , Y10S977/902
摘要： Disclosed are compositions comprising magnetic nanoparticles, a biocompatible coating, and a target-specific ligand. Also disclosed are devices for treating diseased tissue for use with such compositions. Further disclosed are methods for treating diseased tissue, such as cancer, using such compositions and devices, as well as methods for treating diseased tissue utilizing hypertermia.

3. 发明申请

US20090317408A1 LIGAND CONJUGATED THERMOTHERAPY SUSCEPTORS AND METHODS FOR PREPARING SAME 审中-公开
标题翻译： LIGAND CONJUGATED THERMOTHERAPY SUSCEPTORS AND METHODS FOR PREPARTING SAME
公开(公告)号：US20090317408A1
公开(公告)日：2009-12-24
申请号：US12335203
申请日：2008-12-15
申请人： Robert Ivkov , Cordula Gruttner , Knut Meuller , Joachim Teller , Fritz Westphal , Allan Foreman , David B. Kanne , Hsiao-Ling Chin , Paul C. Chinn
发明人： Robert Ivkov , Cordula Gruttner , Knut Meuller , Joachim Teller , Fritz Westphal , Allan Foreman , David B. Kanne , Hsiao-Ling Chin , Paul C. Chinn
IPC分类号： A61K39/395 , C07K16/00 , A61P31/00 , A61P35/00
CPC分类号： A61K41/0052 , A61K47/60 , A61K47/6843 , A61K47/6855
摘要： Magnetic nanoparticles exhibiting enhanced heating ability in thermotherapeutic applications are described, as are several strategies to conjugate such nanoparticles. Methods for using conjugated nanoparticles are also provided.
摘要翻译：描述了在热治疗应用中显示出增强的加热能力的磁性纳米颗粒，以及缀合这种纳米颗粒的几种策略。还提供了使用共轭纳米颗粒的方法。

4. 发明申请

US20080213382A1 THERMOTHERAPY SUSCEPTORS AND METHODS OF USING SAME 审中-公开
标题翻译： THERMOTHERAPY SUSCEPTORS及其使用方法
公开(公告)号：US20080213382A1
公开(公告)日：2008-09-04
申请号：US12017634
申请日：2008-01-22
申请人： Robert Ivkov , Allan Foreman
发明人： Robert Ivkov , Allan Foreman
IPC分类号： A61K9/50 , A61P29/00 , A61P35/00
CPC分类号： A61N1/406 , A61K9/5094 , A61K33/24 , A61K33/26 , A61K33/38 , A61K41/0052
摘要： Untargeted magnetic nanoparticles exhibiting collective behavior and enhanced heating ability in thermotherapeutic applications are described, as are methods for using such untargeted magnetic nanoparticles.
摘要翻译：描述了在热治疗应用中显示集体行为和增强的加热能力的非靶向磁性纳米颗粒，以及使用这种非靶向磁性纳米颗粒的方法。

5. 发明申请

US20050090732A1 Therapy via targeted delivery of nanoscale particles 审中-公开
标题翻译：通过靶向递送纳米级颗粒进行治疗
公开(公告)号：US20050090732A1
公开(公告)日：2005-04-28
申请号：US10696399
申请日：2003-10-28
申请人： Robert Ivkov , Wolfgang Daum , Allan Foreman , Douglas Gwost
发明人： Robert Ivkov , Wolfgang Daum , Allan Foreman , Douglas Gwost
IPC分类号： A61B5/055 , A61N20060101 , A61N1/40 , A61N2/00 , A61N5/04 , A61N5/06 , A61N5/10
CPC分类号： A61N1/406 , A61N2/002 , A61N2/008 , A61N5/04 , A61N5/062 , A61N5/10
摘要： Disclosed are compositions, systems and methods for treating a subject's body, body part, tissue, body fluid cells, pathogens, or other undesirable matter involving the administration of a targeted thermotherapy that comprises a bioprobe (energy susceptive materials that are attached to a target-specific ligand). Such targeted therapy methods can be combined with at least one other therapy technique. Other therapies include hyperthermia, direct antibody therapy, radiation, chemo- or pharmaceutical therapy, photodynamic therapy, surgical or interventional therapy, bone marrow or stem cell transplantation, and medical imaging, such as MRI, PET, SPECT, and bioimpedance. The disclosed therapies may be useful in the treatment of a variety of indications, including but not limited to, cancer of any type, such as bone marrow, lung, vascular, neuro, colon, ovarian, breast and prostate cancer, epitheleoid sarcomas, AIDS, adverse angiogenesis, restenosis, amyloidosis, tuberculosis, cardiovascular plaque, vascular plaque, obesity, malaria, and illnesses due to viruses, such as HIV.
摘要翻译：公开了用于治疗受试者的身体，身体部位，组织，体液细胞，病原体或涉及施用靶向热疗法的其它不期望的物质的组合物，系统和方法，其包括生物探针（附着于靶 - 特异性配体）。这样的靶向治疗方法可以与至少一种其它治疗技术组合。其他疗法包括热疗，直接抗体治疗，放射治疗，化疗或药物治疗，光动力疗法，手术或介入治疗，骨髓或干细胞移植，以及医学成像，如MRI，PET，SPECT和生物阻抗。所公开的疗法可用于治疗各种适应症，包括但不限于任何类型的癌症，例如骨髓，肺，血管，神经，结肠，卵巢，乳腺和前列腺癌，上皮样肉瘤，AIDS ，不良血管生成，再狭窄，淀粉样变性，结核病，心血管斑块，血管斑块，肥胖症，疟疾和由于病毒如HIV引起的疾病。

6. 发明申请

US20070112339A9 Magnetic nanoscale particle compositions, and therapeutic methods related thereto 失效
标题翻译：磁性纳米粒子组合物及其相关治疗方法
公开(公告)号：US20070112339A9
公开(公告)日：2007-05-17
申请号：US11264680
申请日：2005-11-01
申请人： Robert Ivkov
发明人： Robert Ivkov
IPC分类号： A61N5/00
CPC分类号： A61K41/0052 , A61K47/6923 , A61K47/6929 , A61K49/1818 , A61K49/1887 , A61K51/1255 , A61N1/406 , A61N2/002 , A61N2/02 , A61N5/1001 , B82Y5/00 , Y10S977/904
摘要： Disclosed are thermotherapeutic compositions for treating disease material, and methods of targeted therapy utilizing such compositions. These compositions comprise a) stable single domain magnetic particles; b) magnetic nanoparticles comprising aggregates of superparamagnetic grains; or c) magnetic nanoparticles comprising aggregates of stable single magnetic domain crystals and superparamagnetic grains. These compositions may also comprise a radio isotope, potential radioactive isotope, chemotherapeutic agent. These methods comprise the administration to a patient's body, body part, body fluid, or tissue of bioprobes (energy susceptive materials attached to a target-specific ligand), and the application of energy to the bioprobes so as to destroy, rupture, or inactivate the target in the patient. Energy forms, such as AMF, are utilized to provide the energy. The disclosed methods may be useful in the treatment of a variety of indications, including cancers, diseases of the immune system, central nervous system and vascular system, and pathogen-borne diseases.
摘要翻译：公开了用于治疗疾病材料的热治疗组合物，以及利用这种组合物的靶向治疗方法。这些组合物包含a）稳定的单畴磁性颗粒; b）包含超顺磁性颗粒聚集体的磁性纳米颗粒; 或c）包含稳定的单磁畴晶体和超顺磁性晶粒的聚集体的磁性纳米颗粒。这些组合物还可以包含放射性同位素，潜在的放射性同位素，化学治疗剂。这些方法包括向患者的身体，身体部位，体液或生物探针的组织（连接到靶特异性配体的能量敏感材料）的施用，以及向生物探针施加能量以破坏，破裂或灭活患者的目标。能量形式，如AMF，被用来提供能量。所公开的方法可用于治疗各种适应症，包括癌症，免疫系统疾病，中枢神经系统和血管系统以及病原体传播疾病。

7. 发明申请

US20060142749A1 Magnetic nanoscale particle compositions, and therapeutic methods related thereto 失效
标题翻译：磁性纳米粒子组合物及其相关治疗方法
公开(公告)号：US20060142749A1
公开(公告)日：2006-06-29
申请号：US11264680
申请日：2005-11-01
申请人： Robert Ivkov
发明人： Robert Ivkov
IPC分类号： A61N5/00
CPC分类号： A61K41/0052 , A61K47/6923 , A61K47/6929 , A61K49/1818 , A61K49/1887 , A61K51/1255 , A61N1/406 , A61N2/002 , A61N2/02 , A61N5/1001 , B82Y5/00 , Y10S977/904
摘要： Disclosed are thermotherapeutic compositions for treating disease material, and methods of targeted therapy utilizing such compositions. These compositions comprise a) stable single domain magnetic particles; b) magnetic nanoparticles comprising aggregates of superparamagnetic grains; or c) magnetic nanoparticles comprising aggregates of stable single magnetic domain crystals and superparamagnetic grains. These compositions may also comprise a radio isotope, potential radioactive isotope, chemotherapeutic agent. These methods comprise the administration to a patient's body, body part, body fluid, or tissue of bioprobes (energy susceptive materials attached to a target-specific ligand), and the application of energy to the bioprobes so as to destroy, rupture, or inactivate the target in the patient. Energy forms, such as AMF, are utilized to provide the energy. The disclosed methods may be useful in the treatment of a variety of indications, including cancers, diseases of the immune system, central nervous system and vascular system, and pathogen-borne diseases.
摘要翻译：公开了用于治疗疾病材料的热治疗组合物，以及利用这种组合物的靶向治疗方法。这些组合物包含a）稳定的单畴磁性颗粒; b）包含超顺磁性颗粒聚集体的磁性纳米颗粒; 或c）包含稳定的单磁畴晶体和超顺磁性晶粒的聚集体的磁性纳米颗粒。这些组合物还可以包含放射性同位素，潜在的放射性同位素，化学治疗剂。这些方法包括向患者的身体，身体部位，体液或生物探针的组织（连接到靶特异性配体的能量敏感材料）的施用，以及向生物探针施加能量以破坏，破裂或灭活患者的目标。能量形式，如AMF，被用来提供能量。所公开的方法可用于治疗各种适应症，包括癌症，免疫系统疾病，中枢神经系统和血管系统以及病原体传播疾病。

8. 发明授权

US09333369B2 Systems and methods to reduce power deposition in tissue exposed to radio frequency electromagnetic fields 有权
标题翻译：减少暴露于射频电磁场的组织中功率沉积的系统和方法
公开(公告)号：US09333369B2
公开(公告)日：2016-05-10
申请号：US13503520
申请日：2010-10-22
申请人： Robert Ivkov , Ananda Kumar
发明人： Robert Ivkov , Ananda Kumar
IPC分类号： A61N2/02 , A61B5/055 , A61B5/00 , A61N1/40 , G01R33/422
CPC分类号： A61N2/02 , A61B5/055 , A61B5/416 , A61N1/403 , G01R33/422
摘要： An apparatus for exposing a region of interest of an object, animal or person to an alternating magnetic field has a source of radio-frequency electromagnetic radiation arranged to provide the alternating magnetic field in an exposure volume defined by the apparatus, and a shield arranged between the source of radio-frequency electromagnetic radiation and the exposure volume. The shield includes a material that has a sufficient thickness and arrangement to reduce power deposition to at least regions outside of the region of interest of the object, animal or person during exposure in the exposure volume.
摘要翻译：用于将物体，动物或人的感兴趣区域暴露于交变磁场的装置具有放射频率电磁辐射源，用于在由装置限定的曝光体积中提供交变磁场，并且屏蔽层布置在射频电磁辐射源和曝光量。护罩包括具有足够的厚度和布置的材料，以在曝光量期间曝光期间减少对物体，动物或人的感兴趣区域外的至少区域的功能沉积。

9. 发明申请

US20120277517A1 Formulation and Methods for Enhanced Interventional Image-Guided Therapy of Cancer 审中-公开
标题翻译：增强干预性图像引导治疗癌症的制剂和方法
公开(公告)号：US20120277517A1
公开(公告)日：2012-11-01
申请号：US13442305
申请日：2012-04-09
申请人： Robert Ivkov , Eleni Liapi
发明人： Robert Ivkov , Eleni Liapi
IPC分类号： A61M37/00 , A61P35/00 , A61K51/00 , A61K9/10 , A61K33/26
CPC分类号： A61K49/1851 , A61K41/0052 , A61N1/406
摘要： An embodiment in accordance with the present invention provides a thermo-chemoembolization formulation and method for enhanced interventional image-guided therapy for cancer. The T-C formulation includes magnetic iron oxide nano-particles (MIONs) that heat when exposed to an alternating magnetic field (AMF), a liquid tumorphilic drug carrier that enhances tumor retention of the T-C formulation, and a chemotherapeutic or radiotherapeutic agent. The T-C formulation enhances delivery of heat and chemo- or radio-therapeutic agents with hyperthermia produced by magnetic nanoparticles to improve therapeutic outcomes. The magnetic nanoparticles and tumorphilic drug carrier also allow for multimodal image-guided monitoring of treatment and patient follow-up. The method for enhanced interventional image-guided therapy for cancer includes using an AMF to heat the T-C formulation and activate the thermotherapy.
摘要翻译：根据本发明的一个实施方案提供了用于癌症的增强介入图像引导治疗的热化学栓塞制剂和方法。 T-C配方包括当暴露于交替磁场（AMF）时加热的磁性氧化铁纳米颗粒（MION），一种增强T-C制剂的肿瘤保留性的液体恶臭药物载体，以及化学治疗剂或放射治疗剂。 T-C配方通过磁性纳米颗粒产生的热疗增强了热和化疗或放射治疗剂的传递，以改善治疗效果。磁性纳米颗粒和恶性药物载体也允许进行多模式图像引导监测治疗和患者随访。增强介入性图像引导治疗癌症的方法包括使用AMF加热T-C制剂并激活热疗。

10. 发明申请

US20120265000A1 Systems and Methods to Reduce Power Deposition in Tissue Exposed to Radio Frequency Electromagnetic Fields 有权
标题翻译：减少暴露于射频电磁场的组织中的功率沉积的系统和方法
公开(公告)号：US20120265000A1
公开(公告)日：2012-10-18
申请号：US13503520
申请日：2010-10-22
申请人： Robert Ivkov , Ananda Kumar
发明人： Robert Ivkov , Ananda Kumar
IPC分类号： A61N2/02 , H05K9/00
CPC分类号： A61N2/02 , A61B5/055 , A61B5/416 , A61N1/403 , G01R33/422
摘要： An apparatus for exposing a region of interest of an object, animal or person to an alternating magnetic field has a source of radio-frequency electromagnetic radiation arranged to provide the alternating magnetic field in an exposure volume defined by the apparatus, and a shield arranged between the source of radio-frequency electromagnetic radiation and the exposure volume. The shield includes a material that has a sufficient thickness and arrangement to reduce power deposition to at least regions outside of the region of interest of the object, animal or person during exposure in the exposure volume.
摘要翻译：用于将物体，动物或人的感兴趣区域暴露于交变磁场的装置具有放射频率电磁辐射源，用于在由装置限定的曝光体积中提供交变磁场，并且屏蔽层布置在射频电磁辐射源和曝光量。护罩包括具有足够的厚度和布置的材料，以在曝光量期间曝光期间减少对物体，动物或人的感兴趣区域外的至少区域的功能沉积。

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