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1. 发明申请

US20090325164A1 MICROELECTRONIC SENSOR DEVICE FOR DNA DETECTION 有权
标题翻译：用于DNA检测的微电子传感器装置
公开(公告)号：US20090325164A1
公开(公告)日：2009-12-31
申请号：US12303448
申请日：2007-05-24
申请人： Erik Robert Vossenaar , Marc Wilhelmus Gisbert Ponjee , Hendrik Roelof Stapert , Mark Thomas Johnson
发明人： Erik Robert Vossenaar , Marc Wilhelmus Gisbert Ponjee , Hendrik Roelof Stapert , Mark Thomas Johnson
IPC分类号： C12Q1/68 , C12M1/00
CPC分类号： G01N21/6454 , B01L3/5027 , B01L3/50851 , B01L7/525 , B01L7/54 , B01L2200/147 , B01L2300/0636 , B01L2300/0819 , B01L2300/1822 , B01L2300/1827 , C12Q1/6825 , G01N21/0332 , G01N21/6428 , G01N2021/6439 , C12Q2565/1015 , C12Q2527/101 , C12Q2527/107
摘要： The invention relates to a microelectronic sensor device and a method for the investigation of biological target substances (20), for example oligonucleotides like DNA fragments. In one embodiment, the device comprises a reaction surface (RS) to which target specific reactants (10) are attached and which lies between a sample chamber (SC) and an array of selectively controllable heating elements (HE). The temperature profile in the sample chamber (SC) can be controlled as desired to provide for example conditions for a PCR and/or for a controlled melting of hybridizations. The reactant (10) and/or the target substance (20) comprises a label (12) with an observable property, like fluorescence, that changes if the target substance (20) is bound to the reactant (10), said property being detected by an array of sensor elements, for example photosensors (SE). The fluorescence of the label (12) may preferably be transferred by FRET to a different fluorescent label (22) or quenched if the target substance (20) is bound.
摘要翻译：本发明涉及一种微电子传感器装置和一种用于研究生物靶物质（20）的方法，例如DNA片段等寡核苷酸。在一个实施方案中，所述装置包括反应表面（RS），目标特异性反应物（10）附着到所述反应表面（RS），并且位于样品室（SC）和选择性可控制的加热元件（HE）阵列之间。样品室（SC）中的温度曲线可以根据需要进行控制，以提供例如PCR和/或受控熔化杂交的条件。反应物（10）和/或目标物质（20）包含具有可观察性质（如荧光）的标记物（12），如果目标物质（20）与反应物（10）结合，则其变化，所述性质被检测通过传感器元件阵列，例如光电传感器（SE）。标记物（12）的荧光优选通过FRET转移到不同的荧光标记物（22），或者如果靶物质（20）被结合则被淬灭。

2. 发明授权

US08815162B2 Microelectronic sensor device for DNA detection 有权
标题翻译：用于DNA检测的微电子传感器装置
公开(公告)号：US08815162B2
公开(公告)日：2014-08-26
申请号：US12303448
申请日：2007-05-24
申请人： Erik Robbert Vossenaar , Marc Wilhelmus Gijsbert Ponjee , Hendrik Roelof Stapert , Mark Thomas Johnson
发明人： Erik Robbert Vossenaar , Marc Wilhelmus Gijsbert Ponjee , Hendrik Roelof Stapert , Mark Thomas Johnson
IPC分类号： G05D23/00
CPC分类号： G01N21/6454 , B01L3/5027 , B01L3/50851 , B01L7/525 , B01L7/54 , B01L2200/147 , B01L2300/0636 , B01L2300/0819 , B01L2300/1822 , B01L2300/1827 , C12Q1/6825 , G01N21/0332 , G01N21/6428 , G01N2021/6439 , C12Q2565/1015 , C12Q2527/101 , C12Q2527/107
摘要： The invention relates to a microelectronic sensor device and a method for the investigation of biological target substances (20), for example oligonucleotides like DNA fragments. In one embodiment, the device comprises a reaction surface (RS) to which target specific reactants (10) are attached and which lies between a sample chamber (SC) and an array of selectively controllable heating elements (HE). The temperature profile in the sample chamber (SC) can be controlled as desired to provide for example conditions for a PCR and/or for a controlled melting of hybridizations. The reactant (10) and/or the target substance (20) comprises a label (12) with an observable property, like fluorescence, that changes if the target substance (20) is bound to the reactant (10), said property being detected by an array of sensor elements, for example photosensors (SE). The fluorescence of the label (12) may preferably be transferred by FRET to a different fluorescent label (22) or quenched if the target substance (20) is bound.
摘要翻译：本发明涉及一种微电子传感器装置和一种用于研究生物靶物质（20）的方法，例如DNA片段等寡核苷酸。在一个实施方案中，所述装置包括反应表面（RS），目标特异性反应物（10）附着到所述反应表面（RS），并且位于样品室（SC）和选择性可控制的加热元件（HE）阵列之间。样品室（SC）中的温度曲线可以根据需要进行控制，以提供例如PCR和/或受控熔化杂交的条件。反应物（10）和/或目标物质（20）包含具有可观察性质（如荧光）的标记物（12），如果目标物质（20）与反应物（10）结合，则其变化，所述性质被检测通过传感器元件阵列，例如光电传感器（SE）。标记物（12）的荧光优选通过FRET转移到不同的荧光标记物（22），或者如果靶物质（20）被结合则被淬灭。

3. 发明申请

US20090263891A1 DEVICE FOR ANALYZING SAMPLES INCLUDING A GAS EVOLVING MEANS 审中-公开
标题翻译：用于分析样品的装置，包括气体发展手段
公开(公告)号：US20090263891A1
公开(公告)日：2009-10-22
申请号：US12373993
申请日：2007-03-12
申请人： Murray Fulton Gillies , Erik Robbert Vossenaar , Mark Thomas Johnson , Hendrik Roelof Stapert , David Andrew Fish , Ralph Kurt
发明人： Murray Fulton Gillies , Erik Robbert Vossenaar , Mark Thomas Johnson , Hendrik Roelof Stapert , David Andrew Fish , Ralph Kurt
IPC分类号： C12M1/34
CPC分类号： G01N33/54366 , G01N33/54393
摘要： The invention relates to a device for analyzing one or more samples for the presence, amount or identity of one or more target molecules in the samples, comprising one or more capture sites whereby the device comprises a gas evolving means. The gas evolved by the gas evolving means moves unbound target molecules away from the capture site and therefore helps to increase the efficacy of the analysis.
摘要翻译：本发明涉及一种用于分析一个或多个样品中用于样品中一种或多种靶分子的存在，量或同一性的装置，其包含一个或多个捕获位点，由此该装置包括气体逸出装置。通过气体放出手段产生的气体将未结合的靶分子移动离开捕获位点，从而有助于提高分析的功效。

4. 发明申请

US20080196483A1 Substrate Material For Analyzing Fluids 审中-公开
标题翻译：用于分析液体的基材
公开(公告)号：US20080196483A1
公开(公告)日：2008-08-21
申请号：US11996408
申请日：2006-07-10
申请人： Ralph Kurt , Hendrik Roelof Stapert , Mark Thomas Johnson , Dirk Jan Broer , Roel Penterman , Emiel Peeters
发明人： Ralph Kurt , Hendrik Roelof Stapert , Mark Thomas Johnson , Dirk Jan Broer , Roel Penterman , Emiel Peeters
IPC分类号： G01N33/00 , C12M1/00 , B05D5/00
CPC分类号： B01L3/5023 , B01L3/5027 , B01L2300/123 , B01L2400/0406 , B01L2400/0481 , G01N33/54366 , G01N33/544 , G01N33/548 , Y10T428/249921
摘要： The invention relates to a substrate material for analyzing fluids which is elastic and allows radial lateral movement of sample within the substrate material upon application of pressure.
摘要翻译：本发明涉及一种用于分析弹性的流体的基底材料，并且在施加压力时允许样品在基底材料内的径向横向移动。

5. 发明授权

US09675291B2 Modifying a psychophysiological state of a subject 有权
公开(公告)号：US09675291B2
公开(公告)日：2017-06-13
申请号：US12920879
申请日：2009-03-06
申请人： Ralph Braspenning , Mark Thomas Johnson , Ronaldus Maria Aarts
发明人： Ralph Braspenning , Mark Thomas Johnson , Ronaldus Maria Aarts
IPC分类号： A61B5/16 , A61B5/024 , A61B5/0452
CPC分类号： A61B5/16 , A61B5/02405 , A61B5/0452 , A61B5/165
摘要： An apparatus and method for modifying a psychophysiological state of a subject include detecting a psychophysiological measure of the subject; processing the detected physiological measure so as to provide a signal indicative of a psychophysiological state of the subject; and outputting at least one of an audio stimulus, visual stimulus, haptic stimulus, temperature stimulus and scent stimulus to the subject. The output stimulus may be derived from an audio-visual data signal provided to the apparatus. Further, the output stimulus is adjusting in real time based on the signal indicative of a psychophysiological state of the subject.

6. 发明授权

US09610035B2 Method and system for maintaining a state in a subject 有权
公开(公告)号：US09610035B2
公开(公告)日：2017-04-04
申请号：US12920876
申请日：2009-03-05
申请人： Ronaldus Maria Aarts , Mark Thomas Johnson
发明人： Ronaldus Maria Aarts , Mark Thomas Johnson
IPC分类号： A61M21/00 , A61B5/18 , A61B5/0205 , A61B5/024 , A61B5/0245 , A61B5/0456 , A61B5/16 , A61B5/00
CPC分类号： A61B5/18 , A61B5/0205 , A61B5/02405 , A61B5/0245 , A61B5/0456 , A61B5/165 , A61B5/486 , A61M21/00 , A61M2021/0022 , A61M2021/0055 , A61M2021/0066 , A61M2021/0083 , A61M2230/06 , A61M2230/42 , G06F19/00
摘要： A method of maintaining a state in a subject includes measuring one or more physiological parameters of the subject, calculating, using the measured parameter(s), a value, determining if the calculated value is below a lower threshold or above an upper threshold, and generating an output to the subject if the calculated value is determined to be below the lower threshold or above the upper threshold. In one embodiment, the generating an output to the subject includes generating a first output if the calculated value is determined to be below the lower threshold and generating a second output if the calculated value is determined to be above the upper threshold, the second output being different from the first output.

7. 发明授权

US08982041B2 Moving particle display device with intermediate drive electrode 有权
标题翻译：具有中间驱动电极的移动颗粒显示装置
公开(公告)号：US08982041B2
公开(公告)日：2015-03-17
申请号：US12377606
申请日：2007-07-30
申请人： Mark Thomas Johnson , Franciscus Paulus Maria Budzelaar , Murray Fulton Gillies
发明人： Mark Thomas Johnson , Franciscus Paulus Maria Budzelaar , Murray Fulton Gillies
IPC分类号： G09G3/34 , G09G5/00 , G09G5/10 , G02F1/167 , G02F1/1343
CPC分类号： G02F1/167 , G02F1/134363 , G09G3/3446 , G09G2300/0434 , G09G2320/0252
摘要： A display device and a method for driving the display device is disclosed. The display device comprises drive circuitry (35) and a plurality of pixels (PIX1, PIX2, PIX3, PIX4, PIX5, PIX6) having movable charged particles (116). The drive circuitry is configured to apply control signals to the pixels to move the charged particles between first (110) and second (112) regions of each pixel in order to alter the optical appearance of each pixel. The method for each pixel comprises a pre-addressing stage (PRA) of moving the charged particles towards the boundary (114) between the first and second regions, and then an addressing stage (ADD) of moving the particles to one side or the other side of the boundary, in dependence on the desired optical appearance of the pixel.
摘要翻译：公开了一种用于驱动显示装置的显示装置和方法。显示装置包括具有可移动带电粒子（116）的驱动电路（35）和多个像素（PIX1，PIX2，PIX3，PIX4，PIX5，PIX6）。驱动电路被配置为向像素施加控制信号以将带电粒子移动到每个像素的第一（110）和第二（112）区域之间，以改变每个像素的光学外观。每个像素的方法包括将带电粒子移动到第一和第二区域之间的边界（114）的预寻址级（PRA），然后将粒子移动到一侧或另一侧的寻址级（ADD）边界，这取决于像素的期望的光学外观。

8. 发明授权

US08323570B2 Microelectronic sensor device with sensor array 有权
标题翻译：带传感器阵列的微电子传感器
公开(公告)号：US08323570B2
公开(公告)日：2012-12-04
申请号：US12293573
申请日：2007-03-01
申请人： Mark Thomas Johnson , Hendrikus Alfonsus Roelof Stapert , Marc Wilhelmus Gijsbert Ponjee
发明人： Mark Thomas Johnson , Hendrikus Alfonsus Roelof Stapert , Marc Wilhelmus Gijsbert Ponjee
IPC分类号： G01N33/00
CPC分类号： B01L3/50273 , B01L3/5027 , B01L3/502792 , B01L7/52 , B01L2200/147 , B01L2300/0645 , B01L2300/0816 , B01L2300/0819 , B01L2300/1827 , B01L2300/1883 , B01L2400/0406 , B01L2400/0415 , B01L2400/0442 , B01L2400/0448
摘要： The invention relates to different designs of a microelectronic sensor device comprising an array of heating elements (HE) and an array of sensor elements (SE) that are aligned with respect to each other adjacent to a sample chamber (SC). By applying appropriate currents to the heating elements (HE), the sample chamber can be heated according to a desired temperature profile.
摘要翻译：本发明涉及微电子传感器装置的不同设计，该微电子传感器装置包括相对于彼此相邻于样品室（SC）对准的加热元件（HE）阵列和传感器元件阵列（SE）。通过向加热元件（HE）施加适当的电流，可以根据期望的温度分布来加热样品室。

9. 发明授权

US08300006B2 Electrophoretic display unit 有权
标题翻译：电泳显示单元
公开(公告)号：US08300006B2
公开(公告)日：2012-10-30
申请号：US10574146
申请日：2004-09-27
申请人： Guofu Zhou , Masaru Yasui , Mark Thomas Johnson , Robert Waverly Zehner , Karl Raymond Amundson
发明人： Guofu Zhou , Masaru Yasui , Mark Thomas Johnson , Robert Waverly Zehner , Karl Raymond Amundson
IPC分类号： G09G3/34 , G09G3/36 , G09G5/00 , G06F3/038 , G02B26/00
CPC分类号： G09G3/344 , G09G2300/08 , G09G2310/0251 , G09G2310/061 , G09G2320/0204 , G09G2320/0252 , G09G2330/04
摘要： Electrophoretic display units (1) comprising pixels (11) situated between common electrodes (6) and pixel electrodes (5) need, for shortening the total image update times, increased driving voltages across the pixels (11) which endanger transistors (12) coupled to the pixel electrodes (5). These increased driving voltage (V6) to the common electrode (6). To protect the transistors (12) against these increased driving voltages, a setting signal (S1, S2) is supplied to the pixel electrode (5) via the transistor (12) for reducing a voltage across the pixel (11) resulting from a transition in the alternating voltage signal (V6). During driving frame periods (Fd) data pulses (D1, D2, D3, D4, D5, D6) are supplied, and during setting frame periods (Fs), the setting signals (S1, S2) are supplied.
摘要翻译：包括位于公共电极（6）和像素电极（5）之间的像素（11）的电泳显示单元（1）需要用于缩短总的图像更新时间，跨越像素（11）的增加的驱动电压，其使得耦合的晶体管（12）到像素电极（5）。这些增加到公共电极（6）的驱动电压（V6）。为了保护晶体管（12）抵抗这些增加的驱动电压，经由晶体管（12）将设置信号（S1，S2）提供给像素电极（5），用于降低由转变导致的像素（11）两端的电压在交流电压信号（V6）中。在驱动帧周期（Fd）数据脉冲（D1，D2，D3，D4，D5，D6）期间被提供，并且在设置帧周期（Fs）期间，提供设置信号（S1，S2）。

10. 发明申请

US20110292026A1 Display Apparatus with a Display Device and Method of Driving the Display Device 失效
标题翻译：具有显示装置的显示装置和驱动显示装置的方法
公开(公告)号：US20110292026A1
公开(公告)日：2011-12-01
申请号：US13205303
申请日：2011-08-08
申请人： Mark Thomas Johnson
发明人： Mark Thomas Johnson
IPC分类号： G09G5/00
CPC分类号： G09G3/3446 , G09G3/2018 , G09G2300/08 , G09G2320/0204 , G09G2320/041
摘要： A display apparatus (1) comprises a matrix display device (DD) with pixels (10) wherein particles (14) move in a fluid (13) between electrodes (6, 6′, 7). An optical state of the pixels (10) is defined by a value of a drive voltage (VDi) and a duration (Di) of a drive period (TDi) during which the drive voltage (VDi) is present across the pixel (10). A DC-balancing circuit (3) controls the amplitudes of the drive voltages (VDi) and/or durations (Di) of drive periods (TDi) to obtain a substantially zero time-average value (N) across each pixel (10) or across each sub-group of pixels. This control of the amplitude of the drive voltages (VDi) and/or the duration (Di) of the drive periods (TDi) allows minimizing the image retention, without requiring reset pulses causing all pixels (10) to become temporarily white or black. In a preferred embodiment in accordance with the invention, a display device (DD) is used in which a drive voltage (VDi) is supplied to the pixel (10) with a level such that the grey level (or the amount of colorization) does not change anymore after an initial period of time. Now, if applicable, the DC-balancing can be performed by making the duration (Di) of the drive periods (TDi) longer than the initial period of time.
摘要翻译：显示装置（1）包括具有像素（10）的矩阵显示装置（DD），其中颗粒（14）在电极（6,6'，7）之间的流体（13）中移动。像素（10）的光学状态由驱动电压（VDi）的值和跨越像素（10）存在驱动电压（VDi）的驱动周期（TDi）的持续时间（Di）定义，。直流平衡电路（3）控制驱动周期（TDi）的驱动电压（VDi）和/或持续时间（Di）的振幅，以获得跨越每个像素（10）的基本上为零的时间平均值（N）或跨越每个子像素组。对驱动周期（TDi）的驱动电压（VDi）和/或持续时间（Di）的幅度的这种控制允许使图像保持最小化，而不需要使所有像素（10）变得暂时白色或黑色的复位脉冲。在根据本发明的优选实施例中，使用显示装置（DD），其中以像素（10）的方式将驱动电压（VDi）提供给灰度级（或着色量）在最初的时间之后不再改变。现在，如果适用，可以通过使驱动周期（TDi）的持续时间（Di）长于初始时间段来执行直流平衡。

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