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1. 发明授权

US08012736B2 Multi plasmid system for the production of influenza virus 有权
标题翻译：用于生产流感病毒的多质粒系统
公开(公告)号：US08012736B2
公开(公告)日：2011-09-06
申请号：US10423828
申请日：2003-04-25
申请人： Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
发明人： Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
IPC分类号： C12N7/02
CPC分类号： A61K39/145 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N15/86 , C12N15/87 , C12N2760/16122 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16243 , C12N2760/16262
摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
摘要翻译：提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。提供了用于多质粒流感病毒表达系统的双向表达载体。

2. 发明授权

US08722059B2 Multi plasmid system for the production of influenza virus 有权
标题翻译：用于生产流感病毒的多质粒系统
公开(公告)号：US08722059B2
公开(公告)日：2014-05-13
申请号：US13214110
申请日：2011-08-19
申请人： Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
发明人： Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
IPC分类号： A61K39/145 , C12N7/00 , C12N7/04
CPC分类号： A61K39/145 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N15/86 , C12N15/87 , C12N2760/16122 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16243 , C12N2760/16262
摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
摘要翻译：提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。提供了用于多质粒流感病毒表达系统的双向表达载体。

3. 发明申请

US20120020997A1 MULTI PLASMID SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS 有权
标题翻译：用于生产流感病毒的多级PLASMID系统
公开(公告)号：US20120020997A1
公开(公告)日：2012-01-26
申请号：US13214110
申请日：2011-08-19
申请人： Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
发明人： Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
IPC分类号： A61K39/145 , C12N7/04 , C12N7/00 , C07K14/11 , C40B40/08 , C12N5/00 , C12N7/01 , C07H21/04 , C12N7/02 , C12N15/86
CPC分类号： A61K39/145 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N15/86 , C12N15/87 , C12N2760/16122 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16243 , C12N2760/16262
摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
摘要翻译：提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。提供了用于多质粒流感病毒表达系统的双向表达载体。

4. 发明申请

US20090175907A1 Multi Plasmid System For The Production Of Influenza Virus 有权
标题翻译：用于生产流感病毒的多质粒体系
公开(公告)号：US20090175907A1
公开(公告)日：2009-07-09
申请号：US12254131
申请日：2008-10-20
申请人： Erich Hoffman , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
发明人： Erich Hoffman , Hong Jin , Bin Lu , Gregory Duke , George Kemble , Zhongying Chen
IPC分类号： A61K39/145 , C12N7/01 , C12N15/74 , A61P31/16
CPC分类号： C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
摘要翻译：提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。提供了用于多质粒流感病毒表达系统的双向表达载体。另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。

5. 发明授权

US4450116A 3-Oxypropyleneimino-bis-(methylene phosphonic acids) and their salts, process for their manufacture and their use 失效
标题翻译： 3-氧亚丙基亚氨基 - 双（亚甲基膦酸）及其盐，用于制造和使用它们
公开(公告)号：US4450116A
公开(公告)日：1984-05-22
申请号：US398097
申请日：1982-07-14
申请人： Hans-Joachim Morawietz , Erich Hoffman , Johann Hanauer , Kurt Bauer
发明人： Hans-Joachim Morawietz , Erich Hoffman , Johann Hanauer , Kurt Bauer
IPC分类号： B03D1/001 , B03D1/014 , C07F9/38 , C07F9/40 , C07F9/36 , C22B1/00
CPC分类号： C07F9/3817 , B03D1/014 , B03D2201/02 , B03D2203/04
摘要： 3-Alkoxypropylenimino-bis-(methylene phosphonic acids) of the formula ##STR1## wherein R is straight-chain or branched alkyl or alkenyl each having from 2 to 20, preferably 2 to 10, carbon atoms, aryl, preferably phenyl or aralkyl, preferably benzyl, and X is hydrogen, an alkali metal, alkaline earth metal, ammonium, alkylammonium or polyalkylenepolyammonium ion, preferably a sodium, potassium or ammonium ion, a process for their manufacture and their use as collector in the flotation of non-sulfidic ores.
摘要翻译：其中R是直链或支链的烷基或链烯基，各自具有2至20个，优选2至10个碳原子，芳基，优选苯基或芳烷基，优选苯基或芳烷基，优选苄基，X为氢，碱金属，碱土金属，铵，烷基铵或聚亚烷基多铵离子，优选钠，钾或铵离子，其制备方法及其作为非硫化矿石浮选中的收集剂。

6. 发明授权

US4835367A Portable electric radiant fan heater utilizing ceramic panel shielded halogen lamp 失效
标题翻译：便携式电辐射风扇加热器采用陶瓷面板屏蔽卤素灯
公开(公告)号：US4835367A
公开(公告)日：1989-05-30
申请号：US50612
申请日：1987-05-15
申请人： Erich Hoffman
发明人： Erich Hoffman
IPC分类号： F24H3/04
CPC分类号： F24H3/0417
摘要： A portable fan heater wherein the housing has a front opening in register with a ceramic panel which transmits infrared radiation. The panel is located in front of one or more halogen lamps, such as quartz lamps, whose radiation is directed toward the panel by a reflector having a concave side facing the lamp or lamps and having its center of curvature in or close to the panel. One lamp (or the single lamp) is located at the focal point of the reflector. The housing contains a rotary fan which is driven by an electric motor and serves to convey currents of air from several inlets in the rear wall of the housing toward and into the opening. The currents flow through constricted channels which are defined by the outer side of the reflector and the adjacent inwardly convexly curved walls of the housing.
摘要翻译：一种便携式风扇加热器，其中壳体具有与透射红外辐射的陶瓷面板对准的前开口。面板位于一个或多个卤素灯的前面，例如石英灯，其辐射通过具有面向灯或灯的凹面的反射器朝向面板，并且其曲率中心在面板中或靠近面板。一个灯（或单个灯）位于反射器的焦点处。壳体包含由电动机驱动的旋转风扇，用于将空气的流动从壳体的后壁中的多个入口传送到开口中。电流流过由反射器的外侧和壳体的相邻的向内凸出的弯曲壁限定的收缩通道。

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