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1. 发明申请

US20050124667A1 Oxamide inhibitors of plasminogen activator inhibitor-1 审中-公开
标题翻译：纤溶酶原激活物抑制剂的氧酰胺抑制剂1
公开(公告)号：US20050124667A1
公开(公告)日：2005-06-09
申请号：US10969480
申请日：2004-10-20
申请人： Eric Sartori , Magali Maillet , Marie Paugam , Eric Nicolai , Michael Lawrence , Karnail Atwal
发明人： Eric Sartori , Magali Maillet , Marie Paugam , Eric Nicolai , Michael Lawrence , Karnail Atwal
IPC分类号： A61K31/165 , A61K31/277 , A61K31/325 , A61K31/4172 , A61K31/455
CPC分类号： A61K31/165 , A61K31/277 , A61K31/325 , A61K31/4172 , A61K31/455
摘要： Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula at least one compound of formula (I), or a pharmaceutically-acceptable salt, prodrug, stereoismer or solvate thereof, wherein: A is aryl or heteroaryl, X is O or S, and R1-R9 and R18 are defined herein. The invention also pertains to pharmaceutical compositions and compounds within the scope of formula (I) as well as medicaments and articles of manufacture comprising compounds of formula (I).
摘要翻译：公开了治疗与升高的PAI-1水平相关的疾病的方法，包括向有需要的患者施用治疗有效量的至少一种式至少一种式（I）化合物或其药学上可接受的盐，前体药物，立体异构体或溶剂化物，其中：A是芳基或杂芳基，X是O或S，R 1 -R 9和R 18 >在本文中定义。本发明还涉及式（I）范围内的药物组合物和化合物以及包含式（I）化合物的药物和制品。

2. 发明申请

US20050124664A1 Urea thiadiazole inhibitors of plasminogen activator inhibior-1 审中-公开
标题翻译：尿素噻二唑抑制剂纤溶酶原激活物抑制剂-1
公开(公告)号：US20050124664A1
公开(公告)日：2005-06-09
申请号：US10969703
申请日：2004-10-20
申请人： Eric Sartori , Magali Maillet , Marie Paugam , Eric Nicolai , Michael Lawrence
发明人： Eric Sartori , Magali Maillet , Marie Paugam , Eric Nicolai , Michael Lawrence
IPC分类号： A61K31/433 , A61K31/4439 , C07D285/12 , C07D285/135 , C07D405/12 , C07D417/12 , C07D471/04 , C07D417/02
CPC分类号： C07D285/135 , A61K31/433 , A61K31/4439 , C07D405/12 , C07D417/12 , C07D471/04
摘要： Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula (I), or a pharmaceutically-acceptable salt, prodrug, stereoisomer or solvate thereof, wherein: A is aryl o heteroaryl, and R1-R12, are defined herein. The invention also pertains to pharmaceutical compositions and compounds within the scope of formula (I) as well as medicaments and articles of manufacture comprising compounds of formula (I).
摘要翻译：公开了治疗与升高的PAI-1水平相关的疾病的方法，包括向有需要的患者施用治疗有效量的至少一种式（I）化合物或其药学上可接受的盐，前药，立体异构体或溶剂化物，其中：A是芳基o杂芳基，R 1 -R 12，在本文中定义。本发明还涉及式（I）范围内的药物组合物和化合物以及包含式（I）化合物的药物和制品。

3. 发明申请

US20050143384A1 Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 审中-公开
标题翻译：纤溶酶原激活物抑制剂-1的酰胺噻二唑抑制剂
公开(公告)号：US20050143384A1
公开(公告)日：2005-06-30
申请号：US10969692
申请日：2004-10-20
申请人： Eric Sartori , Magali Maillet , Marie Paugam , Eric Nicolai , Michael Lawrence
发明人： Eric Sartori , Magali Maillet , Marie Paugam , Eric Nicolai , Michael Lawrence
IPC分类号： A61K31/433 , A61K31/4439 , A61K31/501 , A61K31/60 , C07D285/12 , C07D285/135 , C07D417/12 , C07D417/02 , C07D285/14
CPC分类号： C07D285/135 , A61K31/433 , A61K31/4439 , A61K31/501 , A61K31/60 , C07D417/12 , A61K2300/00
摘要： Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula at least one compound of formula (I), or a pharmaceutically-acceptable salt, prodrug, stereoisomer or solvate thereof, wherein: A is aryl or heteroaryl and R1—R11, are defined herein. The invention also pertains to pharmaceutical compositions and compounds within the scope of formula (I) as well as medicaments and articles of manufacture comprising compounds of formula (I).
摘要翻译：公开了治疗与升高的PAI-1水平相关的疾病的方法，包括向有需要的患者施用治疗有效量的至少一种式至少一种式（I）化合物或其药学上可接受的盐，前药，立体异构体或其溶剂合物，其中：A是芳基或杂芳基，R 1 -R 11是在本文中定义的。本发明还涉及式（I）范围内的药物组合物和化合物以及包含式（I）化合物的药物和制品。

4. 发明申请

US20130318862A1 PEST CONTROL APPARATUS AND PROCESS OF MANUFACTURE 有权
标题翻译：虫控制装置及其制造工艺
公开(公告)号：US20130318862A1
公开(公告)日：2013-12-05
申请号：US13909879
申请日：2013-06-04
申请人： Michael Lawrence , Ernest Netter , Cheyne Detwiler
发明人： Michael Lawrence , Ernest Netter , Cheyne Detwiler
IPC分类号： A01M1/10 , A01M1/20
CPC分类号： A01M1/2016 , A01G13/10 , A01M1/02 , A01M1/106 , A01M1/2055
摘要： An environmentally friendly apparatus to attract and kill insect pests is described. The apparatus includes two panels, which could be made from one folded sheet, coupled together to form a housing for a pad containing an insect attractant, e.g. a pheromone. The outer surface of the housing has a plurality of louvered vents for dispersion of the scent from the attractant to the environment thus attracting the insect pest. The apparatus is configured to be capable of being on a fruit tree.
摘要翻译：描述了一种吸引和杀虫害虫的环保设备。该装置包括两个面板，其可以由一个折叠的片材制成，联接在一起以形成用于包含昆虫引诱剂的垫的外壳，例如，信息素壳体的外表面具有多个百叶窗通气口，用于将气味从引诱剂分散到环境中，从而吸引害虫。该装置被配置成能够在果树上。

5. 发明授权

US07892188B2 Method and apparatus for characterization of clot formation 有权
标题翻译：用于表征血块形成的方法和装置
公开(公告)号：US07892188B2
公开(公告)日：2011-02-22
申请号：US10971178
申请日：2004-10-22
申请人： William F. Walker , Michael Lawrence , Francesco Viola , Margaret D. Kramer
发明人： William F. Walker , Michael Lawrence , Francesco Viola , Margaret D. Kramer
IPC分类号： A61B5/103 , A61B5/117 , A61B5/00 , A61B8/00
CPC分类号： A61B5/02028 , A61B5/0048 , A61B8/08 , A61B8/485 , G01N29/11 , G01N29/343 , G01N2291/02466 , G01N2291/02475 , G01N2291/02827 , G01N2291/044
摘要： Methods, apparatus and systems for characterizing changes in at least one physical property of soft tissue. A series of acoustic pulses is generated and directed into the soft tissue such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the tissue. Waves reflected off the tissue, or a flexible member that moves with the tissue, are received and measured to estimate at least one characteristic of the physical displacement induced thereby. Repetition of the generating, receiving and estimating steps provides characterization of the at least one physical property over time. Methods, apparatus and systems for characterizing at least one physical property of blood, by generating a series of acoustic pulses and directing the series of pulses into the blood such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the blood. Acoustic pulses and/or optical waves reflected from the blood, or a flexible member in contact with the blood that moves with the blood, are received and measured to estimate at least one characteristic of the physical displacement induced thereby.
摘要翻译：用于表征软组织的至少一种物理性质的变化的方法，装置和系统。产生一系列声脉冲并引导到软组织中，使得至少一个脉冲具有足够高的强度以引起组织的物理位移。从组织反射的波或与组织一起移动的柔性构件被接收和测量以估计由此引起的物理位移的至少一个特征。生成，接收和估计步骤的重复提供了至少一种物理特性随时间的表征。用于表征血液的至少一种物理性质的方法，装置和系统，通过产生一系列声脉冲并将一系列脉冲引导到血液中，使得脉冲中的至少一个具有足够高的强度以引起血液的物理位移血液。接收和测量从血液反射的声波脉冲和/或光波，或与血液一起移动的血液接触的柔性部件，以估计由此引起的物理位移的至少一个特性。

6. 发明申请

US20070099232A1 Ecdysone receptor ligand-binding domain structure 审中-公开
标题翻译：蜕皮激素受体配体结合域结构
公开(公告)号：US20070099232A1
公开(公告)日：2007-05-03
申请号：US10558231
申请日：2004-05-27
申请人： Michael Lawrence , Patricia Pilling , George Lovrecz , Vidana Epa , Jennifer Camichael , Leonie Noyce , Lloyd Graham , Garry Hannan , David Winkler , Ronald Hill
发明人： Michael Lawrence , Patricia Pilling , George Lovrecz , Vidana Epa , Jennifer Camichael , Leonie Noyce , Lloyd Graham , Garry Hannan , David Winkler , Ronald Hill
IPC分类号： G01N33/53
CPC分类号： C07K14/43563 , A01N43/50 , A01N43/76 , A01N43/82 , A01N63/00 , C07H21/02 , C07H21/04 , C07K2299/00
摘要： The present invention relates to structural studies of the functional insect ecdysone receptor. More particularly, the invention relates to the crystal structure of the whitefly ecdysone receptor ligand-binding domain, specifically that of Bemisia tabaci, and uses of the crystal and related structural information to select and screen for compounds that interact with the receptor.
摘要翻译：本发明涉及功能性昆虫蜕皮激素受体的结构研究。更具体地，本发明涉及粉虱蜕皮激素受体配体结合结构域的晶体结构，特别是烟粉虱的晶体结构，以及晶体和相关结构信息的使用来选择和筛选与受体相互作用的化合物。

7. 发明申请

US20060113810A1 Modular overhead console assembly for a vehicle 审中-公开
标题翻译：用于车辆的模块化顶置式控制台组件
公开(公告)号：US20060113810A1
公开(公告)日：2006-06-01
申请号：US10999436
申请日：2004-11-30
申请人： Richard Kuhl , Edward Adams , Martin Kern , George Vidican , Michael Lawrence
发明人： Richard Kuhl , Edward Adams , Martin Kern , George Vidican , Michael Lawrence
IPC分类号： B60R7/04
CPC分类号： B60R11/00 , B60R7/04 , B60R11/02 , B60R2011/0028 , B60R2011/0075 , B60R2011/0084
摘要： A modular overhead console assembly adapted to be mounted to a roof of a vehicle within a passenger compartment of the vehicle. The modular overhead console assembly includes a rail that has a rail base and a rail head extending from the rail base, wherein a track is defined between the rail head and the rail base. The modular overhead console assembly further includes a movable module that slidably mounts to the rail along at least a portion of the length thereof. The movable module includes a base having a portion thereof extending into the track.
摘要翻译：一种适于安装在车辆的乘客舱内的车辆的屋顶上的模块化的顶棚控制台组件。模块化顶置式控制台组件包括轨道，该轨道具有轨道基座和从轨道基座延伸的轨道头部，其中轨道限定在轨道头部和轨道基座之间。模块化顶置式控制台组件还包括可移动模块，其沿其长度的至少一部分可滑动地安装到轨道。可移动模块包括具有延伸到轨道中的一部分的底座。

8. 发明申请

US20140041348A1 ACCESSORY CAP FOR A RESPIRATORY FILTER CARTRIDGE 有权
标题翻译：呼吸过滤器盒附件
公开(公告)号：US20140041348A1
公开(公告)日：2014-02-13
申请号：US13568524
申请日：2012-08-07
申请人： Michael Lawrence , Joseph Rodrigues
发明人： Michael Lawrence , Joseph Rodrigues
IPC分类号： B01D46/42
CPC分类号： A62B23/02 , A62B18/08 , A62B19/00
摘要： An accessory cap for a respiratory cartridge includes a housing having a front wall and a side wall which cooperate to define an interior cavity. The side wall includes a retaining formation configured and arranged to releasably engage and hold the housing on the respiratory cartridge. The housing includes a downwardly facing air passage configured to allow air to pass from an exterior environment to the interior cavity. The accessory cap further includes a pre-filter support web removably received within the interior cavity and spaced inwardly from the front wall. The housing and the pre-filter support web form a pre-filter cavity within the interior cavity adjacent to the front wall. The accessory cap can function as a standalone shower cap, or a pre-filter media can be optionally inserted into the pre-filter cavity so that the accessory cap functions as a combination pre-filter and a shower cap.
摘要翻译：用于呼吸筒的附件盖包括具有前壁和侧壁的壳体，其配合以限定内腔。侧壁包括构造和布置成可释放地接合和保持壳体在呼吸盒上的保持结构。壳体包括面向下的空气通道，其构造成允许空气从外部环境传递到内部空腔。附件盖还包括可移除地容纳在内部空腔内并与前壁向内间隔开的预过滤器支撑腹板。壳体和预过滤器支撑腹板在邻近前壁的内腔内形成预过滤腔。附件盖可以用作独立的淋浴帽，或者可以将预过滤介质可选地插入预过滤器空腔中，使得附件盖用作组合预过滤器和淋浴帽。

9. 发明申请

US20060165466A1 Method for controlling media feed in an imaging apparatus 有权
公开(公告)号：US20060165466A1
公开(公告)日：2006-07-27
申请号：US11041542
申请日：2005-01-24
申请人： Michael Lawrence , Michael Marra , Barry Stout , Jay Vessels , John Writt
发明人： Michael Lawrence , Michael Marra , Barry Stout , Jay Vessels , John Writt
IPC分类号： B41J11/42
CPC分类号： B41J29/38 , B41J11/42
摘要： A method for controlling the media feed of a print media sheet in an imaging apparatus having a media feed roller includes selecting between using absolute positioning of the media feed roller and relative positioning of the media feed roller for various media feed roller moves.

10. 发明申请

US20060071390A1 Speed mode for printer media transport 有权
标题翻译：打印机媒体传输速度模式
公开(公告)号：US20060071390A1
公开(公告)日：2006-04-06
申请号：US10917097
申请日：2004-08-12
申请人： Kevin Johnson , Michael Lawrence , Barry Stout
发明人： Kevin Johnson , Michael Lawrence , Barry Stout
IPC分类号： B65H5/00
CPC分类号： B65H3/0669 , B65H5/06 , B65H2403/422 , B65H2405/332 , B65H2801/12
摘要： A speed mode for a printer (1) which has a pivotally mounted autocompensating system (19) mounted at an intermediate position in paper guide (17). That system (19) is driven by a motor (40) through a slip drive (70, 72, 74). The motor also drives paper feed system (15). When the motor turns in a direction to feed by system (15), the intermediate system is moved away from the paper guide. In basic operation, when a sheet (5) reaches a position to be fed by the intermediate system, the motor is reversed, and the intermediate system pivots against the paper for moving it further through the paper guide. In the speed mode the intermediate system is not employed and all of the feed is by the system at the tray. Since this will not feed shorter sheets, preferably the speed mode must be positively invoked, as by operator input or definitive information in the header of a print job.
摘要翻译：一种用于打印机（1）的速度模式，其具有安装在纸张引导件（17）中的中间位置的可枢转地安装的自动补偿系统（19）。该系统（19）由马达（40）通过滑动驱动（70,72,74）驱动。电机还驱动送纸系统（15）。当电机沿着由系统（15）馈送的方向转动时，中间系统从导纸器移开。在基本操作中，当纸张（5）到达要由中间系统供给的位置时，电动机反向，中间系统相对于纸张枢转，以使纸张进一步移动通过纸张导板。在速度模式下，不使用中间系统，并且所有进给都由系统在托盘处。由于这不会进给较短的纸张，所以优选的速度模式必须被正确地调用，如打印作业的标题中的操作者输入或确定信息。

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