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1. 发明申请

US20160229839A1 Factor XIa Inhibitors 审中-公开
标题翻译：因子XIa抑制剂
公开(公告)号：US20160229839A1
公开(公告)日：2016-08-11
申请号：US15023833
申请日：2014-09-23
申请人： Eric Mertz , Scott D. Edmondson , Ning Shao , Santhosh Neelamkavil , Corey Poker , Zahid Hussain , Zhuyan Guo , Nancy Jo Kevin , Yi Zang , Jiafang He
发明人： Eric Mertz , Scott D. Edmondson , Ning Shao , Santhosh Neelamkavil , Corey Poker , Zahid Hussain , Zhuyan Guo , Nancy Jo Kevin , Yi Zang , Jiafang He
IPC分类号： C07D401/14 , A01N1/02 , C07D401/06 , C07D401/10 , C07D211/60
CPC分类号： C07D401/14 , A01N1/0226 , C07D211/60 , C07D401/06 , C07D401/10 , C12N9/6443 , C12Y304/21027
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译：本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。

2. 发明申请

US20160257668A1 Factor XIa Inhibitors 审中-公开
公开(公告)号：US20160257668A1
公开(公告)日：2016-09-08
申请号：US15027086
申请日：2014-10-06
申请人： Ning SHAO , Scott D. EDMONDSON , Santhosh NEELAMKAVIL , Zhuyan GUO , Eric MERTZ , Yi ZANG , Jiafang HE
发明人： Ning Shao , Scott D. Edmondson , Santhosh Neelamkavil , Zhuyan Guo , Eric Mertz , Yi Zang , Jiafang He
IPC分类号： C07D401/14 , C07C269/06 , C07D401/10
CPC分类号： C07D401/14 , C07C269/06 , C07D401/04 , C07D401/10 , C07D413/14
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

3. 发明授权

US08346439B2 Safety method and device for vehicle rollover prediction using estimated lateral vehicle velocity 有权
标题翻译：使用估计侧向车速的车辆翻车预测的安全方法和装置
公开(公告)号：US08346439B2
公开(公告)日：2013-01-01
申请号：US12565882
申请日：2009-09-24
申请人： Robert Andres , Patrick Messi , Eric Mertz , Holger Faisst
发明人： Robert Andres , Patrick Messi , Eric Mertz , Holger Faisst
IPC分类号： B60R21/0132
CPC分类号： B60R21/0133 , B60R21/0132 , B60R21/01336 , B60R2021/0018 , B60R2021/01327
摘要： A system and method of activating a restraint system of a vehicle is described. The method includes generating a vehicle speed signal that represents a longitudinal speed of a vehicle, generating a lateral acceleration signal that represents a lateral acceleration of the vehicle, filtering the lateral acceleration signal to generate a filtered lateral acceleration signal, comparing the filtered lateral acceleration signal to a predetermined lateral acceleration enable threshold, estimating a lateral speed of the vehicle based on the vehicle speed signal when the filtered lateral acceleration exceeds the predetermined lateral acceleration enable threshold, and activating a restraint system of the vehicle based in part on the estimated lateral velocity.
摘要翻译：描述了启动车辆的约束系统的系统和方法。该方法包括生成表示车辆的纵向速度的车速信号，产生表示车辆的横向加速度的横向加速度信号，对横向加速度信号进行滤波，生成滤波后的横向加速度信号，将滤波后的横向加速度信号到预定的横向加速启用阈值，当所述经过滤的横向加速度超过所述预定的横向加速使能阈值时，基于所述车辆速度信号估计所述车辆的横向速度，并且部分地基于所估计的横向速度来启动所述车辆的约束系统。

4. 发明授权

US08124629B2 Naphthylacetic acids 失效
标题翻译：萘乙酸
公开(公告)号：US08124629B2
公开(公告)日：2012-02-28
申请号：US12614478
申请日：2009-11-09
申请人： Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
发明人： Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
IPC分类号： A61K31/44 , A61K31/192 , C07D211/54 , C07C63/64
CPC分类号： C07D295/26 , C07C57/58 , C07C59/68 , C07C69/76 , C07C255/57 , C07C311/16 , C07C311/29 , C07C317/44 , C07C317/46 , C07C323/62 , C07D231/12 , C07D239/26 , C07D257/04 , C07D317/70
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐和酯，其中X，Q和R 1 -R 6在详细描述和权利要求书中定义。此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。式I化合物是CRTH2受体的拮抗剂或部分激动剂，可用于治疗与该受体相关的疾病和病症，例如哮喘。

5. 发明申请

US20070007066A1 Peak load detection determination for deploying load limiting restraint devices 审中-公开
标题翻译：用于部署负载限制约束装置的峰值负载检测确定
公开(公告)号：US20070007066A1
公开(公告)日：2007-01-11
申请号：US11474812
申请日：2006-06-26
申请人： Eric Mertz
发明人： Eric Mertz
IPC分类号： B60R21/00 , E05F15/00 , B60K28/14
CPC分类号： B60R21/0132 , B60R21/01512 , B60R21/01516 , B60R21/01554 , B60R2021/01279 , B60R2021/01315
摘要： A method of operating a load limiting restraint system including the steps of receiving an acceleration value and also receiving a signal indicative of an occupant size. The signal received of occupant size is combined with the acceleration value to predict a load on the occupant and the restraint system. If the predicted load exceeds a predicted load value then the load limiting device is actuated to gradually reduce and selectively release the seatbelt.
摘要翻译：一种操作负载限制约束系统的方法，包括以下步骤：接收加速度值并且还接收指示乘员大小的信号。接收乘员大小的信号与加速度值组合，以预测乘员和约束系统的负荷。如果预测的载荷超过预测的载荷值，则负载限制装置被致动以逐渐减小并选择性地释放安全带。

6. 发明申请

US20130018043A1 AMINOMETHYL QUINOLONE COMPOUNDS 有权
标题翻译：氨基喹啉酮化合物
公开(公告)号：US20130018043A1
公开(公告)日：2013-01-17
申请号：US13546039
申请日：2012-07-11
申请人： Joseph A. Bilotta , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Stuart Hayden , Nancy-Ellen Haynes , Christine M. Lukacs-Lesburg , Nicholas Marcopulos , Eric Mertz , Lida Qi , Yimin Qian , Sung-Sau So , Jenny Tan , Kshitij C. Thakkar
发明人： Joseph A. Bilotta , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Stuart Hayden , Nancy-Ellen Haynes , Christine M. Lukacs-Lesburg , Nicholas Marcopulos , Eric Mertz , Lida Qi , Yimin Qian , Sung-Sau So , Jenny Tan , Kshitij C. Thakkar
IPC分类号： C07D413/14 , A61K31/5377 , C07D471/04 , A61K31/4375 , C07D401/14 , A61K31/55 , A61K31/551 , A61P29/00 , A61P11/06 , A61P3/10 , A61P25/28 , A61P25/16 , A61P9/10 , A61P35/00 , A61P35/02 , A61P13/12 , A61K31/4709
CPC分类号： C07D215/48 , C07D215/233 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein the variables are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
摘要翻译：本发明涉及JNK抑制剂和用于抑制JNK和治疗JNK介导的病症的相应方法，制剂和组合物。本申请公开了如下式I所述的JNK抑制剂：其中变量如本文所定义。本文公开的化合物和组合物可用于调节JNK的活性并治疗与JNK活性相关的疾病。公开了用于抑制JNK和治疗JNK介导的病症等的方法和制剂，以及本文公开的化合物，以及制备所述化合物的方法和相应的组合物。

7. 发明申请

US20150307461A1 ANTIVIRAL COMPOUNDS 审中-公开
标题翻译：有害化合物
公开(公告)号：US20150307461A1
公开(公告)日：2015-10-29
申请号：US14792722
申请日：2015-07-07
申请人： Joseph A. Bilotta , Zhi Chen , Elbert Chin , Qingjie Ding , Shawn D. Erickson , Stephen D. Gabriel , Klaus G. Klumpp , Han Ma , Eric Mertz , Jean-Marc Plancher , Robert J. Weikert
发明人： Joseph A. Bilotta , Zhi Chen , Elbert Chin , Qingjie Ding , Shawn D. Erickson , Stephen D. Gabriel , Klaus G. Klumpp , Han Ma , Eric Mertz , Jean-Marc Plancher , Robert J. Weikert
IPC分类号： C07D249/14 , C07D403/12 , A61K31/5377 , A61K31/4196 , A61K38/21
CPC分类号： C07D249/14 , A61K31/4196 , A61K31/5377 , A61K38/21 , A61K38/55 , A61K45/06 , C07D403/12 , A61K2300/00
摘要： The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
摘要翻译：本发明公开了式I的化合物：其中式I中的变量如本文所述定义。还公开了含有这些化合物的药物组合物和使用式I化合物预防或治疗HCV感染的方法。

8. 发明授权

US08862333B2 Method of determining the lateral velocity of a vehicle during abnormal driving situations 有权
标题翻译：在异常驾驶情况下确定车辆的横向速度的方法
公开(公告)号：US08862333B2
公开(公告)日：2014-10-14
申请号：US13383862
申请日：2010-07-16
申请人： Robert M. Andres , Holger Faisst , Eric Mertz , Helmut Steurer
发明人： Robert M. Andres , Holger Faisst , Eric Mertz , Helmut Steurer
IPC分类号： B60R22/00
CPC分类号： G01M17/0078 , B60W40/109
摘要： Disclosed is a method to determine a vehicle's lateral velocity during abnormal driving situations of a vehicle during controlled side-impact or rollover crash tests that involve the pulling of a vehicle sideways into an object. A high-resolution, low-range, lateral accelerometer is integrated to determine the lateral velocity. Furthermore, is a method to initiate the integration of the acceleration signal and a method to stop and reset the integration. The method recognizes special conditions associated with abnormal driving situations like controlled crash tests, and therefore will not be active during normal operating conditions. The method also includes a means to handle offset tolerances associated with accelerometers by finding the sensor's zero-g point while the vehicle is at rest.
摘要翻译：公开了一种在涉及将车辆侧向拉入物体的受控侧撞或翻车碰撞试验期间确定车辆的异常驾驶状态期间的车辆横向速度的方法。集成了高分辨率，低范围的横向加速度计来确定横向速度。此外，是启动加速度信号的集成的方法以及停止和重置集成的方法。该方法识别与异常驾驶情况（如受控碰撞测试）相关的特殊情况，因此在正常操作条件下不会起作用。该方法还包括通过在车辆静止时找到传感器的零点而处理与加速度计相关联的偏移公差的装置。

9. 发明授权

US08501732B2 Aminomethyl quinolone compounds 有权
标题翻译：氨甲基喹诺酮化合物
公开(公告)号：US08501732B2
公开(公告)日：2013-08-06
申请号：US13546039
申请日：2012-07-11
申请人： Joseph A. Bilotta , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Stuart Hayden , Nancy-Ellen Haynes , Christine M. Lukacs-Lesburg , Nicholas Marcopulos , Eric Mertz , Lida Qi , Yimin Qian , Sung-Sau So , Jenny Tan , Kshitij C. Thakkar
发明人： Joseph A. Bilotta , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Stuart Hayden , Nancy-Ellen Haynes , Christine M. Lukacs-Lesburg , Nicholas Marcopulos , Eric Mertz , Lida Qi , Yimin Qian , Sung-Sau So , Jenny Tan , Kshitij C. Thakkar
IPC分类号： A61K31/55 , A61K31/551 , A61K31/5375 , A61K31/5377 , A61K31/4427 , A61K31/435 , A61K31/47 , C07D243/08 , C07D401/02 , C07D413/02 , C07D413/14 , C07D471/00 , C07D215/00
CPC分类号： C07D215/48 , C07D215/233 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein the variables are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
摘要翻译：本发明涉及JNK抑制剂和用于抑制JNK和治疗JNK介导的病症的相应方法，制剂和组合物。本申请公开了如下式I所述的JNK抑制剂：其中变量如本文所定义。本文公开的化合物和组合物可用于调节JNK的活性并治疗与JNK活性相关的疾病。公开了用于抑制JNK和治疗JNK介导的病症等的方法和制剂，以及本文公开的化合物，以及制备所述化合物的方法和相应的组合物。

10. 发明申请

US20050004729A1 Roll angle plausibility detection 审中-公开
标题翻译：滚角似真性检测
公开(公告)号：US20050004729A1
公开(公告)日：2005-01-06
申请号：US10877495
申请日：2004-06-25
申请人： Jeffrey Gleacher , Ciprian Lucut , Robert Andres , Andreas Knueppel , Thomas Malbouef , Douglas McConnell , Eric Mertz , Scott Morell
发明人： Jeffrey Gleacher , Ciprian Lucut , Robert Andres , Andreas Knueppel , Thomas Malbouef , Douglas McConnell , Eric Mertz , Scott Morell
IPC分类号： B60R21/00 , B60R21/01 , B60R21/0132 , B60G17/005
CPC分类号： B60R21/01332 , B60R21/0132 , B60R21/0133 , B60R2021/0018 , B60R2021/0119 , B60R2021/01325 , B60R2021/01327
摘要： A vehicle safety system (20) includes a controller (24) that verifies the plausibility of a roll angle indication obtained by processing a roll angular rate sensor (26) output. The controller (24) determines whether an acceleration value corresponding to the roll angle indication is within an expected range. In a disclosed example, the controller (24) utilizes a vertical acceleration value and a first expected range and a lateral acceleration value and a second expected range. When both of the acceleration values are outside of the respective expected range, the controller determines that the roll angle indication is invalid.
摘要翻译：车辆安全系统（20）包括控制器（24），该控制器验证通过处理滚动角速度传感器（26）输出而获得的滚动角度指示的合理性。控制器（24）确定与滚动角度指示对应的加速度值是否在期望范围内。在公开的示例中，控制器（24）利用垂直加速度值和第一预期范围以及横向加速度值和第二预期范围。当两个加速度值都在相应的预期范围之外时，控制器确定滚转角度指示是无效的。

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