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1. 发明授权

US09622778B2 Subcutaneous delivery tool 有权
公开(公告)号：US09622778B2
公开(公告)日：2017-04-18
申请号：US12250670
申请日：2008-10-14
申请人： Eric J. Wengreen , John E. Lovins , Randy S. Roles , Robert J. Nehls
发明人： Eric J. Wengreen , John E. Lovins , Randy S. Roles , Robert J. Nehls
IPC分类号： A61M5/00 , A61M37/00 , A61M31/00 , A61B17/34
CPC分类号： A61B17/3468 , A61B2017/3456 , A61M37/00 , A61M37/0069
摘要： Exemplary embodiments provide subcutaneous implantation tools and methods of implanting a subcutaneous micro-device using the same. Exemplary embodiments provide subcutaneous implantation tools including a syringe body, a dissection body, and a delivery assembly. Additional exemplary embodiments provide methods of implanting a subcutaneous micro-device, including inserting the dissection body of the tool described by the exemplary embodiments into an implantation site, where the dissection body includes a micro-device, and delivering the micro-device.

2. 发明申请

US20100094252A1 SUBCUTANEOUS DELIVERY TOOL 有权
标题翻译： SUBCUTANEOUS DELIVERY工具
公开(公告)号：US20100094252A1
公开(公告)日：2010-04-15
申请号：US12250670
申请日：2008-10-14
申请人： Eric J. Wengreen , John E. Lovins , Randy S. Roles , Robert J. Nehls
发明人： Eric J. Wengreen , John E. Lovins , Randy S. Roles , Robert J. Nehls
IPC分类号： A61M5/315 , A61M5/32
CPC分类号： A61B17/3468 , A61B2017/3456 , A61M37/00 , A61M37/0069
摘要： Exemplary embodiments provide subcutaneous implantation tools and methods of implanting a subcutaneous micro-device using the same. Exemplary embodiments provide subcutaneous implantation tools including a syringe body, a dissection body, and a delivery assembly. Additional exemplary embodiments provide methods of implanting a subcutaneous micro-device, including inserting the dissection body of the tool described by the exemplary embodiments into an implantation site, where the dissection body includes a micro-device, and delivering the micro-device.
摘要翻译：示例性实施例提供皮下植入工具和使用其植入皮下微型装置的方法。示例性实施例提供皮下植入工具，包括注射器主体，解剖体和输送组件。另外的示例性实施例提供了植入皮下微型装置的方法，包括将由示例性实施例描述的工具的解剖体插入植入部位，其中解剖体包括微型装置，并且输送微型装置。

3. 发明授权

US07092759B2 Method of optimizing cardiac resynchronization therapy using sensor signals of septal wall motion 有权
标题翻译：使用间隔壁运动的传感器信号优化心脏再同步治疗的方法
公开(公告)号：US07092759B2
公开(公告)日：2006-08-15
申请号：US10631551
申请日：2003-07-30
申请人： Robert J. Nehls , Todd J. Sheldon
发明人： Robert J. Nehls , Todd J. Sheldon
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36542 , A61N1/3682 , A61N1/3684
摘要： The present invention relates to monitoring septal wall motion of the atrial and/or ventricular chambers of a heart for optimizing cardiac pacing intervals based on signals derived from the monitored wall motion. At least one lead of medical device is equipped with a motion sensor adapted to couple to septal tissue. The device receives and may post-process (e.g., suitably filter, rectify and/or integrate) motion signals to determine acceleration, velocity and/or displacement. During pacing interval optimization the wall motion is measured for those pacing intervals and the pacing interval setting(s) that produce minimal wall motion for chronic therapy delivery. In addition, methods for periodically determining whether to cease or resume delivery of a bi-ventricular pacing therapy to a patient that may have experienced beneficial reverse remodeling of the heart.
摘要翻译：本发明涉及基于从监测的壁运动导出的信号来监测心脏的心房和/或心室的隔膜运动以优化心脏起搏间隔。医疗装置的至少一个引线配备有适于耦合到间隔组织的运动传感器。该装置接收并且可以后处理（例如，适当地过滤，整流和/或积分）运动信号以确定加速度，速度和/或位移。在起搏间期优化期间，针对这些起搏间隔和针对慢性治疗传递产生最小壁运动的起搏间隔设置测量壁运动。此外，定期确定是否停止或恢复双向心室起搏治疗对可能经历有益的逆转重建的病人的患者的方法。

4. 发明授权

US07996084B2 Implantable medical device with automatic ischemia threshold determination 有权
标题翻译：具有自动缺血阈值测定的植入式医疗器械
公开(公告)号：US07996084B2
公开(公告)日：2011-08-09
申请号：US11379290
申请日：2006-04-19
申请人： Lee Stylos , Todd J. Sheldon , Steven N. Lu , William J. Combs , Robert J. Nehls
发明人： Lee Stylos , Todd J. Sheldon , Steven N. Lu , William J. Combs , Robert J. Nehls
IPC分类号： A61N1/08
CPC分类号： A61N1/3702 , A61N1/36514 , A61N1/36542 , A61N1/36557 , A61N1/37252
摘要： An implantable medical device (IMD) performs periodic testing of a patient to determine ischemia threshold information. At selected times while the patient is at rest, the IMD increases the pacing rate over time until it receives feedback either from the patient or from an ischemia sensor. The IMD determines the threshold based upon the pacing rate at the time when the feedback was received. The threshold information can be used to adjust the upper pacing rate that can be used during rate adaptive pacing, to determine the effects of drug therapy, and to provide a general indication of the state of coronary artery disease in the patient. The periodic increase of pacing rate to the ischemic zone also provides a preconditioning of the myocardium to allow the patient greater exercise benefit without angina.
摘要翻译：可植入医疗装置（IMD）执行患者的周期性测试以确定缺血阈值信息。在患者静止时的选定时间，IMD随着时间的推移增加起搏速率，直到其从患者或缺血传感器接收到反馈。 IMD根据接收到反馈时的起搏速率来确定阈值。阈值信息可以用于调整速率自适应起搏期间可以使用的上起搏速率，以确定药物治疗的效果，并提供患者冠状动脉疾病状态的一般指示。对缺血区的起搏速率的周期性增加也提供心肌的预处理，以允许患者在没有心绞痛的情况下更大的运动益处。

5. 发明授权

US07848808B2 System and method for delivery of cardiac pacing in a medical device in response to ischemia 有权
标题翻译：用于在医疗装置中递送心脏起搏以应对局部缺血的系统和方法
公开(公告)号：US07848808B2
公开(公告)日：2010-12-07
申请号：US11364828
申请日：2006-02-28
申请人： Todd J. Sheldon , William J. Combs , Lee Stylos , Steven N. Lu , Robert J. Nehls
发明人： Todd J. Sheldon , William J. Combs , Lee Stylos , Steven N. Lu , Robert J. Nehls
IPC分类号： A61N1/365
CPC分类号： A61N1/37 , A61N1/3627
摘要： An implantable medical device system and method in which the implantable device is adapted to operate in a minimum ventricular pacing mode. The device delivers cardiac pacing pulses in a first pacing mode during a normal mode of operation and upon detecting myocardial ischemia alters the first pacing mode in response to the myocardial ischemia detection.
摘要翻译：一种植入式医疗装置系统和方法，其中所述可植入装置适于以最小心室起搏模式操作。该装置在正常操作模式期间以第一起搏模式递送心脏起搏脉冲，并且在检测心肌缺血时，响应于心肌缺血检测改变第一起搏模式。

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