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1. 发明授权

US5321501A Method and apparatus for optical imaging with means for controlling the longitudinal range of the sample 失效
标题翻译：用于光学成像的方法和装置，其具有用于控制样品的纵向范围的装置
公开(公告)号：US5321501A
公开(公告)日：1994-06-14
申请号：US875670
申请日：1992-04-29
申请人： Eric A. Swanson , David Huang , James G. Fujimoto , Carmen A. Puliafito , Charles P. Lin , Joel S. Schuman
发明人： Eric A. Swanson , David Huang , James G. Fujimoto , Carmen A. Puliafito , Charles P. Lin , Joel S. Schuman
IPC分类号： A61B1/00 , A61B3/10 , A61B3/12 , A61B5/00 , A61B5/103 , A61B10/00 , G01B9/02 , G01B11/00 , G01B11/06 , G01B11/24 , G01J1/00 , G01N21/17 , G01N21/47 , G02B5/18 , G02B27/44 , G11B7/00 , H01S5/14
CPC分类号： G02B26/0875 , A61B1/00096 , A61B1/00172 , A61B1/00183 , A61B3/102 , A61B5/0064 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/6852 , B82Y15/00 , G01B11/00 , G01B11/2441 , G01B9/02002 , G01B9/0201 , G01B9/02019 , G01B9/02027 , G01B9/02063 , G01B9/02087 , G01B9/0209 , G01J1/00 , G01N21/4795 , G02B26/103 , G02B5/1828 , A61B2562/0242 , A61B5/441 , G01B2290/45 , G01B2290/65 , G01B2290/70 , G11B2007/0013 , H01S5/141
摘要： A method and apparatus for performing optical imaging on a sample wherein longitudinal scanning or positioning in the sample is provided by either varying relative optical path lengths for an optical path leading to the sample and to a reference reflector, or by varying an optical characteristic of the output from an optical source applied to the apparatus. Transverse scanning in one or two dimensions is provided on the sample by providing controlled relative movement between the sample and a probe module in such direction and/or by steering optical radiation in the probe module to a selected transverse position. The probe module may be an external module or may be an endoscope or angioscope utilized for scanning internal channels. Multiple optical paths may be provided for parallel scanning and focus may be enhanced by varying the focal point in the sample in synchronism with longitudinal scanning of the sample.
摘要翻译：或者通过对通过样品和参考反射体的光路改变相对光程长度，或者通过改变样品的光学特性来改变样品中的纵向扫描或定位来提供样品的光学成像的方法和装置从施加到该装置的光源输出。通过在样品和探针模块之间以这种方向提供受控的相对运动和/或通过将探针模块中的光学辐射转向到选定的横向位置，在样品上提供一维或二维的横向扫描。探针模块可以是外部模块，也可以是用于扫描内部通道的内窥镜或血管造影仪。可以提供用于并行扫描的多个光路，并且可以通过与样品的纵向扫描同步地改变样品中的焦点来增强焦点。

2. 发明授权

US5459570A Method and apparatus for performing optical measurements 失效
标题翻译：用于执行光学测量的方法和装置
公开(公告)号：US5459570A
公开(公告)日：1995-10-17
申请号：US33194
申请日：1993-03-16
申请人： Eric A. Swanson , David Huang , James G. Fujimoto , Carmen A. Puliafito , Charles P. Lin , Joseph S. Schuman
发明人： Eric A. Swanson , David Huang , James G. Fujimoto , Carmen A. Puliafito , Charles P. Lin , Joseph S. Schuman
IPC分类号： A61B1/00 , A61B3/10 , A61B3/12 , A61B5/00 , A61B5/103 , A61B10/00 , G01B9/02 , G01B11/00 , G01B11/06 , G01B11/24 , G01J1/00 , G01N21/17 , G01N21/47 , G02B5/18 , G02B27/44 , G11B7/00 , H01S5/14 , G01D9/02
CPC分类号： G02B26/0875 , A61B1/00096 , A61B1/00172 , A61B1/00183 , A61B3/102 , A61B5/0064 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/6852 , B82Y15/00 , G01B11/00 , G01B11/2441 , G01B9/02002 , G01B9/0201 , G01B9/02019 , G01B9/02027 , G01B9/02063 , G01B9/02087 , G01B9/0209 , G01J1/00 , G01N21/4795 , G02B26/103 , G02B5/1828 , A61B2562/0242 , A61B5/441 , G01B2290/45 , G01B2290/65 , G01B2290/70 , G11B2007/0013 , H01S5/141
摘要： A method and apparatus for performing various optical measurements is provided utilizing an optical coherence domain refrectometer (OCDR). A short coherence optical radiation source applies optical radiation through like optical paths to a sample and an optical reflector. The optical reflector is movable in accordance with a predetermined velocity profile to permit interferometric scanning of the sample, the resulting output having a Doppler shift frequency modulation. This output may be demodulated and detected to obtain desired measurements and other information. Additional information may be obtained by applying radiation from two or more sources at different wavelengths to the sample and reflector and by separately demodulating the resulting outputs before processing. Birefringent information may be obtained by polarizing the optical radiation used, by suitably modifying the polarization in the sample and reference paths and by dividing the output into orthogonal polarization outputs which are separately demodulated before processing.
摘要翻译：使用光学相干域反射计（OCDR）提供用于执行各种光学测量的方法和装置。短相干光辐射源通过相同的光路将光辐射施加到样品和光反射器。光学反射器可以根据预定的速度分布移动以允许样本的干涉扫描，所得到的输出具有多普勒频移调制。该输出可以被解调和检测以获得期望的测量和其他信息。可以通过将不同波长的两个或更多个源的辐射施加到样品和反射器并且在处理之前单独解调所得到的输出来获得附加信息。双折射信息可以通过对所采用的光辐射进行极化，通过适当地修改样本和参考路径中的极化，并将输出划分为在处理之前被单独解调的正交偏振输出。

3. 发明申请

US20180344147A1 OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY METHODS 审中-公开
公开(公告)号：US20180344147A1
公开(公告)日：2018-12-06
申请号：US16000824
申请日：2018-06-05
申请人： David Huang , Yali Jia
发明人： David Huang , Yali Jia
IPC分类号： A61B3/00 , A61B3/12 , A61B3/14 , A61B3/10
CPC分类号： A61B3/0025 , A61B3/0041 , A61B3/102 , A61B3/1233 , A61B3/1241 , A61B3/14
摘要： Methods of applying OCT angiography are disclosed. In particular, methods of detecting, visualizing and measuring the extent of retinal neovascularization are disclosed. Further disclosed are methods measuring retinal nonperfusion area and choriocapillaris defect area.

4. 发明授权

US09918630B2 Systems and methods of glaucoma diagnosis based on frequency analysis of inner retinal surface profile measured by optical coherence tomography 有权
公开(公告)号：US09918630B2
公开(公告)日：2018-03-20
申请号：US15253597
申请日：2016-08-31
申请人： Ou Tan , David Huang
发明人： Ou Tan , David Huang
IPC分类号： A61B3/12 , A61B3/00 , A61B3/10
CPC分类号： A61B3/1225 , A61B3/0025 , A61B3/102 , G06T7/136 , G06T2207/30041
摘要： A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV) is calculated and the presence or absence of a glaucoma condition is determined based on the RSCV magnitude.

5. 发明授权

US09621334B2 Data transmission method and system 有权
公开(公告)号：US09621334B2
公开(公告)日：2017-04-11
申请号：US12212418
申请日：2008-09-17
申请人： David Huang , Wei-Chih Chang , Tsung-Pao Kuan
发明人： David Huang , Wei-Chih Chang , Tsung-Pao Kuan
IPC分类号： H03D1/00 , H04J11/00 , H04L7/02 , H04B7/04 , H04L7/033
CPC分类号： H04L7/02 , H04B7/04 , H04L7/033
摘要： A data transmission method for a data transmission system including a first device and a second device is disclosed. The method comprises the steps of transmitting a clock signal to synchronize the first device and the second device; transmitting a mode signal from the first device to the second device, wherein the mode signal indicates a transmission mode between the first device and the second device; and transmitting a serial data between the first device and the second device based on the clock signal, wherein the length of the serial data is determined based on the transmission mode.

6. 发明申请

US20170055829A1 SYSTEMS AND METHODS OF GLUACOMA DIAGNOSIS BASED ON FREQUENCY ANALYSIS OF INNER RETINAL SURFACE PROFILE MEASURED BY OPTICAL COHERENCE TOMOGRAPHY 有权
标题翻译：基于通过光学相干测量法测量的内膜表面轮廓的频率分析的GLUACOMA诊断系统和方法
公开(公告)号：US20170055829A1
公开(公告)日：2017-03-02
申请号：US15253597
申请日：2016-08-31
申请人： Ou Tan , David Huang
发明人： Ou Tan , David Huang
IPC分类号： A61B3/12 , A61B3/10 , A61B3/00
CPC分类号： A61B3/1225 , A61B3/0025 , A61B3/102 , G06T7/136 , G06T2207/30041
摘要： A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV) is calculated and the presence or absence of a glaucoma condition is determined based on the RSCV magnitude.
摘要翻译：公开了一种基于从光学相干断层摄影（OCT）图像数据获得的内部限制膜（ILM）的空间频率分析来检测受试者中的青光眼的方法。基于所分析的ILM谱的空间频率含量，计算称为视网膜表面轮廓变异性（RSCV）的量，并且基于RSCV幅度确定青光眼状况的存在或不存在。

7. 发明申请

US20160287071A1 METHODS OF MEASURING TOTAL RETINAL BLOOD FLOW USING EN FACE DOPPLER OCT 审中-公开
标题翻译：使用表面多普勒OCT测量总体血液流量的方法
公开(公告)号：US20160287071A1
公开(公告)日：2016-10-06
申请号：US15089803
申请日：2016-04-04
申请人： Ou Tan , David Huang
发明人： Ou Tan , David Huang
IPC分类号： A61B3/12 , G06T5/00 , G06T7/00 , A61B3/10 , A61B3/00
CPC分类号： A61B3/1233 , A61B3/0025 , A61B3/102 , A61B3/1241 , A61B5/7203 , A61B6/5258 , G06K9/0061 , G06K9/52 , G06K2209/05 , G06T7/0012 , G06T2207/10101 , G06T2207/30041 , G06T2207/30104
摘要： Methods of performing en face Doppler total retinal blood flow measurement are disclosed. The methods involve obtaining a set of structural OCT scans; calculating a noise-reduced set of Doppler phase shift images by dividing the full spectrum OCT fringe data into a set of narrower filtered frequency bands for phase shift calculation; removing bulk motion along a depth direction; detecting retinal vessels in the set of images; applying a phase unwrapping algorithm to the images; classifying the vessels as veins and arteries; and calculating total retinal blood flow based on that classification.
摘要翻译：公开了执行面部多普勒总视网膜血流量测量的方法。该方法涉及获得一组结构OCT扫描; 通过将全谱OCT边缘数据划分成一组较窄的滤波频带以进行相移计算，来计算多普勒相移图像的噪声降低集合; 沿深度方向去除大量运动; 检测该组图像中的视网膜血管; 对图像应用相位解包算法; 将血管分类为静脉和动脉; 并根据该分类计算总视网膜血流量。

8. 发明申请

US20140063806A1 Heat-Dissipating Structure for an LED Lamp 有权
标题翻译： LED灯泡散热结构
公开(公告)号：US20140063806A1
公开(公告)日：2014-03-06
申请号：US13596133
申请日：2012-08-28
申请人： David Huang
发明人： David Huang
IPC分类号： F21V29/00
CPC分类号： F21V29/507 , F21K9/00 , F21V19/0055 , F21V23/023 , F21V29/83 , F21Y2103/33 , F21Y2115/10
摘要： A heat-dissipating structure for LED lamp has a lamp cover, and a power conversion device and a ceramic substrate mounted inside the lamp cover. The lamp cover has multiple heat-dissipating holes and multiple mounting ears. Each mounting ear is formed on an edge of one of the heat-dissipating holes and is bent inwardly with the heat-dissipating hole uncovered. The ceramic substrate is mounted on the mounting ears. The ceramic substrate has multiple LEDs mounted thereon, absorbs heat generated when the LEDs emit light and conducts the heat to the lamp cover through the mounting ears. The heat generated when the LEDs are lit and the power conversion converts a mains power is transferred to a heat convection space between the ceramic substrate and the lamp cover, and is further dissipated to an ambient environment, thereby achieving fast heat dissipation and a light LED lamp without additional heat sink thereon.
摘要翻译：用于LED灯的散热结构具有灯罩，安装在灯罩内部的电力转换装置和陶瓷基板。灯罩有多个散热孔和多个安装耳。每个安装耳形成在一个散热孔的边缘上，并且在散热孔未被覆盖的同时向内弯曲。陶瓷基板安装在安装耳上。陶瓷基板上安装有多个LED，吸收当LED发光时产生的热量，并通过安装耳将热量传导到灯罩。当LED点亮并且功率转换转换为主电源时产生的热量被传递到陶瓷基板和灯罩之间的热对流空间，并且进一步消散到周围环境，从而实现快速散热，并且将LED 灯，其上没有额外的散热器。

9. 发明授权

US08551201B2 Polyurethane composition for CMP pads and method of manufacturing same 有权
标题翻译：用于CMP垫的聚氨酯组合物及其制造方法
公开(公告)号：US08551201B2
公开(公告)日：2013-10-08
申请号：US12537862
申请日：2009-08-07
申请人： Yong Zhang , David Huang , Lu Sun
发明人： Yong Zhang , David Huang , Lu Sun
IPC分类号： B24B1/00 , B24D3/00 , C08G18/00 , C08G18/70
CPC分类号： B24B37/24 , B24D18/00 , C08G18/10 , C08G18/4238 , C08G18/4854 , C08G18/7621 , C08G2101/0066
摘要： Polyurethane composition based on a certain polyether and polyester prepolymer reaction mixture, wherein the composition is utilized in manufacturing chemical mechanical polishing/planarizing (CMP) pads. The CMP pads have low rebound and can dissipate irregular energy as well as stabilize polishing to yield improved uniformity and less dishing of the substrate.
摘要翻译：基于某种聚醚和聚酯预聚物反应混合物的聚氨酯组合物，其中组合物用于制造化学机械抛光/平坦化（CMP）垫。 CMP焊盘具有低回弹性，并且可以消散不规则的能量以及稳定抛光以产生改进的均匀性和较少的衬底凹陷。

10. 发明授权

US08474978B2 Pattern analysis of retinal maps for the diagnosis of optic nerve diseases by optical coherence tomography 有权
标题翻译：通过光学相干断层扫描对视神经疾病诊断的视网膜图的模式分析
公开(公告)号：US08474978B2
公开(公告)日：2013-07-02
申请号：US12139376
申请日：2008-06-13
申请人： David Huang , Ou Tan
发明人： David Huang , Ou Tan
IPC分类号： A61B3/12 , A61B3/10
CPC分类号： G06T7/0012 , A61B3/024 , A61B3/102 , A61B5/0066 , G06K2209/05 , G06K2209/051 , G06T2207/30041
摘要： Methods for analyzing retinal tomography maps to detect patterns of optic nerve diseases such as glaucoma, optic neuritis, anterior ischemic optic neuropathy are disclosed in this invention. The areas of mapping include the macula centered on the fovea, and the region centered on the optic nerve head. The retinal layers that are analyzed include the nerve fiber, ganglion cell, inner plexiform and inner nuclear layers and their combinations. The overall retinal thickness can also be analyzed. Pattern analysis are applied to the maps to create single parameter for diagnosis and progression analysis of glaucoma and optic neuropathy.
摘要翻译：用于分析视网膜断层摄影图的方法用于检测视神经疾病如青光眼，视神经炎，前部缺血性视神经病变的模式在本发明中公开。映射区域包括以中心凹为中心的黄斑，以视神经头为中心的区域。分析的视网膜层包括神经纤维，神经节细胞，内丛状和内核层及其组合。也可以分析整个视网膜厚度。模式分析应用于地图，为青光眼和视神经病变的诊断和进展分析创建单一参数。

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