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1. 发明授权

US09421542B2 System for treating liquids 有权
标题翻译：液体处理系统
公开(公告)号：US09421542B2
公开(公告)日：2016-08-23
申请号：US14527920
申请日：2014-10-30
申请人： Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG
发明人： Michael Hanko , Stefanie Jahn , Axel Fikus
IPC分类号： B01L3/00 , G01N35/10
CPC分类号： B01L3/502715 , B01L3/527 , B01L2200/027 , B01L2300/0867 , B01L2300/123 , B01L2400/0478 , B01L2400/0487 , B01L2400/0605 , B01L2400/065 , B01L2400/0655 , G01N35/1097 , Y10T137/87153
摘要： A system for treating liquids, comprising: especially for analysis and/or synthesis of liquids, a fluidics unit having at least one functional unit; at least one liquid storage unit of the first type; at least one liquid storage unit of second type; a first liquid line; and a second liquid line, wherein a flow of liquid through the first liquid line directed from the fluidics unit to the liquid storage unit of first type is blocked, at least at times, by means of a first valve, and a flow of liquid through the second liquid line in the direction from the liquid storage unit of second type to the fluidics unit is blocked, at least at times, by means of a second valve.
摘要翻译：一种用于处理液体的系统，包括：特别用于液体的分析和/或合成，具有至少一个功能单元的流体单元; 至少一个第一类型的液体储存单元; 至少一个第二类液体储存单元; 第一条液体管线; 以及第二液体管线，其中通过从流体单元指向第一类型的液体存储单元的通过第一液体管线的液体流至少有时通过第一阀被阻塞，并且液体流通过至少有时通过第二阀阻塞从第二类型的液体存储单元到流体单元的方向上的第二液体管线。

2. 发明申请

US20140356880A1 APPARATUS FOR AUTOMATED DETERMINING OF AT LEAST TWO DIFFERENT PROCESS PARAMETERS 审中-公开
标题翻译：用于自动确定两种不同工艺参数的装置
公开(公告)号：US20140356880A1
公开(公告)日：2014-12-04
申请号：US14283425
申请日：2014-05-21
申请人： Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG
发明人： Michael Hanko , Angela Eubisch
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , C12Q1/00 , C12Q3/00
摘要： An apparatus for automated determining of at least two different process parameters of a process liquid of a process, especially a bioprocess, comprising: a first measuring cell, which is embodied to provide a first measurement signal dependent on a first process parameter of a first sample of the process liquid; a second measuring cell, which is embodied to provide a second measurement signal dependent on a second process parameter of a second sample of the process liquid; and a control and evaluation system, which serves for monitoring and/or controlling the process, and which is embodied to receive and to process the first and second measurement signals, especially based on the first measurement signal to determine a measured value of the first process parameter and based on the second measurement signal to determine a measured value of the second process parameter; wherein the first measurement signal and the second measurement signal serve different functions in the context of the monitoring and/or controlling of the process. The first process parameter can be a control parameter (critical process parameter, CPP), and the second process parameter can be a product quality parameter (critical quality attribute, CQA) of the process.
摘要翻译：一种用于自动确定过程，特别是生物过程的工艺液体的至少两个不同工艺参数的装置，包括：第一测量单元，其被实施为提供取决于第一样品的第一工艺参数的第一测量信号的工艺液体; 第二测量单元被实施为提供取决于处理液体的第二样品的第二过程参数的第二测量信号; 以及用于监视和/或控制过程的控制和评估系统，其特征在于基于第一测量信号来体现为接收和处理第一和第二测量信号，以确定第一过程的测量值参数，并且基于所述第二测量信号来确定所述第二过程参数的测量值; 其中所述第一测量信号和所述第二测量信号在所述过程的监视和/或控制的上下文中起不同的作用。第一个过程参数可以是控制参数（关键过程参数，CPP），第二个过程参数可以是过程的产品质量参数（关键质量属性，CQA）。

3. 发明授权

US11125714B2 Potentiometric sensor 有权
公开(公告)号：US11125714B2
公开(公告)日：2021-09-21
申请号：US15007827
申请日：2016-01-27
申请人： Endress + Hauser Conducta Gesellschaft für Mess-und Regeltechnik mbH + Co. KG
发明人： Stefan Wilke , Jens Vettermann , Jens Voigtlander , Magdalena Losik , Michael Hanko
IPC分类号： G01N27/333
摘要： A potentiometric sensor having a measuring half cell with a conductor element, a reference half cell with a reference element, a measuring circuit connected with the conductor element of the measuring half cell and the reference element of the reference half cell and designed to create a measuring signal that is dependent on a potential difference between the conductor element and the reference element. The measuring half cell further includes a housing having a housing chamber closed off by a first ion-selective membrane and contacted by the conductor element, a first inner electrolyte contained within the housing chamber and contacting the ion-selective membrane. The conductor element includes an inner conductor, especially an inner conductor comprising a metallic conductor, connected with the measuring circuit and a gas-tight barrier separating the inner conductor from the first inner electrolyte.

4. 发明授权

US09696273B2 Reference half-cell and electrochemical sensor with the reference half-cell 有权
公开(公告)号：US09696273B2
公开(公告)日：2017-07-04
申请号：US13719363
申请日：2012-12-19
申请人： Endress + Hauser Conducta Gesellschaft für Mess-und Regeltechnik mbH + Co. KG
发明人： Thomas Wilhelm , Thomas Schroter , Michael Hanko , Wolfram Nowak , Thilo Trapp
IPC分类号： G01N27/30 , G01N27/31 , G01N27/333 , G01N27/401 , G01N27/414 , G01N27/416
CPC分类号： G01N27/31 , G01N27/301 , G01N27/333 , G01N27/401 , G01N27/414 , G01N27/416 , Y10T29/417
摘要： A reference half-cell for application in an electrochemical sensor, comprising a housing, in which a chamber containing a reference electrolyte is formed, wherein the reference electrolyte (5, 105) is in contact with a medium surrounding the housing via a liquid junction arranged in a wall of the housing, wherein the liquid junction comprises a porous diaphragm, especially a porous ceramic diaphragm, and wherein the diaphragm has, at least partially, a coating, which comprises at least one metal.

5. 发明申请

US20160216230A1 Potentiometric Sensor 审中-公开
标题翻译：电位传感器
公开(公告)号：US20160216230A1
公开(公告)日：2016-07-28
申请号：US15007827
申请日：2016-01-27
申请人： Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG
发明人： Stefan Wilke , Jens Vettermann , Jens Voigtlander , Magdalena Losik , Michael Hanko
IPC分类号： G01N27/416 , G01N27/36 , G01N27/31 , G01N27/333 , G01N27/414 , G01N27/30
CPC分类号： G01N27/333
摘要： A potentiometric sensor having: a measuring half cell with a conductor element; a reference half cell with a reference element; a measuring circuit that is connected with the conductor element of the measuring half cell and the reference element of the reference half cell, is designed to create a measuring signal that is dependent on a potential difference between the conductor element and the reference element. The measuring half cell further includes: a housing, in which a housing chamber is formed, which is closed off by a first ion-selective membrane and contacted by the conductor element a first inner electrolyte contained within the housing chamber, contacting the ion-selective membrane, wherein the conductor element includes an inner conductor, especially an inner conductor comprising a metallic conductor, that is connected with the measuring circuit and a gas-tight barrier separating the inner conductor from the first inner electrolyte.
摘要翻译：一种电位传感器，具有：具有导体元件的测量半电池; 具有参考元素的参考半单元; 与测量半单元的导体元件和参考半单元的参考元件连接的测量电路被设计成产生取决于导体元件和参考元件之间的电位差的测量信号。测量半单元还包括：外壳，其中形成有容纳室，其被第一离子选择性膜封闭并且与导体元件接触，容纳在容纳室内的第一内部电解质，与离子选择性接触膜，其中所述导体元件包括内导体，特别是包括与所述测量电路连接的金属导体的内导体和将所述内导体与所述第一内电解质分离的气密屏障。

6. 发明申请

US20160178556A1 Electrochemical half cell and method for the production of a half cell 审中-公开
标题翻译：电化学半电池及半电池的制造方法
公开(公告)号：US20160178556A1
公开(公告)日：2016-06-23
申请号：US14971063
申请日：2015-12-16
申请人： Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG
发明人： Michael Hanko , Magdalena Losik , Jens Vettermann
IPC分类号： G01N27/30
CPC分类号： G01N27/30
摘要： An electrochemical half cell comprises: a housing; a potential sensing element at least arranged on some segments inside the housing that is connected electro-conductively with an electrical contact point outside the housing; an electrolyte arranged inside the housing, wherein a plurality of hollow bodies is embedded in the electrolyte, especially distributed evenly inside the volume filled by the electrolyte.
摘要翻译：电化学半电池包括：壳体; 至少布置在所述壳体内部的一些段上的电位感测元件，其电连接到所述壳体外部的电接触点; 布置在壳体内部的电解质，其中多个中空体嵌入电解质中，特别是均匀地分散在由电解质填充的体积内。

7. 发明授权

US09279781B2 Measuring arrangement and method for registering an analyte concentration in a measured medium 有权
标题翻译：在测量介质中记录分析物浓度的测量布置和方法
公开(公告)号：US09279781B2
公开(公告)日：2016-03-08
申请号：US13767016
申请日：2013-02-14
申请人： Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG
发明人： Thomas Wilhelm , Michael Hanko
IPC分类号： G01N27/416 , G01N27/30 , G01N27/333 , G01N27/49
CPC分类号： G01N27/30 , G01N27/302 , G01N27/333 , G01N27/4167 , G01N27/49
摘要： A measuring arrangement for registering a measured variable representing concentration of an analyte in a measured medium, includes: a first electrode modified with a redox active substance, a second electrode, and a measuring circuit, which comprises a voltage source for applying at least one predetermined voltage between the first electrode and a reference, and an apparatus for registering electrical current flowing, in such case, between the first electrode and the second electrode or for registering a variable correlated with the electrical current flowing between the first electrode and the second electrode, wherein the second electrode is modified with the same redox active substance as the first electrode.
摘要翻译：一种测量装置，用于记录测量介质中分析物浓度的测量变量，包括：用氧化还原活性物质，第二电极和测量电路修饰的第一电极，其包括用于施加至少一个预定的在这种情况下，在第一电极和第二电极之间记录电流的装置，或用于记录与在第一电极和第二电极之间流动的电流相关的变量的装置，其中所述第二电极用与所述第一电极相同的氧化还原活性物质进行改性。

8. 发明申请

US20150056110A1 System for Treating Liquids 有权
标题翻译：液体处理系统
公开(公告)号：US20150056110A1
公开(公告)日：2015-02-26
申请号：US14527920
申请日：2014-10-30
申请人： Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG
发明人： Michael Hanko , Stefanie Jahn , Axel Fikus
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/527 , B01L2200/027 , B01L2300/0867 , B01L2300/123 , B01L2400/0478 , B01L2400/0487 , B01L2400/0605 , B01L2400/065 , B01L2400/0655 , G01N35/1097 , Y10T137/87153
摘要： A system for treating liquids, comprising: especially for analysis and/or synthesis of liquids, a fluidics unit having at least one functional unit; at least one liquid storage unit of the first type; at least one liquid storage unit of second type; a first liquid line; and a second liquid line, wherein a flow of liquid through the first liquid line directed from the fluidics unit to the liquid storage unit of first type is blocked, at least at times, by means of a first valve, and a flow of liquid through the second liquid line in the direction from the liquid storage unit of second type to the fluidics unit is blocked, at least at times, by means of a second valve.
摘要翻译：一种用于处理液体的系统，包括：特别用于液体的分析和/或合成，具有至少一个功能单元的流体单元; 至少一个第一类型的液体储存单元; 至少一个第二类液体储存单元; 第一条液体管线; 以及第二液体管线，其中通过从流体单元指向第一类型的液体存储单元的通过第一液体管线的液体流至少有时通过第一阀被阻塞，并且液体流过至少有时通过第二阀阻塞从第二类型的液体存储单元到流体单元的方向上的第二液体管线。

9. 发明申请

US20140356977A1 Method and Apparatus for Performing Automated Affinity Based Assays 审中-公开
标题翻译：执行自动亲和力测定的方法和装置
公开(公告)号：US20140356977A1
公开(公告)日：2014-12-04
申请号：US14283318
申请日：2014-05-21
申请人： Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG
发明人： Michael Hanko , Angela Eubisch
IPC分类号： G01N1/38
CPC分类号： G01N1/38
摘要： A method for performing automated affinity based assays for determining an analyte content of samples of a process medium, wherein individual samples are fed in time intervals sequentially to a measuring system, and wherein the measuring system, in each case, registers a measured value of a measured variable dependent on the analyte content of the samples, characterized in that at least one of the samples is diluted before it is fed to the measuring system, wherein a dilution factor to be applied for dilution of a sample is ascertained from a measured value registered based on a sample supplied earlier to the measuring system.
摘要翻译：一种用于执行基于自动化亲和力的测定法以确定处理介质样品的分析物含量的方法，其中单独的样品按时间间隔顺序地供给到测量系统，并且其中每种情况下测量系统记录一个取决于样品的分析物含量的测量变量，其特征在于，在将样品中的至少一种在进料到测量系统之前被稀释，其中从注册的测量值确定要用于稀释样品的稀释因子基于较早提供给测量系统的样品。

10. 发明授权

US11002703B2 Electrochemical half cell and method for the production of a half cell 有权
公开(公告)号：US11002703B2
公开(公告)日：2021-05-11
申请号：US14971063
申请日：2015-12-16
申请人： Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG
发明人： Michael Hanko , Magdalena Losik , Jens Vettermann
IPC分类号： G01N27/30
摘要： The disclosure includes an electrochemical half-cell including: a housing; a potential sensing element at least arranged on some segments inside the housing and connected electro-conductively with an electrical contact point outside the housing; and an electrolyte arranged inside the housing, wherein a plurality of hollow bodies is embedded in the electrolyte, especially distributed evenly inside the volume filled by the electrolyte.

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