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1. 发明申请

WO2014031192A1 METHOD AND APPARATUS FOR HYSTEROSCOPY AND COMBINED HYSTEROSCOPY AND ENDOMETRIAL BIOPSY 审中-公开
标题翻译：脑膜瘤和组织间质瘤和子宫内膜异位症的方法和装置
公开(公告)号：WO2014031192A1
公开(公告)日：2014-02-27
申请号：PCT/US2013/040992
申请日：2013-05-14
申请人： ENDOSEE CORPORATION , OUYANG, Xiaolong , INDMAN, Paul, D. , DECKMAN, Robert, K. , WANG, Shih-Ping
发明人： OUYANG, Xiaolong , INDMAN, Paul, D. , DECKMAN, Robert, K. , WANG, Shih-Ping
IPC分类号： A61B1/00
CPC分类号： A61B1/303 , A61B1/00006 , A61B1/00032 , A61B1/00034 , A61B1/00048 , A61B1/00052 , A61B1/00057 , A61B1/00066 , A61B1/00071 , A61B1/00078 , A61B1/00091 , A61B1/00094 , A61B1/00103 , A61B1/00105 , A61B1/00114 , A61B1/00124 , A61B1/005 , A61B1/0055 , A61B1/015 , A61B1/05 , A61B1/06 , A61B1/0676 , A61B1/0684 , A61B1/126 , A61B1/307 , A61B1/317 , A61B10/0291 , A61B10/04
摘要： Instruments and methods are described for performing hysteroscopy and/or combined hysteroscopy and endometrial biopsy. According to some embodiments, the handle, electronics and integrated display screen form a re-usable portion of the instrument while the fluid hub and cannula which includes a CMOS imaging module and LED lighting, form a single use portion of the instrument. The cannula is semi-flexible such that the operator can easily grasp the cannula at some intermediate point along the shaft (e.g. 5 inches from the distal tip) to bend and/or steer the cannula during use. According to some embodiments, the distal tip has a larger diameter than the shaft which has been found to improve fluid management during use in some applications.
摘要翻译：描述了用于进行宫腔镜检查和/或组合宫腔镜检查和子宫内膜活检的仪器和方法。根据一些实施例，当包括CMOS成像模块和LED照明的流体轮毂和套管形成仪器的单个使用部分时，手柄，电子器件和集成显示屏幕形成仪器的可重复使用的部分。套管是半柔性的，使得操作者可以容易地沿着轴的某个中间点（例如距离远侧尖端5英寸）抓住套管，以在使用期间弯曲和/或引导套管。根据一些实施例，远侧末端具有比轴更大的直径，已经被发现在一些应用中在使用期间改善流体管理。

2. 发明申请

WO2012151073A2 METHOD AND APPARATUS FOR HYSTEROSCOPY AND ENDOMETRIAL BIOPSY 审中-公开
标题翻译：用于宫腔镜和子宫内膜活检的方法和设备
公开(公告)号：WO2012151073A2
公开(公告)日：2012-11-08
申请号：PCT/US2012/034698
申请日：2012-04-23
申请人： ENDOSEE CORPORATION , OUYANG, Xiaolong , INDMAN, Paul, D. , DECKMAN, Robert, K. , WANG, Shih-Ping
发明人： OUYANG, Xiaolong , INDMAN, Paul, D. , DECKMAN, Robert, K. , WANG, Shih-Ping
IPC分类号： A61B1/018 , A61B10/02 , A61B1/04
CPC分类号： A61B1/00066 , A61B1/00016 , A61B1/00034 , A61B1/00039 , A61B1/0005 , A61B1/00052 , A61B1/00087 , A61B1/00091 , A61B1/00094 , A61B1/00101 , A61B1/00103 , A61B1/00105 , A61B1/00108 , A61B1/00124 , A61B1/00128 , A61B1/00179 , A61B1/015 , A61B1/018 , A61B1/045 , A61B1/05 , A61B1/053 , A61B1/0607 , A61B1/0676 , A61B1/0684 , A61B1/126 , A61B1/303 , A61B10/0275 , A61B10/0291 , A61B10/04 , A61B34/25 , A61B90/361 , A61B2017/00221 , A61B2090/309 , A61B2090/372 , A61M2210/1433
摘要： Methods and devices are described for performing a combined hysteroscopy and endometrial sampling. Techniques for improving visual images include forward facing fluid ports for clearing tissue debris and LED positioning and design. Manufacturability is improved through separately formed tip and shaft pieces. User interface features are described including user-friendly handle-mounted buttons as well the use of an interactive integrated touch screen display. The handle and display can be mated to a docking station for storage and recharging batteries.
摘要翻译：描述了用于执行组合宫腔镜和子宫内膜取样的方法和装置。用于改善视觉图像的技术包括用于清除组织碎片的前向流体端口以及LED定位和设计。可制造性通过单独形成的尖端和轴件得以改善。描述了用户界面功能，包括用户友好的安装在手柄上的按钮以及使用交互式集成触摸屏显示器。手柄和显示器可以配对到扩展坞进行存储和充电电池。

3. 发明申请

WO2014065901A1 LOW-COST INSTRUMENT FOR ENDOSCOPICALLY GUIDED OPERATIVE PROCEDURES 审中-公开
标题翻译：低成本仪器用于内窥镜指导手术程序
公开(公告)号：WO2014065901A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/049074
申请日：2013-07-02
申请人： ENDOSEE CORPORATION , OUYANG, Xiaolong , INDMAN, Paul, D. , DECKMAN, Robert, K. , WANG, Shih-Ping
发明人： OUYANG, Xiaolong , INDMAN, Paul, D. , DECKMAN, Robert, K. , WANG, Shih-Ping
IPC分类号： A61B1/00
CPC分类号： A61B1/303 , A61B1/00006 , A61B1/00034 , A61B1/00052 , A61B1/00066 , A61B1/00071 , A61B1/00094 , A61B1/00103 , A61B1/00105 , A61B1/00114 , A61B1/00124 , A61B1/005 , A61B1/015 , A61B1/05 , A61B1/06 , A61B1/0676 , A61B1/0684 , A61B1/126 , A61B1/307
摘要： Instalments and methods are described for performing endoscopically guided operative procedures. According to some embodiments, a re-usable portion of the instrument includes a handle, electronics and an integrated display screen while a fluid hub and a cannula which includes a CMOS imaging module and LED lighting, form a single use portion of the instrument. The cannula includes a working channel configured to accept an operative device for performing the operative procedures.
摘要翻译：描述了执行内窥镜指导手术程序的分期付款和方法。根据一些实施例，仪器的可重复使用的部分包括手柄，电子器件和集成显示屏，而包括CMOS成像模块和LED照明的流体毂和套管形成仪器的单个使用部分。套管包括工作通道，其构造成接受用于执行操作过程的操作装置。

4. 发明申请

WO2012060932A2 METHOD AND APPARATUS FOR HYSTEROSCOPY AND ENDOMETRIAL BIOPSY 审中-公开
标题翻译：用于脑膜炎和子宫内膜生物学的方法和装置
公开(公告)号：WO2012060932A2
公开(公告)日：2012-05-10
申请号：PCT/US2011/051982
申请日：2011-09-16
申请人： ENDOSEE CORPORATION , OUYANG, Xiaolong , INDMAN, Paul, D. , DECKMAN, Robert, K. , WANG, Shih-Ping
发明人： OUYANG, Xiaolong , INDMAN, Paul, D. , DECKMAN, Robert, K. , WANG, Shih-Ping
IPC分类号： A61B1/00
CPC分类号： A61B1/303 , A61B1/00052 , A61B1/00087 , A61B1/00094 , A61B1/00103 , A61B1/00105 , A61B1/00108 , A61B1/00124 , A61B1/00135 , A61B1/00154 , A61B1/015 , A61B1/018 , A61B10/0291 , A61B18/1485 , A61B90/361 , A61B90/37 , A61B2017/4216 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00559 , A61B2018/00577 , A61B2018/0212 , A61B2018/044 , A61B2090/306 , A61B2090/309 , A61B2090/372 , A61M1/0058 , A61M2210/1433
摘要： Methods and devices are described for performing a combined hysteroscopy and endometrial sampling in a manner that requires only a single insertion of an elongate object through a cervical opening of a patient's uterus. The distal end of an elongate, hollow sampling sheath of an integrated medical device is inserted through the cervical opening and into the uterus. Fluid is infused through the hollow interior of a sampling sheath, and outward through a distal opening into the uterus. The uterus becomes distended by the positive fluid pressure, allowing visualization. The inside surface of the distended uterus is endoscopically viewed by manipulating the integrated medical device in a manner that directs an imaging module attached to the sampling sheath near the distal end to multiple viewing positions. The corresponding video images of the inside surface are viewed on an electronic display screen of the integrated medical device that is positioned near the proximal end of the sampling sheath. After the viewing, and before withdrawing the distal end of the sampling sheath from the uterus, suction is applied to the hollow interior of the sampling sheath, which causes the distending fluid in the uterus to flow back into the sampling sheath through the distal opening, which returns the uterus to a non-distended state. With the uterus in the non- distended state, suction is applied while the integrated medical device is manipulated within the uterus in a manner that causes a sample of endometrium to be sucked into the tubing. The sample of endometrium is severed by at least one sharp edge formed along the distal opening. The sample is thus trapped in the hollow interior of the sampling sheath. Methods and devices are also described for performing a combined hysteroscopy and endometrial ablation in a manner that requires only a single insertion of an elongate object through a cervical opening of a patient's uterus.
摘要翻译：描述了以仅需要通过患者子宫颈部开口单一插入细长物体的方式进行组合宫腔镜检查和子宫内膜取样的方法和装置。集成医疗装置的细长的中空采样鞘的远端插入通过子宫颈开口并进入子宫。流体通过采样鞘的中空内部注入，并通过远端开口进入子宫。子宫由于积极的流体压力而膨胀，从而可视化。扩张子宫的内表面通过以将远端附近的取样鞘的成像模块引导到多个观察位置的方式操纵集成医疗装置来内窥镜观察。在位于采样护套的近端附近的集成医疗装置的电子显示屏上观察内表面的相应视频图像。在观察之后，并且在从子宫拔出取样鞘的远端之前，将吸力施加到采样鞘的中空内部，这使得子宫中的膨胀流体通过远端开口回流到采样鞘中，它将子宫返回到非扩张状态。在子宫处于非扩张状态时，在将子宫内膜样品吸入管内的方式在子宫内操作集成的医疗装置的同时施加抽吸。子宫内膜样本被沿着远端开口形成的至少一个锋利边缘切断。因此样品被捕获在采样鞘的中空内部。还描述了用于以仅需要通过患者子宫颈切口的细长物体的单次插入的方式进行组合宫腔镜检查和子宫内膜切除的方法和装置。

5. 发明公开

EP2709513A2 METHOD AND APPARATUS FOR HYSTEROSCOPY AND ENDOMETRIAL BIOPSY 审中-公开
标题翻译：方法和设备进行思考和子宫内膜活检
公开(公告)号：EP2709513A2
公开(公告)日：2014-03-26
申请号：EP12779463.4
申请日：2012-04-23
申请人： Endosee Corporation
发明人： OUYANG, Xiaolong , INDMAN, Paul, D. , DECKMAN, Robert, K. , WANG, Shih-Ping
IPC分类号： A61B1/045
CPC分类号： A61B1/00066 , A61B1/00016 , A61B1/00034 , A61B1/00039 , A61B1/0005 , A61B1/00052 , A61B1/00087 , A61B1/00091 , A61B1/00094 , A61B1/00101 , A61B1/00103 , A61B1/00105 , A61B1/00108 , A61B1/00124 , A61B1/00128 , A61B1/00179 , A61B1/015 , A61B1/018 , A61B1/045 , A61B1/05 , A61B1/053 , A61B1/0607 , A61B1/0676 , A61B1/0684 , A61B1/126 , A61B1/303 , A61B10/0275 , A61B10/0291 , A61B10/04 , A61B34/25 , A61B90/361 , A61B2017/00221 , A61B2090/309 , A61B2090/372 , A61M2210/1433
摘要： Methods and devices are described for performing a combined hysteroscopy and endometrial sampling. Techniques for improving visual images include forward facing fluid ports for clearing tissue debris and LED positioning and design. Manufacturability is improved through separately formed tip and shaft pieces. User interface features are described including user-friendly handle-mounted buttons as well the use of an interactive integrated touch screen display. The handle and display can be mated to a docking station for storage and recharging batteries.

6. 发明公开

EP2900118A1 METHOD AND APPARATUS FOR HYSTEROSCOPY AND COMBINED HYSTEROSCOPY AND ENDOMETRIAL BIOPSY 审中-公开
标题翻译：方法和装置结合，宫腔镜宫腔镜子宫内膜活检
公开(公告)号：EP2900118A1
公开(公告)日：2015-08-05
申请号：EP13830519.8
申请日：2013-05-14
申请人： Endosee Corporation
发明人： OUYANG, Xiaolong , INDMAN, Paul, D. , DECKMAN, Robert, K. , WANG, Shih-Ping
IPC分类号： A61B1/00
CPC分类号： A61B1/303 , A61B1/00006 , A61B1/00032 , A61B1/00034 , A61B1/00048 , A61B1/00052 , A61B1/00057 , A61B1/00066 , A61B1/00071 , A61B1/00078 , A61B1/00091 , A61B1/00094 , A61B1/00103 , A61B1/00105 , A61B1/00114 , A61B1/00124 , A61B1/005 , A61B1/0055 , A61B1/015 , A61B1/05 , A61B1/06 , A61B1/0676 , A61B1/0684 , A61B1/126 , A61B1/307 , A61B1/317 , A61B10/0291 , A61B10/04
摘要： Instruments and methods are described for performing hysteroscopy and/or combined hysteroscopy and endometrial biopsy. According to some embodiments, the handle, electronics and integrated display screen form a re-usable portion of the instrument while the fluid hub and cannula which includes a CMOS imaging module and LED lighting, form a single use portion of the instrument. The cannula is semi-flexible such that the operator can easily grasp the cannula at some intermediate point along the shaft (e.g. 5 inches from the distal tip) to bend and/or steer the cannula during use. According to some embodiments, the distal tip has a larger diameter than the shaft which has been found to improve fluid management during use in some applications.

7. 发明授权

EP2632318B1 APPARATUS FOR HYSTEROSCOPY AND ENDOMETRIAL BIOPSY 有权
公开(公告)号：EP2632318B1
公开(公告)日：2019-11-27
申请号：EP11838399.1
申请日：2011-09-16
申请人： Endosee Corporation
发明人： OUYANG, Xiaolong , INDMAN, Paul, D. , DECKMAN, Robert, K. , WANG, Shih-Ping
IPC分类号： A61B17/00 , A61B1/00 , A61B10/02 , A61M1/00 , A61B18/14 , A61B17/42 , A61B18/00

8. 发明公开

EP2632318A2 METHOD AND APPARATUS FOR HYSTEROSCOPY AND ENDOMETRIAL BIOPSY 有权
标题翻译：方法和设备进行思考和子宫内膜活检
公开(公告)号：EP2632318A2
公开(公告)日：2013-09-04
申请号：EP11838399.1
申请日：2011-09-16
申请人： Endosee Corporation
发明人： OUYANG, Xiaolong , INDMAN, Paul, D. , DECKMAN, Robert, K. , WANG, Shih-Ping
IPC分类号： A61B1/00
摘要： Methods and devices are described for performing a combined hysteroscopy and endometrial sampling in a manner that requires only a single insertion of an elongate object through a cervical opening of a patient's uterus. The distal end of an elongate, hollow sampling sheath of an integrated medical device is inserted through the cervical opening and into the uterus. Fluid is infused through the hollow interior of a sampling sheath, and outward through a distal opening into the uterus. The uterus becomes distended by the positive fluid pressure, allowing visualization. The inside surface of the distended uterus is endoscopically viewed by manipulating the integrated medical device in a manner that directs an imaging module attached to the sampling sheath near the distal end to multiple viewing positions. The corresponding video images of the inside surface are viewed on an electronic display screen of the integrated medical device that is positioned near the proximal end of the sampling sheath. After the viewing, and before withdrawing the distal end of the sampling sheath from the uterus, suction is applied to the hollow interior of the sampling sheath, which causes the distending fluid in the uterus to flow back into the sampling sheath through the distal opening, which returns the uterus to a non-distended state. With the uterus in the non- distended state, suction is applied while the integrated medical device is manipulated within the uterus in a manner that causes a sample of endometrium to be sucked into the tubing. The sample of endometrium is severed by at least one sharp edge formed along the distal opening. The sample is thus trapped in the hollow interior of the sampling sheath. Methods and devices are also described for performing a combined hysteroscopy and endometrial ablation in a manner that requires only a single insertion of an elongate object through a cervical opening of a patient's uterus.

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