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1. 发明授权

US09980672B2 Single-chambered sweat rate monitoring sensor 有权
公开(公告)号：US09980672B2
公开(公告)日：2018-05-29
申请号：US14801702
申请日：2015-07-16
申请人： Empire Technology Development LLC
发明人： George Charles Peppou , Michael Keoni Manion , Benjamin William Millar
IPC分类号： A61B5/05 , A61B5/00 , A61B10/00
CPC分类号： A61B5/4266 , A61B5/0022 , A61B5/4875 , A61B5/681 , A61B5/6831 , A61B5/6833 , A61B5/7475 , A61B10/0064
摘要： Technologies are generally described to monitor a sweat rate of an area of a skin. A hydration status of a human or non-human entity is monitored based on the sweat rate. The sweat rate is monitored when the sweat rate monitor is detected as sealed against the surface of the skin. The sweat rate monitor is attached to the surface of the skin with an adhesive, or a tape among other schemes to hold the sweat rate monitor in place during a measurement. The sweat rate monitor includes a container to capture an initial amount of sweat that comes out of the surface of the skin. When, the container is detected as filled with the initial amount of sweat, a pump of the sweat rate monitor is actuated to compress the container. The container is compressed to force a volume of the initial amount of sweat in the container out of an ejection port of the sweat rate monitor.

2. 发明授权

US09535043B2 Color change indicator of biofilm formation 有权
标题翻译：生物膜形成的颜色变化指标
公开(公告)号：US09535043B2
公开(公告)日：2017-01-03
申请号：US14130956
申请日：2013-05-31
申请人： Empire Technology Development LLC
发明人： Michael Keoni Manion , George Charles Peppou
IPC分类号： G01N31/22 , A61L29/14 , A61L31/14 , A61F13/42 , G01D7/00 , C12Q1/00 , C12Q1/04 , A61M25/00
CPC分类号： G01N31/222 , A61F13/42 , A61L29/14 , A61L29/148 , A61L31/14 , A61L31/148 , A61M25/0017 , C12Q1/00 , C12Q1/04 , G01D7/00 , G01D7/005
摘要： Technologies are generally described for devices for detection of a biofilm by a color change in a moisture-indicating substance, such as a chemical or a dye. The moisture indicating material may be supported by a substrate and sealed to keep moisture from the moisture indicating material. Alternatively, the moisture indicating material may be supported in a pouch and sealed by the pouch. The color change results from an ingress of moisture accompanying growth of a biofilm. The moisture-indicating substance may be used with indwelling or other devices to detect a biofilm. When the biofilm has sufficiently degraded the seal, an ingress of moisture and its accompanying pH may cause a color change in the moisture-indicating substance to signify the presence of the biofilm. Methods of manufacture and use of the disclosed devices are also described.
摘要翻译：技术通常描述为用于通过水分指示物质如化学品或染料中的颜色变化来检测生物膜的装置。湿气指示材料可以由基底支撑并密封以保持水分不受湿气指示材料的影响。或者，湿气指示材料可以被支撑在袋中并被袋密封。颜色变化是由伴随着生物膜生长所引起的水分进入而产生的。湿气指示物质可与留置或其他装置一起使用以检测生物膜。当生物膜已经充分降解密封时，水分的进入及其伴随的pH可能导致指示指示物质的颜色变化，以表示生物膜的存在。还描述了所公开的装置的制造和使用方法。

3. 发明申请

US20160287164A1 PORTABLE FLOW METER FOR LOW VOLUME APPLICATIONS 有权
标题翻译：便携式流量计用于低体积应用
公开(公告)号：US20160287164A1
公开(公告)日：2016-10-06
申请号：US14675295
申请日：2015-03-31
申请人： Empire Technology Development LLC
发明人： Michael Manion , Benjamin William Millar , George Charles Peppou
IPC分类号： A61B5/00 , F16K31/06 , A61B5/01 , A61B5/11 , A61B5/024 , G01F15/00 , G05D7/06
CPC分类号： A61B5/4266 , A61B5/01 , A61B5/024 , A61B5/1118 , F16K31/0644 , F16K37/005 , F16K99/0048 , F16K2099/0094 , G01F3/02 , G01F15/005 , G01F25/0007 , G01F25/003 , G01F25/0046 , G05D7/0635 , Y10T137/7761
摘要： An apparatus is disclosed that may include a substrate that may have a surface, a channel of a volume that may be defined, at least in part, by the substrate, wherein the channel may have a first end and a second end, a valve may be coupled to the channel at the first end, wherein the valve may be configured to allow a fluid to pass into the channel when the valve is open, and a continuity detector, which may be coupled to the channel at the second end, wherein the continuity detector may be activated when the fluid contacts the continuity detector, wherein the continuity detector may further be configured to provide a signal to close the valve and remove the fluid from the channel. A method for calculating a rate of flow of a fluid collected from a bodily surface into a body-worn device is disclosed.
摘要翻译：公开了一种可以包括可以具有表面的基底，至少部分由基底定义的体积的通道，其中通道可以具有第一端和第二端，阀可以在第一端处联接到通道，其中阀可以被配置为允许流体在阀打开时进入通道，并且连续性检测器可以在第二端耦合到通道，其中，当流体接触连续性检测器时，连续性检测器可以被激活，其中连续性检测器还可以被配置成提供关闭阀门并从通道移除流体的信号。公开了一种用于计算从身体表面收集到身体穿戴装置中的流体的流速的方法。

4. 发明申请

US20160225962A1 NANOPARTICLE GRADIENT REFRACTIVE INDEX ENCAPSULANTS FOR SEMI-CONDUCTOR DIODES 审中-公开
标题翻译：用于半导体二极管的纳米级梯度折射率指数
公开(公告)号：US20160225962A1
公开(公告)日：2016-08-04
申请号：US14610304
申请日：2015-01-30
申请人： Empire Technology Development LLC
发明人： Michael Keoni Manion , Benjamin William Millar , George Charles Peppou
IPC分类号： H01L33/50 , H01L33/00 , H01L33/56
CPC分类号： H01L33/56 , H01L33/502 , H01L2224/48091 , H01L2224/73265 , H01L2933/005 , H01L2924/00014
摘要： A gradient refractive index light emitting diode is disclosed. The light emitting diode includes a die at least partially encapsulated within a polymer, and nanoparticles dispersed within the polymer along a concentration gradient related to the distance from the die. The refractive index of the nanoparticles is different from the refractive index of the polymer.
摘要翻译：公开了一种梯度折射率发光二极管。发光二极管包括至少部分地封装在聚合物内的裸片，并且纳米颗粒沿着与模具的距离相关的浓度梯度分散在聚合物内。纳米粒子的折射率与聚合物的折射率不同。

5. 发明授权

US09717455B2 Portable flow meter for low volume applications 有权
公开(公告)号：US09717455B2
公开(公告)日：2017-08-01
申请号：US14675295
申请日：2015-03-31
申请人： Empire Technology Development LLC
发明人： Michael Manion , Benjamin William Millar , George Charles Peppou
IPC分类号： F16K99/00 , A61B5/00 , A61B5/01 , A61B5/024 , A61B5/11 , F16K31/06 , G01F15/00 , G05D7/06 , F16K37/00 , G01F25/00 , G01F3/02
CPC分类号： A61B5/4266 , A61B5/01 , A61B5/024 , A61B5/1118 , F16K31/0644 , F16K37/005 , F16K99/0048 , F16K2099/0094 , G01F3/02 , G01F15/005 , G01F25/0007 , G01F25/003 , G01F25/0046 , G05D7/0635 , Y10T137/7761
摘要： An apparatus is disclosed that may include a substrate that may have a surface, a channel of a volume that may be defined, at least in part, by the substrate, wherein the channel may have a first end and a second end, a valve may be coupled to the channel at the first end, wherein the valve may be configured to allow a fluid to pass into the channel when the valve is open, and a continuity detector, which may be coupled to the channel at the second end, wherein the continuity detector may be activated when the fluid contacts the continuity detector, wherein the continuity detector may further be configured to provide a signal to close the valve and remove the fluid from the channel. A method for calculating a rate of flow of a fluid collected from a bodily surface into a body-worn device is disclosed.

6. 发明申请

US20160367182A1 PERSPIRATION MONITORING 审中-公开
标题翻译：灵感监测
公开(公告)号：US20160367182A1
公开(公告)日：2016-12-22
申请号：US14741328
申请日：2015-06-16
申请人： EMPIRE TECHNOLOGY DEVELOPMENT LLC
发明人： Benjamin William Millar , George Charles Peppou
IPC分类号： A61B5/00
CPC分类号： A61B5/4266 , A61B5/4875 , A61B5/6801 , A61B5/74 , A61B2560/0412
摘要： A system may include a mesh that includes a non-electrically conductive mesh material. The system may also include a first electrode coupled to the mesh at a first location of the mesh. The system may further include a second electrode coupled to the mesh at a second location of the mesh that is different from the first location. Additionally, the system may include a control unit electrically coupled to the first electrode and the second electrode. The control unit may be configured to generate a notification signal when the first electrode and the second electrode are electrically coupled to each other.
摘要翻译：系统可以包括包括非导电网状材料的网。系统还可以包括在网的第一位置处联接到网的第一电极。该系统还可以包括在网格的与第一位置不同的第二位置处联接到网格的第二电极。另外，该系统可以包括电耦合到第一电极和第二电极的控制单元。控制单元可以被配置为当第一电极和第二电极彼此电耦合时产生通知信号。

7. 发明申请

US20160299405A1 GRADIENT INDEX (GRIN) BACKPLANE ROUTING 审中-公开
标题翻译：梯级索引（GRIN）BACKPLANE路由
公开(公告)号：US20160299405A1
公开(公告)日：2016-10-13
申请号：US15100989
申请日：2014-02-25
申请人： EMPIRE TECHNOLOGY DEVELOPMENT LLC
发明人： Michael Keoni Manion , Benjamin William Millar , George Charles Peppou
IPC分类号： G02F1/295
CPC分类号： G02F1/295 , B29D11/00682 , B82Y20/00 , G02B6/43 , G02F1/19 , G02F2001/291 , G02F2202/36 , G02F2202/40
摘要： Technologies are generally described to employ an optical effect, such as Pockels effect to direct an optical communication signal within a gradient index (GRIN) backplane. An electric field may be created between two or more electrodes located on different surfaces of the GRIN backplane in response to an application of electrical excitation to at least one of the electrodes. The electric field may be configured to change an orientation of nanoparticles in at least a portion of GRIN material comprising the GRIN backplane so as to control a direction of one or more optical pathways within the GRIN backplane. Propagation of an optical communication signal between one or more components mounted on one or more surfaces of the GRIN backplane may be facilitated via the controlled direction of the optical pathways, which may enable control of routing, including switching, of the optical communication signal to a particular optical pathway.
摘要翻译：技术通常被描述为采用光学效应，例如Pockels效应来引导梯度折射率（GRIN）背板内的光通信信号。响应于向至少一个电极施加电激励，可以在位于GRIN背板的不同表面上的两个或更多个电极之间产生电场。电场可以被配置为改变包括GRIN背板的GRIN材料的至少一部分中的纳米颗粒的取向，以便控制GRIN背板内的一个或多个光学路径的方向。可以经由光路的受控方向来促进安装在GRIN背板的一个或多个表面上的一个或多个组件之间的光通信信号的传播，这可以使得能够控制路由，包括将光通信信号切换到特别的光路。

8. 发明授权

US09228996B2 Method and device for detecting device colonization 有权
标题翻译：用于检测装置定殖的方法和装置
公开(公告)号：US09228996B2
公开(公告)日：2016-01-05
申请号：US14114738
申请日：2013-05-31
申请人： Empire Technology Development LLC
发明人： George Charles Peppou , Michael Keoni Manion , Benjamin Matthew Austin , Benjamin William Millar , Benjamin Watson Barens
IPC分类号： G01N33/493 , A61B5/145 , A61M25/00 , A61L29/14 , A61L29/16 , A61B5/00 , A61L31/14 , A61L31/16 , A61F2/82
CPC分类号： G01N33/493 , A61B5/0059 , A61B5/412 , A61B5/4851 , A61B5/6852 , A61F2/82 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/602 , A61M25/0009 , A61M25/0017 , A61M25/0045 , A61M2025/0056 , A61M2205/702 , G01N2800/00 , G01N2800/26
摘要： Technologies are disclosed for a method and a device for detecting device colonization. Disclosed herein is an indwelling medical device configured to detect a biofilm. The device comprises a substrate configured to contact blood and a detecting material, disposed with the substrate, configured to detect the presence of a biofilm thereon. The detecting material is soluble in blood, removable by kidneys from the blood, and passable to urine by the kidneys for detection in the urine. A method for detecting the growth of a biofilm on an indwelling medical and a method for making an indwelling medical device are also disclosed herein.
摘要翻译：公开了用于检测装置定植的方法和装置的技术。本文公开了一种被配置为检测生物膜的留置医疗装置。所述装置包括被配置为接触血液的基底和与所述基底一起设置的检测材料，所述检测材料配置成检测其上存在生物膜。该检测材料可溶于血液，可由肾脏从血液中除去，并可通过肾脏通过尿液进行尿液检测。本文还公开了一种用于检测留置医疗上的生物膜的生长的方法和用于制造留置医疗装置的方法。

9. 发明授权

US10260082B2 Liposomal detection devices and methods for their use and preparation 有权
公开(公告)号：US10260082B2
公开(公告)日：2019-04-16
申请号：US15031710
申请日：2013-10-22
申请人： EMPIRE TECHNOLOGY DEVELOPMENT LLC
发明人： Michael Keoni Manion , George Charles Peppou
IPC分类号： C12Q1/04 , G01N33/58 , G01N33/84 , C12Q1/28 , C12Q1/527 , G01N33/12
摘要： Liposomal detection devices and methods of making and using such devices are disclosed. Such liposomal detection devices may be used to detect microbes by detecting a byproduct of microbial metabolism, or may be used to detect changes in pH and/or changes in temperature. Liposomal detection devices may include a first liposome encapsulating a first destabilizing compound and a second liposome encapsulating a second destabilizing compound. The first liposome may destabilize in response to the detection of the target compound or change to release the first destabilizing compound which may destabilize the second liposome. A matrix, such as a hydrogel matrix, may encase the first liposome and the second liposome.

10. 发明申请

US20170014067A1 SINGLE-CHAMBERED SWEAT RATE MONITORING SENSOR 有权
标题翻译：单层烘干速率监测传感器
公开(公告)号：US20170014067A1
公开(公告)日：2017-01-19
申请号：US14801702
申请日：2015-07-16
申请人： Empire Technology Development LLC
发明人： George Charles Peppou , Michael Keoni Manion , Benjamin William Millar
IPC分类号： A61B5/00 , A61B10/00
CPC分类号： A61B5/4266 , A61B5/0022 , A61B5/4875 , A61B5/681 , A61B5/6831 , A61B5/6833 , A61B5/7475 , A61B10/0064
摘要： Technologies are generally described to monitor a sweat rate of an area of a skin. A hydration status of a human or non-human entity is monitored based on the sweat rate. The sweat rate is monitored when the sweat rate monitor is detected as sealed against the surface of the skin. The sweat rate monitor is attached to the surface of the skin with an adhesive, or a tape among other schemes to hold the sweat rate monitor in place during a measurement. The sweat rate monitor includes a container to capture an initial amount of sweat that comes out of the surface of the skin. When, the container is detected as filled with the initial amount of sweat, a pump of the sweat rate monitor is actuated to compress the container. The container is compressed to force a volume of the initial amount of sweat in the container out of an ejection port of the sweat rate monitor.
摘要翻译：通常描述技术来监测皮肤区域的汗液率。基于汗水率监测人类或非人类实体的水合状态。当检测到汗液速率监测器与皮肤表面密封时，监测汗水率。汗液速率监测器用粘合剂或胶带等附着在皮肤表面，以便在测量过程中将汗液速率监测器保持在适当位置。汗水率监测器包括一个容器，用于捕获从皮肤表面出来的初始量的汗液。当检测到容器充满初始量的汗液时，启动汗液速率监测器的泵以压缩容器。容器被压缩以将容器中的初始汗液量从汗液速率监测器的排出口压出。

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