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1. 发明授权

US07312339B2 Polyene oxazoles and processes for their preparation 失效
标题翻译：聚烯恶唑及其制备方法
公开(公告)号：US07312339B2
公开(公告)日：2007-12-25
申请号：US10865767
申请日：2004-06-14
申请人： James B. McAlpine , Chris M. Farnet , Emmanuel Zazopoulos , Nargis Ismail , Brian O. Bachmann
发明人： James B. McAlpine , Chris M. Farnet , Emmanuel Zazopoulos , Nargis Ismail , Brian O. Bachmann
IPC分类号： C07D207/444 , C07D209/48
CPC分类号： C12R1/60 , C07D263/32 , C07D413/12 , C12P17/14
摘要： Polyene oxazoles of the following formula wherein R3 is selected from H and methyl, are disclosed. Such compounds, and pharmaceutically acceptable salts thereof, may be used in the inhibition of tumor cell growth. The polyene oxazoles and their pharmaceutically acceptable salts may be formulated as pharmaceutical compositions with pharmaceutically acceptable carriers for use in the inhibition of tumor cells. The polyene oxazoles may be obtained from strains of Streptomyces sparsogenes, such as strain 022 having deposit number IDAC 270504-04.
摘要翻译：公开了下式的多烯恶唑，其中R 3选自H和甲基。这些化合物及其药学上可接受的盐可用于抑制肿瘤细胞生长。多烯恶唑及其药学上可接受的盐可以配制成具有用于抑制肿瘤细胞的药学上可接受的载体的药物组合物。多烯恶唑可以从天竺葵链霉菌菌株获得，例如具有保藏号IDAC 270504-04的菌株022。

2. 发明申请

US20100016170A1 HIGH THROUGHPUT METHOD FOR DISCOVERY OF GENE CLUSTERS 审中-公开
标题翻译：用于发现基因簇的高通量方法
公开(公告)号：US20100016170A1
公开(公告)日：2010-01-21
申请号：US11803406
申请日：2007-05-14
申请人： Chris M. Farnet , Alfredo Staffa , Emmanuel Zazopoulos
发明人： Chris M. Farnet , Alfredo Staffa , Emmanuel Zazopoulos
IPC分类号： C40B20/04
CPC分类号： C07K14/36 , C07K14/365 , C12N15/52 , C12P19/62
摘要： A method for identifying gene cluster is disclosed. The method may be used for identifying gene clusters involved in the biosynthesis of natural products. A small insert library of DNA fragments of genomic DNA and a large insert library of DNA fragments of genomic DNA are prepared. Fragments in the small insert library are sequenced and compared by homology comparison under computer control to a database containing genes, gene fragments or proteins known to be involved in the biosynthesis of microbial natural products. Fragments having similar structure to genes, gene fragments or proteins known to be involved in the biosynthesis of naturally occurring metabolites are used as probes to screen the large insert library of genomic DNA to detect gene clusters involved in the biosynthesis of microbial natural products.
摘要翻译：公开了鉴定基因簇的方法。该方法可用于鉴定涉及天然产物生物合成的基因簇。制备基因组DNA的DNA片段的小插入文库和基因组DNA的DNA片段的大插入文库。对小插入片段中的片段进行测序，并通过计算机控制下的同源性比较与包含已知参与微生物天然产物生物合成的基因，基因片段或蛋白质的数据库进行比较。具有与基因相似结构的片段，已知参与天然存在的代谢物的生物合成的基因片段或蛋白质被用作筛选基因组DNA的大插入文库以探测参与微生物天然产物生物合成的基因簇的片段。

3. 发明申请

US20080199940A1 Farnesyl dibenzodiazepinone and processes for its production 失效
标题翻译：法呢基二苯并二氮杂酮及其生产方法
公开(公告)号：US20080199940A1
公开(公告)日：2008-08-21
申请号：US11511586
申请日：2006-08-28
申请人： James B. McAlpine , Emmanuel Zazopoulos , Chris M. Farnet , Mahmood Piraee
发明人： James B. McAlpine , Emmanuel Zazopoulos , Chris M. Farnet , Mahmood Piraee
IPC分类号： C12N1/20 , C07H21/02 , C12N15/00
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to Micromonospora sp. strain 046-ECO11, to the use of ECO-04601 and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of cancer cell growth, bacterial cell growth, mammalian lipoxygenase, and to pharmaceutical compositions comprising ECO-04601 or a pharmaceutically acceptable salt or derivative thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of ECO-04601.
摘要翻译：本发明涉及名为ECO-04601的新型法呢基化二苯并二氮杂酮，其药学上可接受的盐和衍生物，以及获得这些化合物的方法。获得ECO-04601化合物的一种方法是通过培养一种新型的小单孢菌属菌株046-ECO11; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。本发明还涉及小单孢菌属应用046-ECO11，使用ECO-04601及其药学上可接受的盐和衍生物作为药物，特别是其作为癌细胞生长抑制剂，细菌细胞生长，哺乳动物脂氧合酶的用途，以及包含ECO-04601或其药学上可接受的盐或衍生物。最后，本发明涉及参与ECO-04601的生物合成的新型多核苷酸序列及其编码的蛋白质。

4. 发明申请

US20080131943A1 POLYNUCLEOTIDES FOR PRODUCTION OF FARNESYL DIBENZODIAZEPINONES 审中-公开
标题翻译：生产二苯并恶唑酮的多核苷酸
公开(公告)号：US20080131943A1
公开(公告)日：2008-06-05
申请号：US11876636
申请日：2007-10-22
申请人： Chris M. Farnet , Emmanuel Zazopoulos
发明人： Chris M. Farnet , Emmanuel Zazopoulos
IPC分类号： C12P17/10 , C12N15/11 , C12N9/10 , C12N15/00 , C12N1/20
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： This invention provides genes and their encoded proteins, involved in the biosynthesis of farnesyl dibenzodiazepinones, including ECO-04601. The invention relates to expression vectors comprising the genes and to host cells transformed with these vectors. The invention further relates to methods of producing farnesyl dibenzodiazepinone compounds using the genes and proteins of the invention, for example, involving expression of biosynthetic pathway genes in transformed host cells.
摘要翻译：本发明提供了参与法呢基二苯并二氮杂酮生物合成的基因及其编码的蛋白质，包括ECO-04601。本发明涉及包含该基因的表达载体以及用这些载体转化的宿主细胞。本发明还涉及使用本发明的基因和蛋白质生产法呢基二苯并二氮杂酮化合物的方法，例如涉及在转化的宿主细胞中表达生物合成途径基因。

5. 发明授权

US07416868B2 Polyene polyketides, processes for their production and their use as a pharmaceutical 失效
标题翻译：聚烯烃聚合物，其生产方法及其作为药物的用途
公开(公告)号：US07416868B2
公开(公告)日：2008-08-26
申请号：US10760494
申请日：2004-01-21
申请人： Emmanuel Zazopoulos , Chris M. Farnet
发明人： Emmanuel Zazopoulos , Chris M. Farnet
IPC分类号： C12N9/00
CPC分类号： C07H15/203 , C07C215/24 , C07C225/14 , C07C235/28 , C07C237/16 , C07C279/22 , C07C305/14 , C07C2601/10 , C07C2601/14 , C07H15/10 , C07H15/18 , C07H15/26 , C12P7/42 , C12P11/00 , C12P13/001 , C12P13/02 , C12P19/44 , C12R1/465 , Y10S435/886
摘要： This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to the novel strains of Streptomyces aizunensis used to produce these compounds, to the use of these compounds and their pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of fungal cell growth and cancer cell growth. The invention also relates to pharmaceutical compositions comprising these novel polyketides or a pharmaceutically acceptable salts or derivatives thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of these novel polyketides.
摘要翻译：本发明涉及新类型的多烯聚酮化合物，其药学上可接受的盐和衍生物，以及获得化合物的方法。获得这些化合物的一种方法是通过培养新的链霉菌链霉菌菌株; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。本发明还涉及用于制备这些化合物的新型链霉菌Streptomyces aizunensis菌株，使用这些化合物及其药学上可接受的盐和衍生物作为药物，特别是其作为真菌细胞生长抑制剂和癌细胞生长的用途。本发明还涉及包含这些新型聚酮化合物或其药学上可接受的盐或衍生物的药物组合物。最后，本发明涉及参与这些新型聚酮化合物的生物合成的新型多核苷酸序列及其编码的蛋白质。

6. 发明授权

US07101872B2 Farnesyl dibenzodiazepinone, and processes for its production 有权
标题翻译：法呢基二苯并二氮杂酮及其制备方法
公开(公告)号：US07101872B2
公开(公告)日：2006-09-05
申请号：US10762107
申请日：2004-01-21
申请人： Brian O. Bachmann , James B. McAlpine , Emmanuel Zazopoulos , Chris M. Farnet , Mahmood Piraee
发明人： Brian O. Bachmann , James B. McAlpine , Emmanuel Zazopoulos , Chris M. Farnet , Mahmood Piraee
IPC分类号： C07D243/10 , A61K31/55
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to Micromonospora sp. strain 046-ECO11, to the use of ECO-04601 and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of cancer cell growth, bacterial cell growth, mammalian lipoxygenase, and to pharmaceutical compositions comprising ECO-04601 or a pharmaceutically acceptable salt or derivative thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of ECO-04601.
摘要翻译：本发明涉及名为ECO-04601的新型法呢基化二苯并二氮杂酮，其药学上可接受的盐和衍生物，以及获得这些化合物的方法。获得ECO-04601化合物的一种方法是通过培养一种新型的小单孢菌属菌株046-ECO11; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。本发明还涉及小单孢菌属应用046-ECO11，使用ECO-04601及其药学上可接受的盐和衍生物作为药物，特别是其作为癌细胞生长抑制剂，细菌细胞生长，哺乳动物脂氧合酶的用途，以及包含ECO-04601或其药学上可接受的盐或衍生物。最后，本发明涉及参与ECO-04601的生物合成的新型多核苷酸序列及其编码的蛋白质。

7. 发明授权

US07635765B2 Gene encoding a nonribosomal peptide synthetase for the production of ramoplanin 失效
标题翻译：编码非核糖体多肽合成酶的基因用于产生拉莫拉宁
公开(公告)号：US07635765B2
公开(公告)日：2009-12-22
申请号：US11205109
申请日：2005-08-17
申请人： Chris M. Farnet , Emmanuel Zazopoulos , Alfredo Staffa
发明人： Chris M. Farnet , Emmanuel Zazopoulos , Alfredo Staffa
IPC分类号： C07H21/04 , C07K14/00
CPC分类号： C07K14/365 , C12N15/52
摘要： The present invention relates to isolated genetic sequences encoding nonribosomal peptide synthetase (NRPS) proteins which direct the biosynthesis of the antibiotic ramoplanin in microorganisms such as Actinoplanes sp. The isolated gene sequences serve as substrates for bioengineering of antibiotic structures.
摘要翻译：本发明涉及编码非核糖体肽合成酶（NRPS）蛋白质的分离的遗传序列，其指导抗微生物如抗生素拉莫拉宁的生物合成，例如Actinoplanes sp。分离的基因序列作为抗生素结构生物工程的底物。

8. 发明授权

US07521222B2 Farnesyl dibenzodiazepinone and processes for its production 失效
标题翻译：法呢基二苯并二氮杂酮及其生产方法
公开(公告)号：US07521222B2
公开(公告)日：2009-04-21
申请号：US11511586
申请日：2006-08-28
申请人： Emmanuel Zazopoulos , Chris M. Farnet
发明人： Emmanuel Zazopoulos , Chris M. Farnet
IPC分类号： C12N1/20 , C12N15/70 , C07H21/02
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to Micromonospora sp. strain 046-ECO11, to the use of ECO-04601 and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of cancer cell growth, bacterial cell growth, mammalian lipoxygenase, and to pharmaceutical compositions comprising ECO-04601 or a pharmaceutically acceptable salt or derivative thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of ECO-04601.
摘要翻译：本发明涉及名为ECO-04601的新型法呢基化二苯并二氮杂酮，其药学上可接受的盐和衍生物，以及获得这些化合物的方法。获得ECO-04601化合物的一种方法是通过培养一种新型的小单孢菌属菌株046-ECO11; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。本发明还涉及小单孢菌属应用046-ECO11，使用ECO-04601及其药学上可接受的盐和衍生物作为药物，特别是其作为癌细胞生长抑制剂，细菌细胞生长，哺乳动物脂氧合酶的用途，以及包含ECO-04601或其药学上可接受的盐或衍生物。最后，本发明涉及参与ECO-04601的生物合成的新型多核苷酸序列及其编码的蛋白质。

9. 发明申请

US20090069396A1 Polyene Oxazoles and Processes for Their Preparation 审中-公开
标题翻译：聚烯恶唑及其制备方法
公开(公告)号：US20090069396A1
公开(公告)日：2009-03-12
申请号：US11934125
申请日：2007-11-02
申请人： James B. McAlpine , Chris M. Farnet , Emmanuel Zazopoulos , Nargis Ismail , Brian O. Bachmann
发明人： James B. McAlpine , Chris M. Farnet , Emmanuel Zazopoulos , Nargis Ismail , Brian O. Bachmann
IPC分类号： A61K31/422 , C07D263/02 , A61P35/00
CPC分类号： C12R1/60 , C07D263/32 , C07D413/12 , C12P17/14
摘要： This invention relates to novel biologically active polyene oxazoles, their pharmaceutically acceptable salts and derivatives, and to methods of obtaining them. One method for obtaining the compounds is by cultivation of Streptomyces sparsogenes NRRL 2940 or a mutant or variant thereof.
摘要翻译：本发明涉及新的生物活性多烯恶唑，其药学上可接受的盐和衍生物，以及获得它们的方法。用于获得化合物的一种方法是通过培养链霉菌NRRL 2940或其突变体或变体。

10. 发明授权

US07297524B2 Polynucleotides for production of farnesyl dibenzodiazepinones 失效
标题翻译：用于生产法呢基二苯并二氮杂酮的多核苷酸
公开(公告)号：US07297524B2
公开(公告)日：2007-11-20
申请号：US11330123
申请日：2006-01-12
申请人： Chris M. Farnet , Emmanuel Zazopoulos
发明人： Chris M. Farnet , Emmanuel Zazopoulos
IPC分类号： C12N9/10 , C12N15/70 , C12N1/20 , C12P17/16 , C12P21/06 , C07H21/04
CPC分类号： C07D243/38 , A61K38/00 , C12N9/0004 , C12N9/10 , C12N9/1085 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N9/93 , C12N15/52 , C12P17/10 , C12P17/182 , C12R1/29
摘要： This invention provides genes and their encoded proteins, involved in the biosynthesis of farnesyl dibenzodiazepinones, including ECO-04601. The invention relates to expression vectors comprising the genes and to host cell transformed with these vectors. The invention further relates to methods of producing farnesyl dibenzodiazepinone compounds using the genes and proteins of the invention, for example, involving expression of biosynthetic pathway genes in transformed host cells.
摘要翻译：本发明提供了参与法呢基二苯并二氮杂酮生物合成的基因及其编码的蛋白质，包括ECO-04601。本发明涉及包含该基因的表达载体和宿主用这些载体转化的细胞。本发明还涉及使用本发明的基因和蛋白质生产法呢基二苯并二氮杂酮化合物的方法，例如涉及在转化的宿主细胞中表达生物合成途径基因。

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