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1. 发明申请

US20110160285A1 IDENTIFICATION OF MIRNA PROFILES THAT ARE DIAGNOSTIC OF HYPERTROPHIC CARDIOMYOPATHY 审中-公开
标题翻译：鉴别诊断超声心动图的MIRNA轮廓
公开(公告)号：US20110160285A1
公开(公告)日：2011-06-30
申请号：US12921827
申请日：2009-03-12
申请人： Emily Anderson , Anastasia Khvorova , Anita G. Seto , Scott Baskerville , Leslie Leinwand , Kevin G. Sullivan
发明人： Emily Anderson , Anastasia Khvorova , Anita G. Seto , Scott Baskerville , Leslie Leinwand , Kevin G. Sullivan
IPC分类号： A61K31/7105 , C40B30/04 , A61P9/00
CPC分类号： C12Q1/6883 , A61K48/00 , C12Q2600/178
摘要： Disclosed herein are a collection of miRNAs and genes whose expression is altered in hypertrophic cardiomyopathy. Accordingly, these miRNAs and genes, singly or in combination, are useful as molecular markers for diagnosis or prognosis of hypertrophic cardiomyopathy. The miRNAs and genes disclosed can also be therapeutic targets for cardiac hypertrophy. For example, agents such as miRNA mimics, miRNA inhibitors or siRNAs for a given miRNA or gene can be used to modulate the level of these molecules thereby inhibiting or preventing hypertrophic cardiomyopathy.
摘要翻译：本文公开了在增生性心肌病中表达改变的miRNA和基因的集合。因此，这些miRNA和基因单独或组合可用作增生性心肌病的诊断或预后的分子标记物。所公开的miRNA和基因也可以是心脏肥大的治疗靶点。例如，可以使用诸如miRNA模拟物，miRNA抑制剂或用于给定miRNA或基因的siRNA的试剂来调节这些分子的水平，从而抑制或预防肥大性心肌病。

2. 发明授权

US5978539A Optical device having a temperature independent spectral response using nonplanar geometric distortion of a substrate 失效
标题翻译：具有使用基板的非平面几何变形的温度独立光谱响应的光学装置
公开(公告)号：US5978539A
公开(公告)日：1999-11-02
申请号：US943747
申请日：1997-10-03
申请人： Scott T. Davies , Daren Li , Yuan P. Li , Chellappan Narayanan , Kevin G. Sullivan , Jianluo Zhang
发明人： Scott T. Davies , Daren Li , Yuan P. Li , Chellappan Narayanan , Kevin G. Sullivan , Jianluo Zhang
IPC分类号： G02B6/12 , G02B6/122 , G02B6/34 , G02B6/10
CPC分类号： G02B6/1203 , G02B6/12 , G02B6/12007 , G02B6/122
摘要： An optical interconnection device has a passive control mechanism for substantially eliminating thermal effects on optical properties of the apparatus Specifically, the interconnection apparatus includes a control material coupled to an optical circuit substrate, wherein the control material has a thermal expansion coefficient that is different than a substrate thermal expansion coefficient. In response to an increase or decrease an ambient temperature, the control material thermally expands or contracts at a different rate than the substrate to create a non-planar substrate distortion transmitted to the core portion, thereby creating a temperature independent optical path length within the optical core portion.
摘要翻译：光互连装置具有用于基本上消除对该装置的光学特性的热影响的被动控制机构。具体地，该互连装置包括耦合到光电路基板的控制材料，其中控制材料的热膨胀系数不同于基板热膨胀系数。响应于增加或减少环境温度，控制材料以与衬底不同的速率热膨胀或收缩，以产生传输到芯部的非平面衬底失真，从而在光学器件内产生温度无关的光程长度核心部分。

3. 发明授权

US5075562A Method and apparatus for absolute Moire distance measurements using a grating printed on or attached to a surface 失效
标题翻译：使用印刷在表面上或附着于表面的光栅进行绝对莫尔距离测量的方法和装置
公开(公告)号：US5075562A
公开(公告)日：1991-12-24
申请号：US584983
申请日：1990-09-20
申请人： John E. Greivenkamp, Jr. , Russell J. Palum , Kevin G. Sullivan
发明人： John E. Greivenkamp, Jr. , Russell J. Palum , Kevin G. Sullivan
IPC分类号： G01B11/00 , G01B11/02 , G01D5/26 , G01D5/38 , G01S17/89 , G02B7/28
CPC分类号： G01B11/026 , G01D5/38 , G01S17/89 , G02B7/28
摘要： Method and apparatus are disclosed for providing absolute Moire distance measurements of a diffusely reflective surface from a reference position. More particularly, a first grating is located, formed, or printed on the diffusely reflective surface. An image of the first grating is formed on a second grating or detector array by imaging means for generating a Moire pattern that is detected by a detector means. At the reference position of the diffusely reflective surface relative to the imaging means, the periods of the image of the first grating and the second grating match. Movement of the diffusely reflective surface from the reference position in a direction normal thereto, produces a spatially varying intensity pattern at the detector means which results from the shifting and magnification mismatch between the pattern of the image of the first grating and the pattern of the second grating. Measuring the amount of magnification differences between the two patterns provides information related to the instantaneous absolute distance of the diffusely reflective surface from the reference position. Various methods are disclosed for using the information from the detector means for determining the absolute distance measurements.
摘要翻译：公开了用于从参考位置提供漫反射表面的绝对莫尔距离测量的方法和装置。更具体地，第一光栅被定位，形成或印刷在漫反射表面上。第一光栅的图像通过成像装置形成在第二光栅或检测器阵列上，用于产生由检测器装置检测的莫尔图案。在漫反射表面相对于成像装置的参考位置处，第一光栅和第二光栅的图像的周期匹配。漫反射表面在与基准位置垂直的方向上的移动在检测器装置处产生空间变化的强度图案，其由第一光栅的图像的图案与第二光栅的图案之间的偏移和放大失配产生光栅。测量两个图案之间的放大率差异量提供了与漫反射表面从参考位置的瞬时绝对距离相关的信息。公开了使用来自检测器装置的用于确定绝对距离测量的信息的各种方法。

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