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1. 发明申请

US20070066640A1 Heteroaryl-substituted pyrrolo'2,3-b1 pyridine derivatives as crf receptor antagonists 审中-公开
标题翻译：杂芳基取代的吡咯并[2,3-b]吡啶衍生物作为受体拮抗剂
公开(公告)号：US20070066640A1
公开(公告)日：2007-03-22
申请号：US10542196
申请日：2004-01-14
申请人： Emiliano Castiglioni , Romano Di Fabio , Aldo Feriani , Fabrizio Micheli , Fabio Sabbatini , Yves St-Denis
发明人： Emiliano Castiglioni , Romano Di Fabio , Aldo Feriani , Fabrizio Micheli , Fabio Sabbatini , Yves St-Denis
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof, to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF).
摘要翻译：本发明提供了包括其立体异构体，前体药物和药学上可接受的盐或溶剂合物的式（I）化合物，其制备方法，含有它们的药物组合物及其用于治疗由促肾上腺皮质激素释放因子（CRF）介导的病症）。

2. 发明申请

US20070004708A1 Condensed n-heterocyclic compounds and their use as crf receptor antagonists 有权
标题翻译：缩合的N-杂环化合物及其作为crf受体拮抗剂的用途
公开(公告)号：US20070004708A1
公开(公告)日：2007-01-04
申请号：US10552493
申请日：2004-04-07
申请人： Daniele Andreotti , Giovannie Bernasconi , Emiliano Castiglioni , Stefania Contini , Romano Di Fabio , Elettra Fazzolari , Aldo Feriani , Gabriella Gentile , Mario Mattioli , Anna Mingardi , Fabio Sabbatini , Yves St-Denis
发明人： Daniele Andreotti , Giovannie Bernasconi , Emiliano Castiglioni , Stefania Contini , Romano Di Fabio , Elettra Fazzolari , Aldo Feriani , Gabriella Gentile , Mario Mattioli , Anna Mingardi , Fabio Sabbatini , Yves St-Denis
IPC分类号： A61K31/549 , A61K31/519 , A61K31/496 , A61K31/501 , A61K31/4745 , C07D487/02 , C07D471/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof (Formula (I)) wherein the dashed line may represent a double bond; R is aryl or heteroaryl, each of which may be substituted by 1 to 4 groups J selected from: halogen, C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6 alkyl, C2-C6 lkenyl, C2-C6 alkynyl, halo C1-C6 alkoxy, —C(O)R2, nitro, hydroxy, —NR3R4, cyano and or a group Z; R1 is hydrogen, C3-C7 cycloalkyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkyl, halo C1-C6 alkoxy, halogen, NR3R4 or cyano; D, G is —C— optionally substituted; X is carbon or nitrogen; Y is nitrogen or —C— optionally substituted; W is a 4-8 membered ring, which may be saturated or may contain one to three double bonds, and in which:—one carbon atom is replaced by a carbonyl or S(O)m; and—one to four carbon atoms may optionally be replaced by oxygen, nitrogen or NR12, S(O)m, carbonyl, and such ring may be further substituted by 1 to 8 substituents; Z is a 5-6 membered heterocycle, which may be substituted by 1 to 8 R5 groups or a phenyl ring, which may be substituted by 1 to 4 substituents; m is an integer from 0 to 2. to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF).
摘要翻译：本发明提供了包含立体异构体，前体药物和药学上可接受的盐或溶剂合物（式（I））的式（I）化合物，其中虚线可以表示双键; R是芳基或杂芳基，其各自可以被1-4个选自以下的基团取代：卤素，C 1 -C 6烷基，C 1 -C 6烷氧基，卤代C 1 -C 6烷基，C 2 -C 6烯基，C 2 -C 6炔基，卤素 C 1 -C 6烷氧基，-C（O）R 2，硝基，羟基，-NR 3 R 4，氰基和/或Z ; R 1是氢，C 3 -C 7环烷基，C 1 -C 6烷基，C 1 -C 6烷氧基，C 1 -C 6硫代烷基，C 2 -C 6烯基，C 2 -C 6炔基，卤代C 1 -C 6烷基，卤代C 1 -C 6烷氧基，卤素，NR 3 R 4或氰基; D，G是-C-任选取代的; X是碳或氮; Y是氮或-C-任选取代的; W是4-8元环，其可以是饱和的或可以含有一至三个双键，并且其中： - 一个碳原子被羰基或S（O）m取代; 一至四个碳原子可以任选地被氧，氮或NR 12，S（O）m H，羰基取代，并且这种环可进一步被1 至8个取代基; Z是5-6元杂环，其可被1至8个R 5取代基或可被1至4个取代基取代的苯环; m为0至2的整数。其制备方法，含有它们的药物组合物及其用于治疗由促肾上腺皮质激素释放因子（CRF）介导的病症的用途。

3. 发明授权

US09687789B2 Ultrafiltration for preparing outer membrane vesicles 有权
公开(公告)号：US09687789B2
公开(公告)日：2017-06-27
申请号：US10564474
申请日：2004-07-15
申请人： Roberto Olivieri , Fabio Sabbatini , Ilio Marsili
发明人： Roberto Olivieri , Fabio Sabbatini , Ilio Marsili
IPC分类号： C12N1/00 , C12N1/12 , C12N1/02 , C12N1/20 , A61K39/095 , B01D61/14 , B01D61/16 , C12N1/06 , C12R1/36 , C07K14/22 , C12R1/01 , A61K39/00
CPC分类号： B01D61/145 , A61K39/095 , A61K2039/6018 , B01D61/147 , B01D61/16 , B01D2311/04 , B01D2311/16 , C07K14/22 , C12N1/00 , C12N1/005 , C12N1/02 , C12N1/06 , C12N1/20 , C12R1/01 , C12R1/36 , B01D2311/2676
摘要： In place of a step of centrifugation during preparation of outer membrane vesicles (OMVs) from bacteria, the invention utilizes ultrafiltration. This allows much larger amounts of OMV-containing supernatant to be processed in a much shorter time. Thus the invention provides a process for preparing bacterial OMVs, comprising a step of ultrafiltration. The ultrafiltration step is performed on an aqueous suspension of OMVs after they have been prepared from bacteria and the OMVs remain in suspension after the filtration step. The invention is particularly useful for preparing OMVs from Neisseria meningitidis.

4. 发明申请

US20070087017A1 Ultrafiltration for preparing outer membrane vesicles 有权
标题翻译：用于制备外膜囊泡的超滤
公开(公告)号：US20070087017A1
公开(公告)日：2007-04-19
申请号：US10564474
申请日：2004-07-15
申请人： Robert Olivieri , Fabio Sabbatini , Ilio Marsili
发明人： Robert Olivieri , Fabio Sabbatini , Ilio Marsili
IPC分类号： A61K39/095 , C07K14/22
CPC分类号： B01D61/145 , A61K39/095 , A61K2039/6018 , B01D61/147 , B01D61/16 , B01D2311/04 , B01D2311/16 , C07K14/22 , C12N1/00 , C12N1/005 , C12N1/02 , C12N1/06 , C12N1/20 , C12R1/01 , C12R1/36 , B01D2311/2676
摘要： In place of a step of centrifugation during preparation of outer membrane vesicles (OMVs) from bacteria, the invention utilises ultrafiltration. This allows much larger amounts of OMV-containing supernatant to be processed in a much shorter time. Thus the invention provides a process for preparing bacterial OMVs, comprising a step of ultrafiltration. The ultrafiltration step is performed on an aqueous suspension of OMVs after they have been prepared from bacteria and the OMVs remain in suspension after the filtration step. The invention is particularly useful for preparing OMVs from Neisseria meningitidis.
摘要翻译：代替在从细菌制备外膜囊泡（OMV）期间离心的步骤，本发明利用超滤。这允许在更短的时间内处理更多量的含OMV的上清液。因此，本发明提供了一种制备细菌OMV的方法，包括超滤步骤。在从细菌制备OMV的水性悬浮液之后，超滤步骤在OMV的水悬浮液上进行，并且OMV在过滤步骤后保持悬浮。本发明特别适用于从脑膜炎奈瑟球菌制备OMV。

5. 发明申请

US20050089968A1 Culture medium with yeast or soy bean extract as amino acid source and no protein complexes of animal origin 有权
标题翻译：培养基用酵母或大豆提取物作为氨基酸来源，不含动物来源的蛋白质复合物
公开(公告)号：US20050089968A1
公开(公告)日：2005-04-28
申请号：US10979758
申请日：2004-11-03
申请人： Roberto Olivieri , Fabio Sabbatini , Maria Kontakou , Lucia Tagliaferri , Antonella Giglioli , Rino Rappuoli
发明人： Roberto Olivieri , Fabio Sabbatini , Maria Kontakou , Lucia Tagliaferri , Antonella Giglioli , Rino Rappuoli
IPC分类号： A61K39/00 , A61K39/02 , A61K39/05 , A61K39/08 , A61K39/095 , A61K39/10 , A61P31/04 , C12N1/20 , C12N1/21 , C12N5/02 , C12R1/01 , C12N9/88
CPC分类号： C12N1/20 , A61K39/02 , C12R1/21
摘要： The present invention relates to a medium containing non-animal derived proteinaceous material for cultivating patheogenic bacteria to produce an immunogenic factor and processes employing such medium.
摘要翻译：本发明涉及含有非动物来源的蛋白质物质的培养基以产生免疫原性因子并使用这种培养基的方法。

6. 发明授权

US09284526B2 Culture medium with yeast or soy bean extract as amino acid source and no protein complexes of animal origin 有权
标题翻译：培养基用酵母或大豆提取物作为氨基酸来源，不含动物来源的蛋白质复合物
公开(公告)号：US09284526B2
公开(公告)日：2016-03-15
申请号：US10979758
申请日：2004-11-03
申请人： Roberto Olivieri , Fabio Sabbatini , Maria Kontakou , Lucia Tagliaferri , Antonella Giglioli , Rino Rappuoli
发明人： Roberto Olivieri , Fabio Sabbatini , Maria Kontakou , Lucia Tagliaferri , Antonella Giglioli , Rino Rappuoli
IPC分类号： C12N1/20 , C12R1/21
CPC分类号： C12N1/20 , A61K39/02 , C12R1/21
摘要： The present invention relates to a medium containing non-animal derived proteinaceous material for cultivating patheogenic bacteria to produce an immunogenic factor and processes employing such medium.
摘要翻译：本发明涉及含有非动物来源的蛋白质物质的培养基以产生免疫原性因子并使用这种培养基的方法。

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