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1. 发明申请

US20100098768A1 Method of neuroprotection from oxidant injury using metal oxide nanoparticles 审中-公开
标题翻译：使用金属氧化物纳米颗粒的氧化损伤的神经保护方法
公开(公告)号：US20100098768A1
公开(公告)日：2010-04-22
申请号：US12580859
申请日：2009-10-16
申请人： Emanuela Silvana Andreescu , James C. Leiter , Joseph S. Erlichman
发明人： Emanuela Silvana Andreescu , James C. Leiter , Joseph S. Erlichman
IPC分类号： A61K9/14 , A61K33/24 , A61P39/00 , A61P9/10
CPC分类号： A61K9/5094 , A61K33/24 , A61K47/6921 , A61K47/6923
摘要： A metal oxide nanoparticle composition including a cerium oxide nanoparticle and a metal adapted to enhance the neuroprotective activity of the cerium oxide nanoparticle. The metal can include noble metals such as platinum, and rare earth metals such as gadolinium, samarium, titanium, yttrium, zirconium, and a combination thereof Another metal oxide nanoparticle composition including a cerium oxide nanoparticle and a surface modifier, such as polyethylene oxide, polyethylene imine, dextran, polylactic acid, chitosan, alginate, and a combination thereof is provided. A method of using the metal oxide nanoparticle compositions as neuroprotective agents for the inactivation of reactive oxygen species in nervous tissues is also provided. More specifically, a neuroprotective method using the metal oxides such as ceria, yttria, or mixed ceria and yttria (or any of the other referenced metal oxide nanoparticle compositions) before, during, or after an ischemic event.
摘要翻译：一种金属氧化物纳米颗粒组合物，包括氧化铈纳米颗粒和适于增强氧化铈纳米颗粒的神经保护活性的金属。金属可以包括贵金属如铂，和诸如钆，钐，钛，钇，锆的稀土金属及其组合。另外，包括氧化铈纳米颗粒和表面改性剂如聚环氧乙烷的另一种金属氧化物纳米颗粒组合物，提供聚乙烯亚胺，葡聚糖，聚乳酸，壳聚糖，藻酸盐及其组合。还提供了将金属氧化物纳米颗粒组合物用作神经保护剂用于在神经组织中活化氧物质失活的方法。更具体地，在缺血事件之前，期间或之后使用氧化铈，氧化钇或混合二氧化铈和氧化钇（或任何其它所述金属氧化物纳米颗粒组合物）的金属氧化物的神经保护方法。

2. 发明授权

US08969085B2 Portable nanoparticle based assay for rapid detection of food antioxidants (NanoCerac) 有权
标题翻译：用于快速检测食品抗氧化剂（NanoCerac）的便携式纳米粒子测定
公开(公告)号：US08969085B2
公开(公告)日：2015-03-03
申请号：US13971377
申请日：2013-08-20
申请人： Erica Sharpe , Emanuela Silvana Andreescu , Daniel Andreescu
发明人： Erica Sharpe , Emanuela Silvana Andreescu , Daniel Andreescu
IPC分类号： G01N33/02 , G01N21/78 , G01N33/58 , C12Q1/26 , G01N33/18 , G01N21/84
CPC分类号： G01N33/02 , C12Q1/26 , G01N21/78 , G01N21/8483 , G01N31/22 , G01N33/18 , G01N33/1826 , G01N33/587
摘要： Methods and assay for the portable colorimetric detection of an antioxidant in a food sample. The method includes the steps of providing a colorimetric reagent, the reagent including a plurality of ceria nanoparticles immobilized to a support, contacting the colorimetric reagent with the food sample, and detecting an optical property of the colorimetric reagent, where a change in the optical property of the colorimetric reagent is associated with the presence of antioxidant in the food sample. The change in the optical property of the colorimetric reagent is dependent upon the concentration of the antioxidant in the food sample.
摘要翻译：方法和测定食品样品中抗氧化剂的便携式比色检测。该方法包括以下步骤：提供比色试剂，所述试剂包括固定在载体上的多个二氧化铈纳米颗粒，使比色试剂与食品样品接触，并检测比色试剂的光学性质，其中光学性质的变化的比色试剂与食品样品中抗氧化剂的存在相关。比色试剂的光学性质的变化取决于食品样品中抗氧化剂的浓度。

3. 发明申请

US20230125201A1 PORTABLE APPARATUS, MATERIALS AND SENSORS FOR RAPID DETECTION OF PER AND POLY-FLUOROALKYL SUBSTANCES (PFAS) 有权
公开(公告)号：US20230125201A1
公开(公告)日：2023-04-27
申请号：US17973143
申请日：2022-10-25
申请人： Emanuela Silvana Andreescu , Abd Ur Rehman , Daniel Andreescu
发明人： Emanuela Silvana Andreescu , Abd Ur Rehman , Daniel Andreescu
IPC分类号： G01N21/78 , G01N27/48
摘要： A method and sensing system for the determination per and poly-fluoroalkyl substances (PFASs) is disclosed, wherein the probe is based on measurement of the redox activity of a redox indicator. The method includes adding a PFAS compound to an indicator solution, gel, 3D printed object, electrode or a sensing surface containing and measuring the change in the indicator signal as a function of PFAS concentration. Further provided is a portable sensor for rapid monitoring of the presence and PFAS concentrations. The present invention includes deposition of the indicator component within a method, assay, apparatus and sensing platform. Further provided is a composite electrode and sensor with binding and signaling activity for a broad range of PFAS, as well as printing ink compositions that incorporate the redox indicator.

4. 发明申请

US20140220608A1 Reagentless Ceria-Based Colorimetric Sensor 审中-公开
标题翻译：无基于Ceria的比色传感器
公开(公告)号：US20140220608A1
公开(公告)日：2014-08-07
申请号：US14244437
申请日：2014-04-03
申请人： Emanuela Silvana Andreescu , Maryna Ornatska , Cristina R. Ispas , Daniel Andreescu
发明人： Emanuela Silvana Andreescu , Maryna Ornatska , Cristina R. Ispas , Daniel Andreescu
IPC分类号： C12Q1/60 , C12Q1/54 , C12Q1/26
CPC分类号： C12Q1/60 , C12Q1/26 , C12Q1/54 , G01N21/78 , G01N21/8483 , G01N31/228 , G01N33/587 , Y10T436/206664
摘要： A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex. The rate of color change and the intensity of the color are proportional to the amount of analyte present in the sample. Also described is the use of ceria and doped ceria nanoparticles as an oxygen storage/delivery vehicle for oxidase enzymes and applications in biocatalytic processes in anaerobic conditions of interest in biomedicine and bioanalysis. Further described are a variety of related applications of the disclosed technology including clinical diagnosis, in vivo implantable devices, food safety, and fermentation control.
摘要翻译：纳米颗粒，复合纳米颗粒和纳米颗粒涂层形式的比色试剂，包括使用方法，制备方法，相关设备的沉积和组装以及具体应用。比色试剂包括氧化铈纳米颗粒，其用于溶液中或固定在固体支持物上，单独或与氧化酶结合，形成与分析物反应形成有色复合物的活性比色组分。颜色变化率和颜色强度与样品中存在的分析物的量成比例。还描述了二氧化铈和掺杂的二氧化铈纳米颗粒作为用于氧化酶的氧气储存/递送载体的用途以及在生物医药和生物分析中感兴趣的厌氧条件下的生物催化过程中的应用。进一步描述了所公开技术的各种相关应用，包括临床诊断，体内可植入装置，食品安全和发酵控制。

5. 发明公开

US20240018310A1 COMPOSITIONS AND METHODS FOR PRODUCING ELECTRICALLY CONDUCTIVE COORDINATION POLYMERS AND USES THEREOF 审中-公开
公开(公告)号：US20240018310A1
公开(公告)日：2024-01-18
申请号：US17981923
申请日：2022-11-07
申请人： Mohamed H. Hassan , Emanuela Silvana Andreescu
发明人： Mohamed H. Hassan , Emanuela Silvana Andreescu
IPC分类号： C08G83/00 , C08K5/378 , C08K3/28
CPC分类号： C08G83/00 , C08K5/378 , C08K3/28
摘要： Compositions, methods and processes for producing an electrically conductive metal-organic material is disclosed, wherein the material is based on a coordination polymer consisting of a plurality of ligands and metal ions, each coordinated with a ligand to impart conductivity to the material. Further provided are methods of deposition and use to produce conductive textiles, stretchable, flexible and transparent devices and surfaces. The electrically conductive metal-organic material may be used in a variety of fields including wearable electronics, sensors (gas, wearable, sweat, temperature, humidity), batteries, supercapacitors, electronic and pressure sensitive textiles/cotton/paper, electromagnetic shielding fabric, triboelectric nanogenerators, conductive paints/ inks, antistatic coatings, conductive spray for flexible, transparent, and pressure sensitive glass/elastomers/plastics.

6. 发明申请

US20180022604A1 Functional Platform for Rapid Capture and Removal of Nanoparticles 审中-公开
公开(公告)号：US20180022604A1
公开(公告)日：2018-01-25
申请号：US15657905
申请日：2017-07-24
申请人： Emanuela Silvana Andreescu , Ali Othman
发明人： Emanuela Silvana Andreescu , Ali Othman
IPC分类号： B82Y40/00 , B01J23/10 , B22F1/00
CPC分类号： B82Y40/00 , B01J21/04 , B01J21/063 , B01J21/066 , B01J21/08 , B01J23/06 , B01J23/10 , B01J23/18 , B01J23/72 , B01J23/745 , B01J35/0013 , B01J35/002 , B22F1/0025 , B82Y99/00 , C02F2101/20 , C02F2103/007 , C02F2103/06 , C02F2103/16 , C02F2103/346 , C02F2209/105 , C02F2305/08
摘要： Device, method, and system for nanoparticle capture, tracking, and/or detection. A functional paper-based platform is modified with capture ligands to create binding sites for nanoparticles. According to an embodiment, nanoparticle binding produces visual images of the particle content and distribution on the modified sensing surface, which provides capabilities for both NP sequestration and real-time detection. According to an embodiment the system may be utilized for environmental decontamination, fabrication of personal protective equipment, field monitoring, and epidemiological studies. The availability of inexpensive and easy-to-use quantitative methods can facilitate rapid assessment and measurement of NPs concentration and the level of exposure for large scale toxicological and epidemiological testing

7. 发明授权

US08691520B2 Reagentless ceria-based colorimetric sensor 有权
标题翻译：无试剂二氧化铈基比色传感器
公开(公告)号：US08691520B2
公开(公告)日：2014-04-08
申请号：US13156755
申请日：2011-06-09
申请人： Emanuela Silvana Andreescu , Maryna Ornatska , Cristina R. Ispas , Daniel Andreescu
发明人： Emanuela Silvana Andreescu , Maryna Ornatska , Cristina R. Ispas , Daniel Andreescu
IPC分类号： C12Q1/48
CPC分类号： C12Q1/60 , C12Q1/26 , C12Q1/54 , G01N21/78 , G01N21/8483 , G01N31/228 , G01N33/587 , Y10T436/206664
摘要： A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex. The rate of color change and the intensity of the color are proportional to the amount of analyte present in the sample. Also described is the use of ceria and doped ceria nanoparticles as an oxygen storage/delivery vehicle for oxidase enzymes and applications in biocatalytic processes in anaerobic conditions of interest in biomedicine and bioanalysis. Further described are a variety of related applications of the disclosed technology including clinical diagnosis, in vivo implantable devices, food safety, and fermentation control.
摘要翻译：纳米颗粒，复合纳米颗粒和纳米颗粒涂层形式的比色试剂，包括使用方法，制备方法，相关设备的沉积和组装以及具体应用。比色试剂包括氧化铈纳米颗粒，其用于溶液中或固定在固体支持物上，单独或与氧化酶结合，形成与分析物反应形成有色复合物的活性比色组分。颜色变化率和颜色强度与样品中存在的分析物的量成比例。还描述了二氧化铈和掺杂的二氧化铈纳米颗粒作为用于氧化酶的氧气储存/递送载体的用途以及在生物医药和生物分析中感兴趣的厌氧条件下的生物催化过程中的应用。进一步描述了所公开技术的各种相关应用，包括临床诊断，体内可植入装置，食品安全和发酵控制。

8. 发明授权

US10179732B2 Functional platform for rapid capture and removal of nanoparticles 有权
公开(公告)号：US10179732B2
公开(公告)日：2019-01-15
申请号：US15657905
申请日：2017-07-24
申请人： Emanuela Silvana Andreescu , Ali Othman
发明人： Emanuela Silvana Andreescu , Ali Othman
IPC分类号： G01N33/58 , B82Y40/00 , B22F1/00 , B01J23/10 , B01J21/04 , B01J21/06 , B01J21/08 , B01J23/06 , B01J23/18 , B01J23/72 , B01J23/745 , B01J35/00 , C02F101/20 , C02F103/34 , C02F103/06 , C02F103/16 , B82Y99/00 , C02F103/00
摘要： Device, method, and system for nanoparticle capture, tracking, and/or detection. A functional paper-based platform is modified with capture ligands to create binding sites for nanoparticles. According to an embodiment, nanoparticle binding produces visual images of the particle content and distribution on the modified sensing surface, which provides capabilities for both NP sequestration and real-time detection. According to an embodiment the system may be utilized for environmental decontamination, fabrication of personal protective equipment, field monitoring, and epidemiological studies. The availability of inexpensive and easy-to-use quantitative methods can facilitate rapid assessment and measurement of NPs concentration and the level of exposure for large scale toxicological and epidemiological testing.

9. 发明申请

US20140162368A1 Portable Nanoparticle Based Assay For Rapid Detection of Food Antioxidants (NanoCerac) 有权
标题翻译：便携式纳米粒子测定快速检测食品抗氧化剂（NanoCerac）
公开(公告)号：US20140162368A1
公开(公告)日：2014-06-12
申请号：US13971377
申请日：2013-08-20
申请人： Erica Sharpe , Emanuela Silvana Andreescu , Daniel Andreescu
发明人： Erica Sharpe , Emanuela Silvana Andreescu , Daniel Andreescu
IPC分类号： G01N33/02 , G01N33/58
CPC分类号： G01N33/02 , C12Q1/26 , G01N21/78 , G01N21/8483 , G01N31/22 , G01N33/18 , G01N33/1826 , G01N33/587
摘要： Methods and assay for the portable colorimetric detection of an antioxidant in a food sample. According to one aspect the method comprises the steps of providing a colorimetric reagent comprising a plurality of ceria nanoparticles immobilized to a support, contacting the colorimetric reagent with the food sample, and detecting an optical property of the colorimetric reagent, wherein a change in the optical property of the colorimetric reagent is associated with the presence of antioxidant in the food sample, and further wherein the change in the optical property of the colorimetric reagent is dependent upon the concentration of the antioxidant in said food sample.
摘要翻译：方法和测定食品样品中抗氧化剂的便携式比色检测。根据一个方面，该方法包括以下步骤：提供包含固定在载体上的多个二氧化铈纳米颗粒的比色试剂，使比色试剂与食品样品接触，并检测比色试剂的光学性质，其中光学变化比色试剂的性质与食品样品中的抗氧化剂的存在相关，并且其中，比色试剂的光学性质的变化取决于所述食品样品中抗氧化剂的浓度。

10. 发明申请

US20120315659A1 Reagentless Ceria-Based Colorimetric Sensor 有权
标题翻译：无基于Ceria的比色传感器
公开(公告)号：US20120315659A1
公开(公告)日：2012-12-13
申请号：US13156755
申请日：2011-06-09
申请人： Emanuela Silvana Andreescu , Maryna Ornatska , Cristina R. Ispas , Daniel Andreescu
发明人： Emanuela Silvana Andreescu , Maryna Ornatska , Cristina R. Ispas , Daniel Andreescu
IPC分类号： C12Q1/26 , G01N21/00 , G01N33/00
CPC分类号： C12Q1/60 , C12Q1/26 , C12Q1/54 , G01N21/78 , G01N21/8483 , G01N31/228 , G01N33/587 , Y10T436/206664
摘要： A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex. The rate of color change and the intensity of the color are proportional to the amount of analyte present in the sample. Also described is the use of ceria and doped ceria nanoparticles as an oxygen storage/delivery vehicle for oxidase enzymes and applications in biocatalytic processes in anaerobic conditions of interest in biomedicine and bioanalysis. Further described are a variety of related applications of the disclosed technology including clinical diagnosis, in vivo implantable devices, food safety, and fermentation control.
摘要翻译：纳米颗粒，复合纳米颗粒和纳米颗粒涂层形式的比色试剂，包括使用方法，制备方法，相关设备的沉积和组装以及具体应用。比色试剂包括氧化铈纳米颗粒，其用于溶液中或固定在固体支持物上，单独或与氧化酶结合，形成与分析物反应形成有色复合物的活性比色组分。颜色变化率和颜色强度与样品中存在的分析物的量成比例。还描述了二氧化铈和掺杂的二氧化铈纳米颗粒作为用于氧化酶的氧气储存/递送载体的用途以及在生物医药和生物分析中感兴趣的厌氧条件下的生物催化过程中的应用。进一步描述了所公开技术的各种相关应用，包括临床诊断，体内可植入装置，食品安全和发酵控制。

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