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1. 发明申请

US20140316255A1 Raman Imaging Devices and Methods of Molecular Imaging 审中-公开
标题翻译：拉曼成像设备和分子成像方法
公开(公告)号：US20140316255A1
公开(公告)日：2014-10-23
申请号：US14241790
申请日：2012-08-23
申请人： Ellis Garai , Cristina Zavaleta , Michael Mandella , Jonathan Liu , Sanjiv Sam Gambhir , Christopher H. Contag
发明人： Ellis Garai , Cristina Zavaleta , Michael Mandella , Jonathan Liu , Sanjiv Sam Gambhir , Christopher H. Contag
IPC分类号： A61B5/00 , A61B1/07 , A61B10/02 , A61K49/00 , A61B19/00
CPC分类号： A61B5/0075 , A61B1/07 , A61B5/0079 , A61B5/0084 , A61B10/02 , A61B34/20 , A61B2034/2057 , A61K49/0095 , B82Y15/00 , G01J1/0433 , G01J3/0213 , G01J3/0218 , G01J3/18 , G01J3/2803 , G01J3/44 , G01N21/658
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to Raman imaging devices (e.g., Raman endoscope probes) or systems, methods of using Raman agents, Raman imaging devices, and/or systems to image or detect a signal, and the like.
摘要翻译：根据本公开的目的，如本文所体现和广泛描述的，本公开的实施例在一个方面涉及拉曼成像装置（例如，拉曼内窥镜探针）或系统，使用拉曼剂的方法，拉曼成像装置和/或用于对信号进行成像或检测的系统等。

2. 发明申请

US20120330157A1 CONFOCAL MICROSCOPE, SYSTEM AND METHOD THEREFOR 有权
标题翻译：共焦显微镜，其系统及方法
公开(公告)号：US20120330157A1
公开(公告)日：2012-12-27
申请号：US13403614
申请日：2012-02-23
申请人： Michael Mandella , Gordon S. Kino , Christopher H. Contag , Olav Solgaard , Butrus Khuri-Yakub , Omer Oralkan , Jae-Woong Jeong , Paul Cristman , Jonathan T.C. Liu , Hyejun Ra , Jae Eun Hwang
发明人： Michael Mandella , Gordon S. Kino , Christopher H. Contag , Olav Solgaard , Butrus Khuri-Yakub , Omer Oralkan , Jae-Woong Jeong , Paul Cristman , Jonathan T.C. Liu , Hyejun Ra , Jae Eun Hwang
IPC分类号： G02B26/10 , A61B8/13 , A61B1/07
CPC分类号： G02B26/101 , A61B1/00105 , A61B1/043 , A61B5/0068 , A61B8/12 , A61B8/4483 , A61B8/483 , G02B17/0808 , G02B21/0028 , G02B23/2423 , G02B23/26
摘要： Aspects of the present invention are directed to apparatuses, arrangements, systems and methods for collecting information using one or more modalities. As consistent with one or more embodiments, an apparatus includes first and second scanning mirror arrangements having different scanning axes and respectively facing different directions. The first scanning mirror arrangement directs source light and image light in two paths, and the second scanning mirror arrangement directs image light from a target to the first scanning mirror arrangement. The first and second scanning mirror arrangements cooperatively scan source light from the first scanning mirror and via the second scanning mirror to target locations with at least two degrees of freedom, and direct image light from the target locations.
摘要翻译：本发明的方面涉及使用一种或多种方式收集信息的装置，装置，系统和方法。与一个或多个实施例一致，装置包括具有不同扫描轴并且分别朝向不同方向的第一和第二扫描镜装置。第一扫描镜装置将源光和图像光引导成两条路径，第二扫描镜装置将来自目标的图像光引导到第一扫描反射镜装置。第一和第二扫描镜装置将来自第一扫描反射镜的源光和经由第二扫描镜的源光协同扫描至至少两个自由度的目标位置，以及来自目标位置的直接图像光。

3. 发明授权

US09864190B2 Confocal microscope, system and method therefor 有权
公开(公告)号：US09864190B2
公开(公告)日：2018-01-09
申请号：US13403614
申请日：2012-02-23
申请人： Michael Mandella , Gordon S. Kino , Christopher H. Contag , Olav Solgaard , Butrus Khuri-Yakub , Omer Oralkan , Jae-Woong Jeong , Paul Cristman , Jonathan T. C. Liu , Hyejun Ra , Jae Eun Hwang
发明人： Michael Mandella , Gordon S. Kino , Christopher H. Contag , Olav Solgaard , Butrus Khuri-Yakub , Omer Oralkan , Jae-Woong Jeong , Paul Cristman , Jonathan T. C. Liu , Hyejun Ra , Jae Eun Hwang
IPC分类号： A61B10/04 , G02B26/10 , G02B21/00 , G02B23/24 , G02B23/26 , A61B1/00 , A61B1/04 , A61B5/00 , A61B8/12 , A61B8/00 , A61B8/08 , G02B17/08
CPC分类号： G02B26/101 , A61B1/00105 , A61B1/043 , A61B5/0068 , A61B8/12 , A61B8/4483 , A61B8/483 , G02B17/0808 , G02B21/0028 , G02B23/2423 , G02B23/26
摘要： Aspects of the present invention are directed to apparatuses, arrangements, systems and methods for collecting information using one or more modalities. As consistent with one or more embodiments, an apparatus includes first and second scanning mirror arrangements having different scanning axes and respectively facing different directions. The first scanning mirror arrangement directs source light and image light in two paths, and the second scanning mirror arrangement directs image light from a target to the first scanning mirror arrangement. The first and second scanning mirror arrangements cooperatively scan source light from the first scanning mirror and via the second scanning mirror to target locations with at least two degrees of freedom, and direct image light from the target locations.

4. 发明申请

US20050280804A1 Determination of an orientation parameter of an elongate object with a scan beam apparatus 失效
标题翻译：用扫描光束装置确定细长物体的取向参数
公开(公告)号：US20050280804A1
公开(公告)日：2005-12-22
申请号：US10871496
申请日：2004-06-18
申请人： Dale Buermann , Michael Mandella
发明人： Dale Buermann , Michael Mandella
IPC分类号： G01B11/26 , G01C1/00 , G01S5/16 , G01S17/48 , H04N7/18 , H04N9/47
CPC分类号： G01S5/163 , G01B11/26 , G01S17/48
摘要： An elongate object optically determines at least one of its orientation parameters relative to a plane surface. A probe radiation beam is directed from the object at various angles σ to various locations on the plane, where the angle σ is a periodic function of time. Two angularly-selective radiation detectors oriented at fixed angles τ1 and τ2 sense scattered portions of the beam from two locations a two corresponding times. The orientation parameter is computed from a time difference Δt=t2−t1 between the two times.
摘要翻译：细长物体相对于平面表面光学地确定其取向参数中的至少一个。探针辐射束以不同的角度从物体引导到平面上的各种位置，其中角度σ是时间的周期函数。以固定角度τ1和τ2定向的两个角度选择性辐射探测器从两个位置感测来自两个对应时间的波束的散射部分。方向参数是从两次之间的时间差Deltat = t 2 -t 1 1 <1>计算的。

5. 发明授权

US5887009A Confocal optical scanning system employing a fiber laser 失效
标题翻译：共焦光学扫描系统采用光纤激光器
公开(公告)号：US5887009A
公开(公告)日：1999-03-23
申请号：US861590
申请日：1997-05-22
申请人： Michael Mandella , Mark H. Garrett
发明人： Michael Mandella , Mark H. Garrett
IPC分类号： G02B21/00 , H01S3/30
CPC分类号： B82Y15/00 , G02B21/0056 , G02B21/0068
摘要： A confocal optical scanning system using a flexible optical emissive fiber or fiber laser and having a lasing cavity defined within the fiber. The system in-couples a signal beam produced when a probe beam generated by the fiber laser is reflected from a scanned object back into the lasing cavity. The perturbation created in the cavity by the in-coupling of the signal beam is detected by a transducer. Specifically, the perturbation may be the signal beam itself, an oscillation mode of the cavity induced by the in-coupled signal beam or a combination of the signal beam and the probe beam. In a preferred embodiment of the invention the system also has a polarizing assembly for altering a signal polarization of the signal beam and rotate it to either a resonant polarization supported by the cavity or a non-resonant polarization not supported by the cavity.
摘要翻译：一种使用柔性光发射光纤或光纤激光器并具有限定在光纤内的激光腔的共焦光学扫描系统。当由光纤激光器产生的探测光束从被扫描物体反射回到激光腔时，该系统将产生的信号光束进行耦合。通过传感器检测信号束的入耦合在空腔中产生的扰动。具体地，扰动可以是信号光束本身，由耦合信号光束引起的空腔的振荡模式或信号光束和探测光束的组合。在本发明的优选实施例中，系统还具有用于改变信号光束的信号极化并将其旋转到由腔支持的谐振极化或不由腔支持的非共振极化的偏振组件。

6. 发明申请

US20060132907A1 Solid catadioptric lens with two viewpoints 有权
标题翻译：具有两个视点的实心反射折射透镜
公开(公告)号：US20060132907A1
公开(公告)日：2006-06-22
申请号：US11336735
申请日：2006-01-19
申请人： Michael Mandella
发明人： Michael Mandella
IPC分类号： G02B23/00
CPC分类号： G02B3/00 , G02B13/16 , G02B17/0808 , G02B17/086 , G02B17/0896
摘要： A dual viewpoint solid catadioptric lens has a first spherical refractive surface S1 having a center C1 located on an optical axis of the lens and having a radius r1, and a second spherical refractive surface S2 having a center C2 located on the optical axis of the lens and having a radius r2
摘要翻译：双重视点固体反折射透镜具有第一球面折射表面S 1，其中心C 1位于透镜的光轴上并具有半径r 1，第二球面折射表面S 2具有位于该透镜的光轴上的中心C 2 透镜的光轴并具有半径r 2

7. 发明申请

US20050195387A1 Apparatus and method for determining orientation parameters of an elongate object 有权
标题翻译：用于确定细长物体的取向参数的装置和方法
公开(公告)号：US20050195387A1
公开(公告)日：2005-09-08
申请号：US10796236
申请日：2004-03-08
申请人： Guanghua Zhang , Dale Buermann , Michael Mandella , Hector Gonzalez-Banos , Stewart Carl
发明人： Guanghua Zhang , Dale Buermann , Michael Mandella , Hector Gonzalez-Banos , Stewart Carl
IPC分类号： G01B11/26 , G01C1/00
CPC分类号： G01B11/002 , G01B11/272 , G01S17/46 , G06F3/0304 , G06F3/03545
摘要： An apparatus and method employing principles of stereo vision for determining one or more orientation parameters and especially the second and third Euler angles θ, ψ of an elongate object whose tip is contacting a surface at a contact point. The apparatus has a projector mounted on the elongate object for illuminating the surface with a probe radiation in a known pattern from a first point of view and a detector mounted on the elongate object for detecting a scattered portion of the probe radiation returning from the surface to the elongate object from a second point of view. The orientation parameters are determined from a difference between the projected and detected probe radiation such as the difference between the shape of the feature produced by the projected probe radiation and the shape of the feature detected by the detector. The pattern of probe radiation is chosen to provide information for determination of the one or more orientation parameters and can include asymmetric patterns such as lines, ellipses, rectangles, polygons or the symmetric cases including circles, squares and regular polygons. To produce the patterns the projector can use a scanning arrangement or a structured light optic such as a holographic, diffractive, refractive or reflective element and any combinations thereof. The apparatus is suitable for determining the orientation of a jotting implement such as a pen, pencil or stylus.
摘要翻译：一种采用立体视觉原理的装置和方法，用于确定一个或多个取向参数，特别是尖端在接触点处接触表面的细长物体的第二和第三欧拉角θ，psi。该装置具有安装在细长物体上的投影仪，用于从第一角度以已知图案的探测辐射照射表面，以及安装在细长物体上的检测器，用于检测从表面返回的探针辐射的散射部分细长物体从第二个角度来看。取向参数根据投射和检测的探针辐射之间的差异确定，例如由投射的探针辐射产生的特征的形状与由检测器检测到的特征的形状之间的差异。选择探针辐射的图案以提供用于确定一个或多个取向参数的信息，并且可以包括不对称图案，例如线，椭圆，矩形，多边形或包括圆形，正方形和正多边形的对称情况。为了产生图案，投影仪可以使用扫描装置或诸如全息衍射，折射或反射元件的结构化光学元件及其任何组合。该装置适用于确定诸如笔，铅笔或触笔之类的记录工具的取向。

8. 发明授权

US5211065A Apparatus for translating rotational motion to harmonic linear motion 失效
标题翻译：用于将旋转运动转换为谐波线性运动的装置
公开(公告)号：US5211065A
公开(公告)日：1993-05-18
申请号：US762498
申请日：1991-09-19
申请人： Michael Mandella
发明人： Michael Mandella
IPC分类号： F02B75/02 , F02B75/32 , F16H21/32
CPC分类号： F02B75/32 , F16H21/32 , F02B2075/027 , Y10T74/18168 , Y10T74/18208 , Y10T74/18264
摘要： An improved connecting rod assembly for a reciprocating internal combustion engine provides essentially simple harmonic linear motion of a piston, thereby eliminating forces and moments caused by non-simple harmonic linear motion of a piston. The connecting rod assembly of the present invention maintains a uniform distance between a crank pin and a piston. Essentially simple harmonic piston motion also increases engine efficiency by reducing the amount of negative work which results from detonation before top dead center. The connecting rod assembly may include a first member rotatably connected to a crankshaft and having two connection points each spaced a distance A/2 from the crankshaft connection, and second and third members having a length C, arranged in a crossing relationship, and connecting respective ones of the connection points of the first member to respective ones of two connection points on a piston, the piston connection points being spaced apart by a distance B. In one embodiment, the ratios A:B:C are 2:4:5.
摘要翻译：用于往复式内燃机的改进的连杆组件提供活塞的基本上简单的谐波直线运动，从而消除由活塞的非简单谐波直线运动引起的力和力矩。本发明的连杆组件保持曲柄销和活塞之间的均匀距离。基本上简单的谐波活塞运动也可以通过减少在上止点之前引爆的负作用量来提高发动机效率。连杆组件可以包括可旋转地连接到曲轴的第一构件，并且具有两个与曲轴连接件间隔开A / 2的连接点，以及具有以交叉关系布置的长度C的第二和第三构件，第一构件的连接点与活塞上的两个连接点中的相应连接点的一个连接点，活塞连接点间隔开距离B.在一个实施例中，比率A：B：C为2:4:5。

9. 发明申请

US20050168437A1 Processing pose data derived from the pose of an elongate object 有权
标题翻译：处理从细长物体的姿态得出的姿势数据
公开(公告)号：US20050168437A1
公开(公告)日：2005-08-04
申请号：US10769484
申请日：2004-01-30
申请人： Stewart Carl , Michael Mandella , Guanghua Zhang , Hector Gonzalez-Banos
发明人： Stewart Carl , Michael Mandella , Guanghua Zhang , Hector Gonzalez-Banos
IPC分类号： G06F3/01 , G09G5/00
CPC分类号： G06F3/011 , G06F3/03545
摘要： An apparatus and method for processing pose data derived from a pose of an elongate object such as, for example, a jotting implement, a pointer, a robotic arm or a cane. The elongate object has a tip contacting a plane surface with one or more invariant features. The pose of the elongate object is measured optically from on-board by an optical measuring system with the aid of the invariant feature. The pose is used for preparing a corresponding pose data and a subset of the pose data is identified and transmitted to an application such as a user application, where the subset can serve as command data or input data. Since the elongate object moves while its tip is contacting the surface the pose is measured periodically at sufficiently frequent measurement times ti to describe the motion at a desired temporal resolution. The subset can include all or a portion of the orientation data that describe the orientation of the elongate object in space and/or position data of the tip on the surface. The position can be a relative position of the tip with respect to any feature or its previous position, or an absolute position in world coordinates. The subset can also contain a mix of orientation and position data.
摘要翻译：一种用于处理从诸如记录工具，指针，机器人手臂或手杖的细长物体的姿势导出的姿势数据的装置和方法。细长物体具有使平面与一个或多个不变特征接触的尖端。借助于不变特征，通过光学测量系统从板上光学地测量细长物体的姿态。该姿势用于准备对应的姿势数据，并且识别姿势数据的子集并将其发送到诸如用户应用的应用，其中该子集可以用作命令数据或输入数据。由于细长物体在其尖端接触表面时移动，所以以足够频繁的测量时间t i周期性地测量姿态以便以期望的时间分辨率描述运动。子集可以包括描述细长物体在空间中的取向的定向数据的全部或一部分和/或表面上的尖端的位置数据。该位置可以是尖端相对于任何特征或其先前位置或世界坐标中的绝对位置的相对位置。子集还可以包含方向和位置数据的混合。

10. 发明授权

US06181478B2 Ellipsoidal solid immersion lens 失效
标题翻译：椭圆形固体浸没镜头
公开(公告)号：US06181478B2
公开(公告)日：2001-01-30
申请号：US09354841
申请日：1999-07-16
申请人： Michael Mandella
发明人： Michael Mandella
IPC分类号： G02B300
CPC分类号： G01Q60/22 , G02B21/02 , G11B7/1374 , G11B7/1387
摘要： A solid immersion lens (SIL) of refractive index n having an ellipsoidal surface portion defining a geometrical ellipsoid with geometrical foci F1, F2 along a major axis of length M. The ellipsoidal SIL (or ESIL) has an interface surface which is preferably flat and passes near or through the second geometrical focus F2. The geometrical foci F1, F2 are separated by a distance S=M/n, such that a collimated light beam propagating along the major axis M and entering the ESIL through the ellipsoidal surface portion converges to a focus substantially at the second geometrical focus F2. The ESIL finds application in optical systems such as microscopes and optical recording systems.
摘要翻译：具有椭圆表面部分的固体浸没透镜（SIL），其具有限定几何椭圆体，沿着长度M的长轴具有几何焦点F1，F2。椭圆形SIL（或ESIL）具有界面表面，其优选是平坦的，通过第二几何焦点F2附近或通过。几何焦点F1，F2分开距离S = M / n，使得沿着长轴M传播并通过椭圆面表面部分进入ESIL的准直光束基本上收敛到基本上在第二几何焦点F2处的焦点。 ESIL在诸如显微镜和光学记录系统的光学系统中应用。

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