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1. 发明授权

US07531545B2 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of β-secretase (BACE) 有权
标题翻译：可用作β-分泌酶（BACE）抑制剂的2-氨基-3,4-二氢 - 吡啶并[3,4-d]嘧啶衍生物
公开(公告)号：US07531545B2
公开(公告)日：2009-05-12
申请号：US11552792
申请日：2006-10-25
申请人： Ellen E. Baxter , Christopher John Creighton , Yifang Huang , Chi Luo , Michael H. Parker , Allen B. Reitz , Charles H. Reynolds , Tina Morgan Ross , Eric D. Strobel , Brett A. Tounge
发明人： Ellen E. Baxter , Christopher John Creighton , Yifang Huang , Chi Luo , Michael H. Parker , Allen B. Reitz , Charles H. Reynolds , Tina Morgan Ross , Eric D. Strobel , Brett A. Tounge
IPC分类号： A61K31/519 , C07D471/04 , A61P25/28
CPC分类号： C07D213/73 , C07D471/04
摘要： The present invention is directed to novel 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
摘要翻译：本发明涉及新的2-氨基-3,4-二氢 - 吡啶并[3,4-d]嘧啶衍生物，含有它们的药物组合物及其在治疗阿尔茨海默病（AD）和相关疾病中的用途。本发明的化合物是β-分泌酶的抑制剂，也称为β-位点切割酶和BACE，BACE1，Asp2和memapsin2。

2. 发明授权

US07932261B2 Macrocycle derivatives useful as inhibitors of β-secretase (BACE) 有权
标题翻译：可用作分泌抑制剂（BACE）的大分子衍生物
公开(公告)号：US07932261B2
公开(公告)日：2011-04-26
申请号：US11671732
申请日：2007-02-06
申请人： Ellen W. Baxter , François P. Bischoff , Hans De Winter , Chih Yung Ho , Yifang Huang , Michael H. Parker , Allen B. Reitz , Charles H. Reynolds , Eric D. Strobel
发明人： Ellen W. Baxter , François P. Bischoff , Hans De Winter , Chih Yung Ho , Yifang Huang , Michael H. Parker , Allen B. Reitz , Charles H. Reynolds , Eric D. Strobel
IPC分类号： C07D487/04 , A61K31/517
CPC分类号： C07D498/08 , C07D487/08
摘要： The present invention is directed to macrocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
摘要翻译：本发明涉及大环衍生物，含有它们的药物组合物及其在治疗阿尔茨海默病（AD）和相关疾病中的用途。本发明的化合物是分泌酶抑制剂，也被称为“切割酶”和BACE，BACE1，Asp2和memapsin2。

3. 发明授权

US08633322B2 Alkynyl derivatives useful as DPP-1 inhibitors 有权
标题翻译：用作DPP-1抑制剂的炔基衍生物
公开(公告)号：US08633322B2
公开(公告)日：2014-01-21
申请号：US12914244
申请日：2010-10-28
申请人： Michael H. Parker , Dennis J. Hlasta , Yifang Huang , Allen B. Reitz , Edward C. Lawson , Carsten Schubert , Eric Strobel , Brett A. Tounge , Kimberly White , Michael P. Winters , Shyamali Ghosh
发明人： Michael H. Parker , Dennis J. Hlasta , Yifang Huang , Allen B. Reitz , Edward C. Lawson , Carsten Schubert , Eric Strobel , Brett A. Tounge , Kimberly White , Michael P. Winters , Shyamali Ghosh
IPC分类号： A61K31/445 , C07D211/40
CPC分类号： C07C237/16 , C07C317/32 , C07D211/42 , C07D211/46 , C07D217/02 , C07D307/79 , C07D317/28 , C07D401/12 , C07D409/12
摘要： The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译：本发明涉及新型炔基衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。

4. 发明申请

US20110105562A1 ALKYNYL DERIVATIVES USEFUL AS DPP-1 INHIBITORS 有权
标题翻译：适用于DPP-1抑制剂的烷基衍生物
公开(公告)号：US20110105562A1
公开(公告)日：2011-05-05
申请号：US12914244
申请日：2010-10-28
申请人： Michael H. Parker , Dennis J. Hlasta , Yifang Huang , Allen B. Reitz , Edward C. Lawson , Carsten Schubert , Eric Strobel , Brett A. Tounge , Kimberly White , Michael P. Winters , Shyamali Ghosh
发明人： Michael H. Parker , Dennis J. Hlasta , Yifang Huang , Allen B. Reitz , Edward C. Lawson , Carsten Schubert , Eric Strobel , Brett A. Tounge , Kimberly White , Michael P. Winters , Shyamali Ghosh
IPC分类号： A61K31/454 , C07C237/20 , C07D211/46 , C07D401/12 , C07D409/12 , A61K31/165 , A61K31/45 , A61K31/4535 , A61P19/02 , A61P11/06 , A61P11/00 , A61P31/00 , A61P1/00 , A61P9/00
CPC分类号： C07C237/16 , C07C317/32 , C07D211/42 , C07D211/46 , C07D217/02 , C07D307/79 , C07D317/28 , C07D401/12 , C07D409/12
摘要： The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译：本发明涉及新型炔基衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。

5. 发明授权

US08084490B2 Sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders 有权
标题翻译：用于治疗癫痫和相关疾病的氨磺酸盐和磺酰胺衍生物
公开(公告)号：US08084490B2
公开(公告)日：2011-12-27
申请号：US11154443
申请日：2005-06-16
申请人： David F. McComsey , Michael H. Parker , Allen B. Reitz , Bruce E. Maryanoff
发明人： David F. McComsey , Michael H. Parker , Allen B. Reitz , Bruce E. Maryanoff
IPC分类号： A61K31/357 , C07D319/20
CPC分类号： C07D319/20 , C07D311/58 , C07D317/58 , C07D321/10
摘要： The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.
摘要翻译：本发明涉及新型磺酰胺和氨基磺酸酯衍生物，含有它们的药物组合物及其在治疗癫痫和相关疾病中的用途。

6. 发明授权

US08853263B2 Co-therapy for the treatment of epilepsy and related disorders 有权
标题翻译：用于治疗癫痫和相关疾病的联合治疗
公开(公告)号：US08853263B2
公开(公告)日：2014-10-07
申请号：US11750600
申请日：2007-05-18
申请人： Virginia L. Smith-Swintosky , David F. McComsey , Michael H. Parker , Allen B. Reitz , Bruce E. Maryanoff
发明人： Virginia L. Smith-Swintosky , David F. McComsey , Michael H. Parker , Allen B. Reitz , Bruce E. Maryanoff
IPC分类号： C07D311/58 , C07D317/46 , C07D317/70 , C07D319/20 , C07D319/22 , C07D321/10 , A61K31/337 , A61K31/18 , A61K45/06
CPC分类号： A61K31/337 , A61K31/18 , A61K45/06 , C07D311/58 , C07D317/46 , C07D317/70 , C07D319/20 , C07D319/22 , C07D321/10 , A61K2300/00
摘要： The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-fused heterocycle sulfamide derivative and a therapeutically effective amount of one or more anticonvulsant and/or anti-epileptic agents.
摘要翻译：本发明涉及用于治疗癫痫和相关病症的共同治疗，其包括向有需要的受试者施用治疗有效量的苯并稠合的杂环磺酰胺衍生物和治疗有效量的一种或多种更多的抗惊厥药和/或抗癫痫剂。

7. 发明申请

US20110224209A1 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) 有权
标题翻译：作为DIPPTIDYL PEPTIDASE-1（DPP-1）的抑制剂的4,4 - 取代的哌啶衍生物
公开(公告)号：US20110224209A1
公开(公告)日：2011-09-15
申请号：US13043609
申请日：2011-03-09
申请人： Bart L. DeCorte , Renee L. DesJarlais , Yifang Huang , Michael H. Parker , Dennis J. Hlasta
发明人： Bart L. DeCorte , Renee L. DesJarlais , Yifang Huang , Michael H. Parker , Dennis J. Hlasta
IPC分类号： A61K31/4535 , C07D409/06 , C07D409/14 , C07D211/64 , C07D401/06 , C07D417/14 , C07D413/14 , C07D401/14 , A61K31/4545 , A61K31/451 , A61K31/454 , A61K31/445 , A61K31/5377 , A61K31/4725 , A61K31/506 , A61P29/00 , A61P11/06 , A61P11/00 , A61P1/00 , A61P9/00
CPC分类号： C07D409/14 , C12N5/0606
摘要： The present invention is directed to 4,4-di-substituted piperidine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译：本发明涉及4,4-二取代哌啶衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。

8. 发明授权

US08686152B2 4,4-disubstituted piperidine derivatives useful as inhibitors of dipeptidyl peptidase-1 (DPP-1) 有权
标题翻译：可用作二肽基肽酶-1（DPP-1）抑制剂的4,4-二取代哌啶衍生物
公开(公告)号：US08686152B2
公开(公告)日：2014-04-01
申请号：US13043609
申请日：2011-03-09
申请人： Bart L. DeCorte , Renee L. DesJarlais , Yifang Huang , Michael H. Parker , Dennis J. Hlasta
发明人： Bart L. DeCorte , Renee L. DesJarlais , Yifang Huang , Michael H. Parker , Dennis J. Hlasta
IPC分类号： C07D409/06 , C07D405/06 , A61K31/4525 , A61K31/4535
CPC分类号： C07D409/14 , C12N5/0606
摘要： The present invention is directed to 4,4-di-substituted piperidine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译：本发明涉及4,4-二取代哌啶衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。

9. 发明授权

US6156790A C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities 失效
标题翻译：具有抗疟疾，抗增殖和抗肿瘤活性的C-10碳取代的青蒿素样三恶烷化合物
公开(公告)号：US6156790A
公开(公告)日：2000-12-05
申请号：US1242
申请日：1997-12-30
申请人： Gary H. Posner , Soon Hyung Woo , Poonsakdi Ploypradith , Michael H. Parker , Theresa A. Shapiro , Qun Y. Zheng , Christopher Murray , Randall J. Daughenbaugh
发明人： Gary H. Posner , Soon Hyung Woo , Poonsakdi Ploypradith , Michael H. Parker , Theresa A. Shapiro , Qun Y. Zheng , Christopher Murray , Randall J. Daughenbaugh
IPC分类号： C07D493/20 , C07D519/00 , A61K31/335 , C07D493/18
CPC分类号： C07D493/20 , C07D519/00
摘要： The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.
摘要翻译：本发明提供了通过各种碳亲核试剂替代二氢青蒿素中的吡喃糖异头物10-OH基团的两步方法，得到新型C-10碳取代的三恶烷，其结构如下：其中当n为1时， R选自一组未取代或取代的芳基，杂芳基，聚乙二醇，乙炔基或苯甲酰基亚甲基，或烷酰基亚甲基; 或当n为2时，R选自未取代或取代的芳基，杂芳基，聚乙二醇，烯基，烷基，二酮或双 - 乙炔的一组。

10. 发明授权

US06190569B1 Peristaltic filtration hose apparatus and method 有权
标题翻译：蠕动式过滤软管设备及方法
公开(公告)号：US06190569B1
公开(公告)日：2001-02-20
申请号：US09522321
申请日：2000-03-09
申请人： Michael H. Parker
发明人： Michael H. Parker
IPC分类号： B01D3700
CPC分类号： B01D35/26 , B01D29/118 , B01D29/52 , B01D29/603 , B01D29/606 , B01D29/70
摘要： Incorporating a permeable hose within a peristaltic pump results in a unique device that can simultaneously pump, filter and self-clean suspensions, producing a concentrate and clarified liquid stream. This process, termed peristaltic filtration, has wide applicability to a variety of commercial and industrial applications, including dewatering sludge in sand and gravel operations the treatment of water or other streams in industrial plants, municipal wastewater treatment plants, and food processing. The flexing motion that accompanies peristaltic pumping enhances filtration of the suspension by locally increasing the pressure and cleaning the filter by bending the hose to release trapped solids back into the suspension. Peristaltic filtration can be applied to conventional rotary pumps, linear pumps or other configurations. Rotary peristaltic filters are also modular and can be made to be adaptable to a variety of feedstocks.
摘要翻译：将蠕动泵内的可渗透软管结合成一个独特的装置，可以同时泵入，过滤和自清洁悬浮液，产生浓缩液和澄清的液体流。这种称为蠕动过滤的过程广泛适用于各种商业和工业应用，包括在沙子和砾石作业中脱水污泥，处理工业厂房中的水或其他物流，城市污水处理厂和食品加工。伴随蠕动泵送的弯曲运动通过局部增加压力并通过弯曲软管来清洁过滤器来增强悬浮液的过滤，以将滞留的固体释放回悬浮液。蠕动过滤可以应用于传统的旋转泵，线性泵或其他配置。旋转式蠕动式过滤器也是模块化的，可以适应于各种原料。

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