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1. 发明申请

US20060223837A1 Biaryl derived amide modulators of vanilloid VR1 receptor 审中-公开
标题翻译：香草素VR1受体的二芳基衍生的酰胺调节剂
公开(公告)号：US20060223837A1
公开(公告)日：2006-10-05
申请号：US11387894
申请日：2006-03-23
申请人： Ellen Codd , Scott Dax , Christopher Flores , Michelle Jetter , Mark Youngman
发明人： Ellen Codd , Scott Dax , Christopher Flores , Michelle Jetter , Mark Youngman
IPC分类号： A61K31/506 , A61K31/4709 , A61K31/444 , C07D401/02
CPC分类号： C07D291/04 , C07C233/29 , C07C233/55 , C07C237/42 , C07D213/53 , C07D213/75 , C07D233/64 , C07D233/68 , C07D235/06 , C07D271/06 , C07D333/24 , C07D401/04 , C07D401/12
摘要： The invention is directed to novel vanilloid receptor type 1 (VR1) ligands. More specifically, the invention relates to novel biaryl-derived amides that are potent antagonists or agonists of VR1. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译：本发明涉及新型香草素受体1型（VR1）配体。更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的新型联芳基衍生的酰胺。还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。

2. 发明申请

US20080027029A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS 有权
标题翻译：冷门受体-1拮抗剂
公开(公告)号：US20080027029A1
公开(公告)日：2008-01-31
申请号：US11746318
申请日：2007-05-09
申请人： Raymond Colburn , Scott Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark Youngman
发明人： Raymond Colburn , Scott Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark Youngman
IPC分类号： A61K31/67 , A61K31/665 , A61K31/675 , A61P25/00 , A61P29/00 , A61P9/00 , A61P9/12 , C07D495/00 , C07F9/572 , C07F9/655 , C07F9/6553
CPC分类号： C07F9/655354 , C07F9/5728 , C07F9/65517 , C07F9/65586 , C07F9/6561
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要翻译：本发明涉及式（I）的TRPM8拮抗剂。更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。

3. 发明申请

US20070166789A1 Human cyclooxygenase-3 enzyme and uses thereof 有权
标题翻译：人环加氧酶-3酶及其用途
公开(公告)号：US20070166789A1
公开(公告)日：2007-07-19
申请号：US11651705
申请日：2007-01-10
申请人： Ning Qin , Ellen Codd , Christopher Flores , Sui-Po Zhang
发明人： Ning Qin , Ellen Codd , Christopher Flores , Sui-Po Zhang
IPC分类号： C12P21/06 , C12N9/02 , C07H21/04
CPC分类号： C12N9/0083 , A61K38/00
摘要： The present invention provides nucleic acid and polypeptide sequences describing a novel isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase-3. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.
摘要翻译：本发明提供描述环氧合酶的新型同工酶的核酸和多肽序列，这里命名为人环加氧酶-3。本发明的分离的核酸或多肽分子可用于检测测定，基因治疗和筛选测定。

4. 发明申请

US20120184510A1 COLD MENTHOL RECEPTOR-1 ANTAGONISTS 有权
标题翻译：冷门受体-1拮抗剂
公开(公告)号：US20120184510A1
公开(公告)日：2012-07-19
申请号：US13006810
申请日：2011-01-14
申请人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
发明人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
IPC分类号： A61K31/675 , C07F9/28 , C07F9/02 , C07D333/50 , A61K31/67
CPC分类号： C07F9/655354 , C07F9/5728 , C07F9/6541 , C07F9/65517 , C07F9/655345 , C07F9/65586 , C07F9/6561
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要翻译：本发明涉及式（I）的TRPM8拮抗剂。更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。

5. 发明授权

US07645755B2 Inhibitors of c-fms kinase 有权
公开(公告)号：US07645755B2
公开(公告)日：2010-01-12
申请号：US11408096
申请日：2006-04-20
申请人： Carl R. Illig , Shelley K. Ballentine , Jinsheng Chen , Sanath K. Meegalla , M. Jonathan Rudolph , Mark J. Wall , Kenneth J. Wilson , Renee L. Desjarlais , Carl L. Manthey , Christopher Flores , Christopher J. Molloy
发明人： Carl R. Illig , Shelley K. Ballentine , Jinsheng Chen , Sanath K. Meegalla , M. Jonathan Rudolph , Mark J. Wall , Kenneth J. Wilson , Renee L. Desjarlais , Carl L. Manthey , Christopher Flores , Christopher J. Molloy
IPC分类号： A61K31/5377 , A61K31/454 , C07D413/14 , C07D401/02
CPC分类号： C07D307/71 , A61K45/06 , C07D401/12 , C07D401/14 , C07D407/12 , C07D409/12 , C07D409/14
摘要： The invention is directed to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

6. 发明申请

US20060100201A1 Inhibitors of c-fms kinase 有权
标题翻译： c-fms激酶抑制剂
公开(公告)号：US20060100201A1
公开(公告)日：2006-05-11
申请号：US11255043
申请日：2005-10-20
申请人： Carl Illig , Shelley Ballentine , Jinsheng Chen , Sanath Meegalla , M. Jonathan Rudolph , Mark Wall , Kenneth Wilson , Renee DesJarlais , Carl Manthey , Christopher Flores , Christopher Molloy
发明人： Carl Illig , Shelley Ballentine , Jinsheng Chen , Sanath Meegalla , M. Jonathan Rudolph , Mark Wall , Kenneth Wilson , Renee DesJarlais , Carl Manthey , Christopher Flores , Christopher Molloy
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , C07D417/14 , C07D413/14 , C07D405/14
CPC分类号： C07D263/34 , C07D207/34 , C07D233/90 , C07D307/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The invention relates to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.
摘要翻译：本发明涉及式I化合物：其中A，X，R 2和W在本说明书中列出，以及其抑制蛋白酪氨酸的溶剂合物，水合物，互变异构体和药学上可接受的盐激酶，特别是c-fms激酶。治疗自身免疫性疾病的方法和具有炎症成分的疾病; 治疗卵巢癌，子宫癌，乳腺癌，结肠癌，胃癌，毛细胞白血病和非小细胞肺癌的转移; 并治疗疼痛，包括由肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏，炎症和神经源性疼痛; 还提供了骨质疏松症，佩吉特氏病和其它骨吸收介导包括关节炎，假体失败，溶骨性骨肉瘤，骨髓瘤以及与式I化合物对骨的肿瘤转移的其它疾病。

7. 发明申请

US20060189623A1 Inhibitors of c-fms kinase 有权
公开(公告)号：US20060189623A1
公开(公告)日：2006-08-24
申请号：US11408096
申请日：2006-04-20
申请人： Carl Illig , Shelley Ballentine , Jinsheng Chen , Sanath Meegalla , M. Rudolph , Mark Wall , Kenneth Wilson , Renee Desjarlais , Carl Manthey , Christopher Flores , Christopher Molloy
发明人： Carl Illig , Shelley Ballentine , Jinsheng Chen , Sanath Meegalla , M. Rudolph , Mark Wall , Kenneth Wilson , Renee Desjarlais , Carl Manthey , Christopher Flores , Christopher Molloy
IPC分类号： A61K31/496 , C07D409/02 , A61K31/4545 , A61K31/454
CPC分类号： C07D307/71 , A61K45/06 , C07D401/12 , C07D401/14 , C07D407/12 , C07D409/12 , C07D409/14
摘要： The invention is directed to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

8. 发明授权

US5258995A Wireless communication system 失效
标题翻译：无线通信系统
公开(公告)号：US5258995A
公开(公告)日：1993-11-02
申请号：US789292
申请日：1991-11-08
申请人： Chun-Meng Su , Saman Behtash , Keith Jarett , Huihung Lu , Christopher Flores , David G. Messerschmitt
发明人： Chun-Meng Su , Saman Behtash , Keith Jarett , Huihung Lu , Christopher Flores , David G. Messerschmitt
IPC分类号： H03M5/14 , H03M13/31 , H04J1/12 , H04J3/06 , H04J13/16 , H04L25/49 , H04M1/725 , H04K1/00
CPC分类号： H04J1/12 , H03M13/31 , H03M5/145 , H04J3/0605 , H04L25/4908 , H04M1/72502 , H04J13/16
摘要： In the present invention a wireless communication system is disclosed. A base unit communicates with a remote unit. The system comprises means for transmitting, using CDMA, between the base unit and the remote unit, in one of a plurality of frequencies channels selected. In one period of time, the base unit transmits and in another period of time, different from the one period, the remote unit transmits. Further, the system comprises means for changing the one frequency channel selected to another frequency channel, different from the one frequency channel, in response to interference in the one frequency channel. Thus, communication between the base unit and the remote unit is then affected over the another frequency channel.
摘要翻译：在本发明中，公开了一种无线通信系统。基本单元与远程单元通信。该系统包括用于在所选择的多个频率信道之一中使用CDMA在基本单元和远程单元之间进行发送的装置。在一个时间段内，基站单元在远程单元发送的另一个时间段内发送不同于一个周期的时间段。此外，该系统包括用于响应于一个频率信道中的干扰而将选择的一个频率信道改变为与一个频率信道不同的另一频率信道的装置。因此，基本单元和远程单元之间的通信然后在另一频率信道上受到影响。

9. 发明授权

US5212808A Method and an apparatus for re-establishing wireless communication between a base unit and a remote unit 失效
标题翻译：用于在基本单元和远程单元之间重新建立无线通信的方法和装置
公开(公告)号：US5212808A
公开(公告)日：1993-05-18
申请号：US789736
申请日：1991-11-08
申请人： Chun-Meng Su , Keith Jarett , Christopher Flores
发明人： Chun-Meng Su , Keith Jarett , Christopher Flores
IPC分类号： H03M5/14 , H03M13/31 , H04L25/49 , H04M1/725
CPC分类号： H03M5/145 , H03M13/31 , H04L25/4908 , H04M1/72502
摘要： In the present invention a method of re-establishing a wireless communication after a communication break is disclosed. Prior to the communication break, a base unit transmits to a remote unit a table of channels of communication to be used. The base unit also transmits a clock signal value to the remote unit. After a communication break, the remote unit continues to count the clock signals generated from a clock signal source internal thereto. The remote unit applies a function to the value of the clock signal to obtain an entry in the table. The channel of communication associated with the entry in the table is selected by the remote unit. The base unit continues to count the clock signals generated internal thereto. The base unit applies the same function as the function used by the remote unit to the value of the clock signal to obtain an entry in the table. The base unit selects the channel of communication associated with the entry in the table. Thereafter, communication is re-established over the channel of communication associated with the entry in the table.
摘要翻译：在本发明中，公开了在通信中断之后重新建立无线通信的方法。在通信中断之前，基站单元向远程单元发送要使用的通信信道的表。基本单元还向远程单元发送时钟信号值。在通信中断之后，远程单元继续对从其内部的时钟信号源产生的时钟信号进行计数。远程单元对时钟信号的值应用功能，以获得表中的条目。与表中的条目相关联的通信通道由远程单元选择。基本单元继续对其内部产生的时钟信号进行计数。基本单元将与远程单元使用的功能相同的功能应用于时钟信号的值，以获得表中的条目。基本单元选择与表中的条目相关联的通信信道。此后，通过与表中的条目相关联的通信信道重新建立通信。

10. 发明授权

US08629281B2 Cold menthol receptor-1 antagonists 有权
标题翻译：冷薄荷醇受体-1拮抗剂
公开(公告)号：US08629281B2
公开(公告)日：2014-01-14
申请号：US13006810
申请日：2011-01-14
申请人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
发明人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
IPC分类号： C07F9/28
CPC分类号： C07F9/655354 , C07F9/5728 , C07F9/6541 , C07F9/65517 , C07F9/655345 , C07F9/65586 , C07F9/6561
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要翻译：本发明涉及式（I）的TRPM8拮抗剂。更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。

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