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1. 发明申请

US20060030603A1 Novel aryl urea analogs and use thereof as antibacterial agents 审中-公开
标题翻译：新型芳基脲类似物及其作为抗菌剂的用途
公开(公告)号：US20060030603A1
公开(公告)日：2006-02-09
申请号：US10913683
申请日：2004-08-05
申请人： Punit Seth , Dale Robinson , Elizabeth Jefferson , Eric Swayze
发明人： Punit Seth , Dale Robinson , Elizabeth Jefferson , Eric Swayze
IPC分类号： A61K31/44 , A61K31/17 , C07D213/54 , C07C335/12
CPC分类号： C07C275/34 , C07C275/30 , C07C335/16 , C07D207/34 , C07D213/38 , C07D213/61 , C07D307/56
摘要： Antibacterial compounds are described herein having either formula (I) or formula (II): wherein R1A, R1B, R1C, R1D, X, Z, Q, R2A, R2B, R2C and R2D are as defined herein. Compositions comprising compounds of formulas (I) and (II) are also provided.
摘要翻译：本文描述了具有式（I）或式（II）的抗菌化合物：其中R 1A，R 1B，R 1C，R“ X，Z，Q，R 2A，R 2B，R 2C和R 2D， / SUB>如本文所定义。还提供了包含式（I）和（II）化合物的组合物。

2. 发明申请

US20050032805A1 Antimicrobial biaryl compounds 失效
标题翻译：抗生素联芳化合物
公开(公告)号：US20050032805A1
公开(公告)日：2005-02-10
申请号：US10914256
申请日：2004-08-09
申请人： Elizabeth Jefferson , Eric Swayze , Punit Seth , Dale Robinson
发明人： Elizabeth Jefferson , Eric Swayze , Punit Seth , Dale Robinson
IPC分类号： C07D233/50 , A61K31/341 , A61K31/40 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/455 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/513 , A61K31/52 , A61K31/522 , A61P31/04 , C07C237/42 , C07D213/82 , C07D239/47 , C07D239/54 , C07D241/44 , C07D307/68 , C07D333/38 , C07D333/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D473/18 , C07D473/34 , C07D417/14 , C07D43/14
CPC分类号： C07D213/82 , C07D241/44 , C07D307/68 , C07D333/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D473/18 , C07D473/34
摘要： Provided are antibacterial biaryl compounds having micromolar MIC activity against Gram-negative and Gram-positive pathogens, including a methicillin-resistant S. aureus strain.
摘要翻译：提供对革兰氏阴性和革兰氏阳性病原体具有微摩尔MIC活性的抗菌联芳基化合物，包括耐甲氧西林金黄色葡萄球菌菌株。

3. 发明申请

US20090270418A1 PYRAZOLE PYRAZINE AMINE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS THEREOF AND METHODS OF TREATMENT THEREWITH 审中-公开
标题翻译：吡唑类氨基化合物作为激酶抑制剂，其组合物及其处理方法
公开(公告)号：US20090270418A1
公开(公告)日：2009-10-29
申请号：US12350722
申请日：2009-01-08
申请人： Marianne Sloss , Jeffrey McKenna , Won Hyung Yoon , Stephen Norris , Dale Robinson , Jason Parnes , Graziella Shevlin , Paul Erdman , Robert Hilgraf , Ronald Albers , Sayee Hegde , Andrew Wallace , Henry Chan , Loui Madakamutil , Heather Raymon
发明人： Marianne Sloss , Jeffrey McKenna , Won Hyung Yoon , Stephen Norris , Dale Robinson , Jason Parnes , Graziella Shevlin , Paul Erdman , Robert Hilgraf , Ronald Albers , Sayee Hegde , Andrew Wallace , Henry Chan , Loui Madakamutil , Heather Raymon
IPC分类号： A61K31/497 , C07D403/12 , A61P35/00 , C12N9/99
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14 , C07D407/14 , C07D413/14 , C07D417/14
摘要： Provided herein are Pyrazole Pyrazine Amine Compounds having the following structure: Wherein Q and R1-R3 are as defined herein, compositions comprising an effective amount of a Pyrazole Pyrazine Amine Compound and methods for treating or preventing inflammatory conditions, immunological conditions, cancer, neurodegenerative diseases, age-related diseases, cardiovascular diseases and metabolic conditions, or conditions treatable or preventable by inhibition of an IKK, or an IKK pathway, comprising administering an effective amount of a Pyrazole Pyrazine Amine Compound to a patient in need thereof.
摘要翻译：本文提供具有以下结构的吡唑吡嗪胺化合物：其中Q和R 1 -R 3如本文所定义，包含有效量的吡唑吡嗪胺化合物的组合物和治疗或预防炎性病症，免疫学条件，癌症，神经变性疾病的方法，年龄相关疾病，心血管疾病和代谢病症，或通过抑制IKK或IKK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的吡唑吡嗪胺化合物。

4. 发明授权

US4181991A Mattress foundation 失效
标题翻译：床垫基础
公开(公告)号：US4181991A
公开(公告)日：1980-01-08
申请号：US876466
申请日：1978-02-09
申请人： Charles W. Morgan , Dale Robinson , Farouk Farag
发明人： Charles W. Morgan , Dale Robinson , Farouk Farag
IPC分类号： A47C19/02 , A47C23/00 , A47C23/04 , A47C23/30
CPC分类号： A47C23/00 , A47C23/04 , A47C23/30
摘要： An improved mattress foundation particularly suited for use with foam mattresses to provide proper support for the mattress and to duplicate the feel of box springs. The mattress foundation utilizes an upper and lower frame assembly separated by a flexible, resilient material, which may be in the form of blocks, strips or slabs of flexible, resilient material, with the upper frame assembly preferably being somewhat flexible so as to be capable of deforming from its normal planar condition when subjected to more concentrated loads. The material separating the upper and lower frame assemblies are selected to have a resilience which will support the weight of one or two persons while distributed over the mattress foundation without substantial deflection, but which will deflect significantly when subjected to an individual's weight in more concentrated form, such as occurs when an individual sits on the edge of a bed or is getting into or out of the bed.
摘要翻译：一种改进的床垫基础，特别适用于泡沫床垫，为床垫提供适当的支撑和复制弹簧的感觉。床垫基座采用由柔性弹性材料分开的上框架和下框架组件，弹性材料可以是柔性弹性材料的块体，条带或板状的形式，上框架组件优选地具有柔性以使其能够当受到更集中的负荷时，其从正常平面状态变形。选择分离上框架组件和下框架组件的材料具有弹性，其将支撑一个或两个人的重量，同时分布在床垫基座上而没有实质的偏转，但是当以更集中的形式受到个体的重量时，该弹性将显着偏转，例如当个人坐在床边缘或进入或离开床时发生。

5. 发明申请

US20060030624A1 Anticancer agents based on prevention of protein prenylation 失效
公开(公告)号：US20060030624A1
公开(公告)日：2006-02-09
申请号：US11246259
申请日：2005-10-11
申请人： Seth Rose , Steven Ottersberg , Karl Okolotowicz , Dale Robinson , Rosemarie Hartman , Scott Lefler
发明人： Seth Rose , Steven Ottersberg , Karl Okolotowicz , Dale Robinson , Rosemarie Hartman , Scott Lefler
IPC分类号： A61K31/195
CPC分类号： C12Q1/48 , A61K31/12 , A61K31/121 , A61K31/195 , C12N9/1085 , C12N9/99 , C12Y205/01029 , G01N2500/04
摘要： Prenylating enzymes are involved in modifying oncoproteins, such as RAS, so that growth of neoplastic cells becomes uncontrolled. Inactivation of such enzymes can prevent uncontrolled growth. α-Dicarbonyl compounds can be used to covalently modify and thereby inactivate prenylating enzymes such as protein farnesyltransferase and protein geranylgeranyltransferase. The compounds can be designed to enhance affinity and/or specificity for a particular protein substrate.

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