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1. 发明授权

US08523788B2 Device, system and method for examining a body lumen 有权
标题翻译：用于检查体腔的装置，系统和方法
公开(公告)号：US08523788B2
公开(公告)日：2013-09-03
申请号：US12850904
申请日：2010-08-05
申请人： Elisha Rabinovitz , Amit Pascal , Zvika Gilad , Daniel Afik
发明人： Elisha Rabinovitz , Amit Pascal , Zvika Gilad , Daniel Afik
IPC分类号： A61B5/117 , A61B5/103
CPC分类号： A61B5/06 , A61B1/00059 , A61B1/041 , A61B5/061 , A61B5/073 , A61B5/14539 , A61B2562/08
摘要： An in-vivo examining device, system and method for identifying the presence of strictures in the small bowel are provided. The in-vivo examining device includes a monitoring mechanism that becomes deactivated when exposed to in-vivo substances native to the small bowel or the colon, and a degradable device body that includes at least a first body portion which degrades at a slow rate when exposed to in-vivo substances native to the small bowel and at a fast rate when exposed to in-vivo substances native to the colon. The degradation of the degradable device body exposes the monitoring mechanism to substances native to the small bowel or the colon and thus indicates whether the examining device has safely passed through the small bowel or whether it is retained in the small bowel due to strictures in the small bowel.
摘要翻译：提供了用于识别小肠中狭窄存在的体内检查装置，系统和方法。体内检查装置包括当暴露于小肠或结肠原生的体内物质时变得失活的监测机构，以及包括至少第一主体部分的可降解装置主体，其在暴露时以慢速率降解对小肠原生的体内物质，当暴露于结肠原生的体内物质时，速率快。可降解装置主体的降解将监测机制暴露于小肠或结肠原生的物质，从而指示检查装置是否安全地通过小肠，或者是否由于小肠中的狭窄而保留在小肠中肠。

2. 发明申请

US20140206956A1 DEVICE, SYSTEM AND METHOD FOR IN-VIVO IMMUNOASSAY 审中-公开
标题翻译：用于体内免疫测定的装置，系统和方法
公开(公告)号：US20140206956A1
公开(公告)日：2014-07-24
申请号：US14237019
申请日：2012-08-01
申请人： Elisha Rabinovitz , Zvika Gilad , Osnat Sella-Tavor , Amit Pascal
发明人： Elisha Rabinovitz , Zvika Gilad , Osnat Sella-Tavor , Amit Pascal
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1459 , A61B5/1473 , G01N33/53 , A61B5/07
CPC分类号： A61B5/14503 , A61B1/041 , A61B5/0084 , A61B5/061 , A61B5/07 , A61B5/1032 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/1473 , A61B5/6861 , A61B2562/0295 , A61B2562/162 , G01N21/6428 , G01N21/78 , G01N21/8483 , G01N33/5302 , G01N33/54386 , G01N33/558
摘要： In vivo devices, systems and methods for in vivo immunoassay include inserting into a patient's body lumen an in vivo diagnostic device comprising a housing. The housing of the device comprises a chamber, and a chromatography strip for immunoassay of a body lumen substance. The housing may further comprise a casing for the chromatography strip. The casing may comprise a first opening to allow entrance of in vivo liquids into the casing and a second opening into the chamber. The housing may further comprise a sensor to sense a property of the chromatography strip. Following insertion of the device into the patient's body, a sample is collected and the immunoassay is performed in vivo in areas of pathological lesions for a predetermined period of time. An in vivo image may be acquired or other data such as colorimetric or intensity data may be obtained from the chromatography strip.
摘要翻译：用于体内免疫测定的体内装置，系统和方法包括将包括外壳的体内诊断装置插入患者体腔。该装置的外壳包括室和用于体内物质的免疫测定的色谱条。壳体还可以包括用于色谱条的壳体。壳体可以包括允许体内液体进入壳体的第一开口和进入腔室的第二开口。壳体还可以包括感测色谱条的性质的传感器。在将装置插入患者体内后，收集样品，并在病理损伤区域内进行预定时间段的免疫测定。可以获取体内图像，或者可以从色谱条获得其他数据，例如比色或强度数据。

3. 发明申请

US20100305415A1 DEVICE, SYSTEM AND METHOD FOR EXAMINING A BODY LUMEN 有权
标题翻译：用于检查体液的装置，系统和方法
公开(公告)号：US20100305415A1
公开(公告)日：2010-12-02
申请号：US12850904
申请日：2010-08-05
申请人： Elisha Rabinovitz , Amit Pascal , Zvika Gilad , Daniel Shmuel Afik
发明人： Elisha Rabinovitz , Amit Pascal , Zvika Gilad , Daniel Shmuel Afik
IPC分类号： A61B5/07
CPC分类号： A61B5/06 , A61B1/00059 , A61B1/041 , A61B5/061 , A61B5/073 , A61B5/14539 , A61B2562/08
摘要： An in-vivo examining device, system and method for identifying the presence of strictures in the small bowel are provided. The in-vivo examining device includes a monitoring mechanism that becomes deactivated when exposed to in-vivo substances native to the small bowel or the colon, and a degradable device body that includes at least a first body portion which degrades at a slow rate when exposed to in-vivo substances native to the small bowel and at a fast rate when exposed to in-vivo substances native to the colon. The degradation of the degradable device body exposes the monitoring mechanism to substances native to the small bowel or the colon and thus indicates whether the examining device has safely passed through the small bowel or whether it is retained in the small bowel due to strictures in the small bowel.
摘要翻译：提供了用于识别小肠中狭窄存在的体内检查装置，系统和方法。体内检查装置包括当暴露于小肠或结肠原生的体内物质时变得失活的监测机构，以及包括至少第一主体部分的可降解装置主体，其在暴露时以慢速率降解对小肠原生的体内物质，当暴露于结肠原生的体内物质时，速率快。可降解装置主体的降解将监测机制暴露于小肠或结肠原生的物质，从而指示检查装置是否安全地通过小肠，或者是否由于小肠中的狭窄而保留在小肠中肠。

4. 发明授权

US08911368B2 Device, system and method for detection of bleeding 有权
标题翻译：用于检测出血的装置，系统和方法
公开(公告)号：US08911368B2
公开(公告)日：2014-12-16
申请号：US13146482
申请日：2010-01-31
申请人： Elisha Rabinovitz , Amit Pascal , Ori Braun , Zvika Gilad , Osnat Sella-Tavor , Yaniv Birnboim
发明人： Elisha Rabinovitz , Amit Pascal , Ori Braun , Zvika Gilad , Osnat Sella-Tavor , Yaniv Birnboim
IPC分类号： A61B5/05 , A61B5/07 , A61B5/00 , A61B5/02 , A61B5/145 , A61B5/1459
CPC分类号： A61B5/073 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/02042 , A61B5/14539 , A61B5/14542 , A61B5/1459 , A61B5/4283 , A61B5/6861 , A61B2560/0406 , A61B2562/0238
摘要： A device, system and method for detecting bile and blood are provided. The device may comprise a housing having a gap through which in-vivo fluids may flow, illumination sources on one side of the gap, a light detector which is facing the illumination sources and is positioned on the opposite side of the gap for detecting light which passes through the in-vivo fluids, and a transmitter to transmit the detected signals generated according to the detected light. The system may further comprise a receiver to receive the detected signals transmitted by the transmitter, and a processor. The method may comprise comparing the detected signals with a predetermined threshold calculated from the transmission spectra of bile and of blood and determining the presence and/or concentration of bile and blood in-vivo.
摘要翻译：提供了一种用于检测胆汁和血液的装置，系统和方法。该装置可以包括具有间隙的壳体，体内流体可流过该间隙，间隙的一侧上的照明源，面向照明源的光检测器，并位于间隙的相对侧上，用于检测光，穿过体内流体，以及发射器，用于传输根据检测到的光产生的检测信号。系统还可以包括接收器，用于接收由发射器发射的检测信号和处理器。该方法可以包括将检测到的信号与从胆汁和血液的透射光谱计算出的预定阈值进行比较，并确定胆汁和血液在体内的存在和/或浓度。

5. 发明申请

US20110306855A1 DEVICE, SYSTEM AND METHOD FOR DETECTION OF BLEEDING 有权
标题翻译：用于检测出血的装置，系统和方法
公开(公告)号：US20110306855A1
公开(公告)日：2011-12-15
申请号：US13146482
申请日：2010-01-31
申请人： Elisha Rabinovitz , Amit Pascal , Ori Braun , Zvika Gilad , Osnat Sella-Tavor , Yaniv Birnboim
发明人： Elisha Rabinovitz , Amit Pascal , Ori Braun , Zvika Gilad , Osnat Sella-Tavor , Yaniv Birnboim
IPC分类号： A61B5/1459 , A61B6/00
CPC分类号： A61B5/073 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/02042 , A61B5/14539 , A61B5/14542 , A61B5/1459 , A61B5/4283 , A61B5/6861 , A61B2560/0406 , A61B2562/0238
摘要： A device, system and method for detecting bile and blood are provided. The device may comprise a housing having a gap through which in-vivo fluids may flow, illumination sources on one side of the gap, a light detector which is facing the illumination sources and is positioned on the opposite side of the gap for detecting light which passes through the in-vivo fluids, and a transmitter to transmit the detected signals generated according to the detected light. The system may further comprise a receiver to receive the detected signals transmitted by the transmitter, and a processor. The method may comprise comparing the detected signals with a predetermined threshold calculated from the transmission spectra of bile and of blood and determining the presence and/or concentration of bile and blood in-vivo.
摘要翻译：提供了一种用于检测胆汁和血液的装置，系统和方法。该装置可以包括具有间隙的壳体，体内流体可流过该间隙，间隙的一侧上的照明源，面向照明源的光检测器，并位于间隙的相对侧上，用于检测光，穿过体内流体，以及发射器，用于传输根据检测到的光产生的检测信号。系统还可以包括接收器，用于接收由发射器发射的检测信号和处理器。该方法可以包括将检测到的信号与从胆汁和血液的透射光谱计算出的预定阈值进行比较，并确定胆汁和血液在体内的存在和/或浓度。

6. 发明授权

US08515507B2 Device and method for detecting in-vivo pathology 有权
标题翻译：用于检测体内病理学的装置和方法
公开(公告)号：US08515507B2
公开(公告)日：2013-08-20
申请号：US12485665
申请日：2009-06-16
申请人： Elisha Rabinovitz , Osnat Sella-Tavor , Amit Pascal , Noam Emanuel
发明人： Elisha Rabinovitz , Osnat Sella-Tavor , Amit Pascal , Noam Emanuel
IPC分类号： A61B5/1455
CPC分类号： A61B5/0071 , A61B1/041 , A61B1/043 , A61B5/0084
摘要： Devices, systems and methods for detecting in vivo pathology are provided. An in vivo sensing device comprises a reacting layer with at least one type of binding agent attached thereon, a sensor configured for sensing an optical change occurring on the reacting substrate, and at least one illumination source. In-vivo fluids are in constant contact with the reacting substrate so that in vivo marker indicating pathology may bind to the binding agent attached onto the reacting layer and may be viewed by the sensor.
摘要翻译：提供用于检测体内病理学的装置，系统和方法。体内感测装置包括具有附着在其上的至少一种类型的粘合剂的反应层，被配置为感测在反应基底上发生的光学变化的传感器和至少一个照明源。体内流体与反应底物恒定接触，使体内标记指示病理学可以结合附着在反应层上的结合剂并且可以由传感器观察。

7. 发明授权

US09339174B2 Device and method for viewing a body lumen 有权
标题翻译：用于观察体腔的装置和方法
公开(公告)号：US09339174B2
公开(公告)日：2016-05-17
申请号：US12174779
申请日：2008-07-17
申请人： Zvika Gilad , Amit Pascal
发明人： Zvika Gilad , Amit Pascal
IPC分类号： A61B1/00 , A61B1/06 , A61B1/04 , A61B1/05
CPC分类号： A61B1/04 , A61B1/00101 , A61B1/00183 , A61B1/041 , A61B1/053
摘要： A device and method for viewing a body lumen are provided. An assembly of a capsule endoscope and an endoscope is inserted into a body lumen. The capsule endoscope is positioned within the body lumen at a predetermined distance from the endoscope, and images are obtained from opposite sides of a desired location in the body lumen. In vivo procedures may be performed, while images of the procedure are obtained from opposite sides of the procedure location.
摘要翻译：提供了一种用于观察体腔的装置和方法。将胶囊型内窥镜和内窥镜的组装体插入体腔。胶囊型内窥镜位于与内窥镜相隔预定距离的体腔内，从体腔内的所需位置的相对侧获得图像。可以执行体内过程，而从程序位置的相对侧获得程序的图像。

8. 发明授权

US09320417B2 In-vivo optical imaging device with backscatter blocking 有权
标题翻译：具有反向散射阻挡的体内光学成像装置
公开(公告)号：US09320417B2
公开(公告)日：2016-04-26
申请号：US11645787
申请日：2006-12-27
申请人： Amit Pascal , Zvika Gilad , Haim Bezdin
发明人： Amit Pascal , Zvika Gilad , Haim Bezdin
IPC分类号： A61B1/06 , A61B1/05 , A61B1/04
CPC分类号： A61B1/0661 , A61B1/041 , A61B1/051 , A61B1/0607 , A61B1/0676
摘要： The invention provides a device for in-vivo imaging, for example, using an in-vivo imaging device including an imager a lens and an illumination source, all positioned behind a single viewing window. The in-vivo imaging device may include an element to block light from reaching a point of reflection on the inner surface of the viewing window, thereby preventing the light from being received by the imager.
摘要翻译：本发明提供一种用于体内成像的装置，例如，使用包括成像器的体内成像装置的透镜和照明源，所述装置全部位于单个观察窗后。体内成像装置可以包括阻挡光到达观察窗的内表面上的反射点的元件，从而防止光被成像器接收。

9. 发明授权

US08639314B2 Device, system and method for in-vivo imaging of a body lumen 有权
标题翻译：用于体内体内成像的装置，系统和方法
公开(公告)号：US08639314B2
公开(公告)日：2014-01-28
申请号：US11284915
申请日：2005-11-23
申请人： Zvika Gilad , Amit Pascal
发明人： Zvika Gilad , Amit Pascal
IPC分类号： A61B5/00
CPC分类号： A61B1/041 , A61B1/0676 , A61B1/0684
摘要： An in-vivo device, system and a method for imaging a body lumen, typically liquid filled body lumen. The in-vivo device may have a specific gravity of about 1 or a volume to weight ratio that enables it to float. The in-vivo device may include an optical system for viewing through a body lumen liquid and another optical system for viewing through a non liquid medium. The in-vivo device may be moved through the body lumen by the liquid movement in that lumen.
摘要翻译：体内装置，系统和用于对体腔成像（通常为液体填充的体腔）的方法。体内装置可以具有约1的比重或使其能够浮动的体积与重量比。体内装置可以包括用于通过体腔液体观察的光学系统和用于通过非液体介质观察的另一光学系统。体内装置可以通过该内腔中的液体运动而移动通过体腔。

10. 发明申请

US20100010312A1 DEVICE AND METHOD FOR UNIFORM IN VIVO ILLUMINATION 有权
标题翻译：用于在体外照明中统一的装置和方法
公开(公告)号：US20100010312A1
公开(公告)日：2010-01-14
申请号：US12172422
申请日：2008-07-14
申请人： Zvika Gilad , Amit Pascal
发明人： Zvika Gilad , Amit Pascal
IPC分类号： A61B1/06
CPC分类号： A61B1/041 , A61B1/00167 , A61B1/0607 , A61B1/07
摘要： An in vivo imaging device comprises a viewing window, an illumination unit, a lens holder and a light guide. The light guide may be positioned to create uniformly dispersed illumination and to eliminate backscatter from the viewing window. The light guide may guide light from the illumination unit to a desired position within the in vivo device. In one embodiment, the light guide may be embedded into the lens holder.
摘要翻译：体内成像装置包括观察窗，照明单元，透镜保持器和光导。光导可以被定位成产生均匀分散的照明并且消除观察窗的反向散射。光导可以将来自照明单元的光引导到体内装置内的期望位置。在一个实施例中，光导可以嵌入到透镜保持器中。

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