会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明授权
    • Diastereomers of 1-(isopropoxycarbonyloxy)ethyl 3-cephem-4-carboxylate
    • 3-头孢烯-4-羧酸1-(异丙氧基羰基氧基)乙酯的非对映异构体
    • US5461043A
    • 1995-10-24
    • US940367
    • 1992-09-03
    • Gerd FischerElisabeth DefossaUwe GerlachRolf HorleinNorbert KrassRudolf LattrellUlrich StacheTheodor WollmannDieter Isert
    • Gerd FischerElisabeth DefossaUwe GerlachRolf HorleinNorbert KrassRudolf LattrellUlrich StacheTheodor WollmannDieter Isert
    • A61K31/545A61K31/546A61P31/04C07D501/00C07D501/06C07D501/34C07D501/56C07D501/22
    • C07D501/00
    • Enterally absorbable diastereomers of 1-(isopropoxycarbonyloxy)ethyl (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate of the formula I ##STR1## and their physiologically acceptable salts and also diastereomerically pure salts of the compounds of the formula II ##STR2## where HX is a mono- or polybasic acid and where X is an inorganic or organic physiologically acceptable anion, and a process for the preparation of these compounds of the formula I or II, which comprises first precipitating the more sparingly soluble diastereomer of the formula IV in the mixing together of 1 equivalent of a solution of the diastereomer mixture of the formula III with 0.2-2 equivalents of a solution of the acid component HY and separating it off by filtration, then precipitating the more readily soluble diastereomer of the formula IV from the filtration solution, it being possible for the acid component HY to be identical or different in the consecutive partial steps and any desired sequence of addition of different acid components HY being possible, and optionally further purifying the obtained salts by crystallization, are described.
    • 1-(异丙氧羰基氧基)乙基(6R,7R)-7- [2-(2-氨基噻唑-4-基)-2-(Z) - (甲氧基亚氨基)乙酰氨基] -3-(甲氧基甲基)-3 式I的化合物 - 头孢烯-4-羧酸酯及其生理学上可接受的盐以及式II化合物的非对映体纯盐,其中HX是单或多元酸,其中X是无机或有机的 生理上可接受的阴离子,以及制备这些式I或II化合物的方法,其包括首先将式IV的较微溶的非对映体沉淀在1当量的式(I)的非对映体混合物的溶液中, III与0.2-2当量的酸组分HY的溶液并通过过滤分离,然后从过滤溶液中沉淀出更容易溶解的式IV的非对映异构体,酸组分HY可能相同或不同 在一起 描述了部分步骤和任何期望的不同酸组分HY的加入顺序是可能的,并且任选地通过结晶进一步纯化得到的盐。
    • 5. 发明授权
    • Diastereomers of 1-(isopropoxycarbonyloxy) ethyl 3-cephem 4-carboxylate
    • 1-(异丙氧基羰基氧基)乙基3-头孢烯-4-羧酸酯的非对映异构体
    • US5550232A
    • 1996-08-27
    • US447229
    • 1995-05-22
    • Gerd FischerElisabeth DefossaUwe GerlachRolf H orleinNorbert KrassRudolf LattrellUlrich StacheTheodor WollmannDieter Isert
    • Gerd FischerElisabeth DefossaUwe GerlachRolf H orleinNorbert KrassRudolf LattrellUlrich StacheTheodor WollmannDieter Isert
    • A61K31/545A61K31/546A61P31/04C07D501/00C07D501/06C07D501/34C07D501/56C07D501/14
    • C07D501/00
    • Enterally absorbable diastereomers of 1-(isopropoxycarbonyloxy)ethyl (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate of the formula I ##STR1## and their physiologically acceptable salts and also diastereomerically pure salts of the compounds of the formula II ##STR2## where HX is a mono- or polybasic acid and where X is an inorganic or organic physiologically acceptable anion, and a process for the preparation of these compounds of the formula I or II, which comprises first precipitating the more sparingly soluble diastereomer of the formula IV in the mixing together of 1 equivalent of a solution of the diastereomer mixture of the formula III with 0.2-2 equivalents of a solution of the acid component HY and separating it off by filtration, then precipitating the more readily soluble diastereomer of the formula IV from the filtration solution, it being possible for the acid component HY to be identical or different in the consecutive partial steps and any desired sequence of addition of different acid components HY being possible, and optionally further purifying the obtained salts by crystallization, are described.
    • 1-(异丙氧羰基氧基)乙基(6R,7R)-7- [2-(2-氨基噻唑-4-基)-2-(Z) - (甲氧基亚氨基)乙酰氨基] -3-(甲氧基甲基)-3 式I的化合物 - 头孢烯-4-羧酸酯及其生理学上可接受的盐以及式II化合物的非对映体纯盐,其中HX是单或多元酸,其中X是无机或有机的 生理学上可接受的阴离子,以及制备这些式I或II化合物的方法,其包括首先将式IV的较微溶的非对映体沉淀在1当量的式(I)的非对映体混合物的溶液中, III与0.2-2当量的酸组分HY的溶液并通过过滤分离,然后从过滤溶液中沉淀出更容易溶解的式IV的非对映异构体,酸组分HY可能相同或不同 在一起 描述了部分步骤和任何期望的不同酸组分HY的加入顺序是可能的,并且任选地通过结晶进一步纯化得到的盐。