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1. 发明授权

US08765699B2 Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases 有权
标题翻译：寡核糖核苷酸及其用于治疗脱发，急性肾衰竭和其它疾病的方法
公开(公告)号：US08765699B2
公开(公告)日：2014-07-01
申请号：US11237598
申请日：2005-09-27
申请人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
发明人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
IPC分类号： C12N15/113
CPC分类号： C12N15/1135 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2320/30
摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.
摘要翻译：本发明涉及下调人p53基因表达的双链化合物，优选寡核糖核苷酸。本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。本发明还考虑了治疗患有脱发或急性肾功能衰竭或其它疾病的患者的方法，包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。秃发可以通过化学疗法或放射疗法诱发，患者可能患有癌症，特别是乳腺癌。

2. 发明申请

US20150141487A1 OLIGORIBONUCLEOTIDES AND METHODS OF USE THEREOF FOR TREATMENT OF ALOPECIA, ACUTE RENAL FAILURE AND OTHER DISEASES 审中-公开
标题翻译：用于治疗阿片样物质，急性肾衰竭和其他疾病的低分子化合物及其使用方法
公开(公告)号：US20150141487A1
公开(公告)日：2015-05-21
申请号：US14321484
申请日：2014-07-01
申请人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
发明人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
IPC分类号： C12N15/113
CPC分类号： C12N15/1135 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2320/30
摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.
摘要翻译：本发明涉及下调人p53基因表达的双链化合物，优选寡核糖核苷酸。本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。本发明还考虑了治疗患有脱发或急性肾功能衰竭或其它疾病的患者的方法，包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。秃发可以通过化学疗法或放射疗法诱发，患者可能患有癌症，特别是乳腺癌。

3. 发明申请

US20120184597A1 OLIGORIBONUCLEOTIDES AND METHODS OF USE THEREOF FOR TREATMENT OF ALOPECIA, ACUTE RENAL FAILURE AND OTHER DISEASES 审中-公开
标题翻译：用于治疗阿片样物质，急性肾衰竭和其他疾病的低分子化合物及其使用方法
公开(公告)号：US20120184597A1
公开(公告)日：2012-07-19
申请号：US13351923
申请日：2012-01-17
申请人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
发明人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
IPC分类号： A61K31/713 , A61P1/00 , C07H21/02 , A61P25/16 , A61P35/00 , C12N5/071 , A61P17/14 , A61P25/00
CPC分类号： C12N15/1135 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2320/30
摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.
摘要翻译：本发明涉及下调人p53基因表达的双链化合物，优选寡核糖核苷酸。本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。本发明还考虑了治疗患有脱发或急性肾功能衰竭或其它疾病的患者的方法，包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。秃发可以通过化学疗法或放射疗法诱发，患者可能患有癌症，特别是乳腺癌。

4. 发明申请

US20060069056A1 Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases 有权
公开(公告)号：US20060069056A1
公开(公告)日：2006-03-30
申请号：US11237598
申请日：2005-09-27
申请人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
发明人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
IPC分类号： A61K48/00 , C07H21/02
CPC分类号： C12N15/1135 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2320/30
摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.

5. 发明授权

US08148342B2 Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases 有权
标题翻译：寡核糖核苷酸及其用于治疗脱发，急性肾衰竭和其它疾病的方法
公开(公告)号：US08148342B2
公开(公告)日：2012-04-03
申请号：US12008578
申请日：2008-01-11
申请人： Elena Feinstein , Shai Ehrlich
发明人： Elena Feinstein , Shai Ehrlich
IPC分类号： A61K31/70
CPC分类号： C12N15/1135 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2320/30
摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.
摘要翻译：本发明涉及下调人p53基因表达的双链化合物，优选寡核糖核苷酸。本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。本发明还考虑了治疗患有脱发或急性肾功能衰竭或其它疾病的患者的方法，包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。秃发可以通过化学疗法或放射疗法诱发，患者可能患有癌症，特别是乳腺癌。

6. 发明申请

US20090082291A1 Methods of treatment of acute renal failure 有权
标题翻译：急性肾功能衰竭的治疗方法
公开(公告)号：US20090082291A1
公开(公告)日：2009-03-26
申请号：US11827199
申请日：2007-07-10
申请人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
发明人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
IPC分类号： A61K48/00 , A61K31/7052 , A61P13/12
CPC分类号： C12N15/1135 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2320/30
摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.
摘要翻译：本发明涉及下调人p53基因表达的双链化合物，优选寡核糖核苷酸。本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。本发明还考虑了治疗患有脱发或急性肾功能衰竭或其它疾病的患者的方法，包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。秃发可以通过化学疗法或放射疗法诱发，患者可能患有癌症，特别是乳腺癌。

7. 发明授权

US09006196B2 Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases 有权
标题翻译：寡核糖核苷酸及其用于治疗脱发，急性肾衰竭和其它疾病的方法
公开(公告)号：US09006196B2
公开(公告)日：2015-04-14
申请号：US13351923
申请日：2012-01-17
申请人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
发明人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
IPC分类号： C12N15/113 , C07H21/02
CPC分类号： C12N15/1135 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2320/30
摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.
摘要翻译：本发明涉及下调人p53基因表达的双链化合物，优选寡核糖核苷酸。本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。本发明还考虑了治疗患有脱发或急性肾功能衰竭或其它疾病的患者的方法，包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。秃发可以通过化学疗法或放射疗法诱发，患者可能患有癌症，特别是乳腺癌。

8. 发明授权

US07842674B2 Methods of treatment of acute renal failure 有权
标题翻译：急性肾功能衰竭的治疗方法
公开(公告)号：US07842674B2
公开(公告)日：2010-11-30
申请号：US11827199
申请日：2007-07-10
申请人： Elena Feinstein , Shai Ehrlich
发明人： Elena Feinstein , Shai Ehrlich
IPC分类号： A61K31/70 , C07H21/04
CPC分类号： C12N15/1135 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2320/30
摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.
摘要翻译：本发明涉及下调人p53基因表达的双链化合物，优选寡核糖核苷酸。本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。本发明还考虑了治疗患有脱发或急性肾功能衰竭或其它疾病的患者的方法，包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。秃发可以通过化学疗法或放射疗法诱发，患者可能患有癌症，特别是乳腺癌。

9. 发明申请

US20080287382A1 Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases 有权
标题翻译：寡核糖核苷酸及其用于治疗脱发，急性肾衰竭和其它疾病的方法
公开(公告)号：US20080287382A1
公开(公告)日：2008-11-20
申请号：US12008578
申请日：2008-01-11
申请人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
发明人： Elena Feinstein , Daniel Zurr , Shai Ehrlich
IPC分类号： A61K31/713 , A61P13/12
CPC分类号： C12N15/1135 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2320/30
摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.
摘要翻译：本发明涉及下调人p53基因表达的双链化合物，优选寡核糖核苷酸。本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。本发明还考虑了治疗患有脱发或急性肾功能衰竭或其它疾病的患者的方法，包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。秃发可以通过化学疗法或放射疗法诱发，患者可能患有癌症，特别是乳腺癌。

10. 发明授权

US09056903B2 Therapeutic uses of inhibitors of RTP801 有权
标题翻译： RTP801抑制剂的治疗用途
公开(公告)号：US09056903B2
公开(公告)日：2015-06-16
申请号：US13233907
申请日：2011-09-15
申请人： Elena Feinstein , Rami Skaliter
发明人： Elena Feinstein , Rami Skaliter
IPC分类号： C12N15/113 , C07K16/18 , C07K14/47 , C07K16/22 , A61K39/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/4747 , C07K16/22 , C12N15/113 , C12N2310/14 , C12N2310/321 , C12N2310/3521
摘要： The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases respiratory conditions and hearing disorders based upon inhibition of the RTP801 gene and/or protein.
摘要翻译：本发明提供了基于RTP801基因和/或蛋白质的抑制来治疗微血管病症，眼部疾病呼吸系统疾病和听力障碍的新型分子，组合物，方法和用途。

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