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1. 发明授权

US08735145B2 Property effecting and/or property exhibiting compositions for therapeutic and diagnostic uses 有权
公开(公告)号：US08735145B2
公开(公告)日：2014-05-27
申请号：US11929897
申请日：2007-10-30
申请人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Keller , Dean L. Engelhardt
发明人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Keller , Dean L. Engelhardt
IPC分类号： C12N15/00
CPC分类号： C12N15/1132 , C07K14/005 , C07K14/62 , C12N9/1247 , C12N15/87 , C12N2740/16322 , C12Q1/6897 , C12Q1/703 , C12Q2525/301 , C12Q2525/307
摘要： The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits.

2. 发明授权

US08846893B2 Non-ionically bound constructs, and compositions and kits comprising domains 失效
标题翻译：非离子结合构建体，以及包含结构域的组合物和试剂盒
公开(公告)号：US08846893B2
公开(公告)日：2014-09-30
申请号：US08978633
申请日：1997-11-25
申请人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Kelker , Dean L. Engelhardt
发明人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Kelker , Dean L. Engelhardt
IPC分类号： C07H21/04 , C12N15/113 , C12Q1/68 , C12N9/12 , C12Q1/70 , C07K14/005 , C07K14/62 , C12N15/87
CPC分类号： C12N15/1132 , C07K14/005 , C07K14/62 , C12N9/1247 , C12N15/87 , C12N2740/16322 , C12Q1/6897 , C12Q1/703 , C12Q2525/301 , C12Q2525/307
摘要： The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits.
摘要翻译：本发明提供了一组组合物，其用于在细胞内和含有这种细胞的生物系统中实现和/或表现出生物功能和加工中的变化。实际上，这些组合物将化学修饰和/或配体添加与生物学功能相结合。化学修饰和/或配体添加为组合物提供额外的特征，而不会基本上干扰它们的生物学功能。这样的附加特征包括核酸酶抗性，靶向特定细胞或定位于细胞内特定位点的特定细胞受体，并且增加组合物和靶细胞之间的相互作用，并且当需要时减少这些相互作用。本发明还提供了方法和试剂盒。

3. 发明授权

US08742090B2 Property effecting and/or property exhibiting compositions for therapeutic and diagnostic uses 失效
标题翻译：性能影响和/或性能表现出用于治疗和诊断用途的组合物
公开(公告)号：US08742090B2
公开(公告)日：2014-06-03
申请号：US08978632
申请日：1997-11-25
申请人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Kelker , Dean L. Engelhardt
发明人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Kelker , Dean L. Engelhardt
IPC分类号： C07H21/04
CPC分类号： C12N15/1132 , C07K14/005 , C07K14/62 , C12N9/1247 , C12N15/87 , C12N2740/16322 , C12Q1/6897 , C12Q1/703 , C12Q2525/301 , C12Q2525/307
摘要： The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits.
摘要翻译：本发明提供了一组组合物，其用于在细胞内和含有这种细胞的生物系统中实现和/或表现出生物功能和加工中的变化。实际上，这些组合物将化学修饰和/或配体添加与生物学功能相结合。化学修饰和/或配体添加为组合物提供额外的特征，而不会基本上干扰它们的生物学功能。这样的附加特征包括核酸酶抗性，靶向特定细胞或定位于细胞内特定位点的特定细胞受体，并且增加组合物和靶细胞之间的相互作用，并且当需要时减少这种相互作用。本发明还提供了方法和试剂盒。

4. 发明申请

US20080248564A1 NOVEL PROPERTY EFFECTING AND/OR PROPERTY EXHIBITING COMPOSITIONS FOR THERAPEUTIC AND DIAGNOSTIC USES 有权
标题翻译：用于治疗和诊断用途的新型物业效果和/或物业展示组合物
公开(公告)号：US20080248564A1
公开(公告)日：2008-10-09
申请号：US11929897
申请日：2007-10-30
申请人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Kelker , Dean L. Engelhardt
发明人： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Dakai Liu , Norman E. Kelker , Dean L. Engelhardt
IPC分类号： C12N15/00
CPC分类号： C12N15/1132 , C07K14/005 , C07K14/62 , C12N9/1247 , C12N15/87 , C12N2740/16322 , C12Q1/6897 , C12Q1/703 , C12Q2525/301 , C12Q2525/307
摘要： The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits.
摘要翻译：本发明提供了一组组合物，其用于在细胞内和含有这种细胞的生物系统中实现和/或表现出生物功能和加工中的变化。实际上，这些组合物将化学修饰和/或配体添加与生物学功能相结合。化学修饰和/或配体添加为组合物提供额外的特征，而不会基本上干扰它们的生物学功能。这样的附加特征包括核酸酶抗性，靶向特定细胞或定位于细胞内特定位点的特定细胞受体，并且增加组合物和靶细胞之间的相互作用，并且当需要时减少这种相互作用。本发明还提供了方法和试剂盒。

5. 发明申请

US20110097791A1 Novel process, construct and conjugate for producing multiple nucleic acid copies 审中-公开
标题翻译：用于生产多个核酸拷贝的新方法，构建和缀合
公开(公告)号：US20110097791A1
公开(公告)日：2011-04-28
申请号：US10260031
申请日：2003-06-06
申请人： Dean L. Engelhardt , Jannis G. Stavrianopoulos , Elazar Rabbani , James J. Donegan
发明人： Dean L. Engelhardt , Jannis G. Stavrianopoulos , Elazar Rabbani , James J. Donegan
IPC分类号： C12N15/63
CPC分类号： C12N15/10 , C12N15/79 , C12P19/34 , C12Q1/6844 , C12Q1/6853 , C12Q1/6858 , C12Q1/686 , C12Q1/6865 , C12Q2525/203 , C12Q2521/119
摘要： This invention provides inter alia an in vitro process for producing multiple specific nucleic acid copies in which the copies are produced under isostatic conditions, e.g., temperature, buffer and ionic strength, and independently of any requirement for introducing an intermediate structure for producing the copies. In other aspects, the invention provides in vitro processes for producing multiple specific nucleic acid copies in which the products are substantially free of any primer-coded sequences, such sequences having been substantially or all removed from the product to regenerate a primer binding site, thereby allowing new priming events to occur and multiple nucleic acid copies to be produced. This invention further provides a promoter-independent non-naturally occurring nucleic acid construct that produces a nucleic acid copy or copies without using or relying on any gene product that may be coded by the nucleic acid construct. Another aspect of this invention concerns a protein-nucleic acid construct in the form of a conjugate linked variously, e.g., covalent linkage, complementary nucleic acid base-pairing, nucleic acid binding proteins, or ligand receptor binding. Further disclosed in this invention is an in vivo process for producing a specific nucleic acid in which such a protein-nucleic acid construct conjugate is introduced into a cell. A still further aspect of the invention relates to a construct comprising a host promoter, second promoter and DNA sequence uniquely located on the construct. The host transcribes a sequence in the construct coding for a different RNA polymerase which after translation is capable of recognizing its cognate promoter and transcribing from a DNA sequence of interest in the construct with the cognate promoter oriented such that it does not promote transcription from the construct of the different RNA polymerase.
摘要翻译：本发明特别提供用于生产多种特异性核酸拷贝的体外方法，其中拷贝在等静压条件下，例如温度，缓冲液和离子强度下产生，并且独立于引入用于产生拷贝的中间结构的任何要求。在其它方面，本发明提供了用于产生多种特异性核酸拷贝的体外方法，其中产物基本上不含任何引物编码的序列，这些序列基本上或全部从产物中除去以再生引物结合位点，从而允许发生新的引发事件并产生多个核酸拷贝。本发明进一步提供了一种与天然存在的启动子相关的非天然存在的核酸构建体，其不使用或依赖于可由核酸构建体编码的任何基因产物产生核酸拷贝或拷贝。本发明的另一方面涉及以不同方式连接的缀合物形式的蛋白质 - 核酸构建体，例如共价连接，互补核酸碱基配对，核酸结合蛋白或配体受体结合。在本发明中进一步公开的是用于生产其中将这种蛋白质 - 核酸构建体缀合物引入细胞的特异性核酸的体内方法。本发明的另一方面涉及包含宿主启动子，第二启动子和唯一位于构建体上的DNA序列的构建体。宿主转录编码不同RNA聚合酶的构建体中的序列，其在翻译后能够识别其同源启动子并且从构建体中感兴趣的DNA序列转录成同源启动子定向，使得其不促进构建体的转录的不同RNA聚合酶。

6. 发明授权

US06986985B1 Process for producing multiple nucleic acid copies in vivo using a protein-nucleic acid construct 失效
标题翻译：使用蛋白质 - 核酸构建体在体内产生多个核酸拷贝的方法
公开(公告)号：US06986985B1
公开(公告)日：2006-01-17
申请号：US09302816
申请日：1998-03-03
申请人： Dean L. Engelhardt , Jannis G. Stavrianopoulos , Elazar Rabbani , James J. Donegan
发明人： Dean L. Engelhardt , Jannis G. Stavrianopoulos , Elazar Rabbani , James J. Donegan
IPC分类号： C12Q1/68 , C12N15/00 , C12N15/63 , C12N1/20 , C07H21/04
CPC分类号： C12N15/10
摘要： This invention provides in vitro processes for producing copies of specific nucleic acids using protein-nucleic acid constructs which are part of conjugates which are introduced into cells. Illustrative of the elements useful in these constructs for producing copies of specific nucleic acids are promoters, sequences coding for proteins or providing templates for transcription, and RNA polymerases.
摘要翻译：本发明提供使用蛋白质 - 核酸构建体产生特异性核酸拷贝的体外方法，所述构建体是引入细胞的缀合物的一部分。用于产生特异性核酸拷贝的这些构建体中有用的元件的说明是启动子，编码蛋白质的序列或提供用于转录的模板和RNA聚合酶。

7. 发明申请

US20090068731A1 Novel process, construct and conjugate for producing multiple nucleic acid copies 审中-公开
标题翻译：用于生产多个核酸拷贝的新方法，构建和缀合
公开(公告)号：US20090068731A1
公开(公告)日：2009-03-12
申请号：US11809452
申请日：2007-06-01
申请人： Dean L. Engelhardt , Jannis G. Stavrianopoulos , Elazar Rabbani , James J. Donegan
发明人： Dean L. Engelhardt , Jannis G. Stavrianopoulos , Elazar Rabbani , James J. Donegan
IPC分类号： C12N15/63
CPC分类号： C12N15/10 , C12P19/34 , C12Q1/6844 , C12Q1/6853 , C12Q1/6858 , C12Q1/686 , C12Q1/6865 , C12Q2525/203 , C12Q2521/119
摘要： This invention provides inter alia an in vitro process for producing multiple specific nucleic acid copies in which the copies are produced under isostatic conditions, by degradation of primer sequences from extended primers, thereby allowing subsequent priming events on the same template.
摘要翻译：本发明特别提供用于生产多种特异性核酸拷贝的体外方法，其中拷贝在等静态条件下通过从扩展引物降解引物序列，从而允许在相同模板上进行随后的引发事件。

8. 发明授权

US09134302B2 Analyte detection utilizing polynucleotide sequences, composition, process and kit 失效
标题翻译：使用多核苷酸序列，组成，过程和试剂盒的分析物检测
公开(公告)号：US09134302B2
公开(公告)日：2015-09-15
申请号：US08479995
申请日：1995-06-07
申请人： Robert G. Pergolizzi , Jannis G. Stavrianopoulos , Elazar Rabbani , Dean L. Engelhardt , Stan Kline , Paula J. Olsiewski
发明人： Robert G. Pergolizzi , Jannis G. Stavrianopoulos , Elazar Rabbani , Dean L. Engelhardt , Stan Kline , Paula J. Olsiewski
IPC分类号： C07H21/00 , G01N33/53 , C12Q1/68
CPC分类号： G01N33/53 , C12Q1/6813 , C12Q1/6876 , Y10T436/143333
摘要： A method of detecting in a sample an analyte (A) having a molecularly recognizable portion thereon, which comprises: providing (B) a molecular bridging entity having thereon: (i) a portion capable of recognizing the molecularly recognizable portion on the analyte; and (ii) a portion comprising a polynucleotide sequence; and (C) a signalling entity having thereon: (i) a polynucleotide portion capable of annealing to the polynucleotide portion of the bridging entity, thereby to form a stable polynucleotide hybrid, and (ii) a signal generating portion; forming a complex comprising: (1) the analyte (A) complexed through its molecularly recognizable portion to (2) the recognizing portion of the entity (B); the entity (B) being complexed through the polynucleotide portion thereon to (3) the polynucleotide portion of the signalling entity; and detecting a signal by means of the signal generating portion present in the complex.
摘要翻译：在样品中检测其上具有分子可识别部分的分析物（A）的方法，其包括：提供（B）其上具有其上的分子桥接实体：（i）能够识别分析物上的分子识别部分的部分; 和（ii）包含多核苷酸序列的部分; 和（C）其上具有的信令实体：（i）能够退火到所述桥接实体的多核苷酸部分从而形成稳定的多核苷酸杂交体的多核苷酸部分，和（ii）信号产生部分; 形成复合物，其包括：（1）通过其分子可识别部分复合的分析物（A）至（2）实体（B）的识别部分; 实体（B）通过其上的多核苷酸部分复合到（3）信令实体的多核苷酸部分; 以及通过存在于复合体中的信号产生部分来检测信号。

9. 发明授权

US07608274B2 Therapeutic processes and useful compositions therefor 有权
标题翻译：治疗方法及其有用的组合物
公开(公告)号：US07608274B2
公开(公告)日：2009-10-27
申请号：US10470611
申请日：2003-12-08
申请人： Yaron Ilan , Elazar Rabbani , Dean L. Engelhardt , Israel Gotsman , James J. Donegan
发明人： Yaron Ilan , Elazar Rabbani , Dean L. Engelhardt , Israel Gotsman , James J. Donegan
IPC分类号： A61K39/29
CPC分类号： A61K39/0005 , A61K38/00 , A61K39/001 , A61K39/12 , A61K39/292 , A61K2035/122 , A61K2039/5152 , A61K2039/542 , A61K2039/57 , C12N2730/10134
摘要： This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or administering to a subject one or more antigens, or trained or adopted immune cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention.
摘要翻译：本发明提供了用于治疗应用的新方法，包括治疗携带感染性物质或具有受损的自身免疫或免疫病症受损的受试者。本文公开的治疗应用还涉及用含有癌细胞或恶性或癌细胞的恶性肿瘤治疗癌性受试者。还提供了预防受试者感染的疫苗接种过程。所述新方法包括向受试者引入或施用一种或多种抗原或训练或采用的免疫细胞。这些抗原或免疫细胞能够建立或增加至少一种第一特异性免疫应答并减少至少一种第二特异性免疫应答。这些反应包括组分，如细胞免疫反应元件，体液免疫反应元件和细胞因子，后者还包括干扰素和淋巴因子。本发明也提供有用的组合物。

10. 发明申请

US20100021500A1 Processes for treating subjects carrying viral infectious agent 审中-公开
标题翻译：用于治疗携带病毒感染因子的受试者的方法
公开(公告)号：US20100021500A1
公开(公告)日：2010-01-28
申请号：US12583271
申请日：2009-08-18
申请人： Yaron Ilan , Elazar Rabbani , Dean L. Engelhardt , Israel Gotsman , James J. Donegan
发明人： Yaron Ilan , Elazar Rabbani , Dean L. Engelhardt , Israel Gotsman , James J. Donegan
IPC分类号： A61K39/29 , A61K39/00 , A61P37/04
CPC分类号： A61K39/0005 , A61K38/00 , A61K39/001 , A61K39/12 , A61K39/292 , A61K2035/122 , A61K2039/5152 , A61K2039/542 , A61K2039/57 , C12N2730/10134
摘要： This invention provides novel processes for therapeutic applications, including the treatment of subjects carrying infectious agents or having impaired autoimmunity or impaired immune condition. The therapeutic applications disclosed herein are also directed at the treatment of cancerous subjects with malignant tumors containing cancerous cells or malignant or cancerous cells. Vaccination processes for preventing infections in subjects are also provided. The novel processes comprise introducing into or adminstering to a subject one or more antigens, or trained or adopted immune cells. These antigens or immune cells are capable of establishing or increasing at least one first specific immune response and decreasing at least one second specific immune response. Such responses include components, such as cellular immune reaction elements, humoral immune reaction elements and cytokines, the latter also encompassing interferons and lymphokines. Useful compositions are also provided by this invention.
摘要翻译：本发明提供了用于治疗应用的新方法，包括治疗携带感染性物质或具有受损的自身免疫或免疫病症受损的受试者。本文公开的治疗应用还涉及用含有癌细胞或恶性或癌细胞的恶性肿瘤治疗癌性受试者。还提供了预防受试者感染的疫苗接种过程。该新颖方法包括向受试者引入或施用一种或多种抗原或训练或采用的免疫细胞。这些抗原或免疫细胞能够建立或增加至少一种第一特异性免疫应答并减少至少一种第二特异性免疫应答。这些反应包括组分，如细胞免疫反应元件，体液免疫反应元件和细胞因子，后者还包括干扰素和淋巴因子。本发明也提供有用的组合物。

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