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    • 7. 发明公开
    • MEDICINAL COMPOSITIONS FOR CONCOMINANT USE AS ANTICANCER ATENT
    • 医药化妆品
    • EP1331005A1
    • 2003-07-30
    • EP01978983.3
    • 2001-10-31
    • Eisai Co., Ltd.
    • OZAWA, YoichiYOSHIMATSU, KentaroKAI, Junko
    • A61K31/404A61K31/4745A61K31/407A61K31/513A61K31/24A61K31/7068A61K31/704A61K31/337C07D209/08C07D235/06C07D231/56C07D471/04A61P35/00
    • C07D209/30
    • The present invention provides a medicinal composition having an excellent antitumor activity. That is, it provides a medicinal composition comprising a sulfonamide compound, a sulfonate compound or a salt of them, which is represented by the following formula:
      (wherein ring A represents an aromatic ring which may have a substituent group; ring B represents a 6-membered unsaturated hydrocarbon ring which may have a substituent group etc.; ring C represents a 5-membered hetero-ring containing one or two nitrogen atoms, and the ring C may have a substituent group; W represents a single bond or -CH=CH-; X represents -NH- etc.; and Y represents a carbon atom or a nitrogen atom; and Z represents -NH- etc.), particularly N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide or a salt thereof, combined with at least one substance selected from (1) irinotecan hydrochloride trihydrate; (2) mitomycin C; (3) 5-fluorouracil; (4) cisplatin; (5) gemcitabinehydrochloride; (6) doxorubicin; (7) taxol; and (8) a salt of the above-mentioned (1) to (7).
    • 本发明提供具有优异的抗肿瘤活性的药物组合物。 也就是说,提供由下式表示的磺酰胺化合物,磺酸酯化合物或它们的盐的药物组合物:(其中环A表示可具有取代基的芳香环;环B 表示可以具有取代基的6元不饱和烃环等;环C表示含有一个或两个氮原子的5元杂环,环C可以具有取代基; W表示单键或 -CH = CH-; X表示-NH-等; Y表示碳原子或氮原子; Z表示-NH-等),特别是N-(3-氯-1H-吲哚-7-基) )-4-氨磺酰基苯磺酰胺或其盐与至少一种选自(1)盐酸伊立替康三水合物的物质组合; (2)丝裂霉素C; (3)5-氟尿嘧啶; (4)顺铂; (5)吉西他滨盐酸盐; (6)多柔比星; (7)紫杉醇; 和(8)上述(1)至(7)的盐。