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    • 4. 发明授权
    • Sustained release preparation for tissue regeneration therapy
    • 组织再生治疗的缓释制剂
    • US08617614B2
    • 2013-12-31
    • US12446157
    • 2007-10-18
    • Yoshiki SakaiTakahiro Uchida
    • Yoshiki SakaiTakahiro Uchida
    • A61K9/50A61K31/44A01N43/40
    • A61K31/4406A61K9/1647
    • The present invention provides a microsphere with a slow-release period from about two weeks to about four weeks following administration, to enable a higher content of a drug to be included, to suppress an initial burst of the drug, and to maintain an optimal, effective blood concentration during the slow-release period. In a microsphere containing a drug and polylactic acid/glycolic acid (PLGA) copolymer, the amount of PLGA copolymer per part by weight of the drug is from about 3 to about 10 parts by weight; the average particle size of the microsphere is from about 20 to about 50 μm; and (3) the PLGA copolymer has a weight-average molecular weight from about 10,000 to about 50,000 and a PLGA compositional ratio from about 75/25 to about 50/50. The microsphere promotes the production of various endogenous repair factors useful against various tissue disorders.
    • 本发明提供了一种在施用后约两周至约四周的缓释期的微球,以使得能够包含更高含量的药物以抑制药物的初始爆发,并保持最佳, 缓释期有效血药浓度。 在含有药物和聚乳酸/乙醇酸(PLGA)共聚物的微球中,每重量份药物的PLGA共聚物的量为约3至约10重量份; 微球的平均粒径为约20至约50μm; 和(3)PLGA共聚物的重均分子量为约10,000至约50,000,PLGA组成比为约75/25至约50/50。 微球促进了各种可用于各种组织疾病的内源性修复因子的产生。
    • 6. 发明授权
    • Hydraulic actuator control device and hydraulic actuator control method
    • 液压执行器控制装置和液压执行器控制方式
    • US08225763B2
    • 2012-07-24
    • US12443742
    • 2008-01-18
    • Tomohiro NakanoShuji YudaMasakatsu NagaiTakahiro Uchida
    • Tomohiro NakanoShuji YudaMasakatsu NagaiTakahiro Uchida
    • F01L1/34
    • F01L1/344F01L1/3442F01L2001/34426F01L2001/3443F01L2800/00
    • In a hydraulic actuator control device, a changing tendency of responsiveness of a hydraulic actuator to changes in the oil control valve (OCV) drive duty of a virtual OCV is stored as model control characteristics. The ratio of an actual OCV dead zone width to a virtual OCV dead zone width is calculated as an OCV variation correction coefficient. A basic control amount is calculated based on a deviation between an operating amount and a target operating amount of the hydraulic actuator. An actual OCV in-dead-zone control amount is obtained by correcting a virtual OCV in-dead-zone control amount with the OCV variation correction coefficient, and an actual OCV out-of-dead-zone control amount is calculated based on a virtual OCV out-of-dead-zone control amount. The actual OCV control amount is the sum of the actual OCV in-dead-zone control amount and the actual OCV out-of-dead-zone control amount.
    • 在液压致动器控制装置中,作为模型控制特性存储液压致动器对虚拟OCV的油控制阀(OCV)驱动占空比的变化的变化趋势。 实际OCV死区宽度与虚拟OCV死区宽度的比率被计算为OCV变化校正系数。 基于液压致动器的操作量和目标操作量之间的偏差来计算基本控制量。 通过用OCV变化校正系数校正虚拟OCV死区控制量来获得实际的OCV死区控制量,并且基于虚拟的OCV变化校正系数计算实际的OCV死区间控制量 OCV死区控制量。 实际的OCV控制量是实际OCV死区控制量与实际OCV死区间控制量的总和。