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1. 发明授权

US07731937B2 Diagnostic method for paratuberculosis 失效
标题翻译：副结核病的诊断方法
公开(公告)号：US07731937B2
公开(公告)日：2010-06-08
申请号：US10572514
申请日：2003-09-17
申请人： Eiichi Momotani , Yasuyuki Mori , Hirokazu Hikono , Joram Josephat Buza
发明人： Eiichi Momotani , Yasuyuki Mori , Hirokazu Hikono , Joram Josephat Buza
IPC分类号： A61K48/00 , A61K39/04 , C12N5/00
CPC分类号： G01N33/5695 , G01N2333/35 , G01N2333/54 , G01N2333/57
摘要： The present invention is intended to provide a diagnostic method for paratuberculosis by which an animal infected with Mycobacterium avium subsp. Paratuberculosis can be diagnosed at a high sensitivity in the sub-clinical infection stage before the specific antibody level begins to increase and a large number of specimens can be treated. The present invention provides: a diagnostic method for paratuberculosis characterized by collecting the blood of a subject animal, adding an anti-IL-10 antibody and a Mycobacterium avium subsp. Paratuberculosis antigen to the collected blood followed by culture, and then measuring the amount of produced IFNγ in the blood; a diagnostic method for paratuberculosis characterized in that the amount of produced IFNγ in blood is measured by the IFNγ ELISA method; and a diagnostic method for mycobacterial infection characterized by collecting the blood of a subject animal, adding an anti-IL-10 antibody and a mycobacterial antigen to the collected blood followed by culture, and then measuring the amount of produced IFNγ in the blood.
摘要翻译：本发明旨在提供一种用于副结核病的诊断方法，通过该方法，感染了鸟分枝杆菌在特异性抗体水平开始增加之前，可以在亚临床感染阶段以高灵敏度诊断结核分枝杆菌，并且可以治疗大量标本。本发明提供：一种副结核病的诊断方法，其特征在于，收集受试动物的血液，加入抗IL-10抗体和鸟分枝杆菌亚种。将结核杆菌抗原转移到收集的血液中，然后培养，然后测量血液中产生的IFNγ的量; 一种副结核病的诊断方法，其特征在于通过IFNγELISA法测定血液中产生的IFNγ量; 以及分类细菌感染的诊断方法，其特征在于收集受试动物的血液，向收集的血液中加入抗IL-10抗体和分枝杆菌抗原，然后培养，然后测定血液中产生的IFNγ的量。

2. 发明申请

US20080038758A1 Diagnostic Method for Paratuberculosis 失效
标题翻译：结核病诊断方法
公开(公告)号：US20080038758A1
公开(公告)日：2008-02-14
申请号：US10572514
申请日：2003-09-17
申请人： Eiichi Momotani , Yasuyuki Mori , Hirokazu Hikono , Joram Josephat Buza
发明人： Eiichi Momotani , Yasuyuki Mori , Hirokazu Hikono , Joram Josephat Buza
IPC分类号： G01N33/53
CPC分类号： G01N33/5695 , G01N2333/35 , G01N2333/54 , G01N2333/57
摘要： The present invention is intended to provide a diagnostic method for paratuberculosis by which an animal infected with Mycobacterium avium subsp. Paratuberculosis can be diagnosed at a high sensitivity in the sub-clinical infection stage before the specific antibody level begins to increase and a large number of specimens can be treated. The present invention provides: a diagnostic method for paratuberculosis characterized by collecting the blood of a subject animal, adding an anti-IL-10 antibody and a Mycobacterium avium subsp. Paratuberculosis antigen to the collected blood followed by culture, and then measuring the amount of produced IFNγ in the blood; a diagnostic method for paratuberculosis characterized in that the amount of produced IFNγ in blood is measured by the IFNγ ELISA method; and a diagnostic method for mycobacterial infection characterized by collecting the blood of a subject animal, adding an anti-IL-10 antibody and a mycobacterial antigen to the collected blood followed by culture, and then measuring the amount of produced IFNγ in the blood.
摘要翻译：本发明旨在提供一种用于副结核病的诊断方法，通过该方法，感染了鸟分枝杆菌在特异性抗体水平开始增加之前，可以在亚临床感染阶段以高灵敏度诊断结核分枝杆菌，并且可以治疗大量标本。本发明提供：一种副结核病的诊断方法，其特征在于，收集受试动物的血液，加入抗IL-10抗体和鸟分枝杆菌亚种。将结核分枝杆菌抗原转移到收集的血液中，然后培养，然后测量血液中产生的IFNγ量; 一种副结核病的诊断方法，其特征在于通过IFNgamma ELISA法测定血液中产生的IFNγ量; 以及分析病原体感染的诊断方法，其特征在于收集受试动物的血液，向收集的血液中加入抗IL-10抗体和分枝杆菌抗原，然后培养，然后测量血液中产生的IFNγ量。

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