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1. 发明申请

US20140194420A1 AZABENZIMIDAZOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY 有权
标题翻译：具有AMPK活化活性的AZABENZIMIDAZOLE衍生物
公开(公告)号：US20140194420A1
公开(公告)日：2014-07-10
申请号：US14233058
申请日：2012-07-13
申请人： Eiichi Kojima , Keisuke Tonogaki , Nobuyuki Tanaka , Manabu Katou , Akira Ino , Masafumi Iwatsu , Masahiko Fujioka , Yu Hinata , Naoki Ohyabu
发明人： Eiichi Kojima , Keisuke Tonogaki , Nobuyuki Tanaka , Manabu Katou , Akira Ino , Masafumi Iwatsu , Masahiko Fujioka , Yu Hinata , Naoki Ohyabu
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D451/06 , C07D519/00 , C07F9/6561
摘要： Disclosed is a compound which is useful as an AMPK activator.A compound represented by formula: or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen, or substituted or unsubstituted alkyl, R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R1, R2 and R3 are not simultaneously hydrogen, X is a single bond, —S—, —O—, —NR5—, —C(═O)— or the like, R5 is hydrogen, or substituted or unsubstituted alkyl, Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.
摘要翻译：公开了可用作AMPK活化剂的化合物。由式表示的化合物或其药学上可接受的盐，其中R 4是氢，或者取代或未取代的烷基，R 1，R 2和R 3各自独立地是氢，卤素，羟基，氰基，硝基，羧基，取代或未取代的烷基或条件是R 1，R 2和R 3不同时为氢，X为单键，-S - ， - O - ， - NR 5 - ， - C（= O） - 等，R 5为氢或取代或未取代的烷基，Y是取代或未取代的环烷基，取代或未取代的环烯基，取代或未取代的杂环基等。

2. 发明授权

US09567330B2 Azabenzimidazole derivative having AMPK-activating activity 有权
标题翻译：具有AMPK活化活性的偶氮苯并咪唑衍生物
公开(公告)号：US09567330B2
公开(公告)日：2017-02-14
申请号：US14233058
申请日：2012-07-13
申请人： Eiichi Kojima , Keisuke Tonogaki , Nobuyuki Tanaka , Manabu Katou , Akira Ino , Masafumi Iwatsu , Masahiko Fujioka , Yu Hinata , Naoki Ohyabu
发明人： Eiichi Kojima , Keisuke Tonogaki , Nobuyuki Tanaka , Manabu Katou , Akira Ino , Masafumi Iwatsu , Masahiko Fujioka , Yu Hinata , Naoki Ohyabu
IPC分类号： C07D471/04 , C07D519/00 , C07F9/6561 , C07D451/06
CPC分类号： C07D471/04 , C07D451/06 , C07D519/00 , C07F9/6561
摘要： Disclosed is a compound which is useful as an AMPK activator.A compound represented by formula: or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen, or substituted or unsubstituted alkyl, R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R1, R2 and R3 are not simultaneously hydrogen, X is a single bond, —S—, —O—, —NR5—, —C(═O)— or the like, R5 is hydrogen, or substituted or unsubstituted alkyl, Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.
摘要翻译：公开了可用作AMPK活化剂的化合物。由下式表示的化合物或其药学上可接受的盐，其中R 4是氢或取代或未取代的烷基，R 1，R 2和R 3各自独立地是氢，卤素，羟基，氰基，硝基，羧基，取代或未取代的烷基等，条件是R 1，R 2和R 3不同时为氢，X为单键，-S - ， - O - ， - NR 5 - ， - C（= O） - 或 R 5为氢或取代或未取代的烷基，Y为取代或未取代的环烷基，取代或未取代的环烯基，取代或未取代的杂环基等。

3. 发明申请

US20130184240A1 HETERO RING-FUSED IMIDAZOLE DERIVATIVE HAVING AMPK ACTIVATING EFFECT 有权
标题翻译：具有AMPK激活效应的异环结合的咪唑唑衍生物
公开(公告)号：US20130184240A1
公开(公告)日：2013-07-18
申请号：US13822189
申请日：2011-09-08
申请人： Keisuke Tonogaki , Akira Ino , Eiichi Kojima , Manabu Katou , Masafumi Iwatsu , Nobuyuki Tanaka , Masahiko Fujioka
发明人： Keisuke Tonogaki , Akira Ino , Eiichi Kojima , Manabu Katou , Masafumi Iwatsu , Nobuyuki Tanaka , Masahiko Fujioka
IPC分类号： C07D471/04 , C07D495/04 , C07D487/04 , C07D473/30 , C07D473/06 , C07D473/00 , C07D491/08
CPC分类号： C07D471/04 , C07D473/00 , C07D473/06 , C07D473/28 , C07D473/30 , C07D487/04 , C07D491/048 , C07D491/08 , C07D495/04 , C07D513/04 , C07D519/00
摘要： Disclosed is a compound which is useful as an AMPK activator. A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein a group represented by the formula: is a group represented by the formula: R1 is each independently halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like; m is an integer of 0 to 3; R2 is hydrogen, or substituted or unsubstituted alkyl; X is —O—; and Y is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
摘要翻译：公开了可用作AMPK活化剂的化合物。由下式表示的化合物：其药学上可接受的盐或其溶剂合物，其中由下式表示的基团是由下式表示的基团：R 1各自独立地为卤素，羟基，氰基，硝基，羧基，取代或未取代的烷基，取代或未取代的链烯基等; m为0〜3的整数。 R2是氢或取代或未取代的烷基; X是-O-; 并且Y是取代或未取代的芳基，或取代或未取代的杂芳基。

4. 发明授权

US09133186B2 Hetero ring-fused imidazole derivative having AMPK activating effect 有权
标题翻译：具有AMPK活化作用的异环烯基咪唑衍生物
公开(公告)号：US09133186B2
公开(公告)日：2015-09-15
申请号：US13822189
申请日：2011-09-08
申请人： Keisuke Tonogaki , Akira Ino , Eiichi Kojima , Manabu Katou , Masafumi Iwatsu , Nobuyuki Tanaka , Masahiko Fujioka
发明人： Keisuke Tonogaki , Akira Ino , Eiichi Kojima , Manabu Katou , Masafumi Iwatsu , Nobuyuki Tanaka , Masahiko Fujioka
IPC分类号： C07D487/04 , C07D471/04 , C07D473/00 , C07D473/06 , C07D473/28 , C07D491/048 , C07D495/04 , C07D513/04 , C07D473/30 , C07D491/08 , C07D519/00
CPC分类号： C07D471/04 , C07D473/00 , C07D473/06 , C07D473/28 , C07D473/30 , C07D487/04 , C07D491/048 , C07D491/08 , C07D495/04 , C07D513/04 , C07D519/00
摘要： Disclosed is a compound which is useful as an AMPK activator. A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein a group represented by the formula: is a group represented by the formula: R1 is each independently halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like; m is an integer of 0 to 3; R2 is hydrogen, or substituted or unsubstituted alkyl; X is —O—; and Y is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.
摘要翻译：公开了可用作AMPK活化剂的化合物。由下式表示的化合物：其药学上可接受的盐或其溶剂合物，其中由下式表示的基团是由下式表示的基团：R 1各自独立地为卤素，羟基，氰基，硝基，羧基，取代或未取代的烷基，取代或未取代的链烯基等; m为0〜3的整数。 R2是氢或取代或未取代的烷基; X是-O-; 并且Y是取代或未取代的芳基，或取代或未取代的杂芳基。

5. 发明申请

US20080180855A1 Single stopper pin for controlling magnetic head placement in disk drive devices, and methods of making the same 审中-公开
标题翻译：用于控制磁盘驱动装置中的磁头放置的单止动销及其制造方法
公开(公告)号：US20080180855A1
公开(公告)日：2008-07-31
申请号：US11700262
申请日：2007-01-31
申请人： Masahiko Fujioka , Yiu Sing Ho , Yi Wan
发明人： Masahiko Fujioka , Yiu Sing Ho , Yi Wan
IPC分类号： G11B5/55
CPC分类号： G11B5/5569
摘要： A voice coil motor for use in a disk drive device suitable for causing rotation of a head gimbal assembly connected to a first end of the voice coil motor is provided. At least one protrusion may protrude from a second end of the voice coil motor, with the second end of the voice coil motor being opposed to the first end. The voice coil motor may be rotatable to move a head connected to the head gimbal assembly for a read and/or write operation and for parking. The protrusion may be disposed on the voice coil motor so as to cooperate with a single pin to define first and second maximum positions beyond which the voice coil motor cannot rotate. In certain example embodiments, the first maximum position may be a load position limit beyond which the voice coil motor cannot rotate during a read/write operation, and the second maximum position may be a park position limit beyond which the voice coil motor cannot rotate when the head is parked.
摘要翻译：提供一种用于磁盘驱动装置中的音圈电动机，其适于引起连接到音圈电动机的第一端的磁头万向架组件的转动。至少一个突起可以从音圈马达的第二端突出，音圈马达的第二端与第一端相对。音圈马达可以旋转以移动连接到头部万向架组件的头部用于读取和/或写入操作并用于停车。突起可以设置在音圈马达上，以便与单个引脚配合以限定音圈马达不能旋转的第一和第二最大位置。在某些示例性实施例中，第一最大位置可以是加载位置限制，超过该载荷位置限制，音圈电机在读/写操作期间不能旋转，并且第二最大位置可以是停止位置限制，超过该停止位置限制音圈电机不能旋转，头停了。

6. 发明申请

US20100069638A1 SULFONAMIDE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY 有权
标题翻译：具有PGD2受体拮抗活性的磺酰胺衍生物
公开(公告)号：US20100069638A1
公开(公告)日：2010-03-18
申请号：US12622860
申请日：2009-11-20
申请人： Akira Kugimiya , Masahiko Fujioka , Yuki Tachibana , Takami Murashi
发明人： Akira Kugimiya , Masahiko Fujioka , Yuki Tachibana , Takami Murashi
IPC分类号： C07D401/04 , C07D211/44 , C07D241/04 , C07D211/34 , C07D405/12 , C07D413/12
CPC分类号： C07D295/26 , C07D207/14 , C07D207/48 , C07D211/58 , C07D211/70 , C07D211/96 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/74 , C07D231/12 , C07D231/40 , C07D235/08 , C07D235/30 , C07D235/32 , C07D243/08 , C07D261/08 , C07D261/18 , C07D263/32 , C07D263/58 , C07D265/36 , C07D271/10 , C07D277/24 , C07D277/28 , C07D285/12 , C07D285/135 , C07D295/096 , C07D295/155 , C07D307/42 , C07D307/52 , C07D307/56 , C07D307/68 , C07D333/36 , C07D401/12 , C07D413/12
摘要： The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases.A compound of the general formula (II): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.; a pharmaceutically acceptable salt or a hydrate thereof.
摘要翻译：本发明提供具有DP受体拮抗活性的磺酰胺衍生物和含有上述化合物作为活性成分的药物组合物，还含有治疗过敏性疾病的治疗剂。通式（II）的化合物：其中环A为芳族碳环等; 环B为含氮非芳族杂环等; 环C为芳香族碳环等; R1是羧基等; R2独立地为卤素原子等; R3是任选取代的烷氧基等; R4独立地为卤素原子等; R5独立地是任意取代的烷基等; M是磺酰基等。 Y是单键等。 L1是单键等; L2是单键等; k为0，1，2，3或4; n为0,1或2; q为0,1,2或3; 条件是当环B是含有一个或两个氮原子并且环C是苯环的6元含氮杂环时，a）k不为0; 其药学上可接受的盐或其水合物。

7. 发明授权

US08730623B2 Head stack assembly and disk drive unit with the same 有权
标题翻译：头堆叠组件和磁盘驱动器单元相同
公开(公告)号：US08730623B2
公开(公告)日：2014-05-20
申请号：US12656197
申请日：2010-01-20
申请人： Yiusing Ho , Masahiko Fujioka
发明人： Yiusing Ho , Masahiko Fujioka
IPC分类号： G11B21/16 , G11B5/48
CPC分类号： G11B5/5569 , G11B5/4833
摘要： Disclosed is a head stack assembly, which comprises a pivot bearing assembly having a main body which comprising a first end surface and a second end surface, and a flange extended from the main body and located between the first and second end surfaces, the flange having a first interface adjacent the first end surface of the main body and a second interface opposite to the first interface; a drive arm mounted on the main body and secured on the first interface of the flange; and a fantail spacer mounted on the main body and secured on the second interface of the flange.
摘要翻译：公开了一种头部堆叠组件，其包括枢转轴承组件，该枢转轴承组件具有包括第一端面和第二端面的主体，以及从主体延伸并位于第一和第二端面之间的凸缘，凸缘具有邻近主体的第一端面的第一接口和与第一接口相对的第二接口; 驱动臂，其安装在主体上并固定在凸缘的第一界面上; 以及安装在主体上并固定在凸缘的第二界面上的扇形间隔件。

8. 发明授权

US07626811B2 Low profile disk drive unit 有权
标题翻译：低调磁盘驱动器单元
公开(公告)号：US07626811B2
公开(公告)日：2009-12-01
申请号：US11878773
申请日：2007-07-26
申请人： Takehiro Kamigama , Masahiko Fujioka , YiuSing Ho , Yi Wan
发明人： Takehiro Kamigama , Masahiko Fujioka , YiuSing Ho , Yi Wan
IPC分类号： G06F1/16
CPC分类号： G11B33/123
摘要： A low profile disk drive unit includes a disk; a HSA cooperating with the disk; a base plate comprising a bottom portion for supporting the disk and the head stack assembly thereon and a base plate sidewall extending from circumference of the bottom portion; and a top cover comprising a top portion and a top cover sidewall extending from circumference of the top portion and assembled with the base plate; wherein the top cover sidewall is thinner than the base plate sidewall, and the base plate sidewall is lower than the disk with the bottom portion as a reference datum so as to define an airflow channel between a periphery of the disk and the top cover sidewall of the top cover.
摘要翻译：低档盘驱动器单元包括盘; HSA与磁盘协作; 底板，其包括用于支撑盘的底部部分和其上的头部堆叠组件，以及从底部的圆周延伸的底板侧壁; 以及顶盖，其包括从所述顶部的圆周延伸并与所述基板组装的顶部和顶盖侧壁; 其中所述顶盖侧壁比所述基板侧壁更薄，并且所述基板侧壁低于所述盘的底部，作为参考基准，以便在所述盘的周边与所述盘的外围侧壁之间限定气流通道顶盖。

9. 发明授权

US08993763B2 Sulfonamide derivative having PGD2 receptor antagonistic activity 有权
标题翻译：具有PGD2受体拮抗活性的磺酰胺衍生物
公开(公告)号：US08993763B2
公开(公告)日：2015-03-31
申请号：US11992602
申请日：2006-09-25
申请人： Akira Kugimiya , Masahiko Fujioka , Yuki Tachibana , Takami Murashi , Naohiro Onodera
发明人： Akira Kugimiya , Masahiko Fujioka , Yuki Tachibana , Takami Murashi , Naohiro Onodera
IPC分类号： C07D295/26 , C07D417/12 , C07D413/10 , C07D407/10 , C07D207/14 , C07D207/48 , C07D211/58 , C07D211/70 , C07D211/96 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/74 , C07D231/12 , C07D231/40 , C07D235/08 , C07D235/30 , C07D235/32 , C07D243/08 , C07D261/08 , C07D261/18 , C07D263/32 , C07D263/58 , C07D265/36 , C07D271/10 , C07D277/24 , C07D277/28 , C07D285/12 , C07D285/135 , C07D295/096 , C07D295/155 , C07D307/42 , C07D307/52 , C07D307/56 , C07D307/68 , C07D333/36 , C07D401/12 , C07D413/12
CPC分类号： C07D295/26 , C07D207/14 , C07D207/48 , C07D211/58 , C07D211/70 , C07D211/96 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/74 , C07D231/12 , C07D231/40 , C07D235/08 , C07D235/30 , C07D235/32 , C07D243/08 , C07D261/08 , C07D261/18 , C07D263/32 , C07D263/58 , C07D265/36 , C07D271/10 , C07D277/24 , C07D277/28 , C07D285/12 , C07D285/135 , C07D295/096 , C07D295/155 , C07D307/42 , C07D307/52 , C07D307/56 , C07D307/68 , C07D333/36 , C07D401/12 , C07D413/12
摘要： The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases.A compound of the general formula (II): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.; a pharmaceutically acceptable salt or a hydrate thereof.
摘要翻译：本发明提供具有DP受体拮抗活性的磺酰胺衍生物和含有上述化合物作为活性成分的药物组合物，还含有治疗过敏性疾病的治疗剂。通式（II）的化合物：其中环A为芳族碳环等; 环B为含氮非芳族杂环等; 环C为芳香族碳环等; R1是羧基等; R2独立地为卤素原子等; R3是任选取代的烷氧基等; R4独立地为卤素原子等; R5独立地是任意取代的烷基等; M是磺酰基等。 Y是单键等; L1是单键等; L2是单键等; k为0，1，2，3或4; n为0,1或2; q为0,1,2或3; 条件是当环B是含有一个或两个氮原子并且环C是苯环的6元含氮杂环时，a）k不为0; 其药学上可接受的盐或其水合物。

10. 发明授权

US08153793B2 Sulfonamide derivative having PGD2 receptor antagonistic activity 有权
标题翻译：具有PGD2受体拮抗活性的磺酰胺衍生物
公开(公告)号：US08153793B2
公开(公告)日：2012-04-10
申请号：US12622860
申请日：2009-11-20
申请人： Akira Kugimiya , Masahiko Fujioka , Yuki Tachibana , Takami Murashi
发明人： Akira Kugimiya , Masahiko Fujioka , Yuki Tachibana , Takami Murashi
IPC分类号： C07D403/10
CPC分类号： C07D295/26 , C07D207/14 , C07D207/48 , C07D211/58 , C07D211/70 , C07D211/96 , C07D213/38 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/74 , C07D231/12 , C07D231/40 , C07D235/08 , C07D235/30 , C07D235/32 , C07D243/08 , C07D261/08 , C07D261/18 , C07D263/32 , C07D263/58 , C07D265/36 , C07D271/10 , C07D277/24 , C07D277/28 , C07D285/12 , C07D285/135 , C07D295/096 , C07D295/155 , C07D307/42 , C07D307/52 , C07D307/56 , C07D307/68 , C07D333/36 , C07D401/12 , C07D413/12
摘要： The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases.A compound of the general formula (II): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.; a pharmaceutically acceptable salt or a hydrate thereof.
摘要翻译：本发明提供具有DP受体拮抗活性的磺酰胺衍生物和含有上述化合物作为活性成分的药物组合物，还含有治疗过敏性疾病的治疗剂。通式（II）的化合物：其中环A为芳族碳环等; 环B为含氮非芳族杂环等; 环C为芳香族碳环等; R1是羧基等; R2独立地为卤素原子等; R3是任选取代的烷氧基等; R4独立地为卤素原子等; R5独立地是任意取代的烷基等; M是磺酰基等。 Y是单键等; L1是单键等; L2是单键等; k为0，1，2，3或4; n为0,1或2; q为0,1,2或3; 条件是当环B是含有一个或两个氮原子并且环C是苯环的6元含氮杂环时，a）k不为0; 其药学上可接受的盐或其水合物。

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