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    • 1. 发明授权
    • Independent clocking local area network and nodes used for the same
    • 独立时钟局域网和节点使用相同
    • US5241543A
    • 1993-08-31
    • US672640
    • 1991-03-20
    • Eiichi AmadaKunio HiyamaNaoya KobayashiYoshihiro TakiyasuYasuhiko HatekeyamaHaruyuki Nakayama
    • Eiichi AmadaKunio HiyamaNaoya KobayashiYoshihiro TakiyasuYasuhiko HatekeyamaHaruyuki Nakayama
    • H04J3/06H04J3/08H04J3/16H04L12/42H04L12/43H04L12/56H04Q11/04
    • H04J3/0623H04J3/0626H04J3/0647H04J3/08H04J3/1617H04L12/422H04L12/43H04Q11/0478H04J2203/0042H04J2203/0082H04J2203/0089H04J3/0685H04L2012/5652H04L2012/5672
    • In a local area network composed of transmission lines for interconnecting a plurality of subordinate networks including synchronous apparatuses and a plurality of nodes which connect the subordinate networks to the transmission lines, information is transferred using a fixed length frame, a clock source which generates an independent clock signal and a circuit which generates a fixed length frame with the oscillation frequency of the clock source as a reference are provided in each node so as to adopt an independent clocking system, and distribution of a common synchronizing clock required for synchronous apparatuses is made by transmission while embedding transition point information of a synchronizing clock in a specific space in the fixed length frame. Further, each node generates a fixed length transmission frame with an independent clock signal, and on the other hand, there are provided in each node, from the requirement that information quantity applied to a network is made constant, a circuit for extracting a received clock, a storage device for storing received information temporarily, and an information outgoing quantity control circuit in which information quantity which is sent out in one frame is increased when the information quantity stored in the storage device becomes more than a predetermined first reference value and information quantity which is sent out in one frame is decreased when the information quantity stored in the storage device becomes less than a predetermined second reference value.
    • 在由包括同步装置的多个下属网络和将下属网络连接到传输线路的多个节点互连的传输线路构成的局域网中,使用固定长度的帧传送信息,产生独立的时钟源 时钟信号和以时钟源的振荡频率为基准产生固定长度帧的电路设置在每个节点中,以便采用独立的时钟系统,同步装置所需的公共同步时钟的分配由 同时将同步时钟的转换点信息嵌入固定长度帧中的特定空间中。 此外,每个节点产生具有独立时钟信号的固定长度传输帧,另一方面,从应用于网络的信息量变为恒定的要求,在每个节点中提供用于提取接收时钟的电路 用于临时存储接收到的信息的存储装置,以及信息输出量控制电路,当存储在存储装置中的信息量变得超过预定的第一参考值和信息量时,在一帧中发送的信息量增加 当存储在存储装置中的信息量变得小于预定的第二参考值时,在一帧中发送的信息量减少。
    • 6. 发明申请
    • Air Motor and Electric Painting Device
    • 气动马达和电动喷涂装置
    • US20140217205A1
    • 2014-08-07
    • US13504397
    • 2011-11-28
    • Naoya KobayashiTsuyoshi NakamuraYuu Koiwa
    • Naoya KobayashiTsuyoshi NakamuraYuu Koiwa
    • F01D1/02B05B5/03
    • F01D1/026B05B3/002B05B5/03B05B5/0415F01D1/023F01D1/06
    • An air motor and an electric painting device improves driving efficiency, and includes a housing, a main shaft inserted inside of the housing, an impeller fixed concentrically with the main shaft to an inserted portion of the main shaft and having a plurality of turbine blades formed on the outer periphery, bearings for rotatably supporting the main shaft and the impeller, and a nozzle having a tubular or hole-shaped channel for ejecting compressed air to the respective turbine blades for rotating the impeller along the circumference. When M1=ve/a0 where ve denotes flow velocity of the compressed air in an entrance of the channel of the nozzle, and a0 denotes acoustic velocity, the length of the channel of the nozzle is set to a dimension of a calculated value or greater using a predetermined expression.
    • 气动马达和电喷涂装置提高驱动效率,并且包括壳体,插入壳体内部的主轴,与主轴同心地固定到主轴的插入部分的叶轮,并且形成有多个涡轮叶片 在外周上具有用于可旋转地支撑主轴和叶轮的轴承,以及具有用于将压缩空气喷射到各个涡轮机叶片以沿着圆周旋转叶轮的管状或孔形通道的喷嘴。 当M1 = ve / a0时,ve表示喷嘴通道入口处的压缩空气的流速,a0表示声速,喷嘴的通道长度设定为计算值以上的尺寸 使用预定表达式。
    • 7. 发明授权
    • Insulin expressing human pancreatic islet cell line capable of reversibly proliferating and use thereof
    • 胰岛素表达人胰岛细胞系,其能够可逆地增殖并使用
    • US07629168B2
    • 2009-12-08
    • US10578260
    • 2003-11-10
    • Noriaki TanakaNaoya KobayashiMichiki NarushimaYoshihito Tanaka
    • Noriaki TanakaNaoya KobayashiMichiki NarushimaYoshihito Tanaka
    • C12P5/06C12P21/06C12P21/04A61K48/00
    • C12N5/0676A61K35/12C12N2510/04
    • A reversibly immortalized human pancreatic islet cell line containing an hTERT gene and an SV40T gene each interposed between a pair of LoxP sequences, characterized in that it is capable of producing insulin and enhancing expression of insulin after excising the hTERT gene and the SV40T gene, in particular, NAKT-13 (deposited with International Patent Organism Depository, National Institute of Advanced Industrial Science and Technology, address: AIST Tsukuba Central 6, 1-1, Higashi 1-Chome, Tsukuba-shi, Ibaraki-ken, 305-8566 Japan, deposited date: Sep. 4, 2003, accession number: FERM BP-08461) or a passage cell line thereof; a human pancreatic islet cell obtained by excising the hTERT gene and the SV40T gene from the reversibly immortalized human pancreatic islet cell line or passage cell line thereof; and use of these cells. By using the reversibly immortalized human pancreatic islet cell line of the invention insulin-producing cells can be easily and surely obtained in a number enough to meet the demand.
    • 一种含有hTERT基因和SV40T基因的可逆永生人胰岛细胞系,每个插入一对LoxP序列之间,其特征在于能够在切除hTERT基因和SV40T基因之后产生胰岛素并增强胰岛素的表达, 特别是NAKT-13(保藏于国立先进工业科学与技术研究所国际专利生物保藏中心,地址:日本茨城市茨城市筑波市东1町1-1-1筑波中央6-1号日本305-8566 ,保藏日期:2003年9月4日,登录号:FERM BP-08461)或其传代细胞系; 通过从可逆永生化人胰岛细胞系或其传代细胞系中切除hTERT基因和SV40T基因获得的人胰岛细胞; 并使用这些细胞。 通过使用本发明的可逆永生人胰岛细胞系,可以容易且可靠地获得足够数量的胰岛素产生细胞以满足需求。
    • 8. 发明申请
    • Reversibly immortalized mammalian liver cells and use thereof
    • 可逆永生化的哺乳动物肝细胞及其用途
    • US20090148424A1
    • 2009-06-11
    • US10594544
    • 2004-03-31
    • Naoya KobayashiNoriaki TanakaMichinori Kohara
    • Naoya KobayashiNoriaki TanakaMichinori Kohara
    • A61K35/12C12N5/06C12N5/08A01N1/02C12N15/00
    • C12N5/067A01K2207/15A01K2227/106A01K2267/035A61K35/12A61M1/3689C12N2510/04C12N2800/30
    • The present invention provides a reversibly immortalized mammalian liver cell line, especially CYNK-1 (deposited with International Patent Organism Depository, National Institute of Advanced Industrial Science and Technology, address: AIST Tsukuba Central 6, 1-1, Higashi 1-Chome, Tsukuba-shi, Ibaraki-ken, 305-8566 Japan, deposited date: Mar. 10, 2004, accession number: FERM BP-08657) comprising an immortalizing gene interposed between a pair of site-specific recombination sequences and a suicide gene in the outside of the pair of site-specific recombination sequences, characterized in that the suicide gene can exhibit its function after excision of the pair of site-specific recombination sequences, or passage cell line thereof; a mammalian liver cell obtained by excising the immortalizing gene from the reversibly immortalized mammalian liver cell line or passage cell line thereof; and use of these cells. By utilizing the reversibly immortalized mammalian liver cell line of the present invention enables the obtainment of the number of the liver cells and utilization as materials for artificial liver reactors and cell preparations.
    • 本发明提供了可逆地永生化的哺乳动物肝细胞系,特别是CYNK-1(保藏在国际专利生物保藏中心,国立先进工业科学和技术研究所,地址:筑波中心6-1-1,Higashi 1-Chome,Tsukuba -shi,Ibaraki-ken,305-8566日本,保藏日期:2004年3月10日,登录号:FERM BP-08657),其包含插入一对位点特异性重组序列之间的永生化基因和外部的自杀基因 的特异性重组序列,其特征在于,自杀基因可以在切除一对位点特异性重组序列或其通过细胞系后显示其功能; 通过从可逆永生化的哺乳动物肝细胞系或其通过细胞系切除永生化基因获得的哺乳动物肝细胞; 并使用这些细胞。 通过利用本发明的可逆永生化的哺乳动物肝细胞系,可以获得肝细胞的数量和用作人造肝反应器和细胞制剂的材料。