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1. 发明授权

US08569259B2 Adenosine analogs and their use 失效
标题翻译：腺苷类似物及其用途
公开(公告)号：US08569259B2
公开(公告)日：2013-10-29
申请号：US12515033
申请日：2007-11-16
申请人： Efrat Ben-Zeev , Vincent Jacques , Yael Marantz , A. Sekar Reddy , Zhaoda Zhang , Oren Becker , Dilara McCauley , Pini Orbach , Sharon Shacham , Ashis K. Saha , Michael Xie
发明人： Efrat Ben-Zeev , Vincent Jacques , Yael Marantz , A. Sekar Reddy , Zhaoda Zhang , Oren Becker , Dilara McCauley , Pini Orbach , Sharon Shacham , Ashis K. Saha , Michael Xie
IPC分类号： A61K31/70 , A01N43/04 , C07H19/00 , C07H19/04 , C07H19/20
CPC分类号： A61K31/7076 , A61K31/7034 , A61K31/7072 , C07H15/203 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00
摘要： Provided are adenosine analog compounds of the general formula that act as P2Y receptors, e.g., the P2Y2 receptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer.
摘要翻译：提供了作为P2Y受体的通式的腺苷类似物化合物，例如P2Y2受体，包括药物组合物; （COPD），哮喘，便秘，慢性特发性便秘，口干（口腔干燥症），牙龈疾病，以及由辐射和化学治疗癌症引起的胃肠道问题。

2. 发明申请

US20110237529A1 Adenosine Analogs and Their Use 失效
标题翻译：腺苷类似物及其用途
公开(公告)号：US20110237529A1
公开(公告)日：2011-09-29
申请号：US12515033
申请日：2007-11-16
申请人： Efrat Ben-Zeev , Vincent Jacques , Yael Marantz , A. Sekar Reddy , Zhaoda Zhang , Oren Becker , Dilara Mccauley , Pini Orbach , Sharon Shacham , Ashis K. Saha , Michael Xie
发明人： Efrat Ben-Zeev , Vincent Jacques , Yael Marantz , A. Sekar Reddy , Zhaoda Zhang , Oren Becker , Dilara Mccauley , Pini Orbach , Sharon Shacham , Ashis K. Saha , Michael Xie
IPC分类号： A61K31/7076 , C07H15/203 , C07H7/04 , C07H7/06 , C07H17/02 , C07H19/20 , A61K31/7064 , A61P11/00 , A61P1/04 , A61P1/02 , A61P1/00 , A61P1/10 , C12N5/071
CPC分类号： A61K31/7076 , A61K31/7034 , A61K31/7072 , C07H15/203 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00
摘要： The invention provides adenosine analog compounds that act at P2Y receptors, e.g., the P2Y2 receptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer.
摘要翻译：本发明提供了在P2Y受体（例如P2Y2受体）上起作用的腺苷类似物化合物，包括药物组合物; （COPD），哮喘，便秘，慢性特发性便秘，口干（口腔干燥症），牙龈疾病，以及由辐射和化学治疗癌症引起的胃肠道问题。

3. 发明申请

US20100210633A1 CARBOXAMIDE COMPOUNDS AND THEIR USE 审中-公开
标题翻译：羧酰胺化合物及其用途
公开(公告)号：US20100210633A1
公开(公告)日：2010-08-19
申请号：US12445134
申请日：2007-10-12
申请人： Jian Lin , Dongli Chen , Steffi Koerner , Rosa E. Melendez , Pradyumma Mohanty , Efrat Ben-Zeev , Merav Fichman , Yael Marantz , Oren Becker , Dilara McCauley , Pini Orbach , Ashis K. Saha , Sharon Shacham , Michael Xie
发明人： Jian Lin , Dongli Chen , Steffi Koerner , Rosa E. Melendez , Pradyumma Mohanty , Efrat Ben-Zeev , Merav Fichman , Yael Marantz , Oren Becker , Dilara McCauley , Pini Orbach , Ashis K. Saha , Sharon Shacham , Michael Xie
IPC分类号： A61K31/541 , C07D405/06 , A61K31/453 , A61P3/10 , A61P3/04 , A61P37/06 , A61P17/06 , A61P9/10 , A61P13/12 , A61P1/16 , C07D211/62 , A61K31/445 , C07D207/16 , A61K31/40 , A61K31/4525 , C07D413/10 , A61K31/454 , C07D405/14 , A61K31/496 , C07D401/06 , A61K31/4545 , C07D401/04 , C07D417/06 , C07D413/06 , A61K31/5377
CPC分类号： C07D405/06 , C07D207/08 , C07D207/16 , C07D211/62 , C07D401/04 , C07D401/06 , C07D401/10 , C07D405/14 , C07D407/06 , C07D409/14 , C07D411/14 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/14
摘要： Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译：本文描述了趋化因子受体拮抗剂，特别是作为趋化因子CCR2受体的拮抗剂的式（I）化合物，包括药物组合物及其用于治疗或预防与单核细胞积聚，淋巴细胞积聚或白细胞积聚相关的疾病的用途。

4. 发明申请

US20100184749A1 BENZOTHIADIAZINE COMPOUNDS AND THEIR USE 审中-公开
标题翻译：苯并噻嗪化合物及其用途
公开(公告)号：US20100184749A1
公开(公告)日：2010-07-22
申请号：US12445149
申请日：2007-10-12
申请人： Merav Fichman , Rosa E. Melendez , Pradyumna Mohanty , Jian Lin , Dilara McCauley , Boaz Inbal , Mercedes Lobera , Pini Orbach , Ori Kalid , Dongli Chen , Yael Marantz , Michael Xie , Sharon Shacham , Oren Becker
发明人： Merav Fichman , Rosa E. Melendez , Pradyumna Mohanty , Jian Lin , Dilara McCauley , Boaz Inbal , Mercedes Lobera , Pini Orbach , Ori Kalid , Dongli Chen , Yael Marantz , Michael Xie , Sharon Shacham , Oren Becker
IPC分类号： A61K31/549 , C07D417/06 , A61P37/06 , A61P17/06 , A61P19/02 , A61P9/10 , A61P11/00 , A61P13/12 , A61P1/16 , A61P3/10
CPC分类号： C07D285/16
摘要： Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.
摘要翻译：本文描述了趋化因子受体拮抗剂，特别是作为趋化因子CCR2受体的拮抗剂的式（I）化合物，包括药物组合物及其用于治疗或预防与单核细胞积聚，淋巴细胞积聚或白细胞积聚相关的疾病的用途。

5. 发明授权

US09450977B2 Systems and methods for updating content detection devices and systems 有权
公开(公告)号：US09450977B2
公开(公告)日：2016-09-20
申请号：US13546915
申请日：2012-07-11
申请人： Yu Fang , Michael Xie
发明人： Yu Fang , Michael Xie
IPC分类号： H04L29/06 , G06F21/56
CPC分类号： H04L63/145 , G06F21/56 , G06F21/567 , H04L63/02 , H04L63/0227 , H04L63/1408 , H04L63/1416 , H04L63/1425 , H04L63/1441
摘要： A method of updating a content detection module includes obtaining content detection data, and transmitting the content detection data to a content detection module, wherein the transmitting is performed not in response to a request from the content detection module. A method of sending content detection data includes obtaining content detection data, selecting an update station from a plurality of update stations, and sending the, content detection data to the selected update station. A method of building a content detection system includes establishing a first communication link between a central station and an update station, the central station configured to transmit content detection data to the update station, and establishing a second communication link between the update station and a content detection module.

6. 发明授权

US08588226B2 Integrated security switch 有权
公开(公告)号：US08588226B2
公开(公告)日：2013-11-19
申请号：US12539801
申请日：2009-08-12
申请人： Michael Xie , Jing Shang , Anthony James , Shaohong Wei
发明人： Michael Xie , Jing Shang , Anthony James , Shaohong Wei
IPC分类号： H04L12/26 , H04J1/16 , G08C15/00 , G06F11/00 , G01R31/08
CPC分类号： H04L63/0281 , H04L47/20 , H04L63/02 , H04L63/0209
摘要： An integrated security switch and related method for managing connectivity and security among networks. The integrated security switch includes a security function connectable with a first network and at least one switching function connectable with a second network. A common management interface driven by both command line interface and graphic user interface protocols manages the switching function via a management path dedicated between the security function and the switching function. The common management interface enables secure switching of traffic to flow via a traffic path dedicated between the switching function and the security function. Typically, the traffic is a flow of data between the Internet and a group of networked users such as a wide area network.

7. 发明授权

US08443450B1 Operation of a dual instruction pipe virus co-processor 有权
标题翻译：双重指挥管病毒协处理器的操作
公开(公告)号：US08443450B1
公开(公告)日：2013-05-14
申请号：US12641309
申请日：2009-12-17
申请人： Xu Zhou , Lin Huang , Michael Xie
发明人： Xu Zhou , Lin Huang , Michael Xie
IPC分类号： G06F12/14 , G08B23/00
CPC分类号： G06F21/561 , G06F9/3867 , G06F9/3885 , G06F21/55 , G06F21/56 , G06F21/564 , G06F21/568 , G06F21/755 , G06F2221/031 , H04L63/1408 , H04L63/1416 , H04L63/1425 , H04L63/1433
摘要： Circuits and methods are provided for detecting, identifying and/or removing undesired content. According to one embodiment, a method for virus processing content objects is provided. A type associated with a content object is determined. Based on the type, a subset of instructions is read from a virus signature memory containing intermixed op-codes of a first instruction type associated with primitive instructions and of a second instruction type associated with Content Pattern Recognition (CPR) instructions. Then, instructions of the first instruction type are assigned for execution to a primitive instruction pipe of a virus co-processor and instructions of the second instruction type are assigned for execution to a CPR instruction pipe of the virus co-processor. An instruction is executed by the CPR instruction pipe, including accessing a portion of the content object from a system memory and comparing the portion of the content object against a string associated with the instruction.
摘要翻译：电路和方法被提供用于检测，识别和/或去除不需要的内容。根据一个实施例，提供了一种病毒处理内容对象的方法。确定与内容对象相关联的类型。基于该类型，从包含与原语指令相关联的第一指令类型和与内容模式识别（CPR）指令相关联的第二指令类型的混合操作码的病毒签名存储器读取指令子集。然后，分配第一指令类型的指令用于执行病毒协处理器的原语指令管道，并且将第二指令类型的指令分配给执行到病毒协处理器的CPR指令管道。由CPR指令管道执行指令，包括从系统存储器访问内容对象的一部分，并将内容对象的部分与与该指令相关联的字符串进行比较。

8. 发明授权

US08239949B2 Managing network traffic flow 有权
标题翻译：管理网络流量
公开(公告)号：US08239949B2
公开(公告)日：2012-08-07
申请号：US12403839
申请日：2009-03-13
申请人： Michael Xie
发明人： Michael Xie
IPC分类号： G06F11/00
CPC分类号： H04L63/1416 , H04L43/04 , H04L43/10 , H04L63/0236 , H04L63/0245 , H04L63/1425 , H04L63/1441 , H04L63/145
摘要： A method for managing network traffic flow is provided. The method includes receiving network traffic content, storing at least a portion of the network traffic content to a memory, sending a copy of the network traffic content to a processor, which determines whether the network traffic content contains content desired to be detected. Another method for managing network traffic flow includes receiving network traffic content, flagging the network traffic content, sending the flagged network traffic content to a module, which is configured to pass unflagged data to a user and prevent flagged data from being sent to the user, and sending a copy of the network traffic content to a processor, which determines whether the network traffic content contains content desired to be detected.
摘要翻译：提供了一种管理网络流量的方法。该方法包括接收网络业务内容，将至少一部分网络业务内容存储到存储器，向处理器发送网络业务内容的副本，该处理器确定网络业务内容是否包含期望被检测的内容。用于管理网络流量流的另一种方法包括接收网络流量内容，标记网络流量内容，将标记的网络业务内容发送到模块，该模块被配置为将未标记的数据传递给用户，并防止标记的数据被发送给用户，以及将网络业务内容的副本发送到处理器，处理器确定网络业务内容是否包含期望被检测的内容。

9. 发明授权

US08140660B1 Content pattern recognition language processor and methods of using the same 有权
公开(公告)号：US08140660B1
公开(公告)日：2012-03-20
申请号：US10624452
申请日：2003-07-21
申请人： Joseph Wells , Michael Xie
发明人： Joseph Wells , Michael Xie
IPC分类号： G06F15/173
CPC分类号： H04L63/1416 , H04L43/04 , H04L43/10 , H04L63/0236 , H04L63/0245 , H04L63/1425 , H04L63/1441 , H04L63/145
摘要： A device for detecting network traffic content is provided. The device includes a processor configured to receive a signature associated with content desired to be detected, and execute one or more functions based on the signature to determine whether network traffic content matches the content desired to be detected. The signature is defined by one or more predicates. A computer readable medium for use to detect network traffic content is also provided. The computer readable medium includes a memory storing one or more signatures, each of the one or more signatures associated with content desired to be detected. Each of the one or more signatures is defined by one or more predicates, and each of the one or more predicates can be compiled into a byte code stream that controls a logic of a network traffic screening device.

10. 发明授权

US08020202B2 Firewall interface configuration to enable bi-directional VoIP traversal communications 有权
标题翻译：防火墙接口配置，实现双向VoIP穿越通信
公开(公告)号：US08020202B2
公开(公告)日：2011-09-13
申请号：US12776415
申请日：2010-05-09
申请人： Michael Xie
发明人： Michael Xie
IPC分类号： G06F7/04 , H04L29/06
CPC分类号： H04L63/0281 , H04L29/06027 , H04L29/12094 , H04L61/1529 , H04L61/2521 , H04L63/0236 , H04L63/0245 , H04L63/029 , H04L65/1006 , H04L65/1009 , H04L65/1043 , H04L65/1066 , H04L69/22
摘要： Methods and systems for an intelligent network protection gateway (NPG) and network architecture are provided. According to one embodiment, a firewall provides network-layer protection to internal hosts against unauthorized access by hosts of an external network by performing network address translation (NAT) processing of Internet Protocol (IP) addresses. The firewall changes data in headers of VoIP packets and corresponding data contents of the VoIP packets, to enable bi-directional VoIP communications. An external VoIP interface of the firewall receives incoming VoIP packets having a user alias (e.g., an email address) and an indication regarding a VoIP port of external interface. The packets are directed to an appropriate internal host by the firewall performing port address forwarding based on the port indication to a Session Initiation Protocol (SIP) server within the internal network that maintains a mapping of user aliases to private addresses of the internal hosts.
摘要翻译：提供了智能网络保护网关（NPG）和网络架构的方法和系统。根据一个实施例，防火墙通过执行因特网协议（IP）地址的网络地址转换（NAT）处理，为内部主机提供网络层保护，防止外部网络的主机的未经授权的访问。防火墙改变VoIP报文头部的数据和VoIP数据包的相应数据内容，实现双向VoIP通信。防火墙的外部VoIP接口接收具有用户别名（例如，电子邮件地址）的传入VoIP分组以及关于外部接口的VoIP端口的指示。防火墙通过防火墙根据端口指示将数据包引导到适当的内部主机，该端口地址转发将内部网络中的会话发起协议（SIP）服务器维护到用户别名映射到内部主机的私有地址。

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