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1. 发明申请

WO2018165556A1 EXPANDABLE SHEATH WITH LONGITUDINALLY EXTENDING REINFORCING MEMBERS 审中-公开
公开(公告)号：WO2018165556A1
公开(公告)日：2018-09-13
申请号：PCT/US2018/021757
申请日：2018-03-09
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： ZHOU, Pu , BULMAN, Erik , BIAN, Baigui
IPC分类号： A61F2/24 , A61F2/966 , A61M25/00
摘要： An expandable delivery sheath includes an elastic outer tubular layer and an inner tubular layer. The inner tubular layer include a thick wall portion integrally connected to a thin wall portion. The thin wall portion can include longitudinal reinforcing members/rods that facilitate unfolding during the passage of the implant, thus decreasing the push force and increasing the consistency of the push force. The inner tubular layer can have a non-expanded or folded condition wherein the thin wall portion folds onto an outer surface of the thick wall portion under urging of the elastic outer tubular layer. When an implant passes therethrough, the outer tubular layer stretches and the inner tubular layer unfolds into an expanded lumen diameter. Once the implant passes, the outer tubular layer again urges the inner tubular layer into the non-expanded condition with the sheath reassuming its smaller profile.

2. 发明申请

WO2017040284A1 CONTROLLED BALLOON DEPLOYMENT 审中-公开
标题翻译：控制气球部署
公开(公告)号：WO2017040284A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/048995
申请日：2016-08-26
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： ZHU, Yidong, M. , ZHOU, Pu , BULMAN, Erik , BIAN, Baigui
IPC分类号： A61F2/958 , A61F2/24
CPC分类号： A61F2/2433 , A61F2/958 , A61F2250/0039 , A61M2025/1059 , A61M2025/1081
摘要： The methods and devices disclosed herein promote temporal control of balloon inflation patterns. The devices include a covering for a portion of the balloon that compresses the balloon portion during the inflation process. This enables the distal portion of a balloon to be inflated prior to the proximal portion of a balloon, creating a tapered shape at lower inflation pressures. This is especially useful during transvascular implantation procedures, as it prevents dislodgement of an implant mounted on the balloon. As inflation continues, pressure exerted on the balloon by the covering is overcome such that the proximal region of the balloon inflates, forming a shape with generally straighter sides than the tapered shape, thereby expanding the cardiovascular device.
摘要翻译：本文公开的方法和装置促进球囊充气模式的时间控制。这些装置包括用于在膨胀过程期间压缩气囊部分的气囊的一部分的覆盖物。这使得球囊的远端部分在球囊的近端部分之前被充气，在较低的充气压力下产生锥形形状。这在经血管植入手术期间特别有用，因为它可防止安装在气囊上的植入物的移位。当膨胀持续时，通过覆盖物施加在气囊上的压力被克服，使得球囊的近侧区域膨胀，形成具有比锥形形状大致更直的侧面的形状，从而使心血管装置膨胀。

3. 发明申请

WO2016164079A1 EXPANDABLE SHEATH 审中-公开
标题翻译：可膨胀的沙子
公开(公告)号：WO2016164079A1
公开(公告)日：2016-10-13
申请号：PCT/US2015/065089
申请日：2015-12-10
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： ZHOU, Pu , BULMAN, Erik , GEISER, Timothy, A. , VALDEZ, Michael, G. , ZHU, Yidong, M. , BIAN, Baigui , TRAN, Sonny , WHITE, Richard, D. , LE, Thanh, Huy , LE, Tung, T. , GOWDAR, Alpana, Kiran
IPC分类号： A61M25/00 , A61M25/06
CPC分类号： A61M25/0662 , A61F2/2433 , A61F2/958 , A61F2002/011 , A61M25/0023 , A61M2025/0024
摘要： A delivery sheath includes an elastic outer tubular layer and an inner tubular layer having a thick wall portion integrally connected to a thin wall portion. The inner tubular layer can have a compressed or folded condition wherein the thin wall portion folds onto an outer surface of the thick wall portion under urging of the elastic outer tubular layer. When an implant passes therethrough, the outer tubular layer stretches and the inner tubular layer unfolds into an expanded lumen diameter. Once the implant passes, the outer tubular layer again urges the inner tubular layer into the compressed condition with the sheath reassuming its smaller profile. The sheath may also include selectively placed longitudinal rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion and collapse, thereby reducing the push force needed to advance the implant through the sheath's lumen.
摘要翻译：输送护套包括弹性外管状层和内管状层，其具有与薄壁部分一体连接的厚壁部分。内部管状层可以具有压缩或折叠状态，其中薄壁部分在弹性外部管状层的推动下折叠到厚壁部分的外表面上。当植入物通过其中时，外管层延伸并且内管层展开成扩张的内腔直径。一旦植入物通过，外管层再次促使内管层进入压缩状态，护套重建其较小的轮廓。护套还可以包括选择性地放置的纵向杆，其介导内部和外部管状层之间的摩擦，以便于容易的膨胀和塌缩，从而减少使植入物通过护套的内腔所需的推动力。

4. 发明申请

WO2018136973A1 EXPANDABLE SHEATH 审中-公开
公开(公告)号：WO2018136973A1
公开(公告)日：2018-07-26
申请号：PCT/US2018/014921
申请日：2018-01-23
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： BULMAN, Erik , ZHOU, Pu
IPC分类号： A61F2/24 , A61M25/00
摘要： Disclosed herein are expandable introducer sheaths and methods of making and using the same. The sheaths minimize trauma to a patient's vasculature by allowing for temporary expansion of a portion of the sheath to accommodate passage of a delivery system for a cardiovascular device, then return to a non-expanded state after the passage of the device. The sheath includes an elongated annular member having longitudinally extending channels that facilitate the sheath' s temporary expansion. The channels are positioned in such a way that, upon expansion, they enable the movement of protruding contact surfaces toward the inner and outer surfaces of the annular member, reducing friction between the surface and the passing device. Some embodiments of the expandable sheath include an elastic outer layer that pushes the protruding contact surfaces back towards their original positions after the passage of the device.

5. 发明申请

WO2019036413A1 HEART VALVE FRAME DESIGN WITH NON-UNIFORM STRUTS 审中-公开
公开(公告)号：WO2019036413A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/046609
申请日：2018-08-14
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： GAO, Yong , ZHOU, Pu , ZHAO, Tianwen , WU, Jeffrey
IPC分类号： A61F2/24 , A61B17/34
摘要： An implantable prosthetic valve assembly, according to one embodiment, comprises a frame assembly including a plurality of struts and a prosthetic valve secured inside the frame assembly by sutures. The sutures are inward of the outermost surface of an outer periphery of the frame assembly. In certain embodiments the struts contain recesses in which sutures can be disposed. In other embodiments, the struts can have holes through them which the sutures pass through. The implantable prosthetic valve assembly can also be collapsed within a catheter such that an outermost surface of a periphery of the frame assembly touches the catheter but the sutures are spaced apart from the catheter or are flush with the outer surface of the frame.

6. 发明申请

WO2016164082A1 EXPANDABLE SHEATH WITH ELASTOMERIC CROSS SECTIONAL PORTIONS 审中-公开
标题翻译：具有弹性横截面部分的可膨胀的管道
公开(公告)号：WO2016164082A1
公开(公告)日：2016-10-13
申请号：PCT/US2015/065578
申请日：2015-12-14
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： ZHOU, Pu , BULMAN, Erik , GAO, Yong , BIAN, Baigui , ZHU, Yidong, M. , WILLIAMS, David, Delon
IPC分类号： A61M29/00 , A61M29/02
CPC分类号： A61F2/2427 , A61F2/97 , A61F2250/0018 , A61M25/0054 , A61M25/01 , A61M25/0662 , A61M25/0668 , A61M2025/0024 , A61M2025/0681
摘要： An expandable introducer sheath for passage of implant delivery catheters, such as catheters for delivery of prosthetic heart valves. The expandable sheath balances the amounts, shapes and positions of various stiff and elastic structures in the sheath to selectively program the expandability and buckling stiffness of the sheath. The expandable sheath can include, for example, an expandable tubular layer that includes alternating stiff and elastic wall portions of a single radial thickness. The combination of stiff and elastic wall portions allow for torque and push strength to advance the expandable sheath while at the same time accommodating temporary expansion. The expandable sheath can also be reinforced with a tubular layer of braided fibers or a stent structure for additional strength. Other embodiments include selective use of slots or gaps at the distal end of a stiff wall portion to enhance expandability and distribute strain.
摘要翻译：用于植入物输送导管（例如用于输送假体心脏瓣膜的导管）通过的可扩张的导引鞘。可扩张护套平衡护套中各种刚性和弹性结构的数量，形状和位置，以选择性地编程护套的可膨胀性和屈曲刚度。可膨胀护套可以包括例如包括单个径向厚度的交替的刚性和弹性壁部分的可膨胀管状层。刚性和弹性壁部分的组合允许扭矩和推动强度推进可膨胀护套，同时容纳临时膨胀。可膨胀护套还可以用编织纤维的管状层或用于附加强度的支架结构来增强。其他实施例包括在刚性壁部分的远端选择性地使用槽或间隙以增强可扩展性和分布应变。

7. 发明申请

WO2016081279A1 INFLATABLE DEVICE WITH ETCHED MODIFICATIONS 审中-公开
标题翻译：具有蚀刻修改的可充电器件
公开(公告)号：WO2016081279A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/060443
申请日：2015-11-12
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： ZHOU, Pu , TIAN, Bin , ZHU, Yidong, M.
IPC分类号： A61M25/10
CPC分类号： A61M25/1029 , A61M2025/1031 , A61M2025/1086 , B23K26/0624 , B23K26/361 , B23K26/362 , B23K26/402 , B23K2203/42 , B23K2203/50
摘要： Inflatable devices are disclosed including a surface which has a network of polymer chains and is configured to be inflatable into a therapeutically or diagnostically useful shape, and at least one ultrashort laser pulse-formed modification in the surface. The network can, for example, include a network morphology that is substantially unchanged by modification with the ultrashort pulse laser. Ultrashort laser pulses can be laser pulses equal to or less than 1000 picoseconds in duration. Advantageously, the etching process uses a relatively low-heat laser to avoid significant heating of surrounding polymers while modifying the surface (and other structures) of the device. The process is configured so that the polymer chain morphology adjacent the modification is substantially unaffected by the low-heat laser. The resulting inflatable device has customized surface features while still retaining substantially homogenous polymer network morphology. This preserves the elasticity, especially the surface elasticity, of the inflatable device.
摘要翻译：公开了充气装置，其包括具有聚合物链网络并被配置为可膨胀成治疗或诊断上有用的形状的表面，以及表面中的至少一个超短激光脉冲形成的修饰。例如，网络可以包括通过使用超短脉冲激光器进行修改而基本上不变的网络形态。超短激光脉冲可以是等于或小于1000皮秒的激光脉冲。有利地，蚀刻工艺使用相对低热的激光器来避免周围聚合物的显着加热，同时改变装置的表面（和其它结构）。该方法被配置成使得邻近修饰的聚合物链形态基本上不受低热激光的影响。所得到的充气装置具有定制的表面特征，同时仍然保持基本均匀的聚合物网络形态。这保持了充气装置的弹性，特别是表面弹性。

8. 发明公开

EP3741420A1 EXPANDABLE SHEATH 审中-实审
公开(公告)号：EP3741420A1
公开(公告)日：2020-11-25
申请号：EP20161966.5
申请日：2015-12-10
申请人： Edwards Lifesciences Corporation
发明人： ZHOU, Pu , BULMAN, Erik , GEISER, Timothy A. , VALDEZ, Michael G. , ZHU, Yidong M. , BIAN, Baigui , TRAN, Sonny , WHITE, Richard D. , LE, Thanh Huy , LE, Tung T. , GOWDAR, Alpana Kiran
IPC分类号： A61M25/06 , A61F2/24 , A61F2/958 , A61M25/00
摘要： A delivery sheath includes an elastic outer tubular layer and an inner tubular layer having a thick wall portion integrally connected to a thin wall portion. The inner tubular layer can have a compressed or folded condition wherein the thin wall portion folds onto an outer surface of the thick wall portion under urging of the elastic outer tubular layer. When an implant passes therethrough, the outer tubular layer stretches and the inner tubular layer unfolds into an expanded lumen diameter. Once the implant passes, the outer tubular layer again urges the inner tubular layer into the compressed condition with the sheath reassuming its smaller profile. The sheath may also include selectively placed longitudinal rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion and collapse, thereby reducing the push force needed to advance the implant through the sheath's lumen.

9. 发明公开

EP3570784A1 EXPANDABLE SHEATH 有权
公开(公告)号：EP3570784A1
公开(公告)日：2019-11-27
申请号：EP18741951.0
申请日：2018-01-23
申请人： Edwards Lifesciences Corporation
发明人： BULMAN, Erik , ZHOU, Pu
IPC分类号： A61F2/24 , A61M25/00

10. 发明公开

EP3340945A1 CONTROLLED BALLOON DEPLOYMENT 有权
公开(公告)号：EP3340945A1
公开(公告)日：2018-07-04
申请号：EP16842686.4
申请日：2016-08-26
申请人： Edwards Lifesciences Corporation
发明人： ZHU, Yidong, M. , ZHOU, Pu , BULMAN, Erik , BIAN, Baigui
IPC分类号： A61F2/958 , A61F2/24
CPC分类号： A61F2/2433 , A61F2/958 , A61F2250/0039 , A61M2025/1059 , A61M2025/1081
摘要： The methods and devices disclosed herein promote temporal control of balloon inflation patterns. The devices include a covering for a portion of the balloon that compresses the balloon portion during the inflation process. This enables the distal portion of a balloon to be inflated prior to the proximal portion of a balloon, creating a tapered shape at lower inflation pressures. This is especially useful during transvascular implantation procedures, as it prevents dislodgement of an implant mounted on the balloon. As inflation continues, pressure exerted on the balloon by the covering is overcome such that the proximal region of the balloon inflates, forming a shape with generally straighter sides than the tapered shape, thereby expanding the cardiovascular device.

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