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    • 5. 发明授权
    • Nanoloom for controlling polymer assembly
    • 用于控制聚合物组装的纳米结构
    • US08206773B2
    • 2012-06-26
    • US11992611
    • 2006-09-27
    • Jeffrey W. RubertiGregory J. KowalskiDaniel Burkey
    • Jeffrey W. RubertiGregory J. KowalskiDaniel Burkey
    • A61L33/00
    • A61L33/00B82Y30/00C08L89/06
    • Systems, devices, and methods are provided for assembling polymer-forming molecular components such that highly-structured arrays of polymer strands, such as collagen fibrils, are formed without the need for cells. A polymer nanoloom is designed to control the self-assembly of monomers into fibrils and related tissue constructs including ligament, tendon, cartilage, and bone. A nanoloom system comprises a polymer printhead, a temperature controller, and a movable substrate for polymer printing. A polymer printhead contains one or more nanoreactors that can control the assembly of collagen fibrils or other polymers on a nanoscale. Methods are provided for temperature-driven, enzyme-driven, and cholesteric assembly of collagen or other polymers into two- or three-dimensional tissue constructs.
    • 提供了用于组装聚合物形成分子组分的系统,装置和方法,使得形成高度结构化的聚合物链的阵列,例如胶原纤维,而不需要细胞。 聚合物纳米结构设计用于控制单体自身装配成原纤维和相关组织构造,包括韧带,腱,软骨和骨。 纳米液体系统包括聚合物打印头,温度控制器和用于聚合物印刷的可移动基底。 聚合物打印头包含一个或多个可以控制胶原原纤维或其它聚合物在纳米级上的装配的纳米反应器。 提供了将温度驱动,酶驱动和胶原蛋白或其它聚合物胆固醇装配成二维或三维组织构建体的方法。