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1. 发明授权

US09149440B2 Nanoparticles for drug-delivery 有权
标题翻译：用于药物输送的纳米颗粒
公开(公告)号：US09149440B2
公开(公告)日：2015-10-06
申请号：US10570461
申请日：2004-09-02
申请人： Edward Turos , Jeung-Yeop Shim
发明人： Edward Turos , Jeung-Yeop Shim
IPC分类号： A61K9/50 , A61K9/16 , A61K9/51
CPC分类号： A61K9/5138 , A61K9/5192
摘要： This invention relates to polymeric nanoparticles useful for drug delivery with target molecules bonded to the surface of the particles and having sizes of up to 1000 nm, preferably 1 nm to 400 nm, more preferably 1 nm to 200 nm, that are dispersed homogeneously in aqueous solution. The target drug/target substance is covalently bonded to the novel polymeric nanoparticles to secure them from outer intervention in vivo or cell culture in vitro until they are exposed at the target site within the cell. This invention also relates to microemulsion polymerization techniques useful for preparing the novel nanoparticles.
摘要翻译：本发明涉及用于药物递送的聚合物纳米颗粒，其中靶分子键合到颗粒的表面，并且具有高达1000nm，优选1nm至400nm，更优选1nm至200nm的尺寸，其均匀分散在水性解。目标药物/靶物质共价键合到新型聚合物纳米颗粒上以确保它们在体外免受外部干预或体外细胞培养，直到它们暴露于细胞内的靶位点。本发明还涉及可用于制备新型纳米颗粒的微乳液聚合技术。

2. 发明申请

US20070190160A1 Nanoparticles for drug-delivery 有权
标题翻译：用于药物输送的纳米颗粒
公开(公告)号：US20070190160A1
公开(公告)日：2007-08-16
申请号：US10570461
申请日：2004-09-02
申请人： Edward Turos , Jeung-Yeop Shim
发明人： Edward Turos , Jeung-Yeop Shim
IPC分类号： A61K9/50 , A61K9/16
CPC分类号： A61K9/5138 , A61K9/5192
摘要： This invention relates to polymeric nanoparticles useful for drug delivery with target molecules bonded to the surface of the particles and having sizes of up to 1000 nm, preferably 1 nm to 400 nm, more preferably 1 nm to 200 nm, that are dispersed homogeneously in aqueous solution. The target drug/target substance is covalently bonded to the novel polymeric nanoparticles to secure them from outer intervention in vivo or cell culture in vitro until they are exposed at the target site within the cell. This invention also relates to microemulsion polymerization techniques useful for preparing the novel nanoparticles.
摘要翻译：本发明涉及用于药物递送的聚合物纳米颗粒，其中靶分子键合到颗粒的表面，并且具有高达1000nm，优选1nm至400nm，更优选1nm至200nm的尺寸，其均匀分散在水性解。目标药物/靶物质共价键合到新型聚合物纳米颗粒上以确保它们在体外免受外部干预或体外细胞培养，直到它们暴露于细胞内的靶位点。本发明还涉及可用于制备新型纳米颗粒的微乳液聚合技术。

3. 发明授权

US5994447A Organic-inorganic complex composition for coating metal surface 失效
标题翻译：用于涂覆金属表面的有机 - 无机复合组合物
公开(公告)号：US5994447A
公开(公告)日：1999-11-30
申请号：US885476
申请日：1997-06-30
申请人： Jeung-Yeop Shim , Houng-Ook Kim , Ki-Myong Song
发明人： Jeung-Yeop Shim , Houng-Ook Kim , Ki-Myong Song
IPC分类号： C09D163/02 , C08G59/16 , C09D163/00 , C08K3/00
CPC分类号： C08G59/1461 , C09D163/00
摘要： Disclosed is an aqueous organic-inorganic complex coating composition for a thin film which has a good curing characteristic at a low temperature and various good characteristics. The organic-inorganic complex coating composition for a steel sheet comprises about 100 weight parts of a water-soluble acrylic or vinyl modified organic high polymer resin, about 5 to 100 weight parts of a silica-based inorganic compound and about 1 to 50 weight parts of a curing agent based on the solid content of the water-soluble organic high polymer resin. The thin coating layer formed on the steel sheet using the organic-inorganic complex coating composition of the present invention has a good curing characteristic at a low temperature. Moreover, alkaline-resistance, corrosion-resistance, adhesiveness to the material, electrodeposition coating characteristic, anti-powdering characteristic, continuous weldability, and work efficiency of the coating are good. Moreover, since the coating composition of the present invention includes the acrylic or vinyl modified epoxy resin as a main component, an energy conservation problem and an environmental pollution problem can be solved. Further, working stability is good and the probability of a fire is decreased.
摘要翻译：公开了一种薄膜水性有机 - 无机复合涂料组合物，其在低温下具有良好的固化特性和各种良好的特性。用于钢板的有机 - 无机复合涂料组合物包含约100重量份的水溶性丙烯酸或乙烯基改性有机高分子树脂，约5至100重量份的二氧化硅基无机化合物和约1至50重量份的固化剂，基于水溶性有机高分子树脂的固体含量。使用本发明的有机 - 无机复合涂料组合物在钢板上形成的薄涂层在低温下具有良好的固化特性。此外，耐碱性，耐腐蚀性，对材料的粘附性，电沉积涂层特性，抗粉化特性，连续焊接性和涂层的工作效率良好。此外，由于本发明的涂料组合物包括丙烯酸或乙烯基改性环氧树脂作为主要成分，因此可以解决节能问题和环境污染问题。此外，工作稳定性好，火灾的可能性降低。

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