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1. 发明授权

US4923332A High temperature resistant oil boom flotation core 失效
标题翻译：耐高温油斗浮选芯
公开(公告)号：US4923332A
公开(公告)日：1990-05-08
申请号：US309416
申请日：1989-02-10
申请人： Stephen M. Sanocki , Donald D. Johnson , Edward M. Fischer
发明人： Stephen M. Sanocki , Donald D. Johnson , Edward M. Fischer
IPC分类号： E02B15/04 , E02B15/06
CPC分类号： E02B15/08 , E02B15/0814 , E02B15/0821 , E02B15/0885
摘要： A high temperature resistant flotation core and a high temperature resistant oil containment boom which allows for the in-situ burning of spilled or leaked oil during offshore oil spill cleanup operations are disclosed. The boom can also be used for precautionary fire containment during non-burn oil spill cleanups and can be easily recovered and redeployed.

2. 发明授权

US5174969A Roll-pack diesel particulate filter 失效
标题翻译：滚筒式柴油颗粒过滤器
公开(公告)号：US5174969A
公开(公告)日：1992-12-29
申请号：US681150
申请日：1991-04-05
申请人： Edward M. Fischer , Donald D. Johnson , Stephen M. Sanocki
发明人： Edward M. Fischer , Donald D. Johnson , Stephen M. Sanocki
IPC分类号： F01N3/02 , F01N3/021 , F01N3/022 , F02B3/06
CPC分类号： F01N3/0211 , F01N3/0226 , F01N2330/00 , F01N2330/08 , F02B3/06 , Y02T10/20 , Y10S55/10 , Y10S55/30
摘要： An efficient, economical, compact diesel particulate filter comprising a casing radially filled with a bundle of tubes comprising woven, braided, or knitted inorganic yarn, wherein each tube is at least about twice the length of the bundle, and is folded at one end to prevent exhaust from traveling through the hollow of the tube without passing through its wall.
摘要翻译：一种高效，经济，紧凑的柴油微粒过滤器，其包括径向填充有包括编织，编织或针织无机纱线的管束的壳体，其中每个管至少约束长度的两倍，并且在一端折叠防止排气穿过管的中空而不穿过其壁。

3. 发明授权

US5326968A Photoelectric sensor with a circular polarizing lens attached to its housing 失效
标题翻译：具有圆形偏振透镜的光电传感器连接到其外壳
公开(公告)号：US5326968A
公开(公告)日：1994-07-05
申请号：US30947
申请日：1993-03-12
申请人： Donald D. Johnson , Surrinder S. Puri , Jim Yee
发明人： Donald D. Johnson , Surrinder S. Puri , Jim Yee
IPC分类号： G01D5/34 , G02B27/28 , H01L31/167 , G02F1/01
CPC分类号： H01L31/167 , G01D5/344 , G02B27/28
摘要： A photoelectric sensor is adapted for use in specific applications which require the additional attachment of a circular polarizer. A piece of circular polarizer material is general disc-shaped with two planar surfaces and a peripheral circular surface. The outer periphery of the disc-shaped circular polarizer is encapsulated within a generally annular molded rim. The molded rim is provided with a protrusion that is generally circular and extends from one of the generally flat surfaces of the rim material. The protrusion facilitates the attachment of the rim to the operative face of a photoelectric sensor through the process of ultrasonic welding. Advantages achieved by this device include the facilitated attachment of the circular polarizer to a photoelectric sensor, the protection of the outer peripheral edges of the laminations of the circular polarizer and the avoidance of distortions of the circular polarizer during the manufacturing process.
摘要翻译：光电传感器适用于需要额外附加圆偏振器的具体应用。一片圆偏振片材料是一般盘形的，具有两个平面和圆周表面。盘形圆形偏光镜的外周被封装在大致环形的模制轮缘内。模制的边缘设置有大体为圆形并从边缘材料的大致平坦表面中的一个延伸的突起。突起有助于通过超声波焊接的过程将轮缘附接到光电传感器的操作面。通过该装置实现的优点包括将圆偏振器方便地附着到光电传感器，保护圆偏振片的叠片的外围边缘以及避免在制造过程中圆偏振器的变形。

4. 发明授权

US09040310B2 Antibody-nanoparticle conjugates and methods for making and using such conjugates 有权
标题翻译：抗体 - 纳米颗粒缀合物和制备和使用这种缀合物的方法
公开(公告)号：US09040310B2
公开(公告)日：2015-05-26
申请号：US13640944
申请日：2011-04-27
申请人： Julia Ashworth-Sharpe , Chol Steven Yun , Zhanna Zhilina , Adrian E. Murillo , Donald D. Johnson , Michael Farrell , Jerome W. Kosmeder , Christopher Bieniarz
发明人： Julia Ashworth-Sharpe , Chol Steven Yun , Zhanna Zhilina , Adrian E. Murillo , Donald D. Johnson , Michael Farrell , Jerome W. Kosmeder , Christopher Bieniarz
IPC分类号： G01N33/544 , G01N33/68 , C07F9/12 , C07F9/50 , C07F9/572 , C07F9/655 , G01N33/531 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54346 , C07F9/12 , C07F9/5004 , C07F9/5022 , C07F9/5045 , C07F9/5728 , C07F9/65515 , C07F9/65517 , C07F9/65522 , G01N33/531 , G01N33/553 , G01N33/587 , G01N33/6854 , G01N2333/916
摘要： Disclosed herein are antibody-nanoparticle conjugates that include two or more nanoparticles (such as gold, palladium, platinum, silver, copper, nickel, cobalt, iridium, or an alloy of two or more thereof) directly linked to an antibody or fragment thereof through a metal-thiol bond. Methods of making the antibody-nanoparticle conjugates disclosed herein include reacting an arylphosphine-nanoparticle composite with a reduced antibody to produce an antibody-nanoparticle conjugate. Also disclosed herein are methods for detecting a target molecule in a sample that include using an antibody-nanoparticle conjugate (such as the antibody-nanoparticle conjugates described herein) and kits for detecting target molecules utilizing the methods disclosed herein.
摘要翻译：本文公开了抗体 - 纳米颗粒缀合物，其包括直接连接到抗体或其片段的两个或更多个纳米颗粒（例如金，钯，铂，银，铜，镍，钴，铱或其两种或多种的合金）金属硫醇键。制备本文公开的抗体 - 纳米颗粒缀合物的方法包括使芳基膦 - 纳米颗粒复合物与还原抗体反应以产生抗体 - 纳米颗粒缀合物。本文还公开了用于检测样品中靶分子的方法，其包括使用抗体 - 纳米颗粒缀合物（例如本文所述的抗体 - 纳米颗粒缀合物）和利用本文公开的方法检测靶分子的试剂盒。

5. 外观设计

USD333629S Photoelectric sensor housing 失效
公开(公告)号：USD333629S
公开(公告)日：1993-03-02
申请号：US801129
申请日：1991-12-02
申请人： Donald D. Johnson
设计人： Donald D. Johnson

6. 发明授权

US5100807A Phenylacetylglutamine (PAG) analytical test 失效
标题翻译：苯甲酰胺（PAG）分析测试
公开(公告)号：US5100807A
公开(公告)日：1992-03-31
申请号：US110155
申请日：1987-10-19
申请人： Maciej B. Adamczyk , Hossein A. Ghanbari , Donald D. Johnson
发明人： Maciej B. Adamczyk , Hossein A. Ghanbari , Donald D. Johnson
IPC分类号： C07C237/06 , C07C237/22 , C07D493/10 , C07K14/00 , C07K14/76 , C07K16/44 , C09B11/00 , C09B11/28 , G01N33/53 , G01N33/531 , G01N33/533 , G01N33/542 , G01N33/58 , G01N33/68
CPC分类号： G01N33/5308 , G01N33/531 , G01N33/582 , G01N33/6812 , Y10S436/822
摘要： The present invention is directed to a fluorescence polarization immunoassay for determining the phenylacetylglutamine (PAG) content in body fluids, to the various components needed for preparing and carrying out such an assay, and to the methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for preparing them. The assay is conducted by measuring the degree of polarization of plane polarized light that has been passed through a solution continuing sample, antiserum and tracer.

7. 发明授权

US5648272A Reagents and methods for the detection and quantification of thyroxine in fluid samples 失效
公开(公告)号：US5648272A
公开(公告)日：1997-07-15
申请号：US443833
申请日：1995-05-18
申请人： Maciej Adamczyk , Donald D. Johnson , Phillip G. Mattingly , Diana E. Clarisse , Joan D. Tyner , Mary M. Perkowitz
发明人： Maciej Adamczyk , Donald D. Johnson , Phillip G. Mattingly , Diana E. Clarisse , Joan D. Tyner , Mary M. Perkowitz
IPC分类号： G01N33/53 , C07D493/10 , C07F9/6561 , C07K1/113 , C07K14/00 , C07K14/575 , C07K14/76 , C07K14/765 , C07K14/795 , C07K16/00 , C07K16/18 , C07K16/26 , C07K16/44 , G01N33/532 , G01N33/533 , G01N33/542 , G01N33/78
CPC分类号： C07D493/10 , C07F9/6561 , C07K16/18 , C07K16/44 , G01N33/532 , G01N33/533 , G01N33/78 , Y10S436/817 , Y10S530/807
摘要： Immunoassay methods and reagents for the specific quantification of thyroxine in a test sample are disclosed employing antibodies prepared with thyroxine derivatives of the formula: ##STR1## wherein P is an immunogenic carrier material and X is a linking moiety. The present invention also describes the synthesis of unique labelled reagent of the formula: ##STR2## wherein Q is a detectable moiety and W is a linking moiety, preferably fluorescein or a fluorescein derivative.

8. 发明授权

US07256008B2 Determination of concentration of FK778 by competitive immunoassay 失效
标题翻译：通过竞争性免疫测定法测定FK778的浓度
公开(公告)号：US07256008B2
公开(公告)日：2007-08-14
申请号：US11327711
申请日：2006-01-06
申请人： Thomas G. Spring , Elaine M. Brate , Shelley Holets-McCormack , Rajarathnam E. Reddy , Donald D. Johnson , Yon-Yih Chen , You Pan
发明人： Thomas G. Spring , Elaine M. Brate , Shelley Holets-McCormack , Rajarathnam E. Reddy , Donald D. Johnson , Yon-Yih Chen , You Pan
IPC分类号： G01N33/00
CPC分类号： G01N33/9493
摘要： Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridinium label, (b) an antibody to FK778 not conjugated to a label, (c) a solid phase containing an antibody to a first hapten, e.g., a fluorescein hapten, and (d) a bihapten comprising a first hapten and FK778 or an analogue of FK778, e.g., a bihapten comprising a fluorescein hapten and a FK778 hapten. In another aspect, the method and kit involve the use of (a) antibody to FK778, (b) a bihapten comprising FK778 or an analogue of FK778 and a first hapten, e.g., a bihapten comprising the fluorescein hapten and the hapten of FK778 or an analogue of FK778, and (c) a pretreatment reagent.
摘要翻译：通过免疫测定，优选竞争性免疫测定法测量生物样品中FK778的浓度的方法和试剂盒。一方面，该方法和试剂盒涉及使用（a）与标记缀合的FK778的抗体，例如吖啶标记，（b）与标记物不缀合的FK778的抗体，（c）含有第一半抗原的抗体，例如荧光素半抗原，和（d）包含第一半抗原和FK778或FK778的类似物的双突变体，例如包含荧光素半抗原和FK778半抗原的双突变体。另一方面，该方法和试剂盒涉及使用（a）FK778的抗体，（b）包含FK778或类似物FK778的双突变体和第一半抗原，例如包含荧光素半抗原的双突变体和FK778的半抗原或 FK778的类似物，（c）预处理试剂。

9. 发明授权

US5688921A Reagents and methods for the detection and qualification of thyroxine in fluid samples 失效
公开(公告)号：US5688921A
公开(公告)日：1997-11-18
申请号：US443834
申请日：1995-05-18
申请人： Maciej Adamczyk , Donald D. Johnson , Phillip G. Mattingly , Diana E. Clarisse , Joan D. Tyner , Mary M. Perkowitz
发明人： Maciej Adamczyk , Donald D. Johnson , Phillip G. Mattingly , Diana E. Clarisse , Joan D. Tyner , Mary M. Perkowitz
IPC分类号： C07D493/10 , C07F9/6561 , C07K16/18 , C07K16/44 , C09B11/08 , G01N33/532 , G01N33/533 , G01N33/78 , C07K17/00
CPC分类号： C07D493/10 , C07F9/6561 , C07K16/18 , C07K16/44 , C09B11/08 , G01N33/532 , G01N33/533 , G01N33/78 , Y10S436/80 , Y10S530/807
摘要： Immunoassay methods and reagents for the specific quantification of thyroxine in a test sample are disclosed employing antibodies prepared with thyroxine derivatives of the formula: ##STR1## wherein P is an immunogenic carrier material and X is a linking moiety. The present invention also describes the synthesis of unique labelled reagent of the formula: ##STR2## wherein Q is a detectable moiety and W is a linking moiety, preferably fluorescein or a fluorescein derivative.

10. 发明授权

US5593896A Reagents and methods for the detection and quantification of thyroxine in fluid samples 失效
公开(公告)号：US5593896A
公开(公告)日：1997-01-14
申请号：US275064
申请日：1994-07-13
申请人： Maciej Adamczyk , Donald D. Johnson , Phillip G. Mattingly , Diana E. Clarisse , Joan D. Tyner , Mary M. Perkowitz
发明人： Maciej Adamczyk , Donald D. Johnson , Phillip G. Mattingly , Diana E. Clarisse , Joan D. Tyner , Mary M. Perkowitz
IPC分类号： G01N33/53 , C07D493/10 , C07F9/6561 , C07K1/113 , C07K14/00 , C07K14/575 , C07K14/76 , C07K14/765 , C07K14/795 , C07K16/00 , C07K16/18 , C07K16/26 , C07K16/44 , G01N33/532 , G01N33/533 , G01N33/542 , G01N33/78
CPC分类号： C07D493/10 , C07F9/6561 , C07K16/18 , C07K16/44 , G01N33/532 , G01N33/533 , G01N33/78 , Y10S436/817 , Y10S530/807
摘要： Immunoassay methods and reagents for the specific quantification of thyroxine in a test sample are disclosed employing antibodies prepared with thyroxine derivatives of the formula: ##STR1## wherein P is an immunogenic carrier material and X is a linking moiety. The present invention also describes the synthesis of unique labelled reagent of the formula: ##STR2## wherein Q is a detectable moiety and W is a linking moiety, preferably fluorescein or a fluorescein derivative.

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