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1. 发明授权

US06899727B2 Deployment system for intraluminal devices 有权
标题翻译：管腔内装置的部署系统
公开(公告)号：US06899727B2
公开(公告)日：2005-05-31
申请号：US09767314
申请日：2001-01-22
申请人： Joseph P. Armstrong , Edward H. Cully , Edward E. Shaw , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph P. Armstrong , Edward H. Cully , Edward E. Shaw , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61F2/86 , A61F2/06
CPC分类号： A61F2/97 , A61F2/86 , A61F2/95 , A61F2/958 , A61F2002/9511 , A61F2002/9522 , A61F2002/9583 , A61F2250/0071
摘要： A constraining sheath for use around an endoprosthesis (e.g., a stent device, with or without a graft covering), which may be a balloon expandable endoprosthesis but more preferably is a self-expanding prosthesis. The endoprosthesis is coaxially enclosed within the constraining sheath, which is an outer, disruptable, preferably implantable tubular sheath, preferably made of ePTFE. The constraining sheath and endoprosthesis are preferably mounted together as an assembly on an angioplasty balloon for delivery. Deployment of the endoprosthesis entails inflating the angioplasty balloon to a pressure sufficient to disrupt or break the constraining sheath in a prescribed fashion, thereby allowing a self-expanding endoprosthesis to spontaneously deploy. The constraining sheath of ePTFE may be attached to the endoprosthesis and implanted along with the device, or alternatively attached to the balloon catheter shaft and removed with the balloon catheter.
摘要翻译：用于内置假体周围使用的约束护套（例如，具有或不具有移植物覆盖物的支架装置），其可以是球囊可膨胀内置假体，但更优选是自膨胀假体。内置假体同轴地封闭在约束护套内，约束鞘是外部的，可破坏的，优选可植入的管状护套，优选地由ePTFE制成。约束鞘和内假体优选地作为组件安装在血管成形术气囊上用于递送。内窥镜假体的部署需要将血管成形术气囊膨胀至足以以规定的方式破坏或打破约束鞘的压力，从而允许自膨胀内置假体自发部署。 ePTFE的约束鞘可以连接到内置假体并与装置一起植入，或者替代地附接到球囊导管轴并且用球囊导管去除。

2. 发明授权

US08177832B2 Endoluminal expansion system 有权
标题翻译：腔内扩张系统
公开(公告)号：US08177832B2
公开(公告)日：2012-05-15
申请号：US12876779
申请日：2010-09-07
申请人： Joseph R. Armstrong , Edward H. Cully , Craig T. Nordhausen , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Craig T. Nordhausen , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61F2/82
CPC分类号： A61F2/958 , A61F2/95 , A61F2/97 , A61F2002/9511
摘要： An endoprosthesis expansion system having, in combination, a delivery component such as a length of catheter tubing having at its distal end an intermediate sheath component, and an inner tube within the full length of the delivery catheter and intermediate sheath component. The inner tube has a protrusion affixed to its distal end, and an expandable endoprosthesis is fitted in a compacted state about the intermediate sheath, immediately proximal to the protrusion. If the endoprosthesis is a self-expanding endoprosthesis (as is preferred), an exterior constraining sheath is required around the outer surface of the endoprosthesis. Following insertion of the endoprosthesis and delivery system into a body conduit (such as a blood vessel) and transport of the endoprosthesis to the desired site within the body conduit, the endoprosthesis is deployed by axially moving the protrusion against the system, thereby applying a radially directed outward force and causing simultaneous dilatation of the intermediate sheath and disruption of the exterior constraining sheath. Disruption of the exterior constraining sheath, in the case of a self-expanding prosthesis, releases the stored energy in the formerly constrained prosthesis, allowing it to expand and accomplish full deployment against the luminal surface of the body conduit at the desired site.
摘要翻译：一种内置假体扩张系统，其组合具有输送部件，例如一段长度的导管，其远端具有中间护套部件，并且在输送导管和中间护套部件的整个长度内具有内管。内管具有固定在其远端的突起，并且可伸缩的内假体围绕中间护套紧密地装配在紧固突起的近侧。如果内置假体是自扩张的内置假体（如优选的），则需要在内假体的外表面周围的外约束护套。在将内假体和输送系统插入身体导管（例如血管）中并将内假体运送到体导管内的期望部位之后，通过将凸起轴向移动抵靠系统来展开内假体，从而施加径向引导向外的力并引起中间鞘的同时扩张和外部约束鞘的破坏。在自扩张假体的情况下，外部约束护套的破坏释放在先前约束的假体中的储存能量，允许其膨胀并且在所需位置处对体导管的腔表面完全完全展开。

3. 发明授权

US06981982B2 Method of producing low profile stent and graft combination 有权
公开(公告)号：US06981982B2
公开(公告)日：2006-01-03
申请号：US10083451
申请日：2002-02-25
申请人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61M29/00
CPC分类号： A61F2/07 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/954 , A61F2/97 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/825 , A61F2002/9505 , A61F2002/9511 , A61F2002/9522 , A61F2220/0075 , A61F2230/0054 , Y10T29/53987
摘要： Large diameter self-expanding endoprosthetic devices, such as stents and stent grafts for delivery to large diameter vessels, such as the aorta, are disclosed having very small compacted delivery dimensions. Devices with deployed dimensions of 26 to 40 mm or more are disclosed that are compacted to extremely small dimensions of 5 mm or less, enabling percutaneous delivery of said devices without the need for surgical intervention. Compaction efficiencies are achieved by combining unique material combinations with new forms of restraining devices, compaction techniques, and delivery techniques. These inventive devices permit consistent percutaneous delivery of large vessel treatment devices. Additionally, small endoprosthetic devices are disclosed that can be compacted to extremely small dimensions for delivery through catheter tubes of less than 1 mm diameter.

4. 发明授权

US07753945B2 Deployment system for an endoluminal device 有权
标题翻译：内窥镜装置的部署系统
公开(公告)号：US07753945B2
公开(公告)日：2010-07-13
申请号：US10637986
申请日：2003-08-08
申请人： Steven R. Bruun , Edward H. Cully , James W. Mann , Mark J. Ulm , Michael J. Vonesh
发明人： Steven R. Bruun , Edward H. Cully , James W. Mann , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61F2/06 , A61F11/00
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958 , A61F2/97 , A61F2002/9511
摘要： The present invention is directed to a deployment system for an endoluminal device. The deployment system includes a confining sheath placed around a compacted endoluminal device. A deployment line is provided in the system that is an integral extension of the sheath. As the deployment line is actuated, the sheath retracts from around the compacted endoluminal device. As the sheath retracts from around the endoluminal device, material from the sheath may be converted into deployment line. Once the sheath is retracted from around the compacted endoluminal device, the endoluminal device expands in configuration and repairs vascular or cardiac structures of an implant recipient. Any remaining sheath material is removed from the implantation site along with the deployment line. The deployment system also includes an endo-prosthesis mounting member placed between the endoluminal device and an underlying catheter. The endo-prosthesis mounting member serves to cushion and retain the endoluminal device when constrained by the sheath and may assist in expansion of the endoluminal device when unconstrained by the sheath.
摘要翻译：本发明涉及一种用于腔内装置的部署系统。部署系统包括围绕压实的腔内装置放置的限制鞘。在系统中提供了一个部署线，该线是护套的整体延伸。随着部署线被致动，护套从紧凑的腔内装置周围缩回。当护套从内腔装置周围缩回时，来自护套的材料可以被转换成展开线。一旦护套从紧凑的腔内装置周围缩回，腔内装置在构型上扩张并修复植入物接受者的血管或心脏结构。任何剩余的护套材料与植入线一起从植入部位移除。所述展开系统还包括放置在腔内装置和下面的导管之间的内腔假体安装构件。假体内固定构件用于在被护套约束时缓冲和保持内腔装置，并且可以在不受护套约束时有助于腔内装置的膨胀。

5. 发明授权

US09056001B2 Method of producing low profile stent and graft combination 有权
公开(公告)号：US09056001B2
公开(公告)日：2015-06-16
申请号：US12567562
申请日：2009-09-25
申请人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
IPC分类号： B30B11/22 , A61F2/07 , A61F2/844 , A61F2/86 , A61F2/954 , A61F2/97 , A61F2/90 , A61F2/91 , A61F2/06 , A61F2/82 , A61F2/95 , A61F2/89
CPC分类号： A61F2/07 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/954 , A61F2/97 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/825 , A61F2002/9505 , A61F2002/9511 , A61F2002/9522 , A61F2220/0075 , A61F2230/0054 , Y10T29/53987
摘要： Large diameter self-expanding endoprosthetic devices, such as stents and stent grafts for delivery to large diameter vessels, such as the aorta, are disclosed having very small compacted delivery dimensions. Devices with deployed dimensions of 26 to 40 mm or more are disclosed that are compacted to extremely small dimensions of 5 mm or less, enabling percutaneous delivery of said devices without the need for surgical intervention. Compaction efficiencies are achieved by combining unique material combinations with new forms of restraining devices, compaction techniques, and delivery techniques. These inventive devices permit consistent percutaneous delivery of large vessel treatment devices. Additionally, small endoprosthetic devices are disclosed that can be compacted to extremely small dimensions for delivery through catheter tubes of less than 1 mm diameter.

6. 发明申请

US20100331956A1 ENDOLUMINAL EXPANSION SYSTEM 有权
标题翻译：内膜扩张系统
公开(公告)号：US20100331956A1
公开(公告)日：2010-12-30
申请号：US12876779
申请日：2010-09-07
申请人： Joseph R. Armstrong , Edward H. Cully , Craig T. Nordhausen , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Craig T. Nordhausen , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61F2/84
CPC分类号： A61F2/958 , A61F2/95 , A61F2/97 , A61F2002/9511
摘要： An endoprosthesis expansion system having, in combination, a delivery component such as a length of catheter tubing having at its distal end an intermediate sheath component, and an inner tube within the full length of the delivery catheter and intermediate sheath component. The inner tube has a protrusion affixed to its distal end, and an expandable endoprosthesis is fitted in a compacted state about the intermediate sheath, immediately proximal to the protrusion. If the endoprosthesis is a self-expanding endoprosthesis (as is preferred), an exterior constraining sheath is required around the outer surface of the endoprosthesis. Following insertion of the endoprosthesis and delivery system into a body conduit (such as a blood vessel) and transport of the endoprosthesis to the desired site within the body conduit, the endoprosthesis is deployed by axially moving the protrusion against the system, thereby applying a radially directed outward force and causing simultaneous dilatation of the intermediate sheath and disruption of the exterior constraining sheath. Disruption of the exterior constraining sheath, in the case of a self-expanding prosthesis, releases the stored energy in the formerly constrained prosthesis, allowing it to expand and accomplish full deployment against the luminal surface of the body conduit at the desired site.
摘要翻译：一种内置假体扩张系统，其组合具有输送部件，例如一段长度的导管，其远端具有中间护套部件，并且在输送导管和中间护套部件的整个长度内具有内管。内管具有固定在其远端的突起，并且可伸缩的内假体围绕中间护套紧密地装配在紧固突起的近侧。如果内置假体是自扩张的内置假体（如优选的），则需要在内假体的外表面周围的外约束护套。在将内假体和输送系统插入身体导管（例如血管）中并将内假体运送到体导管内的期望部位之后，通过将凸起轴向移动抵靠系统来展开内假体，从而施加径向引导向外的力并引起中间鞘的同时扩张和外部约束鞘的破坏。在自扩张假体的情况下，外部约束护套的破坏释放在先前约束的假体中的储存能量，允许其膨胀并且在所需位置处对体导管的腔表面完全完全展开。

7. 发明授权

US07691109B2 Method of producing low profile stent and graft combination 有权
标题翻译：生产薄型支架和移植物组合的方法
公开(公告)号：US07691109B2
公开(公告)日：2010-04-06
申请号：US11230757
申请日：2005-09-19
申请人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61F11/00 , A61M29/00
CPC分类号： A61F2/07 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/954 , A61F2/97 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/825 , A61F2002/9505 , A61F2002/9511 , A61F2002/9522 , A61F2220/0075 , A61F2230/0054 , Y10T29/53987
摘要： Large diameter self-expanding endoprosthetic devices, such as stents and stent grafts for delivery to large diameter vessels, such as the aorta, are disclosed having very small compacted delivery dimensions. Devices with deployed dimensions of 26 to 40 mm or more are disclosed that are compacted to extremely small dimensions of 5 mm or less, enabling percutaneous delivery of said devices without the need for surgical intervention. Compaction efficiencies are achieved by combining unique material combinations with new forms of restraining devices, compaction techniques, and delivery techniques. These inventive devices permit consistent percutaneous delivery of large vessel treatment devices. Additionally, small endoprosthetic devices are disclosed that can be compacted to extremely small dimensions for delivery through catheter tubes of less than 1 mm diameter.
摘要翻译：公开了大直径自膨胀假体内装置，例如用于输送到大直径血管，例如主动脉的支架和支架移植物，具有非常小的紧凑的输送尺寸。公开了具有26至40mm或更大的尺寸的装置，其被压实至5mm或更小的极小尺寸，能够经皮地输送所述装置，而不需要外科手术。压实效率通过将独特的材料组合与新形式的约束装置，压实技术和输送技术相结合来实现。这些本发明的装置允许大容量处理装置的一致的经皮输送。此外，公开了可以压缩至极小尺寸的小型假体内装置，以通过小于1mm直径的导管输送。

8. 发明授权

US07198636B2 Deployment system for an endoluminal device 有权
标题翻译：内窥镜装置的部署系统
公开(公告)号：US07198636B2
公开(公告)日：2007-04-03
申请号：US10346598
申请日：2003-01-17
申请人： Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
发明人： Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61M1/00 , A61F11/00
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958
摘要： The present invention is directed to a deployment system for an endoluminal device. The deployment system includes a confining sheath placed around a compacted endoluminal device. A deployment line is provided in the system that is an integral extension of the sheath. As the deployment line is actuated, the sheath retracts from around the compacted endoluminal device. As the sheath retracts from around the endoluminal device, material from the sheath may be converted into deployment line. Once the sheath is retracted from around the compacted endoluminal device, the endoluminal device expands in configuration and repairs vascular or cardiac structures of an implant recipient. Any remaining sheath material is removed from the implantation site along with the deployment line.
摘要翻译：本发明涉及一种用于腔内装置的部署系统。部署系统包括围绕压实的腔内装置放置的限制鞘。在系统中提供了一个部署线，该线是护套的整体延伸。随着部署线被致动，护套从紧凑的腔内装置周围缩回。当护套从内腔装置周围缩回时，来自护套的材料可以被转换成展开线。一旦护套从紧凑的腔内装置周围缩回，腔内装置在构型上扩张并修复植入物接受者的血管或心脏结构。任何剩余的护套材料与植入线一起从植入部位移除。

9. 发明授权

US06827731B2 Deployment system for intraluminal devices 有权
标题翻译：管腔内装置的部署系统
公开(公告)号：US06827731B2
公开(公告)日：2004-12-07
申请号：US10054772
申请日：2002-01-22
申请人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
发明人： Joseph R. Armstrong , Edward H. Cully , Mark J. Ulm , Michael J. Vonesh
IPC分类号： A61F206
CPC分类号： A61F2/97 , A61F2/86 , A61F2/95 , A61F2/958 , A61F2002/9511 , A61F2002/9522 , A61F2002/9583 , A61F2250/0071
摘要： A constraining sheath for use around an endoprosthesis (e.g., a stent device, with or without a graft covering), which may be a balloon expandable endoprosthesis but more preferably is a self-expanding prosthesis. The endoprosthesis is coaxially enclosed within the constraining sheath, which is an outer, disruptable, preferably implantable tubular sheath, preferably made of ePTFE. The constraining sheath and endoprosthesis are preferably mounted together as an assembly on an angioplasty balloon for delivery. Deployment of the endoprosthesis entails inflating the angioplasty balloon to a pressure sufficient to disrupt or break the constraining sheath in a prescribed fashion, thereby allowing a self-expanding endoprosthesis to spontaneously deploy. The constraining sheath of ePTFE may be attached to the endoprosthesis and implanted along with the device, or alternatively attached to the balloon catheter shaft and removed with the balloon catheter. The angioplasty balloon's working length is preferably shorter than the length of the endoprosthesis. An endoprosthesis assembly incorporating a constraining sheath according to one embodiment of the invention is also provided with an additional packaging sheath.
摘要翻译：用于内置假体周围使用的约束护套（例如，具有或不具有移植物覆盖物的支架装置），其可以是球囊可膨胀内置假体，但更优选是自膨胀假体。内置假体同轴地封闭在约束护套内，约束鞘是外部的，可破坏的，优选可植入的管状护套，优选地由ePTFE制成。约束鞘和内假体优选地作为组件安装在血管成形术气囊上用于递送。内窥镜假体的部署需要将血管成形术气囊膨胀至足以以规定的方式破坏或打破约束鞘的压力，从而允许自膨胀内置假体自发部署。 ePTFE的约束鞘可以连接到内置假体并与装置一起植入，或者替代地附接到球囊导管轴并且用球囊导管去除。血管成形术球囊的工作长度优选地短于内假体的长度。根据本发明的一个实施例的包含约束护套的假体内装配体还具有附加的包装护套。

10. 发明授权

US09381018B2 Device for rapid repair of body conduits 有权
公开(公告)号：US09381018B2
公开(公告)日：2016-07-05
申请号：US13149696
申请日：2011-05-31
申请人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
发明人： Edward H. Cully , Jeffrey B. Duncan , Keith M. Flury , Paul D. Goodman , Wayne D. House , Vrad W. Levering , Philip P. Off , Daniel M. O'Shea , Michael J. Vonesh , Jason M. Wiersdorf
IPC分类号： A61F2/84 , A61B17/11 , A61F2/07 , A61F2/97 , A61B17/06 , A61F2/06 , A61F2/30 , A61F2/89
CPC分类号： A61F2/07 , A61B17/06166 , A61B17/11 , A61B2017/1107 , A61F2/064 , A61F2/844 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2/958 , A61F2/97 , A61F2002/075 , A61F2002/30713 , A61F2220/0075 , A61F2220/0091 , A61F2250/0087
摘要： A self-expanding stent-graft provided in a diametrically compacted state for implantation and retained preferably by a constraining sheath, useful for the temporary or permanent repair of injured, partially or entirely transected body conduits including blood vessels. It may be used under direct visualization to quickly stop or substantially reduce loss of blood from such damaged vessels and to quickly re-establish perfusion distal to the injury site. The device would typically be implanted under emergency room conditions but also be used in field situations by trained medical technicians. After an end of the device is inserted into a blood vessel through the injury access, deployment preferably initiates from the device end in a direction moving toward the middle of the length of the device by directionally releasing the constraining sheath. In a preferred embodiment, the two opposing ends of the device are individually deployable from the compacted, small diameter intended for insertion into a vessel, to the larger diameter at which they fit interferably into a portion of the vessel.

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