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1. 发明授权

US4139614A Anthelmintic phosphonamidate and phosphoramidate compositions and methods of use 失效
标题翻译：驱虫剂膦酰胺酸酯和氨基磷酸酯组合物和使用方法
公开(公告)号：US4139614A
公开(公告)日：1979-02-13
申请号：US662744
申请日：1976-03-01
申请人： Edward E. Kilbourn , Ernest Weiler , William D. Weir
发明人： Edward E. Kilbourn , Ernest Weiler , William D. Weir
IPC分类号： C07F9/24 , C07F9/44 , C07F9/58 , C07F9/6509 , A61K31/66 , C07F9/38
CPC分类号： C07F9/650988 , C07F9/2454 , C07F9/4461 , C07F9/588
摘要： This invention relates to novel anthelmintic compositions containing as the essential active ingredient, a compound of the formula: ##STR1## wherein R.sup.1 is cylcoalkyl, or optionally substituted aralkyl, aryl, pyridyl, or pyrazinyl;R.sup.2 is hydrogen, alkyl, cycloalkyl, alkoxyalkyl, alkylthioalkyl, cyanoalkyl, alkenyl, or optionally substituted aralkyl or aryl;R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached form an optionally substituted morpholino or piperidino group;R.sup.3 is hydrogen, alkyl, cycloalkyl, alkenyl, or optionally substituted aralkyl or aryl;R.sup.4 is alkoxy, haloalkoxy, dialkylamino, alkylthio, phenoxy or phenylthio; andR.sup.5 is alkyl, alkoxy, haloalkoxy, dialkylamino, alkylthio, phenyl, phenoxy or phenylthio; andX is oxygen or sulfur;And pharmaceutically acceptable metal salts and metal salt complexes thereof, and to methods of employing them in the treatment of intestinal parasites in animals, e.g. mammals, fish, and birds.
摘要翻译：本发明涉及含有作为必需活性成分的下式化合物的新型驱肠剂组合物：其中R 1为环烷基或任选取代的芳烷基，芳基，吡啶基或吡嗪基; R2是氢，烷基，环烷基，烷氧基烷基，烷硫基烷基，氰基烷基，烯基或任选取代的芳烷基或芳基; R1和R2与它们所连接的氮原子一起形成任选取代的吗啉代或哌啶子基; R3是氢，烷基，环烷基，烯基或任选取代的芳烷基或芳基; R4是烷氧基，卤代烷氧基，二烷基氨基，烷硫基，苯氧基或苯硫基; R 5为烷基，烷氧基，卤代烷氧基，二烷基氨基，烷硫基，苯基，苯氧基或苯硫基; X为氧或硫; 和药学上可接受的金属盐和金属盐复合物，以及在处理动物肠内寄生虫的方法中的应用。肉类，鱼类和禽类。

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