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1. 发明授权

US06713627B2 Processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol 失效
标题翻译：制备（R）-α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇的方法
公开(公告)号：US06713627B2
公开(公告)日：2004-03-30
申请号：US10043498
申请日：2002-01-11
申请人： Edward D. Daugs , Jonathan C. Evans , Hans-Wolfram Flemming , Thomas Heinz Eduard Hilpert , Johannes Nicolaas Koek , Frederick M. Laskovics , Sandra K. Stolz-Dunn , Ian A. Tomlinson
发明人： Edward D. Daugs , Jonathan C. Evans , Hans-Wolfram Flemming , Thomas Heinz Eduard Hilpert , Johannes Nicolaas Koek , Frederick M. Laskovics , Sandra K. Stolz-Dunn , Ian A. Tomlinson
IPC分类号： C07D21122
CPC分类号： C07D211/32 , C07D211/22
摘要： The present invention provides various processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme:
摘要翻译：本发明提供制备（R）-α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇的各种方法。这些过程可以通过以下方案来表征：

2. 发明授权

US08722944B2 Process for olefin etherification 有权
标题翻译：烯烃醚化方法
公开(公告)号：US08722944B2
公开(公告)日：2014-05-13
申请号：US12430171
申请日：2009-04-27
申请人： Edward D. Daugs , Derrick W. Flick , Cynthia L. Rand , Michael L. Tulchinsky , Wanglin Yu
发明人： Edward D. Daugs , Derrick W. Flick , Cynthia L. Rand , Michael L. Tulchinsky , Wanglin Yu
IPC分类号： C07C41/06 , C07C43/12
CPC分类号： C07C41/06 , C07C41/42 , Y02P20/127 , C07C43/12
摘要： The invention relates to processes for the etherification of olefins with alcohols. According to one aspect, a heterogeneous etherification catalyst is used under conditions that permit limiting the contact time between the desired product and the catalyst, thereby mitigation reverse reactions. According to a second aspect, a recycling process is used that significantly increases the yield of desired product.
摘要翻译：本发明涉及烯烃与醇醚化的方法。根据一个方面，在允许限制所需产物和催化剂之间的接触时间的条件下使用异相醚化催化剂，从而减轻逆向反应。根据第二方面，使用显着增加所需产物的产率的再循环方法。

3. 发明授权

US08507719B2 Crystalline solid and amorphous forms of (−)-halofenate and methods related thereto 有权
标题翻译：（ - ） - 卤化物的结晶固体和无定形形式及其相关方法
公开(公告)号：US08507719B2
公开(公告)日：2013-08-13
申请号：US13470142
申请日：2012-05-11
申请人： Edward D. Daugs , Eric J. Hagen , Jason A. Hanko , David H. Louks
发明人： Edward D. Daugs , Eric J. Hagen , Jason A. Hanko , David H. Louks
IPC分类号： C07C67/02
CPC分类号： C07C233/18 , A61K9/0053 , A61K31/216 , C07B2200/07 , C07B2200/13 , C07C235/78
摘要： The present invention provides crystalline solid and amorphous forms of (−)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (−)-halofenate.
摘要翻译：本发明提供（ - ） - 卤代苯甲酸酯的结晶固体和无定形形式。结晶固体形式可以用于各种药物组合物中，并且对于预防和/或治疗与哺乳动物血脂沉积相关的病症，特别是涉及2型糖尿病和高脂血症的疾病特别有效。本发明还涉及一种用于预防或治疗哺乳动物的2型糖尿病和高脂血症的方法，其包括施用治疗有效量的（ - ） - 氟酸盐的结晶固体和无定形形式的步骤。

4. 发明申请

US20080221018A1 Crystalline solid and amorphous forms of (-)- halofenate and methods related thereto 有权
标题翻译：（ - ） - 卤化物的结晶固体和无定形形式及其相关方法
公开(公告)号：US20080221018A1
公开(公告)日：2008-09-11
申请号：US11408609
申请日：2006-04-20
申请人： Edward D. Daugs , Eric J. Hagen , Jason A. Hanko , David H. Louks
发明人： Edward D. Daugs , Eric J. Hagen , Jason A. Hanko , David H. Louks
IPC分类号： A61K38/28 , C07C69/00 , A61K31/216 , A61P9/00 , A61P3/10 , A61K31/426
CPC分类号： C07C233/18 , A61K9/0053 , A61K31/216 , C07B2200/07 , C07B2200/13 , C07C235/78
摘要： The present invention provides crystalline solid and amorphous forms of (−)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (−)-halofenate.
摘要翻译：本发明提供（ - ） - 卤代苯甲酸酯的结晶固体和无定形形式。结晶固体形式可以用于各种药物组合物中，并且对于预防和/或治疗与哺乳动物血脂沉积相关的病症，特别是涉及2型糖尿病和高脂血症的疾病特别有效。本发明还涉及一种用于预防或治疗哺乳动物的2型糖尿病和高脂血症的方法，其包括施用治疗有效量的（ - ） - 氟酸盐的结晶固体和无定形形式的步骤。

5. 发明授权

US06777562B1 Preparation of a trans-calanolide ketone intermediate and chiral separation of calanolide alcohols to give racemic calanolide A 失效
标题翻译：制备反式丙烯醇酮中间体和手性分离甘油醇醇，得到外消旋的丙内酰胺A
公开(公告)号：US06777562B1
公开(公告)日：2004-08-17
申请号：US10369984
申请日：2003-02-19
申请人： Edward D. Daugs
发明人： Edward D. Daugs
IPC分类号： C07D49314
CPC分类号： C07D493/14
摘要： The method of the invention comprises a process for synthesizing a trans-calanolide A ketone intermediate used in the synthesis of racemic trans-calanolide A. The invention further comprises a method for removing a racemic calanolide B diastereomer from a mixture of calanolide A and calanolide B diastereomers formed in the last step of the synthesis of calanolide A by crystallization.
摘要翻译：本发明的方法包括合成用于合成外消旋反式 - 正切内酯A的反式正己内酯A酮中间体的方法。本发明还包括一种从胼cal醇A和卡立拉宁B的混合物中除去外消旋的丙烯内酯B非对映异构体的方法在通过结晶合成甘露糖苷A的最后步骤中形成的非对映异构体。

6. 发明授权

US09180384B2 Apparatus and process for using olefin as an azeotropic entrainer for isolating 1,3-DICHLORO-2-propanol from a 2,2′-oxybis (1-chloropropane) waste stream 有权
标题翻译：使用烯烃作为共沸夹带剂从2,2'-氧双（1-氯丙烷）废物流中分离1,3-二氯-2-丙醇的装置和方法
公开(公告)号：US09180384B2
公开(公告)日：2015-11-10
申请号：US13990356
申请日：2011-12-07
申请人： Mahesh Ratnakar Sawant , Edward D. Daugs , Mark R. Smit
发明人： Mahesh Ratnakar Sawant , Edward D. Daugs , Mark R. Smit
IPC分类号： C07C29/80 , C07C29/86 , C07C29/74 , C07C29/78 , B01D3/36 , C07C29/82
CPC分类号： B01D3/36 , C07C29/74 , C07C29/78 , C07C29/80 , C07C29/82 , C07C29/86 , C07C31/36
摘要： Disclosed are a process and an apparatus for using an olefin as an azeotropic entrainer to isolate a target organic compound from a waste stream. The olefin may be, for example, 1-decene, 1-dodecene, or 1-tetradecene. The target organic compound may be 1,3-dichloro-2-propanol in waste stream comprising a 2,2′-oxybis(1-chloropropane).
摘要翻译：公开了一种使用烯烃作为共沸夹带剂从废物流中分离目标有机化合物的方法和装置。烯烃可以是例如1-癸烯，1-十二碳烯或1-十四碳烯。目标有机化合物可以是包含2,2'-氧双（1-氯丙烷）的废物流中的1,3-二氯-2-丙醇。

7. 发明授权

US08558029B2 Process for the continuous production of high purity phenolic glycol ether 有权
标题翻译：连续生产高纯度酚醛二醇醚的方法
公开(公告)号：US08558029B2
公开(公告)日：2013-10-15
申请号：US12745648
申请日：2008-12-08
申请人： Max Tirtowidjojo , Edward D. Daugs
发明人： Max Tirtowidjojo , Edward D. Daugs
IPC分类号： C07C43/23
CPC分类号： C07C41/03 , Y02P20/582 , C07C43/23
摘要： Phenolic glycol ethers, e.g., ethylene glycol phenyl ether, are prepared by a continuous, nonaqueous process comprising the steps of (A) contacting under isothermal reactive conditions in a first reactor or reaction zone an alkylene oxide, e.g., ethylene oxide, with (i) a stoichiometric molar excess of a phenolic compound, e.g., phenol, and (ii) a catalytic amount of a base, e.g., sodium hydroxide, homogeneously dispersed throughout the phenolic compound, to form a first intermediate phenolic glycol ether product, (Bj transferring the first intermediate phenolic glycol ether product to a second reactor or reaction zone, and (C) subjecting the first intermediate phenolic glycol ether product to adiabatic reactive conditions in the second reactor or reaction zone to form a second intermediate phenolic glycol ether product comprising phenolic glycol ether, unreacted phenolic compound, catalyst, water and byproduct glycols. In addition, the mono-/di-product weight ratio can be adjusted by increasing or decreasing the amount of base catalyst employed.
摘要翻译：酚醛二醇醚，例如乙二醇苯基醚，通过连续的非水性方法制备，包括以下步骤：（A）在等温反应条件下在第一反应器或反应区中接触环氧烷，例如环氧乙烷与（i ）化学计量摩尔过量的酚类化合物，例如苯酚，和（ii）催化量的碱，例如均匀分散在整个酚类化合物中的氢氧化钠，形成第一中间体酚二醇醚产物（Bj转移将第一中间体酚二醇醚产物加入到第二反应器或反应区中，和（C）使第一中间体酚二醇醚产物在第二反应器或反应区中进行绝热反应条件以形成包含酚二醇的第二中间体酚二醇醚产物醚，未反应的酚类化合物，催化剂，水和副产物二醇，另外，单/二产物重量比可以通过增加或减少所用的碱催化剂的量。

8. 发明申请

US20120078008A1 Process for Reducing Inorganics from and Concentrating Anionic Surfactant Solutions 有权
标题翻译：减少阴离子表面活性剂溶液无机物浓缩的方法
公开(公告)号：US20120078008A1
公开(公告)日：2012-03-29
申请号：US13242963
申请日：2011-09-23
申请人： Edward D. Daugs
发明人： Edward D. Daugs
IPC分类号： C07C303/44
CPC分类号： C07C303/44 , C07C309/10
摘要： A process including contacting one or more Strecker sulfonation reaction products of one or more halogenated alkyl ethers in the presence of sulfite with one or more polar water soluble organic solvents selected from acetone, methyl ethyl ketone, the C2-C5 alkyl alcohols, and the like, to form an extraction mixture; allowing the extraction mixture to separate into an aqueous phase and an organic phase; and separating the aqueous phase from the organic phase; wherein the one or more Strecker sulfonation reaction products each comprise at least 30 percent by weight of one or more inorganic salts and the organic phase following separation comprises less than 20 percent by weight of one or more inorganic salts, is provided.
摘要翻译：一种方法，包括在亚硫酸盐存在下使一种或多种卤代烷基醚的一种或多种磺化反应产物与一种或多种选自丙酮，甲基乙基酮，C 2 -C 5烷基醇等的极性水溶性有机溶剂接触，形成提取混合物; 使萃取混合物分离成水相和有机相; 并将水相与有机相分离; 其中一个或多个Strecker磺化反应产物各自包含至少30重量％的一种或多种无机盐，分离后的有机相包含小于20重量％的一种或多种无机盐。

9. 发明授权

US07671231B2 Process for making amino acids 失效
标题翻译：制备氨基酸的方法
公开(公告)号：US07671231B2
公开(公告)日：2010-03-02
申请号：US11333937
申请日：2006-01-18
申请人： Michael C. Lloyd , Edward D. Daugs , Cynthia L. Rand , Wei-Jun Peng
发明人： Michael C. Lloyd , Edward D. Daugs , Cynthia L. Rand , Wei-Jun Peng
IPC分类号： C07C227/12
CPC分类号： C07C227/32 , C07D317/30 , C12P13/04 , C12P41/006
摘要： A process for making an amino acid by the steps of: (a) contacting a compound of formula I with a hydroformylation catalyst and synthesis gas to produce a mixture of aldehyde compounds comprising the formulas IIa, IIb and IIc; (b) reacting the mixture of aldehyde compounds from step (a) to produce a mixture of derivative compounds; (c) contacting the mixture of derivative compounds from step (b) with an enantioselective hydrolase enzyme in the presence of water to produce an L-amino acid having the formula IV; (d) isolating the amino acid having the formula IV in substantially pure form, wherein in formulas I, IIa, IIb, IIc, IIIa, IIIb, IIIc and IV, R is H, alkyl or aryl and R1 and R2 are the same or different alkyl groups and wherein R1 and R2 may be fused.
摘要翻译：通过以下步骤制备氨基酸的方法：（a）使式I化合物与加氢甲酰化催化剂和合成气接触以产生包含式IIa，IIb和IIc的醛化合物的混合物; （b）使来自步骤（a）的醛化合物的混合物反应以产生衍生化合物的混合物; （c）在水存在下将来自步骤（b）的衍生化合物的混合物与对映选择性水解酶接触以产生具有式IV的L-氨基酸; （d）以基本上纯的形式分离具有式IV的氨基酸，其中在式I，IIa，IIb，IIc，IIIa，IIIb，IIIc和IV中，R是H，烷基或芳基，R 1和R 2相同或不同的烷基，其中R 1和R 2可以稠合。

10. 发明授权

US08987506B2 Process for reducing inorganics from and concentrating anionic surfactant solutions 有权
标题翻译：从阴离子表面活性剂溶液中减少无机物并浓缩的方法
公开(公告)号：US08987506B2
公开(公告)日：2015-03-24
申请号：US13242963
申请日：2011-09-23
申请人： Edward D. Daugs
发明人： Edward D. Daugs
IPC分类号： C07C309/00 , C07C303/44
CPC分类号： C07C303/44 , C07C309/10
摘要： A process including contacting one or more Strecker sulfonation reaction products of one or more halogenated alkyl ethers in the presence of sulfite with one or more polar water soluble organic solvents selected from acetone, methyl ethyl ketone, the C2-C5 alkyl alcohols, and the like, to form an extraction mixture; allowing the extraction mixture to separate into an aqueous phase and an organic phase; and separating the aqueous phase from the organic phase; wherein the one or more Strecker sulfonation reaction products each comprise at least 30 percent by weight of one or more inorganic salts and the organic phase following separation comprises less than 20 percent by weight of one or more inorganic salts, is provided.
摘要翻译：一种方法，包括在亚硫酸盐存在下使一种或多种卤代烷基醚的一种或多种磺化反应产物与一种或多种选自丙酮，甲基乙基酮，C 2 -C 5烷基醇等的极性水溶性有机溶剂接触，形成提取混合物; 使萃取混合物分离成水相和有机相; 并将水相与有机相分离; 其中一个或多个Strecker磺化反应产物各自包含至少30重量％的一种或多种无机盐，分离后的有机相包含小于20重量％的一种或多种无机盐。

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