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1. 发明授权

US07947307B2 Methods and compositions for imaging 有权
标题翻译：成像方法和组成
公开(公告)号：US07947307B2
公开(公告)日：2011-05-24
申请号：US11228577
申请日：2005-09-16
申请人： Edward A. Fisher , Zahi A. Fayad , Gwendalyn Randolph , Jonathan Feig , Eugene Trogan
发明人： Edward A. Fisher , Zahi A. Fayad , Gwendalyn Randolph , Jonathan Feig , Eugene Trogan
IPC分类号： A61K9/14
CPC分类号： A61K49/1806 , A61K49/1812 , A61K51/1224 , B82Y5/00 , Y10S977/797 , Y10S977/803 , Y10S977/808 , Y10S977/915 , Y10S977/92 , Y10S977/93
摘要： The present invention is directed to compositions useful as imaging agents for use in monitoring atherosclerotic plaque regression using, for example, MRI, CT, Gamma-scintigraphy, or optical imaging techniques. Methods and compositions of using the same are described.
摘要翻译：本发明涉及可用作用于使用例如MRI，CT，伽玛 - 闪烁扫描或光学成像技术监测动脉粥样硬化斑块回归的成像剂的组合物。描述了使用该方法和组合物的方法和组合物。

2. 发明授权

US08097283B2 Methods and compositions for imaging 有权
标题翻译：成像方法和组成
公开(公告)号：US08097283B2
公开(公告)日：2012-01-17
申请号：US10557094
申请日：2005-01-14
申请人： Edward A. Fisher , Zahi A. Fayad , Kevin J. Williams
发明人： Edward A. Fisher , Zahi A. Fayad , Kevin J. Williams
IPC分类号： A61K9/16
CPC分类号： A61K49/1806 , A61K49/1812 , A61K51/1224 , B82Y5/00 , Y10S977/797 , Y10S977/803 , Y10S977/808 , Y10S977/915 , Y10S977/92 , Y10S977/93
摘要： The present invention is directed to synthetic nanoparticles useful as imaging agents for use in MRI, CT, Gamma-scintigraphy, or optical imaging techniques. The synthetic nanoparticles comprise at least one apolipoprotein that is not an apoB lipoprotein, at least one amphipathic lipid, and at least one metallic or non-metallic contrast agent linked through a chelator to a component of the nanoparticle, wherein the one metallic or non-metallic contrast agent is present in an amount of between 5% to about 50% (w/w) of the nanoparticle, and the nanoparticle has a diameter of from about 5 nm to about 50 nm. Compositions and kits comprising the synthetic nanoparticles and methods of making and using the same are also provided.
摘要翻译：本发明涉及用作用于MRI，CT，伽玛 - 闪烁扫描或光学成像技术的成像剂的合成纳米颗粒。合成纳米颗粒包含至少一种不是apoB脂蛋白的载脂蛋白，至少一种两亲脂质，以及通过螯合剂与纳米颗粒的组分连接的至少一种金属或非金属造影剂，其中所述一种金属或非金属，金属造影剂以纳米颗粒的5％至约50％（w / w）的量存在，并且纳米颗粒的直径为约5nm至约50nm。还提供了包含合成纳米颗粒的组合物和试剂盒及其制备和使用方法。

3. 发明授权

US06201028B1 Methods and compositions for prevention and treatment of atherosclerosis and hyperlipidemia with non-steroidal anti-inflammatory drugs 失效
标题翻译：用非甾体抗炎药预防和治疗动脉粥样硬化和高脂血症的方法和组合物
公开(公告)号：US06201028B1
公开(公告)日：2001-03-13
申请号：US09208613
申请日：1998-12-08
申请人： Steven Shiff , Edward A. Fisher , I. Bernard Weinstein , Hayes M. Dansky , Urnani Reiss
发明人： Steven Shiff , Edward A. Fisher , I. Bernard Weinstein , Hayes M. Dansky , Urnani Reiss
IPC分类号： A01N4340
CPC分类号： A61K31/606 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/5415 , A61K31/616 , A61K45/06 , Y10S514/824
摘要： Methods and compositions for the prevention and/or treatment of cardiovascular diseases, the methods comprising administering to individuals in need thereof, an effective amount of a non-steroidal anti-inflammatory drug alone or in combination with other conventional therapies to induce apoptosis, reduce proliferation, induce quiescence, inhibit cell migration, or influence cell differentiation of the cells in the vascular wall and or/induce hypolipidemia.
摘要翻译：用于预防和/或治疗心血管疾病的方法和组合物，所述方法包括向有需要的个体施用有效量的非甾体抗炎药单独或与其它常规治疗组合以诱导凋亡，减少增殖，诱导静止，抑制细胞迁移或影响细胞在血管壁中的分化和/或诱导低血脂症。

4. 发明授权

US5203632A Gas turbine pyrometer filtering system 失效
标题翻译：燃气轮机高温计过滤系统
公开(公告)号：US5203632A
公开(公告)日：1993-04-20
申请号：US874323
申请日：1992-04-24
申请人： Edward A. Fisher , Keith L. Gehring
发明人： Edward A. Fisher , Keith L. Gehring
IPC分类号： G01J5/00
CPC分类号： G01J5/0022 , G01J2005/0033
摘要： A gas turbine pyrometer filtering method and system uses a pyrometer to measure the high pressure turbine blade temperatures using infrared optical detection techniques. The pyrometer signal can be cluttered by positively biased noise. The turbine speed and the pyrometer electrical signal are alternately sampled by an analog to digital converter, and several revolutions of pyrometer data are stored in the local RAM. A data compression algorithm then selects single samples, at evenly spaced intervals, which results in a given number of revolutions, containing an exact number of data points of aligned data in RAM. This data is passed to a clutter rejection filter which then passes only the lowest value for each of the points in all revolutions of data. Thus, the revolutions of acquired data are reduced into a single revolution of filtered data for the current sampling. This single revolution of filtered data in then enter into a circular queue and the last element is discarded. The data is then passed through a second clutter rejection filter, and the output is a smooth temperature profile of the turbine blades, free of clutter.
摘要翻译：燃气轮机高温计过滤方法和系统使用高温计使用红外光学检测技术来测量高压涡轮叶片温度。高温计信号可以通过正偏置的噪声杂乱。涡轮转速和高温计电信号由模拟数字转换器交替采样，几公里高温计数据存储在本地RAM中。然后，数据压缩算法以均匀间隔的间隔选择单个样本，这导致给定的转数，其中包含RAM中对齐数据的精确数量的数据点。该数据被传递到杂波抑制滤波器，该滤波器然后仅在所有数据转数中的每个点通过最低值。因此，所获取的数据的转数被减少为用于当前采样的经过滤数据的单次转。过滤数据的单次革命然后进入循环队列，最后一个元素被丢弃。然后将数据通过第二杂波抑制滤波器，并且输出是涡轮叶片的平滑温度分布，没有杂波。

5. 发明授权

US06620853B1 Methods and compositions for prevention and treatment of restenosis with non-steroidal anti-inflammatory drugs 失效
标题翻译：用非甾体抗炎药预防和治疗再狭窄的方法和组合物
公开(公告)号：US06620853B1
公开(公告)日：2003-09-16
申请号：US09456633
申请日：1999-12-08
申请人： Steven Shiff , Edward A. Fisher , Hayes M. Dansky , Ernane Reis
发明人： Steven Shiff , Edward A. Fisher , Hayes M. Dansky , Ernane Reis
IPC分类号： A61K31192
CPC分类号： A61K31/606 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/5415 , A61K31/616 , A61K45/06 , Y10S514/824
摘要： Methods and compositions for the prevention and/or treatment of vascular restenosis, the methods comprising administering to individuals in need thereof, an effective amount of a non-steroidal anti-inflammatory drug alone or in combination with other conventional therapies to induce apoptosis, reduce proliferation, induce quiescence, inhibit cell migration, or influence cell differentiation of the cells in the vascular wall and or/induce hypolipidemia.
摘要翻译：用于预防和/或治疗血管再狭窄的方法和组合物，所述方法包括向有需要的个体施用有效量的非甾体抗炎药单独或与其它常规治疗组合以诱导凋亡，减少增殖，诱导静止，抑制细胞迁移或影响细胞在血管壁中的分化和/或诱导低血脂症。

6. 发明授权

US5233254A Conical rotor for switched reluctance machine 失效
标题翻译：开关磁阻电机锥形转子
公开(公告)号：US5233254A
公开(公告)日：1993-08-03
申请号：US858805
申请日：1992-03-27
申请人： Edward A. Fisher , Eike Richter
发明人： Edward A. Fisher , Eike Richter
IPC分类号： H02K1/24 , H02K5/173 , H02K19/10
CPC分类号： H02K1/24 , H02K19/103 , H02K5/1735
摘要： The invention comprises a motor including a stator having stator teeth. The motor further includes a rotor having rotor teeth wherein the rotor is mounted on a shaft which is supported by a bearing. According to the present invention, the rotor is conically shaped such that the gap between the rotor and stator increases in proportion to the distance from the bearing.
摘要翻译：本发明包括具有定子齿的定子的电机。电动机还包括具有转子齿的转子，其中转子安装在由轴承支撑的轴上。根据本发明，转子是锥形的，使得转子和定子之间的间隙与从轴承的距离成比例地增加。

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