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1. 发明授权

US08639329B2 Circuits and methods for artifact elimination 有权
标题翻译：电路和消除方法
公开(公告)号：US08639329B2
公开(公告)日：2014-01-28
申请号：US11511794
申请日：2006-08-29
申请人： Edgar A. Brown , James D. Ross , Richard A. Blum , Stephen P. DeWeerth
发明人： Edgar A. Brown , James D. Ross , Richard A. Blum , Stephen P. DeWeerth
IPC分类号： A61N1/00 , A61B5/05
CPC分类号： G01N37/00 , A61B5/04 , A61B5/04001 , A61B5/7217 , A61N1/3605 , A61N1/3704 , G01N33/4836
摘要： Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants.
摘要翻译：公开了提供电刺激物理系统的能力的装置和方法，并且主动地消除由刺激产生的信号采集（伪影）的干扰。在电路中实现的技术和消除干扰的方法将放电路径连接到系统的物理接口，以去除在刺激期间积累的电荷。通过将放电路径放置在包括记录前置放大器和AC耦合电路的反馈回路中，物理接口被带回其预刺激偏移电压。所公开的装置和方法可以与压电换能器，超声波装置，光二极管以及可极化和不可极化的电极一起使用。所公开的装置可用于可植入装置，体外或体内用脊椎动物和无脊椎动物神经组织，肌肉纤维，胰岛细胞，成骨细胞，破骨细胞，细菌，藻类，真菌，原生生物和植物的装置。

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