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1. 发明授权

US4613569A Stabilized composition of tetrazolium salts 失效
标题翻译：四唑盐的稳定组成
公开(公告)号：US4613569A
公开(公告)日：1986-09-23
申请号：US593192
申请日：1984-03-27
申请人： Edda Geisler , Helmut Feuerstein , Hans Lange
发明人： Edda Geisler , Helmut Feuerstein , Hans Lange
IPC分类号： G01N33/82 , C12Q1/26 , C12Q1/32 , G01N33/48 , G01N33/52 , C12Q1/28 , C12Q1/54
CPC分类号： C12Q1/32 , G01N33/52 , Y10S435/805 , Y10S435/81 , Y10S436/903 , Y10T436/142222 , Y10T436/144444 , Y10T436/146666 , Y10T436/201666 , Y10T436/2525
摘要： The present invention provides stabilized compositions of tetrazolium salts for analytical purposes, wherein they contain 1 to 10 moles of a complex-forming acid which is soluble in polar solvents per mole of tetrazolium salt.The present invention also provides a process for the detection of reducing materials, wherein one of the above stabilized compositions is added to a test batch.
摘要翻译：本发明提供用于分析目的的稳定的四唑盐组合物，其中它们含有1至10摩尔的络合物形成酸，其每摩尔四唑鎓盐可溶于极性溶剂。本发明还提供了一种用于检测还原材料的方法，其中将一种上述稳定的组合物加入到试验批料中。

2. 发明授权

US4847196A Stabilized composition of tetrazolium salts 失效
标题翻译：四唑盐的稳定组成
公开(公告)号：US4847196A
公开(公告)日：1989-07-11
申请号：US147568
申请日：1988-01-19
申请人： Edda Geisler , Helmut Feuerstein , Hans Lange
发明人： Edda Geisler , Helmut Feuerstein , Hans Lange
IPC分类号： G01N33/82 , C12Q1/26 , C12Q1/32 , G01N33/48 , G01N33/52
CPC分类号： C12Q1/32 , G01N33/52 , Y10S435/805 , Y10S435/81 , Y10S436/903 , Y10T436/142222 , Y10T436/144444 , Y10T436/146666 , Y10T436/201666 , Y10T436/2525
摘要： The present invention provides stabilized compositions of tetrazolium salts for analytical purposes which contain 1 to 10 moles of a complex forming acid which is soluble in polar solvents, per mole of tetrazolium salt. Additionally, the invention provides a process for the detection of reducing materials, wherein a stabilized composition as described is added to a test batch.
摘要翻译：为了分析目的，本发明提供用于分析目的的稳定的四唑盐组合物，其含有每摩尔四唑鎓盐可溶于极性溶剂的1-10摩尔络合物形成的酸。另外，本发明提供了用于检测还原材料的方法，其中将所述的稳定化组合物加入到测试批料中。

3. 发明授权

US4605629A Method of eluting reagent from reagent strips for chemical analyses and reagent strip therefor 失效
标题翻译：从试剂条中洗脱试剂的方法进行化学分析和试剂条
公开(公告)号：US4605629A
公开(公告)日：1986-08-12
申请号：US634667
申请日：1984-07-27
申请人： Hans Lange , Edda Geisler , Wolfgang Werner
发明人： Hans Lange , Edda Geisler , Wolfgang Werner
IPC分类号： C12Q1/52 , G01N31/22 , G01N33/52 , G01N21/78
CPC分类号： G01N31/22 , G01N33/525 , Y10S435/805
摘要： The present invention provides a method of improving reagent elution from a reagent strip comprising a handle on one end which is affixed an absorbent carrier impregnated with a reagent. The absorbent carrier is pressed against the handle by a thin mesh which is stuck or sealed on to the handle on opposite sides of the carrier.Another mesh is between the carrier and the handle. When the carrier is immersed in a liquid, the meshes improve the elution of the reagent into the liquid.
摘要翻译：本发明提供了一种改进试剂从试剂洗脱的方法，该试剂条在一端具有手柄，该手柄固定着浸渍有试剂的吸收载体。吸收性载体通过在载体的相对侧上被卡住或密封在手柄上的细网被压靠在手柄上。另一个网格在载体和手柄之间。当载体浸没在液体中时，网眼会提高试剂在液体中的溶出度。

4. 发明授权

US5910246A Device for isolating nucleic acids 失效
公开(公告)号：US5910246A
公开(公告)日：1999-06-08
申请号：US617696
申请日：1996-04-01
申请人： Thomas Walter , Michael Fritz , Herbert Harttig , Hans Lange , Rolf Lerch
发明人： Thomas Walter , Michael Fritz , Herbert Harttig , Hans Lange , Rolf Lerch
IPC分类号： G01N33/50 , B01J20/00 , B01L3/14 , B04B5/02 , B04B7/18 , C07H1/06 , C07H21/00 , C12M1/00 , C12Q1/68 , G01N15/06 , G01N33/53
CPC分类号： B01L3/5021 , C07H1/06
摘要： Device for the isolation of nucleic acids from a liquid sample by introducing the liquid into the device through an inlet opening and passage of the sample through a nucleic acid binding material and discharging of the resulting liquid through an outlet opening, wherein the nucleic acid binding material is inserted through the outlet opening during the manufacture of the device and the outlet opening is narrowed in order to hold the material. The device is particularly simple and reliable to manufacture but yet ensures that nucleic acids can be isolated without contamination.

5. 再颁专利

USRE35803E Blood lancet device for and method withdrawing blood for diagnostic purposes 失效
标题翻译：用于诊断目的的血液刺血针装置和方法取出血液
公开(公告)号：USRE35803E
公开(公告)日：1998-05-19
申请号：US609627
申请日：1996-03-01
申请人： Hans Lange , Dirk Bocker , Hermann Edelmann , Wolfgang Rudinger , Herbert Argauer
发明人： Hans Lange , Dirk Bocker , Hermann Edelmann , Wolfgang Rudinger , Herbert Argauer
IPC分类号： A61B5/151 , A61B5/15 , A61B17/32
CPC分类号： A61B5/15194 , A61B5/150022 , A61B5/150183 , A61B5/150412 , A61B5/15113 , A61B5/15117 , A61B5/1513
摘要： Blood lancet device for withdrawing blood for diagnostic purposes, in which with the aid of a lancet drive (3) in a housing (1) a lancet holder (6) with a lancet (34) positioned in it and moveable along a predetermined, straight puncture path is moved until the tip (35) of the lancet emerges from the outlet (84), in order to produce a wound in a body part adjoining the outlet (84). The lancet holder (6) also serves to retract the lancet (34) into a position in which the tip (35) is again positioned within the housing (1). In order to make possible a puncture involving especially little pain, the lancet drive (3) has a rotary/sliding transmission system (4) whose input side (16) is formed by a transmission member which is rotatable about an axis of rotation parallel to the predetermined puncture path. This input-side transmission member (5) of the rotary/sliding transmission system is coupled with the elastic drive element (9) of the lancet drive (3) and converts a torque transmitted to the transmission member (5) into a longitudinal displacement in the direction of the predetermined puncture path, which is transmitted to the lancet holder (6). .Iadd.A method for withdrawing blood for diagnostic purposes using the blood lancet device is also presented..Iaddend.
摘要翻译：一种用于诊断用于抽出血液的血液针刺装置，其中借助于壳体（1）中的刺血针驱动器（3），具有定位在其中的刺血针（34）的刺血针保持器（6），并且可沿着预定的直线穿刺路径移动直到柳叶刀的尖端（35）从出口（84）出来，以便在与出口（84）相邻的主体部分中产生卷绕。柳叶刀套（6）还用于将柳叶刀（34）缩回到其中尖端（35）再次位于壳体（1）内的位置。为了使可能的穿刺特别小的疼痛，刺血针驱动器（3）具有旋转/滑动传动系统（4），其输入侧（16）由传动构件形成，该传动构件可绕平行于预定穿刺路径。旋转/滑动传动系统的输入侧传动部件（5）与柳叶刀驱动装置（3）的弹性驱动元件（9）相连接，并将传递到传动部件（5）的转矩变换为纵向位移传送到柳叶刀套（6）的预定穿刺路径的方向。还提出了使用血液穿刺装置进行诊断的血液提取方法。

6. 发明授权

US5846489A System for opening closures of vessels and for the contamination-free operation of reaction sequences 失效
标题翻译：用于打开船只关闭和反应序列无污染操作的系统
公开(公告)号：US5846489A
公开(公告)日：1998-12-08
申请号：US834043
申请日：1997-04-11
申请人： Gerhard Bienhaus , Hans Lange
发明人： Gerhard Bienhaus , Hans Lange
IPC分类号： G01N35/02 , B01L3/14 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N35/00 , G01N35/04 , G01N1/00 , G01N35/10
CPC分类号： B01L3/50825 , G01N35/0099 , G01N2035/00287 , G01N2035/0405 , Y10T436/11 , Y10T436/25
摘要： System for the automatic operation of reactions using several vessels which can be closed by individual closures using a device for automatically opening the closures.
摘要翻译：使用几个容器进行反应的自动操作的系统，该容器可以通过使用用于自动打开盖子的装置的单独闭合来关闭。

7. 发明授权

US4439527A Composition and method for the detection of hydrogen peroxide 失效
标题翻译：用于检测过氧化氢的组合物和方法
公开(公告)号：US4439527A
公开(公告)日：1984-03-27
申请号：US385760
申请日：1982-06-07
申请人： Bernd Pakebusch , Carsten A. Carstensen , Bernward Sojka , Hans Lange
发明人： Bernd Pakebusch , Carsten A. Carstensen , Bernward Sojka , Hans Lange
IPC分类号： G01N33/50 , C12Q1/28 , G01N31/00 , G01N21/78
CPC分类号： C12Q1/28 , C12Q2326/96 , Y10S436/904 , Y10T436/206664
摘要： Means and method for the detection of hydrogen peroxide or of hydrogen peroxide-forming substrates, consisting of 4-aminoantipyrine and an aromatic amine or phenol and a neutral to weakly acid buffer as well as other additives and reagents which form H.sub.2 O.sub.2 with the substrate and which are known for use in Trinder's reaction, the 4-aminoantipyrine, in the immiscible state before use, being separate from the acid buffer and from the other reagents if any, and being mixed with a small amount of an alkaline buffer having a pH of 8.5 to 14.0, the two compositions being combined, in a quantity ratio to one another that is suitable for the detection test, in a single package or in a single-use unit.
摘要翻译：用于检测过氧化氢或形成过氧化氢的底物的方法和方法，由4-氨基安替比林和芳族胺或苯酚和中性至弱酸性缓冲剂以及与底物形成H 2 O 2的其它添加剂和试剂组成，其中已知Trinder反应中使用4-氨基安替比林，在使用前不混溶状态，与酸缓冲液和其他试剂分离，如果有的话，并与少量pH为8.5的碱性缓冲液混合至14.0，两种组合物在单个包装或一次性单元中以彼此的量相互组合，适合于检测试验。

8. 发明授权

US3964870A Diagnostic composition for the determination of glucose 失效
标题翻译：用于测定葡萄糖的诊断组成
公开(公告)号：US3964870A
公开(公告)日：1976-06-22
申请号：US555327
申请日：1975-03-04
申请人： Hugo Tiedemann , Bernward Sojka , Hans Lange , Hans-Georg Rey , Peter Rieckmann
发明人： Hugo Tiedemann , Bernward Sojka , Hans Lange , Hans-Georg Rey , Peter Rieckmann
IPC分类号： G01N33/66 , C12Q1/54 , G01N31/14 , G01N31/22 , G01N33/16
CPC分类号： C12Q1/54
摘要： Glucose contained in urine is determined by contacting a sample with a diagnostic composition comprising an absorbent carrier impregnated with glucose oxidase, peroxidase, an indicator compound such as o-tolidine, and as a buffer, 2-(N-morpholino)-ethane-sulfonic acid.
摘要翻译：通过使样品与包含浸渍有葡萄糖氧化酶，过氧化物酶，指示剂化合物如邻甲苯吡啶的缓冲液的诊断组合物接触，测定尿中的葡萄糖，作为缓冲剂，将2-（N-吗啉代） - 乙磺酸酸。

9. 发明授权

US06287867B1 Asymmetric porous membranes 失效
标题翻译：不对称多孔膜
公开(公告)号：US06287867B1
公开(公告)日：2001-09-11
申请号：US08296855
申请日：1994-08-26
申请人： Herbert Harttig , Hartmut Merdes , Hans Lange , Manfred Zeiler
发明人： Herbert Harttig , Hartmut Merdes , Hans Lange , Manfred Zeiler
IPC分类号： G01N3350
CPC分类号： G01N33/525 , B01L3/5023 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B01L2400/084 , G01N1/34 , G01N33/521 , G01N2001/4016
摘要： The invention concerns the use of an asymmetric porous membrane for the evenly distributed concentration of a substance which is not or not substantially adsorbed to the membrane and which is brought into contact with the membrane in the form of a membrane-wetting solution on the fine-pored side of the membrane.
摘要翻译：本发明涉及使用不对称多孔膜来均匀分布浓度的物质，该物质不是或基本上不吸附到膜上，并且以薄膜润湿溶液的形式与膜接触，沉积在膜的侧面。

10. 发明授权

US06244256B1 High-temperature coolant loop for cooled exhaust gas recirculation for internal combustion engines 有权
标题翻译：用于内燃机冷却废气再循环的高温冷却液回路
公开(公告)号：US06244256B1
公开(公告)日：2001-06-12
申请号：US09413873
申请日：1999-10-07
申请人： John C. Wall , Markus Flik , Hans Lange
发明人： John C. Wall , Markus Flik , Hans Lange
IPC分类号： F02B4708
CPC分类号： F02B29/0425 , F02M26/05 , F02M26/16 , F02M26/24 , F02M26/28 , Y02T10/146
摘要： An EGR system for an internal combustion engine has a separate, secondary high-temperature cooling loop, in addition to a primary cooling loop. In the secondary cooling loop, coolant flows through a secondary high-temperature exhaust gas cooler, which is located upstream of the primary exhaust gas cooler. A large amount of heat is transferred from the exhaust gases to the coolant in the secondary high-temperature cooling loop. The heat absorbed by the high-temperature coolant is rejected in a secondary high-temperature radiator. Heat absorbed by the primary coolant is rejected in a primary radiator. The two radiators occupy the same amount of frontal area as a single radiator used in a conventional single-stage EGR cooling system, but overall reject more heat to the ambient. In an alternate arrangement, the EGR system for a liquid-cooled internal combustion engine has a single exhaust gas cooler which is cooled by an EGR cooling loop that is independent of the engine cooling system. The EGR cooling loop includes a secondary radiator located adjacent the primary engine cooling radiator, and the two radiators together occupy the same frontal area as a single radiator used in a conventional single-stage EGR cooling system, but overall reject more heat to the ambient.
摘要翻译：除了主冷却回路之外，用于内燃机的EGR系统具有单独的二次高温冷却回路。在二次冷却回路中，冷却剂流过位于主排气冷却器上游的二级高温废气冷却器。在二次高温冷却回路中，大量的热量从废气转移到冷却剂。高温冷却剂吸收的热量在二次高温散热器中被排除。主冷却剂吸收的热量在初级辐射器中被排除。两个散热器与常规单级EGR冷却系统中使用的单个散热器占据相同的正面面积，但是总体上将更多的热量排除到环境中。在替代布置中，用于液冷内燃机的EGR系统具有单独的废气冷却器，其被独立于发动机冷却系统的EGR冷却回路冷却。 EGR冷却回路包括位于主发动机冷却散热器附近的次级散热器，并且两个散热器一起占据与常规单级EGR冷却系统中使用的单个散热器相同的前部区域，但是总体上将更多的热量排除到环境中。

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