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1. 发明申请

US20050263044A1 Method of molding load-bearing articles from compressible cores and heat malleable coverings 有权
标题翻译：从可压缩芯和热可塑性覆盖物成型承载物品的方法
公开(公告)号：US20050263044A1
公开(公告)日：2005-12-01
申请号：US10858184
申请日：2004-06-01
申请人： Ed Bearse , Thomas Bohan , David Hedley , Alan Lewis
发明人： Ed Bearse , Thomas Bohan , David Hedley , Alan Lewis
IPC分类号： B29C51/12 , B29C51/16 , B29C51/42 , B65D19/00 , B29D9/00
CPC分类号： B29C44/569 , B29C47/003 , B29C47/004 , B29C47/0042 , B29C47/0054 , B29C51/12 , B29C51/165 , B29C51/427 , B29C65/02 , B29C65/08 , B29C65/10 , B29C66/1122 , B29C66/433 , B29C66/71 , B29C66/727 , B29C66/7315 , B29C66/73151 , B29C66/73921 , B29C66/8242 , B29C66/8322 , B29C66/83221 , B29C66/91411 , B29C66/91645 , B29C66/91931 , B29C2035/0822 , B29C2791/001 , B29K2105/04 , B29K2995/007 , B29K2995/0089 , B29L2009/00 , B29L2031/7178 , B65D19/0018 , B65D2519/00034 , B65D2519/00069 , B65D2519/00273 , B65D2519/00288 , B65D2519/00318 , B65D2519/00338 , B65D2519/00562 , B65D2519/00835 , B29K2023/04 , B29K2023/10 , B29K2025/04 , B29K2069/00 , B29K2071/12 , B29K2067/00 , B29K2025/08 , B29K2025/06 , B29K2023/12 , B29K2023/065 , B29K2023/0633 , B29K2023/06
摘要： Load-bearing article are manufactured from shape defining compressible cores and thermoplastic shells. The manufacture of these articles requires specific methods and tools. Articles that can be manufactured using these methods include relatively lightweight pallets with high load-bearing capacity.
摘要翻译：承载制品由形状限定可压缩芯和热塑性壳制成。这些制品的制造需要具体的方法和工具。可以使用这些方法制造的制品包括具有高承载能力的相对轻质的托盘。

2. 发明申请

US20080272511A1 METHOD OF MOLDING LOAD-BEARING ARTICLES FROM COMPRESSIBLE CORES AND HEAT MALLEABLE COVERINGS 有权
公开(公告)号：US20080272511A1
公开(公告)日：2008-11-06
申请号：US12173973
申请日：2008-07-16
申请人： Ed Bearse , Thomas Bohan , David Hedley , Alan Lewis
发明人： Ed Bearse , Thomas Bohan , David Hedley , Alan Lewis
IPC分类号： B29C45/14 , B32B3/26 , B29C33/40 , B28B7/24
CPC分类号： B29C44/569 , B29C47/003 , B29C47/004 , B29C47/0042 , B29C47/0054 , B29C51/12 , B29C51/165 , B29C51/427 , B29C65/02 , B29C65/08 , B29C65/10 , B29C66/1122 , B29C66/433 , B29C66/71 , B29C66/727 , B29C66/7315 , B29C66/73151 , B29C66/73921 , B29C66/8242 , B29C66/8322 , B29C66/83221 , B29C66/91411 , B29C66/91645 , B29C66/91931 , B29C2035/0822 , B29C2791/001 , B29K2105/04 , B29K2995/007 , B29K2995/0089 , B29L2009/00 , B29L2031/7178 , B65D19/0018 , B65D2519/00034 , B65D2519/00069 , B65D2519/00273 , B65D2519/00288 , B65D2519/00318 , B65D2519/00338 , B65D2519/00562 , B65D2519/00835 , B29K2023/04 , B29K2023/10 , B29K2025/04 , B29K2069/00 , B29K2071/12 , B29K2067/00 , B29K2025/08 , B29K2025/06 , B29K2023/12 , B29K2023/065 , B29K2023/0633 , B29K2023/06
摘要： Load-bearing articles are manufactured from shape defining compressible cores and thermoplastic shells. The manufacture of these articles requires specific methods and tools. Articles that can be manufactured using these methods include relatively lightweight pallets with high load-bearing capacity.

3. 发明授权

US07837923B2 Method of molding load-bearing articles from compressible cores and heat malleable coverings 有权
标题翻译：从可压缩芯和热可塑性覆盖物成型承载物品的方法
公开(公告)号：US07837923B2
公开(公告)日：2010-11-23
申请号：US12173973
申请日：2008-07-16
申请人： Ed Bearse , Thomas Bohan , David Hedley , Alan Lewis
发明人： Ed Bearse , Thomas Bohan , David Hedley , Alan Lewis
IPC分类号： B29C67/20 , B29C45/14 , B29B13/00
CPC分类号： B29C44/569 , B29C47/003 , B29C47/004 , B29C47/0042 , B29C47/0054 , B29C51/12 , B29C51/165 , B29C51/427 , B29C65/02 , B29C65/08 , B29C65/10 , B29C66/1122 , B29C66/433 , B29C66/71 , B29C66/727 , B29C66/7315 , B29C66/73151 , B29C66/73921 , B29C66/8242 , B29C66/8322 , B29C66/83221 , B29C66/91411 , B29C66/91645 , B29C66/91931 , B29C2035/0822 , B29C2791/001 , B29K2105/04 , B29K2995/007 , B29K2995/0089 , B29L2009/00 , B29L2031/7178 , B65D19/0018 , B65D2519/00034 , B65D2519/00069 , B65D2519/00273 , B65D2519/00288 , B65D2519/00318 , B65D2519/00338 , B65D2519/00562 , B65D2519/00835 , B29K2023/04 , B29K2023/10 , B29K2025/04 , B29K2069/00 , B29K2071/12 , B29K2067/00 , B29K2025/08 , B29K2025/06 , B29K2023/12 , B29K2023/065 , B29K2023/0633 , B29K2023/06
摘要： Load-bearing articles are manufactured from shape defining compressible cores and thermoplastic shells. The manufacture of these articles requires specific methods and tools. Articles that can be manufactured using these methods include relatively lightweight pallets with high load-bearing capacity.
摘要翻译：承载制品由形状可定义可压缩芯和热塑性外壳制成。这些制品的制造需要具体的方法和工具。可以使用这些方法制造的制品包括具有高承载能力的相对轻质的托盘。

4. 发明申请

US20080265460A1 METHOD OF MOLDING LOAD-BEARING ARTICLES FROM COMPRESSIBLE CORES AND HEAT MALLEABLE COVERINGS 审中-公开
标题翻译：从可压缩线和热弹性覆盖物成型负载轴承的方法
公开(公告)号：US20080265460A1
公开(公告)日：2008-10-30
申请号：US12171195
申请日：2008-07-10
申请人： Ed Bearse , Thomas Bohan , David Hedley , Alan Lewis
发明人： Ed Bearse , Thomas Bohan , David Hedley , Alan Lewis
IPC分类号： B29C43/18
CPC分类号： B29C44/569 , B29C48/0011 , B29C48/0012 , B29C48/0017 , B29C48/12 , B29C51/12 , B29C51/165 , B29C51/427 , B29C65/02 , B29C65/08 , B29C65/10 , B29C66/1122 , B29C66/433 , B29C66/71 , B29C66/727 , B29C66/7315 , B29C66/73151 , B29C66/73921 , B29C66/8242 , B29C66/8322 , B29C66/83221 , B29C66/91411 , B29C66/91645 , B29C66/91931 , B29C2035/0822 , B29C2791/001 , B29K2105/04 , B29K2995/007 , B29K2995/0089 , B29L2009/00 , B29L2031/7178 , B65D19/0018 , B65D2519/00034 , B65D2519/00069 , B65D2519/00273 , B65D2519/00288 , B65D2519/00318 , B65D2519/00338 , B65D2519/00562 , B65D2519/00835 , B29K2023/04 , B29K2023/10 , B29K2025/04 , B29K2069/00 , B29K2071/12 , B29K2067/00 , B29K2025/08 , B29K2025/06 , B29K2023/12 , B29K2023/065 , B29K2023/0633 , B29K2023/06
摘要： Load-bearing articles are manufactured from shape defining compressible cores and thermoplastic shells. The manufacture of these articles requires specific methods and tools. Articles that can be manufactured using these methods include relatively lightweight pallets with high load-bearing capacity.
摘要翻译：承载制品由形状可定义可压缩芯和热塑性外壳制成。这些制品的制造需要具体的方法和工具。可以使用这些方法制造的制品包括具有高承载能力的相对轻质的托盘。

5. 发明授权

US07413698B2 Method of molding load-bearing articles from compressible cores and heat malleable coverings 有权
标题翻译：从可压缩芯和热可塑性覆盖物成型承载物品的方法
公开(公告)号：US07413698B2
公开(公告)日：2008-08-19
申请号：US10858184
申请日：2004-06-01
申请人： Ed Bearse , Thomas Bohan , David Hedley , Alan Lewis
发明人： Ed Bearse , Thomas Bohan , David Hedley , Alan Lewis
IPC分类号： B32B37/00 , B29C67/20 , B29C47/00 , B29B13/00
CPC分类号： B29C44/569 , B29C47/003 , B29C47/004 , B29C47/0042 , B29C47/0054 , B29C51/12 , B29C51/165 , B29C51/427 , B29C65/02 , B29C65/08 , B29C65/10 , B29C66/1122 , B29C66/433 , B29C66/71 , B29C66/727 , B29C66/7315 , B29C66/73151 , B29C66/73921 , B29C66/8242 , B29C66/8322 , B29C66/83221 , B29C66/91411 , B29C66/91645 , B29C66/91931 , B29C2035/0822 , B29C2791/001 , B29K2105/04 , B29K2995/007 , B29K2995/0089 , B29L2009/00 , B29L2031/7178 , B65D19/0018 , B65D2519/00034 , B65D2519/00069 , B65D2519/00273 , B65D2519/00288 , B65D2519/00318 , B65D2519/00338 , B65D2519/00562 , B65D2519/00835 , B29K2023/04 , B29K2023/10 , B29K2025/04 , B29K2069/00 , B29K2071/12 , B29K2067/00 , B29K2025/08 , B29K2025/06 , B29K2023/12 , B29K2023/065 , B29K2023/0633 , B29K2023/06
摘要： Load-bearing articles are manufactured from shape defining compressible cores and thermoplastic shells. The manufacture of these articles requires specific methods and tools. Articles that can be manufactured using these methods include relatively lightweight pallets with high load-bearing capacity.
摘要翻译：承载制品由形状可定义可压缩芯和热塑性外壳制成。这些制品的制造需要具体的方法和工具。可以使用这些方法制造的制品包括具有高承载能力的相对轻质的托盘。

6. 发明申请

US20130174762A1 RECONFIGURABLE LOAD-BEARING ARTICLE 审中-公开
标题翻译：可重载负载条款
公开(公告)号：US20130174762A1
公开(公告)日：2013-07-11
申请号：US13822953
申请日：2012-04-16
申请人： David Hedley , Thomas Bohan
发明人： David Hedley , Thomas Bohan
IPC分类号： B65D19/00 , B23P19/04 , B65D19/40
CPC分类号： B65D19/0026 , B23P19/04 , B65D19/40 , B65D2203/10 , B65D2519/00034 , B65D2519/00069 , B65D2519/00104 , B65D2519/00273 , B65D2519/00288 , B65D2519/00293 , B65D2519/00323 , B65D2519/00333 , B65D2519/00402 , B65D2519/00412 , B65D2519/00562 , B65D2519/00567 , B65D2519/00572 , B65D2519/00736 , B65D2519/0099 , Y10T29/49826
摘要： The present application is directed to a reconfigurable load-bearing article (10) including a deck unit (12) and at least two supports (14) configured to be coupled to the deck unit, the supports including at least one spacer receiving member configured to receive and releasably engage a spacer (16). The load-bearing article is reconfigurable to form any suitable load- bearing article and may be used to provide a lightweight, durable, strong, multipurpose pallet having a four-way forklift entry.
摘要翻译：本申请涉及包括甲板单元（12）和构造成联接到甲板单元的至少两个支撑件（14）的可重新配置的承载物品（10），所述支撑件包括至少一个间隔件接收构件，其构造成接收和可释放地接合间隔件（16）。承重制品可重构以形成任何合适的承重制品，并且可用于提供具有四向叉车入口的轻质耐用，坚固的多功能托盘。

7. 发明授权

US07803523B2 Whole blood preparation for cytometric analysis of cell signaling pathways 有权
标题翻译：全血制备细胞信号传导途径的细胞分析
公开(公告)号：US07803523B2
公开(公告)日：2010-09-28
申请号：US10928570
申请日：2004-08-27
申请人： Sue Chow , David Hedley , T. Vincent Shankey , Patricia Grom
发明人： Sue Chow , David Hedley , T. Vincent Shankey , Patricia Grom
IPC分类号： A01N1/02 , G01N1/00
CPC分类号： G01N33/80 , Y10T436/107497 , Y10T436/108331 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375
摘要： This invention is directed to a method for preparation of a biological sample for measurement of protein epitopes that allows for the preservation of intracellular protein epitopes and detection of signal transduction pathways based on the ability to capture transient activation states of the epitopes. The method provided by the invention allows for the rapid fixation of biological samples containing red blood cells, to ensure that epitopes of signal transduction molecules and other intracellular protein epitopes are preserved in the active state. The method of the invention further allows for lysis of red blood cells, thereby making it a useful method for cytometric analysis of biological samples, including, for example, whole blood, bone marrow aspirates, peritoneal fluids, and other red blood cell containing samples. The invention also provides a method to recover or “unmask” epitopes on intracellular antigens that have been made inaccessible by the cross linking fixative necessary to fix the sample. Significantly, the methods of the invention allow preservation and analysis of phospho-epitope levels in biological samples taken directly from patients to determine disease-specific characteristics.
摘要翻译：本发明涉及一种用于制备用于测量蛋白质表位的生物样品的方法，其允许基于捕获表位的瞬时激活状态的能力来保留细胞内蛋白质表位和检测信号转导途径。本发明提供的方法允许快速固定含有红细胞的生物样品，以确保信号转导分子和其他细胞内蛋白质表位的表位保持活跃状态。本发明的方法还允许红细胞溶解，从而使其成为生物样品的细胞分析的有用方法，包括例如全血，骨髓抽吸物，腹膜液和其它含红细胞的样品。本发明还提供了一种在细胞内抗原上恢复或“揭开”表位的方法，这些表位已经被固定样品所必需的交联固定剂制成。显着地，本发明的方法允许保存和分析直接从患者获取的生物样品中的磷酸化表位水平，以确定疾病特异性特征。

8. 发明申请

US20070105165A1 Composite profiles of cell antigens and target signal transduction proteins for analysis and clinical management of hematologic cancers 审中-公开
标题翻译：细胞抗原和靶信号转导蛋白的复合谱，用于分析和临床管理血液癌
公开(公告)号：US20070105165A1
公开(公告)日：2007-05-10
申请号：US11267948
申请日：2005-11-04
申请人： Charles Goolsby , T. Shankey , David Hedley , James Jacobberger , Stanley Shackney
发明人： Charles Goolsby , T. Shankey , David Hedley , James Jacobberger , Stanley Shackney
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , G01N33/5052 , G01N2800/52
摘要： The present invention is directed to methods for establishing a composite marker profile for a sample derived from an individual suspected having a neoplastic condition. A composite marker profile of the invention allows for identification of prognostically and therapeutically relevant subgroups of neoplastic conditions and prediction of the clinical course of an individual. The methods of the invention provide tools useful in choosing a therapy for an individual afflicted with a neoplastic condition, including methods for assigning a risk group, methods of predicting an increased risk of relapse, methods of predicting an increased risk of developing secondary complications, methods of choosing a therapy for an individual, methods of determining the efficacy of a therapy in an individual, and methods of determining the prognosis for an individual. In particular, the method of the present invention discloses a method for establishing a composite marker profile that can serve as a prognostic indicator to predict whether the course of a neoplastic condition in a individual will be aggressive or indolent, thereby aiding the clinician in managing the patient and evaluating the modality of treatment to be used. In particular embodiments disclosed herein, the methods of the invention are directed to establishing a composite marker profile for a leukemia selected from the group consisting of Chronic Lymphocytic Leukemia (CLL), Acute Myelogenous Leukemia (AML), Chronic Myelogenous Leukemia (CML), and Acute Lymphocytic Leukemia (ALL).
摘要翻译：本发明涉及用于建立来自疑似具有肿瘤状况的个体的样品的复合标记物谱的方法。本发明的复合标记物分布允许鉴定预后和治疗相关的肿瘤病症亚组和个体临床病程的预测。本发明的方法提供了用于选择患有肿瘤病症的个体的治疗的工具，包括分配风险组的方法，预测复发风险增加的方法，预测发生继发性并发症的风险增加的方法，方法选择个体治疗的方法，确定个体治疗功效的方法以及确定个体预后的方法。特别地，本发明的方法公开了一种建立复合标记物谱的方法，该方法可用作预后指标以预测个体肿瘤状况的进程是否是侵略性或惰性的，由此帮助临床医师管理患者和评估使用的治疗方式。在本文公开的特定实施方案中，本发明的方法涉及建立选自慢性淋巴细胞性白血病（CLL），急性骨髓性白血病（AML），慢性骨髓性白血病（CML）和急性淋巴细胞性白血病（ALL）。

9. 发明申请

US20060046272A1 Whole blood preparation for cytometric analysis of cell signaling pathways 有权
标题翻译：全血制备细胞信号传导途径的细胞分析
公开(公告)号：US20060046272A1
公开(公告)日：2006-03-02
申请号：US10928570
申请日：2004-08-27
申请人： Sue Chow , David Hedley , T. Shankey , Patricia Grom
发明人： Sue Chow , David Hedley , T. Shankey , Patricia Grom
IPC分类号： G01N33/567 , G01N33/53
CPC分类号： G01N33/80 , Y10T436/107497 , Y10T436/108331 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375
摘要： This invention is directed to a method for preparation of a biological sample for measurement of protein epitopes that allows for the preservation of intracellular protein epitopes and detection of signal transduction pathways based on the ability to capture transient activation states of the epitopes. The method provided by the invention allows for the rapid fixation of biological samples containing red blood cells, to ensure that epitopes of signal transduction molecules and other intracellular protein epitopes are preserved in the active state. The method of the invention further allows for lysis of red blood cells, thereby making it a useful method for cytometric analysis of biological samples, including, for example, whole blood, bone marrow aspirates, peritoneal fluids, and other red blood cell containing samples. The invention also provides a method to recover or “unmask” epitopes on intracellular antigens that have been made inaccessible by the cross linking fixative necessary to fix the sample. Significantly, the methods of the invention allow preservation and analysis of phospho-epitope levels in biological samples taken directly from patients to determine disease-specific characteristics.
摘要翻译：本发明涉及一种用于制备用于测量蛋白质表位的生物样品的方法，其允许基于捕获表位的瞬时激活状态的能力来保留细胞内蛋白质表位和检测信号转导途径。本发明提供的方法允许快速固定含有红细胞的生物样品，以确保信号转导分子和其他细胞内蛋白质表位的表位保持活跃状态。本发明的方法还允许红细胞溶解，从而使其成为生物样品的细胞分析的有用方法，包括例如全血，骨髓抽吸物，腹膜液和其它含红细胞的样品。本发明还提供了一种在细胞内抗原上恢复或“揭开”表位的方法，这些表位已经被固定样品所必需的交联固定剂制成。显着地，本发明的方法允许保存和分析直接从患者获取的生物样品中的磷酸化表位水平，以确定疾病特异性特征。

10. 发明申请

US20100261204A1 Composite Profiles of Cell Antigens and Target Signal Transduction Proteins for Analysis and Clinical Management of Hematologic Cancers 审中-公开
标题翻译：复合型细胞抗原和目标信号转导蛋白用于分析和临床管理的血液癌
公开(公告)号：US20100261204A1
公开(公告)日：2010-10-14
申请号：US12696702
申请日：2010-01-29
申请人： Charles GOOLSBY , T. Vincent Shankey , David Hedley , James Jacobberger , Stanley Shackney
发明人： Charles GOOLSBY , T. Vincent Shankey , David Hedley , James Jacobberger , Stanley Shackney
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , G01N33/5052 , G01N2800/52
摘要： The present invention is directed to methods for establishing a composite marker profile for a sample derived from an individual suspected having a neoplastic condition. A composite marker profile of the invention allows for identification of prognostically and therapeutically relevant subgroups of neoplastic conditions and prediction of the clinical course of an individual. The methods of the invention provide tools useful in choosing a therapy for an individual afflicted with a neoplastic condition, including methods for assigning a risk group, methods of predicting an increased risk of relapse, methods of predicting an increased risk of developing secondary complications, methods of choosing a therapy for an individual, methods of determining the efficacy of a therapy in an individual, and methods of determining the prognosis for an individual. In particular, the method of the present invention discloses a method for establishing a composite marker profile that can serve as a prognostic indicator to predict whether the course of a neoplastic condition in a individual will be aggressive or indolent, thereby aiding the clinician in managing the patient and evaluating the modality of treatment to be used. In particular embodiments disclosed herein, the methods of the invention are directed to establishing a composite marker profile for a leukemia selected from the group consisting of Chronic Lymphocytic Leukemia (CLL), Acute Myelogenous Leukemia (AML), Chronic Myelogenous Leukemia (CML), and Acute Lymphocytic Leukemia (ALL).
摘要翻译：本发明涉及用于建立来自疑似具有肿瘤状况的个体的样品的复合标记物谱的方法。本发明的复合标记物分布允许鉴定预后和治疗相关的肿瘤病症亚组和个体临床病程的预测。本发明的方法提供了用于选择患有肿瘤病症的个体的治疗的工具，包括分配风险组的方法，预测复发风险增加的方法，预测发生继发性并发症的风险增加的方法，方法选择个体治疗的方法，确定个体治疗功效的方法以及确定个体预后的方法。特别地，本发明的方法公开了一种建立复合标记物谱的方法，该方法可用作预后指标以预测个体肿瘤状况的进程是否是侵略性或惰性的，由此帮助临床医师管理患者和评估使用的治疗方式。在本文公开的特定实施方案中，本发明的方法涉及建立选自慢性淋巴细胞性白血病（CLL），急性骨髓性白血病（AML），慢性骨髓性白血病（CML）和急性淋巴细胞性白血病（ALL）。

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