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1. 发明公开

EP3558448A1 A SENSORY INFORMATION COMPLIANT SPINAL CORD STIMULATION SYSTEM FOR THE REHABILITATION OF MOTOR FUNCTIONS 有权
公开(公告)号：EP3558448A1
公开(公告)日：2019-10-30
申请号：EP17826212.7
申请日：2017-12-19
申请人： Ecole Polytechnique Fédérale de Lausanne (EPFL)
发明人： FORMENTO, Emanuele , CAPOGROSSO, Marco , MICERA, Silvestro , COURTINE, Grégoire , MINASSIAN, Karen
IPC分类号： A61N1/05 , A61N1/36

2. 发明公开

EP4378520A1 SYSTEM FOR SELECTIVE SPATIOTEMPORAL STIMULATION OF THE SPINAL CORD 审中-公开
公开(公告)号：EP4378520A1
公开(公告)日：2024-06-05
申请号：EP24164138.0
申请日：2015-12-22
申请人： Ecole Polytechnique Fédérale de Lausanne (EPFL)
发明人： BLOCH, Jocelyne , COURTINE, Grègoire , WENGER, Nikolaus , MICERA, Silvestro , CAPOGROSSO, Marco
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/36139 , A61B5/4836
摘要： The present invention refers to systems for selective spatiotemporal electrical neurostimulation of the spinal cord. In particular, it is an object of the invention a system comprising: a signal processing device receiving signals from the subject and operating signal-processing algorithms to elaborate stimulation parameter settings, operatively connected with an Implantable Pulse Generator (IPG) receiving stimulation parameter settings from said signal processing device and able to simultaneously deliver independent current or voltage pulses to one or more multiple electrode arrays; operatively connected with one or more multi-electrode arrays suitable to cover at least a portion of the spinal cord of said subject for applying to said subject a selective spatiotemporal stimulation of the spinal circuits and/or dorsal roots, wherein said IPG is operatively connected with said one or more multi-electrode arrays to provide a multipolar stimulation. Such system advantageously allows achieving effective control of locomotor functions in a subject in need thereof by stimulating the spinal cord, in particular the dorsal roots, with spatiotemporal selectivity.

3. 发明公开

EP3184145A1 SYSTEM FOR SELECTIVE SPATIOTEMPORAL STIMULATION OF THE SPINAL CORD 有权
标题翻译：系统选择性时空刺激的脊髓
公开(公告)号：EP3184145A1
公开(公告)日：2017-06-28
申请号：EP15201930.3
申请日：2015-12-22
申请人： Ecole Polytechnique Fédérale de Lausanne (EPFL)
发明人： BLOCH, Jocelyne , COURTINE, Grégoire , WENGER, Nikolaus , MICERA, Silvestro , CAPOGROSSO, Marco
IPC分类号： A61N1/36
CPC分类号： A61N1/36003 , A61B5/0488 , A61B5/4836 , A61N1/0553 , A61N1/36067 , A61N1/36139
摘要： The present invention refers to systems for selective spatiotemporal electrical neurostimulation of the spinal cord. In particular, it is an object of the invention a system comprising: a signal processing device receiving signals from the subject and operating signal-processing algorithms to elaborate stimulation parameter settings, operatively connected with an Implantable Pulse Generator (IPG) receiving stimulation parameter settings from said signal processing device and able to simultaneously deliver independent current or voltage pulses to one or more multiple electrode arrays; operatively connected with one or more multi-electrode arrays suitable to cover at least a portion of the spinal cord of said subject for applying to said subject a selective spatiotemporal stimulation of the spinal circuits and/or dorsal roots, wherein said IPG is operatively connected with said one or more multi-electrode arrays to provide a multipolar stimulation. Such system advantageously allows achieving effective control of locomotor functions in a subject in need thereof by stimulating the spinal cord, in particular the dorsal roots, with spatiotemporal selectivity.
摘要翻译：本发明涉及用于脊髓的选择性时空电神经刺激的系统。具体而言，本发明的一个目的是提供一种系统，包括：信号处理设备，接收来自受试者的信号并操作信号处理算法以详细阐述刺激参数设置，该刺激参数设置可操作地与从可植入脉冲发生器（IPG）所述信号处理装置并且能够同时传送独立的电流或电压脉冲到一个或多个多电极阵列; 可操作地与一个或多个适合于覆盖所述对象的脊髓的至少一部分的多电极阵列连接，用于向所述对象施加对脊髓回路和/或背根的选择性时空刺激，其中所述IPG可操作地与所述一个或多个多电极阵列提供多极刺激。这样的系统有利地允许通过以时空选择性刺激脊髓，特别是背根来有效控制有需要的受试者的运动功能。

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