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1. 发明授权

US5276268A Phosphinothricin-resistance gene, and its use 失效
标题翻译：氯氰菊酯抗性基因及其用途
公开(公告)号：US5276268A
公开(公告)日：1994-01-04
申请号：US736316
申请日：1991-07-29
申请人： Eckhard Strauch , Walter Arnold , Renate Alijah , Wolfgang Wohlleben , Alfred Puhler , Peter Eckes , Gunter Donn , Eugen Uhlmann , Friedrich Hein , Friedrich Wengenmayer
发明人： Eckhard Strauch , Walter Arnold , Renate Alijah , Wolfgang Wohlleben , Alfred Puhler , Peter Eckes , Gunter Donn , Eugen Uhlmann , Friedrich Hein , Friedrich Wengenmayer
IPC分类号： C12N9/10 , C12N15/64 , C12N15/82 , C12P41/00 , A01H4/00 , C12N5/14 , C12N15/31
CPC分类号： C12N9/1029 , C12N15/64 , C12N15/8209 , C12N15/8277 , C12P41/007
摘要： The phosphinothricin (PTC)-resistance gene isolated from the genome of Streptomyces viridochromogenes DSM 40736 is, after adaptation to the codon usage in plants, synthesized and incorporated into gene structures which make plants resistant to PTC after expression therein.
摘要翻译：从植物链霉菌（Streptomyces viridochromogenes）DSM 40736的基因组中分离出的膦丝菌素（PTC） - 抗性基因，在适应于植物中的密码子使用之后，合成并掺入基因结构中，使得植物在其表达后能耐PTC。

2. 发明授权

US5834265A Multifunctional RNA having self-processing activity, the preparation thereof and the use thereof 失效
标题翻译：具有自身加工活性的多功能RNA，其制备及其用途
公开(公告)号：US5834265A
公开(公告)日：1998-11-10
申请号：US459324
申请日：1995-06-02
申请人： Hubert Mullner , Eugen Uhlmann , Peter Eckes , Rudolf Schneider , Bernadus Uijtewaal
发明人： Hubert Mullner , Eugen Uhlmann , Peter Eckes , Rudolf Schneider , Bernadus Uijtewaal
IPC分类号： A01H1/00 , A01H5/00 , A01N57/16 , A01N63/00 , C07H21/02 , C07H21/04 , C12N5/10 , C12N9/00 , C12N15/113 , C12N15/82 , C12N15/63 , A61K48/00 , C12N5/04
CPC分类号： C12N15/113 , C12N15/1131 , C12N15/8283 , C12N2310/111 , C12N2310/12 , C12N2310/121
摘要： A multifunctional RNA having self-processing activity, the preparation thereof and the use thereof Host cells can be transformed so that they express ribozyme RNA and antisense RNA which are connected with each other via a spacer. The RNA molecules can, for example, be complementary to a certain viral RNA. Plants which have been transformed with genes coding for RNA of this type show a significantly improved resistance to viruses.
摘要翻译：具有自身加工活性的多功能RNA及其制备及其用途宿主细胞可以转化，以便它们表达通过间隔物相互连接的核酶RNA和反义RNA。 RNA分子可以例如与某种病毒RNA互补。已经用编码这种类型的RNA的基因转化的植物显示出显着提高的对病毒的抗性。

3. 发明授权

US5707840A Multifunctional RNA having self-processing activity, the preparation thereof and the use thereof 失效
标题翻译：具有自身加工活性的多功能RNA，其制备及其用途
公开(公告)号：US5707840A
公开(公告)日：1998-01-13
申请号：US313608
申请日：1994-09-29
申请人： Hubert Mullner , Eugen Uhlmann , Peter Eckes , Rudolf Schneider , Bernadus Uijtewaal
发明人： Hubert Mullner , Eugen Uhlmann , Peter Eckes , Rudolf Schneider , Bernadus Uijtewaal
IPC分类号： A01H1/00 , A01H5/00 , A01N57/16 , A01N63/00 , C07H21/02 , C07H21/04 , C12N5/10 , C12N9/00 , C12N15/113 , C12N15/82 , C12N15/00 , A01N43/04 , C12N5/00
CPC分类号： C12N15/113 , C12N15/1131 , C12N15/8283 , C12N2310/111 , C12N2310/12 , C12N2310/121
摘要： A multifunctional RNA having self-processing activity, the preparation thereof and the use thereof. Host cells can be transformed so that they express ribozyme RNA and antisense RNA which are connected with each other via a spacer. The RNA molecules can, for example, be complementary to a certain viral RNA. Plants which have been transformed with genes coding for RNA of this type show a significantly improved resistance to viruses.
摘要翻译：具有自身加工活性的多功能RNA及其制备方法及其用途。宿主细胞可以转化，使得它们表达通过间隔物彼此连接的核酶RNA和反义RNA。 RNA分子可以例如与某种病毒RNA互补。已经用编码这种类型的RNA的基因转化的植物显示出显着提高的对病毒的抗性。

4. 发明申请

US20110244025A1 MODIFIED OLIGORIBONUCLEOTIDE ANALOGS WITH ENHANCED IMMUNOSTIMULATORY ACTIVITY 审中-公开
标题翻译：改良的寡核苷酸类似物与增强的免疫活性
公开(公告)号：US20110244025A1
公开(公告)日：2011-10-06
申请号：US12946379
申请日：2010-11-15
申请人： Eugen Uhlmann , Arthur M. Krieg , Grayson B. Lipford
发明人： Eugen Uhlmann , Arthur M. Krieg , Grayson B. Lipford
IPC分类号： A61K9/127 , C07H21/02 , A61K39/00 , A61P11/00 , A61P31/14 , A61P35/00 , A61P37/08 , A61P37/04 , A61P11/06 , C12N5/02 , B82Y5/00
CPC分类号： C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/3183 , C12N2310/321 , C12N2310/3515 , C12N2310/3529
摘要： The invention provides immunostimulatory compositions and methods for their use. In particular, the immunostimulatory compositions of the invention include RNA-like polymers that incorporate an immunostimulatory sequence motif and at least one chemical modification to confer improved stability against nuclease degradation and improved activity. Specific modifications involving phosphate linkages, nucleotide analogs, and combinations thereof are provided. Compositions of the invention optionally include an antigen and can be used to stimulate an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an to allergic condition, or asthma. Modified oligoribonucleotide analogs of the invention are believed to stimulate Toll-like receptors TLR7 and TLR8.
摘要翻译：本发明提供免疫刺激组合物及其使用方法。特别地，本发明的免疫刺激组合物包括纳入免疫刺激序列基序的RNA样聚合物和至少一种化学修饰，以提供改善的对核酸酶降解的稳定性和改善的活性。提供了涉及磷酸键，核苷酸类似物及其组合的具体修饰。本发明的组合物任选地包括抗原并且可以用于刺激免疫应答。还提供了可用于治疗感染，癌症，过敏性疾病或哮喘的受试者的组合物和方法。据信本发明的修饰的寡核糖核苷酸类似物刺激Toll样受体TLR7和TLR8。

5. 发明授权

US07956043B2 5′ CpG nucleic acids and methods of use 失效
标题翻译： 5'CpG核酸和使用方法
公开(公告)号：US07956043B2
公开(公告)日：2011-06-07
申请号：US10735592
申请日：2003-12-11
申请人： Arthur M. Krieg , Marion Jurk , Jorg Vollmer , Eugen Uhlmann
发明人： Arthur M. Krieg , Marion Jurk , Jorg Vollmer , Eugen Uhlmann
IPC分类号： A61K45/00 , A61K47/00 , A61K31/70 , A01N43/04
CPC分类号： C12N15/117 , A61K2039/55561 , C07H21/04 , C12N2310/315
摘要： The invention relates to a class of CpG immunostimulatory oligonucleotides containing a 5′TCG motif or a CG at or near the 5′ end that are useful for stimulating an immune response.
摘要翻译：本发明涉及一类含有5'5GG基序或在5'端或附近的可用于刺激免疫应答的CpG免疫刺激性寡核苷酸。

6. 发明申请

US20110098456A1 IMMUNE STIMULATORY OLIGONUCLEOTIDE ANALOGS CONTAINING MODIFIED SUGAR MOIETIES 有权
标题翻译：含有改性糖酵母的免疫刺激寡核苷酸模拟物
公开(公告)号：US20110098456A1
公开(公告)日：2011-04-28
申请号：US12681800
申请日：2008-09-09
申请人： Eugen Uhlmann , Harald Debelak , Marion Jurk , Markus Weber
发明人： Eugen Uhlmann , Harald Debelak , Marion Jurk , Markus Weber
IPC分类号： C07H21/04 , C07H21/02
CPC分类号： A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/32 , C12N2310/322
摘要： The invention relates to oligonucleotides including at least one FANA substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof.
摘要翻译：本发明涉及包含至少一种FANA取代的核苷酸类似物和嘧啶 - 嘌呤二核苷酸的寡核苷酸。本发明还涉及药物组合物及其使用方法。

7. 发明申请

US20100285041A1 Class A Oligonucleotides with Immunostimulatory Potency 审中-公开
标题翻译： A类具有免疫刺激效能的寡核苷酸
公开(公告)号：US20100285041A1
公开(公告)日：2010-11-11
申请号：US12600364
申请日：2008-05-15
申请人： Eugen Uhlmann , Jörg Vollmer , Arthur Mertz Kreig
发明人： Eugen Uhlmann , Jörg Vollmer , Arthur Mertz Kreig
IPC分类号： A61K39/00 , C07H21/04 , A61P35/00 , A61P31/00 , A61P37/08 , A61P37/04 , A61P11/06
CPC分类号： A61K39/39 , A61K2039/55561
摘要： The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
摘要翻译：本发明提供了包含CpG基序的免疫刺激性核酸及其在刺激免疫中的用途。

8. 发明授权

US07550582B2 Polyamide nucleic acid derivatives and agents, and processes for preparing them 失效
标题翻译：聚酰胺核酸衍生物和试剂，及其制备方法
公开(公告)号：US07550582B2
公开(公告)日：2009-06-23
申请号：US11855443
申请日：2007-09-14
申请人： Eugen Uhlmann , Gerhard Breipohl , David William Will
发明人： Eugen Uhlmann , Gerhard Breipohl , David William Will
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07K14/003 , A61K38/00 , Y10T436/143333
摘要： The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or groups which increase the binding affinity of the PNA derivative for nucleic acids. The invention furthermore relates to a process for preparing the above-mentioned PNA derivatives and to their use as pharmaceuticals or diagnostic agents.
摘要翻译：本发明涉及在C末端或在PNA主链的C和N末端携带一个或多个磷酰基的PNA衍生物。磷酰基在适当的情况下携带一个或多个标记基团，用于交联的基团，促进细胞内摄取的基团，或增加PNA衍生物对核酸的结合亲和力的基团。本发明还涉及制备上述PNA衍生物的方法及其作为药物或诊断剂的用途。

9. 发明授权

US07485421B2 Polyamide-oligonucleotide derivatives, their preparation and use 失效
标题翻译：聚酰胺 - 寡核苷酸衍生物，其制备和用途
公开(公告)号：US07485421B2
公开(公告)日：2009-02-03
申请号：US10939214
申请日：2004-09-10
申请人： Eugen Uhlmann , Gerhard Breipohl
发明人： Eugen Uhlmann , Gerhard Breipohl
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07H21/00 , A61K47/59 , A61K47/595 , A61K47/60 , A61K47/605 , C07K14/003
摘要： Polyamide-oligonucleotide derivatives of the formula F[(DNA-Li)q(PNA-Li)r(DNA-Li)s(PNA)t]xF′ wherein q, r, s, t are, independently of one another, zero or 1, where the total of two or more adjacent q, r, s and t≧2; x is 1 to 20; DNA is a nucleic acid such as DNA or RNA or a known derivative thereof; Li is a covalent linkage between DNA and PNA, where the covalent linkage comprises a bond or an organic radical with at least one atom from the series consisting of C, N, O or S; PNA is a polyamide structure which contains at least one nucleotide base which is different from thymine; and F and F′ are end groups and/or are linked together by a covalent bond, and the physiologically tolerated salts thereof, a process for their preparation and their use as pharmaceutical, as gene probe and as primer, are described.
摘要翻译： F [（DNA-Li）q（PNA-Li）r（DNA-Li）s（（N-1））其中q，r，s，t彼此独立地为0或1，其中总共为两个或更多个相邻的q，r，s和t> = 2; x为1〜20; DNA是核酸如DNA或RNA或其已知衍生物; Li是DNA与PNA之间的共价连接，其中共价连接包含与C，N，O或S组成的系列中至少一个原子的键或有机基团; PNA是含有与胸腺嘧啶不同的至少一个核苷酸碱基的聚酰胺结构; 并且F和F'是端基和/或通过共价键连接在一起，并且描述了其生理学上耐受的盐，它们的制备方法及其作为药物的用途，作为基因探针和引物。

10. 发明授权

US07241882B2 Polyamide nucleic acid derivatives, and agents, and processes for preparing them 有权
标题翻译：聚酰胺核酸衍生物和试剂，及其制备方法
公开(公告)号：US07241882B2
公开(公告)日：2007-07-10
申请号：US10863999
申请日：2004-06-09
申请人： Eugen Uhlmann , Gerhard Breipohl , David William Will
发明人： Eugen Uhlmann , Gerhard Breipohl , David William Will
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07H21/00
摘要： The present invention relates to PNA derivatives which carry, at the N terminus of the PNA backbone, a phosphoryl radical. The phosphoryl radical can be, for example, a phosphate radical, or a substituted phosphoryl radical, with substituted phosphoryl derivatives carrying, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or groups which increase the binding affinity of the PNA derivative for nucleic acids. The invention furthermore relates to a process for preparing the abovementioned PNA derivatives and to their use as pharmaceuticals and diagnostic agents.
摘要翻译：本发明涉及在PNA主链的N末端携带磷酰基的PNA衍生物。磷酰基可以是例如磷酸根或取代的磷酰基，其中取代的磷酰基衍生物在适当的情况下携带一个或多个标记基团，交联基团，促进细胞内摄取的基团或增加结合的基团 PNA衍生物对核酸的亲和力。本发明还涉及制备上述PNA衍生物的方法及其作为药物和诊断剂的用途。

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