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1. 发明申请

WO2016076994A1 HIGH CAPACITY STRUCTURES AND MONOLITHS VIA PASTE IMPRINTING 审中-公开
标题翻译：高容量结构和单体通过油漆印刷
公开(公告)号：WO2016076994A1
公开(公告)日：2016-05-19
申请号：PCT/US2015/055088
申请日：2015-10-12
申请人： EXXONMOBIL UPSTREAM RESEARCH COMPANY , FOWLER, Tracy, A. , SMITH, Thomas, M. , CUTLER, Joshua, I. , WALP, Jenna, L.
发明人： FOWLER, Tracy, A. , SMITH, Thomas, M. , CUTLER, Joshua, I. , WALP, Jenna, L.
IPC分类号： C04B38/00 , B01J35/00 , C04B28/24
CPC分类号： B01J35/04 , B01J29/06 , B01J37/0244 , B32B3/12 , B32B37/0076 , B32B38/0012 , B32B2255/06 , B32B2255/20 , B32B2311/00 , C04B28/24 , C04B38/008 , C04B2111/00612 , C04B2111/00637 , C04B2111/0081 , C04B12/04 , C04B14/047 , C04B24/383
摘要： The disclosure relate generally to structures, forms, and monoliths, and methods of preparing the same. This disclosure can produce uniform structured passageways or channels of active material, including adsorbent or catalyst, by imprinting or molding features into a paste on a support that can be subsequently assembled into a gas or liquid treating structure, i.e. a monolith. The paste, which can include an active material, binder, and other potential additives, can be applied to the support or pushed through a support (as in a mesh) as a thin film. The paste can be imprinted, stamped, shaped or otherwise handled to give features of desired height, shape, width, and positioning. When stacked or rolled, the features of one layer contact a subsequent layer, which seal to form passageways. The resulting structure can have high cell-density (>1000 cells per square inch) and a large volume fraction of active material.
摘要翻译：本公开一般涉及结构，形式和整体以及制备它们的方法。本公开可以通过将特征压印或模制成在支撑体上的糊料中而产生均匀的结构化通道或活性材料通道，包括吸附剂或催化剂，其可以随后组装成气体或液体处理结构，即整料。可以将包含活性物质，粘合剂和其它潜在添加剂的糊剂施加到支撑体上或者通过作为薄膜的支撑体（如网状物）推动。糊状物可以被印刷，冲压，成型或以其他方式处理，以提供所需高度，形状，宽度和定位的特征。当堆叠或卷起时，一层的特征接触后续层，密封以形成通道。所得结构可以具有高的细胞密度（> 1000个细胞/平方英寸）和大体积分数的活性物质。

2. 发明公开

EP3218326A1 HIGH CAPACITY STRUCTURES AND MONOLITHS VIA PASTE IMPRINTING 有权转让
标题翻译：高容量结构和通过粘贴印刷的单片
公开(公告)号：EP3218326A1
公开(公告)日：2017-09-20
申请号：EP15791812.9
申请日：2015-10-12
申请人： ExxonMobil Upstream Research Company
发明人： FOWLER, Tracy, A. , SMITH, Thomas, M. , CUTLER, Joshua, I. , WALP, Jenna, L.
IPC分类号： C04B38/00 , B01J35/00 , C04B28/24
摘要： The disclosure relate generally to structures, forms, and monoliths, and methods of preparing the same. This disclosure can produce uniform structured passageways or channels of active material, including adsorbent or catalyst, by imprinting or molding features into a paste on a support that can be subsequently assembled into a gas or liquid treating structure, i.e. a monolith. The paste, which can include an active material, binder, and other potential additives, can be applied to the support or pushed through a support (as in a mesh) as a thin film. The paste can be imprinted, stamped, shaped or otherwise handled to give features of desired height, shape, width, and positioning. When stacked or rolled, the features of one layer contact a subsequent layer, which seal to form passageways. The resulting structure can have high cell-density (>1000 cells per square inch) and a large volume fraction of active material.
摘要翻译：本公开总体上涉及结构，形式和整料以及制备它们的方法。本公开可通过将特征压印或模制到支撑物上的糊剂中而产生均匀结构化的通道或活性材料通道，包括吸附剂或催化剂，所述通道或通道随后可组装成气体或液体处理结构，即整料。可以包括活性材料，粘合剂和其他潜在添加剂的糊剂可以被施加到支撑件上或者作为薄膜被推过支撑件（如在网状物中）。可以压印，冲压，成型或以其他方式处理该膏以提供期望的高度，形状，宽度和定位的特征。当堆叠或卷绕时，一层的特征接触后续层，该密封形成通道。所得到的结构可以具有高细胞密度（>每平方英寸1000个细胞）和大体积分数的活性物质。

3. 发明授权

EP3218326B1 HIGH CAPACITY STRUCTURES AND MONOLITHS VIA PASTE IMPRINTING 有权转让
公开(公告)号：EP3218326B1
公开(公告)日：2020-03-04
申请号：EP15791812.9
申请日：2015-10-12
申请人： ExxonMobil Upstream Research Company
发明人： FOWLER, Tracy, A. , SMITH, Thomas, M. , CUTLER, Joshua, I. , WALP, Jenna, L.
IPC分类号： C04B38/00 , B01J35/00 , C04B28/24

4. 发明申请

WO2009017491A1 METHODS FOR PURIFYING ANTIBODIES USING CERAMIC HYDROXYAPATITE 审中-公开
标题翻译：使用陶瓷羟基磷灰石来治疗抗体的方法
公开(公告)号：WO2009017491A1
公开(公告)日：2009-02-05
申请号：PCT/US2007/071055
申请日：2007-06-13
申请人： SMITHKLINE BEECHAM CORPORATION , MAZZOLA, Gregory, J. , SMITH, Thomas, M.
发明人： MAZZOLA, Gregory, J. , SMITH, Thomas, M.
IPC分类号： C07K1/22
CPC分类号： C07K1/20 , C07K1/18 , C07K16/065
摘要： This invention relates to the purification of monoclonal antibodies from mammalian cell culture fluid utilizing sequential, orthogonal chromatography and filtration techniques resulting in material of high purity and quality that is suitable for human administration. The method involves capturing an IgG product using immobilized protein A affinity chromatography, followed by at least one ion exchange technique prior to adsorbing the IgG to hydroxyapatite and selectively eluting the product in a single isocratic step to achieve purification from impurities and simultaneously reducing multiple types of impurities including but not limited to IgG aggregates, residual protein A, non-IgG proteins, host cell proteins, viral particles, and DNA.
摘要翻译：本发明涉及使用顺序，正交色谱和过滤技术从哺乳动物细胞培养液中纯化单克隆抗体，产生适于人类施用的高纯度和高质量的材料。该方法包括使用固定化蛋白A亲和色谱法捕获IgG产物，接着在将IgG吸附到羟基磷灰石之前进行至少一种离子交换技术，并在单个等度梯度步骤中选择性洗脱产物，以实现纯化从杂质中同时降低多种类型杂质包括但不限于IgG聚集体，残留蛋白A，非IgG蛋白，宿主细胞蛋白，病毒颗粒和DNA。

5. 发明申请

WO2003054153A3 APYRASE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING SAME 审中-公开
公开(公告)号：WO2003054153A3
公开(公告)日：2003-07-03
申请号：PCT/US2002/039643
申请日：2002-12-12
申请人： UNIVERSITY OF CINCINNATI , SMITH, Thomas, M. , KIRLEY, Terence, L.
发明人： SMITH, Thomas, M. , KIRLEY, Terence, L.
IPC分类号： C12N33/53
摘要： The present invention provides novel isolated polynucleotides encoding a novel extracellular nucleotidase, which belongs to a new family of calcium dependent apyrases. Also provided are antibodies that immunospecifically bind to the apyrase polypeptide or any derivative (including fusion derivative), variant, mutant or fragment of the novel polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the apyrase polypeptide, polynucleotide and antibody are utilized in the treatment of vascular disorders, including disorders characterized by platelet aggregation.

6. 发明申请

WO2003054153A2 APYRASE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译： APYRASE多肽和编码相同的核酸
公开(公告)号：WO2003054153A2
公开(公告)日：2003-07-03
申请号：PCT/US2002/039643
申请日：2002-12-12
申请人： UNIVERSITY OF CINCINNATI , SMITH, Thomas, M. , KIRLEY, Terence, L.
发明人： SMITH, Thomas, M. , KIRLEY, Terence, L.
IPC分类号： C12N
CPC分类号： C12N9/14 , A61K38/00
摘要： The present invention provides novel isolated polynucleotides encoding a novel extracellular nucleotidase, which belongs to a new family of calcium dependent apyrases. Also provided are antibodies that immunospecifically bind to the apyrase polypeptide or any derivative (including fusion derivative), variant, mutant or fragment of the novel polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the apyrase polypeptide, polynucleotide and antibody are utilized in the treatment of vascular disorders, including disorders characterized by platelet aggregation.
摘要翻译：本发明提供了新的分离的多核苷酸，其编码新的细胞外核苷酸酶，其属于钙依赖性腺苷三磷酸双磷酸酶的新家族。还提供了与腺苷三磷酸双磷酸酶多肽或新多肽，多核苷酸或抗体的任何衍生物（包括融合衍生物），变体，突变体或片段免疫特异性结合的抗体。本发明另外提供了其中腺苷三磷酸双磷酸酶多肽，多核苷酸和抗体用于治疗血管疾病，包括以血小板聚集为特征的疾病的方法。

7. 发明申请

WO2008024259A1 METHOD AND APPARATUS FOR CONNECTING A CALLER PREVIOUSLY DIVERTED TO VOICEMAIL 审中-公开
标题翻译：用于连接先前传播给VOICEMAIL的电话的方法和装置
公开(公告)号：WO2008024259A1
公开(公告)日：2008-02-28
申请号：PCT/US2007/018126
申请日：2007-08-15
申请人： AT & T CORP , HANSON, Karrie, Jo , HENDERSON, Donnie , SMITH, Thomas, M.
发明人： HANSON, Karrie, Jo , HENDERSON, Donnie , SMITH, Thomas, M.
IPC分类号： H04M3/20 , H04M3/436 , H04M3/533
CPC分类号： H04W4/12 , H04M3/53333
摘要： Disclosed is a method and apparatus for enabling communication between a first party and a second party. The method and apparatus determine that the second party is calling the first party while the first party is leaving a message on the voicemail of the second party. The message is then aborted and the first party is connected to the second party.
摘要翻译：公开了一种用于实现第一方和第二方之间的通信的方法和装置。当第一方在第二方的语音邮件上留下消息时，该方法和装置确定第二方正在呼叫第一方。然后中止消息，并且第一方连接到第二方。

8. 发明申请

WO2007140317A3 USE OF INHIBITORS OF CYTOSOLIC PH0SPH0LIPASE A2 IN THE TREATMENT OF THROMBOSIS 审中-公开
公开(公告)号：WO2007140317A3
公开(公告)日：2007-12-06
申请号：PCT/US2007/069772
申请日：2007-05-25
申请人： WYETH , CLERIN, Valerie , LEE, Katherine , SMITH, Thomas, M.
发明人： CLERIN, Valerie , LEE, Katherine , SMITH, Thomas, M.
IPC分类号： A61K31/405
摘要： This invention provides methods for the use of substituted indole compounds of the general formula: (I) and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds in the treating or preventing thrombosis in a mammal, or preventing progression of symptoms of thrombosis.

9. 发明申请

WO2004085931A2 A THERMAL FLUID HEATER 审中-公开
标题翻译：热流道加热器
公开(公告)号：WO2004085931A2
公开(公告)日：2004-10-07
申请号：PCT/US2004/008240
申请日：2004-03-18
申请人： SMITH, Thomas, M.
发明人： SMITH, Thomas, M.
IPC分类号： F24H
CPC分类号： F24H1/41 , F24H1/38 , F24H1/44 , F28F2245/06
摘要： The invention is an improved thermal fluid heater that is energy efficient and pollution free. The fluid is preferably preheated prior to entering the heating chamber with the recycled exhaust gas. By preheating the fluid prior to reaching the heater chamber thereby saves heating cost of the fluid. The thermal fluid heater preferably contains a U-shaped tube or serpentine finned tubes that permits a fluid to travel through the tube and has an outer channel that permits the recycled gas or steam to travel through it. The fluid then travels through at least one IR heater. The temperature of the exiting fluid can be controlled and used as a heating source.
摘要翻译：本发明是一种改进的热流体加热器，其能量效率高，无污染。流体优选在被再循环废气进入加热室之前预热。通过在到达加热器室之前预热流体，从而节省流体的加热成本。热流体加热器优选地包含U形管或蛇形翅片管，其允许流体穿过管并且具有允许再循环气体或蒸汽穿过其的外部通道。然后流体穿过至少一个IR加热器。排出流体的温度可以被控制并用作加热源。

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