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1. 发明申请

WO2006025979A2 MODULATORS OF NUCLEAR RECEPTORS 审中-公开
标题翻译：核受体调节剂
公开(公告)号：WO2006025979A2
公开(公告)日：2006-03-09
申请号：PCT/US2005026353
申请日：2005-07-24
申请人： EXELIXIS INC , BAYNE CHRISTOPHER D , JOHNSON ALAN T , LU SHAO-PO , MOHAN RAJU , NYMAN MICHAEL C , SCHWEIGER EDWIN J , STEVENS WILLIAM C JR , WANG HAIXIA , XIE YINONG , BANNEN LYNNE CANNE , CHAN DIVA SZE-MING , HUANG PING , JAMMALAMADAKA VASU , KHOURY RICHARD G , MAC MORRISON B , PARKS JASON JEVIOUS , WANG YONG , XU WEI
发明人： BAYNE CHRISTOPHER D , JOHNSON ALAN T , LU SHAO-PO , MOHAN RAJU , NYMAN MICHAEL C , SCHWEIGER EDWIN J , STEVENS WILLIAM C JR , WANG HAIXIA , XIE YINONG , BANNEN LYNNE CANNE , CHAN DIVA SZE-MING , HUANG PING , JAMMALAMADAKA VASU , KHOURY RICHARD G , MAC MORRISON B , PARKS JASON JEVIOUS , WANG YONG , XU WEI
IPC分类号： A61K31/4439 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
CPC分类号： C07D401/12 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
摘要： Compounds of the invention, such as compounds of formula (I), where n, m, A, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译：本发明的化合物，例如其中n，m，A，R 1，R 2，R 3，R 4和R 5如本文所定义的式（I）化合物可用作肝X受体活性的调节剂。还公开了含有该化合物的药物组合物和使用该化合物的方法。

2. 发明申请

WO2006025979A9 MODULATORS OF NUCLEAR RECEPTORS 审中-公开
公开(公告)号：WO2006025979A9
公开(公告)日：2006-04-20
申请号：PCT/US2005026353
申请日：2005-07-24
申请人： EXELIXIS INC , BAYNE CHRISTOPHER D , JOHNSON ALAN T , LU SHAO-PO , MOHAN RAJU , NYMAN MICHAEL C , SCHWEIGER EDWIN J , STEVENS WILLIAM C JR , WANG HAIXIA , XIE YINONG , BANNEN LYNNE CANNE , CHAN DIVA SZE-MING , HUANG PING , JAMMALAMADAKA VASU , KHOURY RICHARD G , MAC MORRISON B , PARKS JASON JEVIOUS , WANG YONG , XU WEI
发明人： BAYNE CHRISTOPHER D , JOHNSON ALAN T , LU SHAO-PO , MOHAN RAJU , NYMAN MICHAEL C , SCHWEIGER EDWIN J , STEVENS WILLIAM C JR , WANG HAIXIA , XIE YINONG , BANNEN LYNNE CANNE , CHAN DIVA SZE-MING , HUANG PING , JAMMALAMADAKA VASU , KHOURY RICHARD G , MAC MORRISON B , PARKS JASON JEVIOUS , WANG YONG , XU WEI
IPC分类号： A61K31/4439 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
CPC分类号： C07D401/12 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
摘要： Compounds of the invention, such as compounds of formula (I), where n, m, A, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.

3. 发明申请

WO2004058717A8 ISOQUINOLINONE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS 审中-公开
标题翻译：异喹啉酮衍生物及其作为治疗剂的用途
公开(公告)号：WO2004058717A8
公开(公告)日：2004-08-19
申请号：PCT/US0340275
申请日：2003-12-17
申请人： X CEPTOR THERAPEUTICS INC , SANKYO CO , JOHNSON ALAN T , KANEKO SATORU , MOHAN RAJU , ODA KOZO , SCHWEIGER EDWIN J
发明人： JOHNSON ALAN T , KANEKO SATORU , MOHAN RAJU , ODA KOZO , SCHWEIGER EDWIN J
IPC分类号： A61P3/06 , C07D217/24 , C07D405/04 , C07D409/04 , A61K31/4704 , C07D401/12
CPC分类号： C07D405/04 , C07D217/24 , C07D409/04
摘要： This invention is directed to isoquinolinone derivatives and their use in modulating the activity of orphan nuclear receptors, pharmaceutical compositions containing such derivatives, and methods of using such derivatives in treating disease-states associated with nuclear receptor activity.
摘要翻译：本发明涉及异喹啉酮衍生物及其在调节孤核受体活性中的用途，含有该衍生物的药物组合物，以及使用该衍生物治疗与核受体活性有关的疾病状态的方法。

4. 发明申请

WO2012021677A3 LARGE-SCALE GRAPHENE SHEET: ARTICLES, COMPOSITIONS, METHODS AND DEVICES INCORPORATING SAME 审中-公开
标题翻译：大规格石墨片：与其合成的文章，组成，方法和设备
公开(公告)号：WO2012021677A3
公开(公告)日：2012-08-09
申请号：PCT/US2011047369
申请日：2011-08-11
申请人： UNIV PENNSYLVANIA , JOHNSON ALAN T , LUO ZHENGTANG
发明人： JOHNSON ALAN T , LUO ZHENGTANG
IPC分类号： C01B31/00
CPC分类号： C01B32/186 , B82Y30/00 , B82Y40/00 , C01B32/194 , C01B2204/02 , C01B2204/20 , C01B2204/32 , H01L21/02425 , H01L21/0243 , H01L21/02527 , H01L21/0262 , H01L21/02658 , H01L21/28506 , H01L29/1606 , H01L29/7782
摘要： Provided are methods for growing large-size, uniform graphene layers on planarized substrates using Chemical Vapor Deposition (CVD) at atmospheric pressure; graphene produced according to these methods may have a single layer content exceeding 95%. Field effect transistors fabricated by the inventive process have room temperature hole mobilities that are a factor of 2-5 larger than those measured for samples grown on commercially-available copper foil substrates.
摘要翻译：提供了在大气压下使用化学气相沉积（CVD）在平坦化衬底上生长大尺寸均匀石墨烯层的方法; 根据这些方法生产的石墨烯可以具有超过95％的单层含量。通过本发明方法制造的场效应晶体管具有比在商业上可获得的铜箔衬底上生长的样品测量的室温孔迁移率高2-5倍的室温空穴迁移率。

5. 发明申请

WO9709297A3 SYNTHESIS AND USE OF RETINOID COMPOUNDS HAVING NEGATIVE HORMONE AND/OR ANTAGONIST ACTIVITIES 审中-公开
标题翻译：具有负激素和/或拮抗剂活性的复方化合物的合成和用途
公开(公告)号：WO9709297A3
公开(公告)日：1997-08-28
申请号：PCT/US9613779
申请日：1996-08-23
申请人： ALLERGAN INC , KLEIN ELLIOTT S , JOHNSON ALAN T , STANDEVEN ANDREW M , BEARD RICHARD L , GILLETT SAMUEL J , DUONG TIEN T , NAGPAL SUNIL , VULIGONDA VIDYASAGAR , TENG MIN , CHANDRARATNA ROSHANTHA A
发明人： KLEIN ELLIOTT S , JOHNSON ALAN T , STANDEVEN ANDREW M , BEARD RICHARD L , GILLETT SAMUEL J , DUONG TIEN T , NAGPAL SUNIL , VULIGONDA VIDYASAGAR , TENG MIN , CHANDRARATNA ROSHANTHA A
IPC分类号： C07D317/26 , A61K31/15 , A61K31/192 , A61K31/215 , A61K31/216 , A61K31/341 , A61K31/352 , A61K31/357 , A61K31/37 , A61K31/381 , A61K31/382 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/47 , A61K38/09 , A61P5/00 , A61P39/02 , C07C20060101 , C07C57/50 , C07C63/33 , C07C63/331 , C07C63/49 , C07C63/66 , C07C63/72 , C07C63/74 , C07C65/19 , C07C65/28 , C07C65/38 , C07C69/48 , C07C69/618 , C07C69/76 , C07C69/773 , C07C69/90 , C07C69/94 , C07C233/81 , C07C245/10 , C07C327/48 , C07C335/06 , C07C403/20 , C07D20060101 , C07D213/55 , C07D215/12 , C07D277/20 , C07D277/30 , C07D307/54 , C07D311/58 , C07D333/24 , C07D335/06 , C07F7/08 , C07C69/78 , C07D307/16
CPC分类号： C07D335/06 , C07C57/50 , C07C63/33 , C07C63/49 , C07C63/66 , C07C63/72 , C07C63/74 , C07C65/19 , C07C65/28 , C07C65/38 , C07C69/618 , C07C69/76 , C07C69/90 , C07C69/94 , C07C233/81 , C07C245/10 , C07C327/48 , C07C2602/10 , C07D213/55 , C07D277/30 , C07D307/54 , C07D333/24 , C07F7/0818
摘要： The invention provides a compound of the formula wherein X is S, O, NR' where R' is H or alkyl of 1 to 6 carbons, or X is ÄC(R1)2Ün where R1 is independently H or alkyl of 1 to 6 carbons, and n is an integer between 0 and 2; R2 is hydrogen, lower alkyl of 1 to 6 carbons, F, Cl, Br, I, CF3, fluoro substituted alkyl of 1 to 6 carbons, OH, SH, alkoxy of 1 to 6 carbons, or alkylthio of 1 to 6 carbons; R3 is hydrogen, lower alkyl of 1 to 6 carbons or F; m is an integer having the value 0-3; o is an integer having the value 0-3; Y is a phenyl or naphthyl group, or heteroaryl selected from a group consisting of pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl and pyrrazolyl, said phenyl and heteroaryl groups being optionally substituted with one or two R2 groups; A is (CH2)q where q is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR8, CONR9R10, -CH2OH, CH2OR11, CH2OCOR11, CHO, CH(OR12)2, CHOR13O, -COR7, CR7(OR12)2, CR7OR13O, or tri-lower alkylsilyl, where R7 is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R8 is an alkyl group of 1 to 10 carbons or trimethylsilylalkyl where the alkyl group has 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R8 is phenyl or lower alkylphenyl, R9 and R10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower alkylphenyl, R11 is lower alkyl, phenyl or lower alkylphenyl, R12 is lower alkyl, and R13 is divalent alkyl radical of 2-5 carbons, and R14 is (R15)r-phenyl, (R15)r-naphthyl, or (R15)r-heteroaryl where the heteroaryl group has 1 to 3 heteroatoms selected from the group consisting of O, S and N, r is an integer having the values of 0-5, and R15 is independently H, F, Cl, Br, I, NO2, N(R8)2, N(R8)COR8, NR8CON(R8)2, OH, OCOR8, OR8, CN, an alkyl group having 1 to 10 carbons, fluoro substituted alkyl group having 1 to 10 carbons, an alkenyl group having 1 to 10 carbons and 1 to 3 double bonds, alkynyl group having 1 to 10 carbons and 1 to 3 triple bonds, or a trialkylsilyl or trialkylsilyloxy group where the alkyl groups independently have 1 to 6 carbons; R16 is H, lower alkyl of 1 to 6 carbons; R17 is H, lower alkyl of 1 to 6 carbons, OH or OCOR11, and p is zero or 1, with the proviso that when p is 1 then there is no R17 substituent group, and m is an integer between 0 and 2.

6. 发明申请

WO2008147480A3 HYDROXAMIC ACID DERIVATIVES OF 3-PHENYL PROPIONIC ACIDS USEFUL AS THRAPEUTIC AGENTS FOR TREATING ANTHRAX POISONING 审中-公开
标题翻译：用于治疗荨麻疹中毒的3-异丙基丙酸的异羟肟酸衍生物
公开(公告)号：WO2008147480A3
公开(公告)日：2009-02-26
申请号：PCT/US2008001207
申请日：2008-01-30
申请人： PANTHERA BIOPHARNA LLC , JOHNSON ALAN T , JIAO GUAN-SHENG
发明人： JOHNSON ALAN T , JIAO GUAN-SHENG
IPC分类号： C07C259/06 , A61K31/164 , A61P39/02
CPC分类号： C07C259/06 , C07B2200/07
摘要： Compounds having the formula (I) wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of 3 -phenyl-propionic acid and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.
摘要翻译：具有式（I）的化合物（其中符号具有说明书中描述的含义）是3-苯基 - 丙酸的异羟肟酸衍生物并且能够抑制炭疽细菌感染的致死作用，并且可用于治疗炭疽中毒。

7. 发明申请

WO2009008905A4 HYDROXAMIC ACID DERIVATIVES OF PHENOXY-ACETIC ACIDS AND ANALOGS USEFUL AS THERAPEUTIC AGENTS FOR TREATING ANTHRAX POISONING 审中-公开
标题翻译：用于治疗荨麻疹中毒的用作治疗剂的苯氧乙酸和类似物的羟氨酸衍生物
公开(公告)号：WO2009008905A4
公开(公告)日：2009-03-05
申请号：PCT/US2008001260
申请日：2008-01-30
申请人： PANTHERA BIOPHARMA LLC , JOHNSON ALAN T , GUAN-SHENG JIAO , KIM SEONGJIN
发明人： JOHNSON ALAN T , GUAN-SHENG JIAO , KIM SEONGJIN
IPC分类号： C07C259/06 , A61K31/165 , A61K31/341 , A61K31/381 , A61K31/4545 , A61P31/04 , C07C317/44 , C07C321/28 , C07D307/52 , C07D333/20 , C07D401/06
CPC分类号： C07C259/06 , C07C317/44 , C07C323/60 , C07D211/26 , C07D307/52 , C07D333/20
摘要： Compounds having the formula : (I) wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of phenoxy-acetic acids and analogs capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.
摘要翻译：具有下式的化合物：（I）其中各符号具有说明书中所描述的含义是能够通过炭疽病菌抑制感染的致死作用的苯氧基 - 乙酸和类似物的异羟肟酸衍生物，并在由炭疽治疗中毒的有用。

8. 发明申请

WO2008147480A8 HYDROXAMIC ACID DERIVATIVES OF 3-PHENYL PROPIONIC ACIDS USEFUL AS THRAPEUTIC AGENTS FOR TREATING ANTHRAX POISONING 审中-公开
标题翻译：三苯基丙酸的羟基酸衍生物作为治疗神经毒素的治疗药物有用
公开(公告)号：WO2008147480A8
公开(公告)日：2009-01-15
申请号：PCT/US2008001207
申请日：2008-01-30
申请人： PANTHERA BIOPHARNA LLC , JOHNSON ALAN T , JIAO GUAN-SHENG
发明人： JOHNSON ALAN T , JIAO GUAN-SHENG
IPC分类号： C07C259/06 , A61K31/164 , A61P39/02
CPC分类号： C07C259/06 , C07B2200/07
摘要： Compounds having the formula (I) wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of 3 -phenyl-propionic acid and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.
摘要翻译：具有式（I）的化合物，其中符号具有本说明书中描述的含义，是3-苯基 - 丙酸的异羟肟酸衍生物，能够抑制炭疽细菌感染的致死作用，可用于治疗炭疽中毒。

9. 发明专利

CA1318334C HOIST AND ACCUMULATOR ARM APPARATUS 未知
公开(公告)号：CA1318334C
公开(公告)日：1993-05-25
申请号：CA591119
申请日：1989-02-15
申请人： JOHNSON ALAN T
发明人： JOHNSON ALAN T
IPC分类号： B65G59/08 , B65G59/02
摘要： An apparatus for continuously feeding the individual elements from tiered loads has a hoist, including both vertical and horizontal support members, which can both be pivoted back to come in contact with an accumulator arm assembly by the motion of a rotatable support base, thereby allowing the load to be raised upwards along an angular load path. The accumulator arm assembly includes a carriage assembly which can slide part of the way down the load path, and independently extendable accumulator arms for extending beneath the bottom of the tiered load once approximately one-half of the load has been unloaded down the load-discharging members to the fixed and predeterminable load discharging point, where it can be processed on a conventional feed table. After the accumulator arms have been extended and have begun to raise the remainder of the load along the last portion of the load path, the hoist is free to return to its initial position and accept a second load of material. In an alternate embodiment the hoist is omitted, thereby providing an accumulator arm assembly which can be retrofitted into, and used in conjunction with, existing hoists.

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