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1. 发明申请

WO2011071565A1 TGR5 AGONISTS 审中-公开
标题翻译： TGR5激励
公开(公告)号：WO2011071565A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/045195
申请日：2010-08-11
申请人： EXELIXIS, INC. , BOLLU, Venkataiah , BOREN, Brant, Clayton , DALGARD, Jackline , FLATT, Brenton, T. , HAQ, Nadia , HUDSON, Sarah , MOHAN, Raju , MORRISSEY, Michael , PRATT, Benjamin
发明人： BOLLU, Venkataiah , BOREN, Brant, Clayton , DALGARD, Jackline , FLATT, Brenton, T. , HAQ, Nadia , HUDSON, Sarah , MOHAN, Raju , MORRISSEY, Michael , PRATT, Benjamin
IPC分类号： C07D233/64 , C07D233/84 , C07D403/12 , A61K31/4178 , A61K31/4164 , A61K31/4439 , A61K31/454 , A61K31/496 , A61P3/04
CPC分类号： C07D487/08 , A61K31/4164 , A61K31/4178 , A61K31/4196 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/4995 , A61K31/5377 , C07D233/64 , C07D233/84 , C07D249/12 , C07D295/15 , C07D401/12 , C07D403/12
摘要： TGR5 agonists of structural formula VIII(Q), wherein X, R 1, R 2 , and R 5 are defined in the specification, pharmaceutically acceptable salts thereof, compositions thereof, and use of the compounds and compositions for treating diseases. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases.
摘要翻译：结构式VIII（Q）的TGR5激动剂，其中X，R 1，R 2和R 5在本说明书中定义，其药学上可接受的盐，其组合物，以及化合物和组合物用于治疗疾病的用途。本发明还包括在化合物中和用于制备药物中的用途，特别是用于治疗疾病。

2. 发明申请

WO2010093845A1 TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY 审中-公开
标题翻译：用作TGR5治疗糖尿病和肥胖的激素的三唑和咪唑衍生物
公开(公告)号：WO2010093845A1
公开(公告)日：2010-08-19
申请号：PCT/US2010/023981
申请日：2010-02-12
申请人： EXELIXIS, INC. , BOLLU, Venkataiah , BOREN, Brant, Clayton , DALGARD, Jackline, Eve , FLATT, Brenton, T. , HAQ, Nadia , HUDSON, Sarah , MOHAN, Raju , MORRISSEY, Michael , PRATT, Benjamin , WANG, Tie-lin
发明人： BOLLU, Venkataiah , BOREN, Brant, Clayton , DALGARD, Jackline, Eve , FLATT, Brenton, T. , HAQ, Nadia , HUDSON, Sarah , MOHAN, Raju , MORRISSEY, Michael , PRATT, Benjamin , WANG, Tie-lin
IPC分类号： C07D233/64 , C07D233/84 , C07D233/90 , C07D249/12 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/14 , A61K31/4178 , A61K31/4196 , A61P3/04
CPC分类号： C07D233/84 , C07D233/64 , C07D233/90 , C07D249/12 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/14
摘要： The present invention comprises TGR5 agonists of structural formula I, wherein X, R 1 , R 2 , and R 5 are defined herein, as well as N-oxides of them and pharmaceutically acceptable salts thereof. The invention further comprises composition comprising the compounds, N-oxides, and/or pharmaceutically acceptable salts thereof. The invention also comprises use of the compounds and compositions for treating diseases in which TGR5 is a mediator or is implicated. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases in which TGR5 is a mediator or is implicated.
摘要翻译：本发明包括结构式I的TGR5激动剂，其中X，R 1，R 2和R 5在本文中定义，以及它们的N-氧化物及其药学上可接受的盐。本发明还包括含有化合物，N-氧化物和/或其药学上可接受的盐的组合物。本发明还包括使用化合物和组合物来治疗其中TGR5是介质或涉及的疾病。本发明还包括在药物中和用于制备药物中的用途，特别是用于治疗其中TGR5是介质或涉及的疾病。

3. 发明申请

WO2004052366A1 2-AMINOCARBONYL-QUINOLINE COMPOUNDS AS PLATELET ADENOSINE DIPHOSPHATE RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 2-氨基羰基喹啉化合物作为平板腺苷二磷酸酯受体拮抗剂
公开(公告)号：WO2004052366A1
公开(公告)日：2004-06-24
申请号：PCT/US2003/039079
申请日：2003-12-09
申请人： SCHERING AKTIENGESELLSCHAFT , BRYANT, Judi , BUCKMAN, Brad , ISLAM, Imadul , MOHAN, Raju , MORRISSEY, Michael , WEI, Guo, Ping , XU, Wei , YUAN, Shendong
发明人： BRYANT, Judi , BUCKMAN, Brad , ISLAM, Imadul , MOHAN, Raju , MORRISSEY, Michael , WEI, Guo, Ping , XU, Wei , YUAN, Shendong
IPC分类号： A61K31/4709
CPC分类号： C07D405/12 , C07D215/48 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I), where m, n, R 1 , R 2 , R 3 , R 4 and R 6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.
摘要翻译：本文描述式（I）化合物，其中m，n，R 1，R 2，R 3，R 4和R 6可用作血小板二磷酸腺苷的抑制剂。本文还描述了含有这些化合物的药物组合物，使用这些化合物作为抗血栓形成剂的方法和合成这些化合物的方法。

4. 发明申请

WO2005102529A1 MULTI-WELL APPARATUS 审中-公开
标题翻译：多设备
公开(公告)号：WO2005102529A1
公开(公告)日：2005-11-03
申请号：PCT/US2005/007757
申请日：2005-03-08
申请人： EXELIXIS, INC. , HAGER, David, Clarence , DONALDSON, Jeffrey, D. , KEARNEY, Patrick , KELLER, Douglas, O. , LEAHY, James, William , MERCER, Robert, D. , MORRISSEY, Michael , SWARTWOOD, Troy, M.
发明人： HAGER, David, Clarence , DONALDSON, Jeffrey, D. , KEARNEY, Patrick , KELLER, Douglas, O. , LEAHY, James, William , MERCER, Robert, D. , MORRISSEY, Michael , SWARTWOOD, Troy, M.
IPC分类号： B01L3/02
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00313 , B01J2219/00319 , B01J2219/00333 , B01J2219/00423 , B01L3/5025 , B01L3/50255 , B01L3/563 , B01L3/5635 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2200/0642 , B01L2400/0487 , B01L2400/049 , C40B60/14 , G01N35/1074 , Y10T436/25
摘要： A multi-well assembly (10) according to one embodiment comprises a multi-well block (12) and a guide plate (14). The multi-well block defines a plurality of wells (18), with each well having a fluid-impermeable bottom surface (22). The guide plate defines a plurality of fluid passageways corresponding to the wells of the multi-well block. The guide plate is configured such that, whenever the guide plate is registered with the multi-well block, fluid communication is established between each well and an associated fluid passageway. The guide plate enables iterative chemical or biological processes using multiple multi-well blocks. A seal plate (70) is configured to cut fluid communication conferred by the guide plate via registration with the guide plate, or via registration with the multi-well block (once the guide plate is removed). The seal plate allows iterative chemical or biological processes within a single multi-well block.
摘要翻译：根据一个实施例的多孔组件（10）包括多孔块（12）和引导板（14）。多孔块限定多个井（18），其中每个井具有不透液体的底表面（22）。引导板限定对应于多井区块的井的多个流体通道。引导板被构造成使得每当导板与多孔块对准时，在每个井和相关联的流体通道之间建立流体连通。引导板使得能够使用多个多孔块的迭代化学或生物过程。密封板（70）被构造成通过与引导板对准或者通过与多孔块对准（一旦导板被移除）来切割由引导板赋予的流体连通。密封板允许单个多孔块内的迭代化学或生物过程。

5. 发明申请

WO2002072269A1 MULTI-WELL APPARATUS 审中-公开
标题翻译：多设备
公开(公告)号：WO2002072269A1
公开(公告)日：2002-09-19
申请号：PCT/US2002/007038
申请日：2002-03-08
申请人： EXELIXIS, INC. , HAGER, David, C. , DONALDSON, Jeffrey, D. , KEARNEY Patrick , KELLER, Douglas, O. , LEAHY, James, W. , MERCER, Robert, D. , MORRISSEY, Michael , SWARTWOOD, Troy, M.
发明人： HAGER, David, C. , DONALDSON, Jeffrey, D. , KEARNEY Patrick , KELLER, Douglas, O. , LEAHY, James, W. , MERCER, Robert, D. , MORRISSEY, Michael , SWARTWOOD, Troy, M.
IPC分类号： B01L11/00
CPC分类号： B01L3/5635 , B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00313 , B01J2219/00315 , B01J2219/00319 , B01J2219/00333 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01J2219/00585 , B01J2219/00599 , B01L3/5025 , B01L3/50255 , B01L3/563 , B01L2200/025 , B01L2200/141 , B01L2300/0829 , C40B50/08 , C40B60/14 , Y10T436/25375 , Y10T436/2575
摘要： A multi-well assembly (10) comprises a multi-well block (12) and a guide plate.(14) The multi-well block (12) has a plurality of wells (18) each with a fluid-impermeable bottom surface (22). The guide plate (14) has a plurality of fluid passageways (34) corresponding to the wells (18) of the multi-well block (12). The guide plate (14) is configured to establish fluid communication between each well (18) and an associated fluid passageway (34) when the guide plate (14) is aligned with the multi-well block (12).
摘要翻译：多孔组件（10）包括多孔块（12）和引导板（14）。多孔块（12）具有多个井（18），每个孔具有不透液体的底表面（ 22）。引导板（14）具有与多孔块（12）的井（18）对应的多个流体通道（34）。引导板（14）构造成当导板（14）与多孔块（12）对准时，在每个井（18）和相关联的流体通道（34）之间建立流体连通。

6. 发明申请

WO2012098555A1 DIRECT CARRIER BILLING 审中-公开
标题翻译：直接运输费
公开(公告)号：WO2012098555A1
公开(公告)日：2012-07-26
申请号：PCT/IN2011/000045
申请日：2011-01-20
申请人： GOOGLE INC. , SATYAPAL, Arjun , MORRISSEY, Michael , SAHA, Indradeep
发明人： SATYAPAL, Arjun , MORRISSEY, Michael , SAHA, Indradeep
IPC分类号： G06Q40/00
CPC分类号： G06Q30/04
摘要： A method for purchasing services from a user device is provided. Such a device may provide a way to provide for billing for the purchases at a service provider such as a wireless carrier. A transaction system for purchasing services from a user device is also provided.
摘要翻译：提供了一种从用户设备购买服务的方法。这样的设备可以提供一种方式来提供在例如无线运营商的服务提供商处的购买的计费。还提供了用于从用户设备购买服务的交易系统。

7. 发明申请

WO2014018632A1 PREDICTION OF TREATMENT RESPONSE TO JAK/STAT INHIBITOR 审中-公开
标题翻译：预防JAK / STAT抑制剂的治疗反应
公开(公告)号：WO2014018632A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051824
申请日：2013-07-24
申请人： NOVARTIS AG , CAO, Alexander , MORRISSEY, Michael , SONKIN, Dmitriy , PALMER, Michael
发明人： CAO, Alexander , MORRISSEY, Michael , SONKIN, Dmitriy , PALMER, Michael
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K31/519 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： The invention includes, in part, a method of selecting a subject having cancer for treatment with a JAK/STAT inhibitor and a method of determining if a therapeutically effective dose of a JAK/STAT inhibitor has been administered.
摘要翻译：本发明部分地包括选择具有用于用JAK / STAT抑制剂治疗的癌症的受试者的方法和确定是否施用治疗有效剂量的JAK / STAT抑制剂的方法。

8. 发明申请

WO2004031978A1 SYSTEM AND METHOD FOR PROCESSING ALPHANUMERIC CHARACTERS FOR DISPLAY ON A DATA PROCESSING DEVICE 审中-公开
标题翻译：用于处理用于在数据处理装置上显示的ALPHANUMER字符的系统和方法
公开(公告)号：WO2004031978A1
公开(公告)日：2004-04-15
申请号：PCT/US2003/031435
申请日：2003-10-01
申请人： DANGER, INC. , THEIS, Ronald, L., A. , MORRISSEY, Michael
发明人： THEIS, Ronald, L., A. , MORRISSEY, Michael
IPC分类号： G06F15/16
CPC分类号： H04L67/16 , H04L29/06 , H04L69/329
摘要： A system is described comprising: character analysis logic configured at a data service to analyze original content requested by a data processing device, the original content containing one or more original characters; the character analysis logic being further configured to determine, based on the analysis, whether any original characters within the original content are not displayable by the data processing device; and character conversion logic configured at the data service to convert the original content into unoriginal content comprised of one or more displayable characters if one or more of the original characters are not displayable by the data processing device, each of the displayable characters corresponding to one or more of the original characters which are not displayable on the data processing device; wherein the data service is configured to transmit the converted content to the data processing device.
摘要翻译：一种系统，包括：字符分析逻辑，配置在数据服务处以分析由数据处理设备请求的原始内容，原始内容包含一个或多个原始字符; 所述字符分析逻辑还被配置为基于所述分析来确定所述原始内容中的任何原始字符是否不被所述数据处理设备显示; 以及字符转换逻辑，其被配置在所述数据服务处，以将所述原始内容转换为由一个或多个可显示字符组成的原始内容，如果所述原始字符中的一个或多个不能由所述数据处理设备显示，则每个所述可显示字符对应于一个或多个可显示字符，更多在数据处理设备上不可显示的原始字符; 其中所述数据服务被配置为将所转换的内容发送到所述数据处理设备。

9. 发明公开

EP2396304A1 TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY 审中-公开
标题翻译：咪唑衍生物用作TGR5激动剂糖尿病和肥胖症的治疗
公开(公告)号：EP2396304A1
公开(公告)日：2011-12-21
申请号：EP10704701.1
申请日：2010-02-12
申请人： Exelixis, Inc.
发明人： BOLLU, Venkataiah , BOREN, Brant, Clayton , DALGARD, Jackline, Eve , FLATT, Brenton, T. , HAQ, Nadia , HUDSON, Sarah , MOHAN, Raju , MORRISSEY, Michael , PRATT, Benjamin , WANG, Tie-lin , GU, Xiao-Hui. , MARTIN, Richard.
IPC分类号： C07D233/64 , C07D233/84 , C07D233/90 , C07D249/12 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/14 , A61K31/4178 , A61K31/4196 , A61P3/04
CPC分类号： C07D233/84 , C07D233/64 , C07D233/90 , C07D249/12 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/14
摘要： The present invention comprises TGR5 agonists of structural formula I, wherein X, R
1 , R
2 , and R
5 are defined herein, as well as N-oxides of them and pharmaceutically acceptable salts thereof. The invention further comprises composition comprising the compounds, N-oxides, and/or pharmaceutically acceptable salts thereof. The invention also comprises use of the compounds and compositions for treating diseases in which TGR5 is a mediator or is implicated. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases in which TGR5 is a mediator or is implicated.

10. 发明公开

EP2509960A1 TGR5 AGONISTS 审中-公开
标题翻译： TGR5激动剂
公开(公告)号：EP2509960A1
公开(公告)日：2012-10-17
申请号：EP10747545.1
申请日：2010-08-11
申请人： Exelixis, Inc.
发明人： BOLLU, Venkataiah , BOREN, Brant, Clayton , DALGARD, Jackline , FLATT, Brenton, T. , HAQ, Nadia , HUDSON, Sarah , MOHAN, Raju , MORRISSEY, Michael , PRATT, Benjamin
IPC分类号： C07D233/64 , C07D233/84 , C07D403/12 , A61K31/4178 , A61K31/4164 , A61K31/4439 , A61K31/454 , A61K31/496 , A61P3/04
CPC分类号： C07D487/08 , A61K31/4164 , A61K31/4178 , A61K31/4196 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/4995 , A61K31/5377 , C07D233/64 , C07D233/84 , C07D249/12 , C07D295/15 , C07D401/12 , C07D403/12
摘要： TGR5 agonists of structural formula VIII(Q), wherein X, R
1, R
2 , and R
5 are defined in the specification, pharmaceutically acceptable salts thereof, compositions thereof, and use of the compounds and compositions for treating diseases. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases.

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