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1. 发明专利

JP2017113007A 結合組織成長因子を対象とするアンチセンスオリゴヌクレオチドおよびその使用审中-公开
公开(公告)号：JP2017113007A
公开(公告)日：2017-06-29
申请号：JP2017012167
申请日：2017-01-26
申请人：エクスカリアード・ファーマシューティカルズ,インコーポレイテッド , Excaliard Pharmaceuticals Inc , アイシス・ファーマシューティカルズ・インコーポレイテッドIsis Pharmaceuticals, Inc. , Isis Pharmaceuticals Inc , アイシス・ファーマシューティカルズ・インコーポレイテッドIsis Pharmaceuticals, Inc.
发明人： DEAN NICHOLAS M , FOULKES J GORDON , O'DONNELL NIALL , BENNETT C FRANK , FREIER SUSAN M
IPC分类号： C12N15/09 , C12N15/113
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要：【課題】結合組織成長因子(CTGF)の発現を阻害できる修飾されたオリゴヌクレオチドを含む化合物及び組成物、並びに過剰増殖症及び線維性疾患の治療方法、前記化合物を用いて創傷治癒に起因する瘢痕を減少させる方法を提供する。【解決手段】連結した12〜30のヌクレオシドからなる修飾オリゴヌクレオチドを含み、その少なくとも12の核酸塩基からなる配列部分が、特定の核酸配列から選択される特定の領域内に存在する化合物。【選択図】なし

2. 发明专利

JP2013099338A Antisense oligonucleotide directed against connective tissue growth factor and use thereof 有权
标题翻译：针对连接组织生长因子的抗原寡核苷酸及其用途
公开(公告)号：JP2013099338A
公开(公告)日：2013-05-23
申请号：JP2012287043
申请日：2012-12-28
申请人： Excaliard Pharmaceuticals Inc , エクスカリアード・ファーマシューティカルズ,インコーポレイテッド , Isis Pharmaceuticals Inc , アイシス・ファーマシューティカルズ・インコーポレイテッドIsis Pharmaceuticals, Inc.
发明人： DEAN NICHOLAS M , FOULKES J GORDON , O'DONNELL NIALL , BENNETT C FRANK , FREIER SUSAN M
IPC分类号： C12N15/113
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： PROBLEM TO BE SOLVED: To provide new antisense oligonucleotides useful for treating hyperprolific disorders and fibrotic diseases, and for reducing scarring resulting from wound healing.SOLUTION: This invention provides compounds and compositions which comprise modified oligonucleotides capable of inhibitory expression of connective tissue growth factor, as well as methods for treating hyperprolific disorders and fibrotic diseases, and for reducing scarring resulting from wound healing using such compounds.
摘要翻译：要解决的问题：提供可用于治疗过度增生性疾病和纤维化疾病以及用于减少伤口愈合引起的瘢痕形成的新型反义寡核苷酸。解决方案：本发明提供了包含能够抑制结缔组织生长因子的表达的修饰的寡核苷酸的化合物和组合物，以及用于治疗过度扩张性疾病和纤维化疾病的方法，以及用于减少由这些化合物引起的伤口愈合引起的瘢痕形成。版权所有（C）2013，JPO＆INPIT

3. 发明申请

WO2010042281A9 ANTISENSE OLIGONUCLEOTIDES DIRECTED AGAINST CONNECTIVE TISSUE GROWTH FACTOR AND USES THEREOF 审中-公开
标题翻译：针对连接组织生长因子的抗原寡核苷酸及其用途
公开(公告)号：WO2010042281A9
公开(公告)日：2011-10-06
申请号：PCT/US2009054973
申请日：2009-08-25
申请人： EXCALIARD PHARMACEUTICALS INC , ISIS PHARMACEUTICALS INC
发明人： DEAN NICHOLAS M , FOULKES J GORDON , O DONNELL NIALL , BENNETT C FRANK , FREIER SUSAN M
IPC分类号： A61K48/00 , C12N15/113
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.

4. 发明专利

NZ601660A Antisense oligonucleotides directed against connective tissue growth factor and uses thereof 未知
公开(公告)号：NZ601660A
公开(公告)日：2014-05-30
申请号：NZ60166009
申请日：2009-08-25
申请人： EXCALIARD PHARMACEUTICALS INC , ISIS PHARMACEUTICALS INC
发明人： DEAN NICHOLAS M , FOULKES J GORDON , O’DONNELL NIALL , BENNETT C FRANK , FREIER SUSAN M
IPC分类号： A61K48/00 , C12N15/113
摘要： 601660 Disclosed is a compound which comprises a modified oligonucleotide consisting of 12 -30 linked nucleosides, at least a 12 nucleobase sequence portion of which is complementary to nucleotides within the region selected from nucleotides 718-751, 1388-1423, 2728-2797, 1394-1423, 1659-1689, 2100-2129 and 1399-1423 of SEQ ID NO: 9, wherein the modified oligonucleotide comprises (a) a gap segment consisting of linked deoxynucleosides; (b) a 5’ wing segment consisting of linked modified nucleosides; and (c) a 3’ wing segment consisting of linked modified nucleosides; wherein the gap segment is positioned between the 5’ wing segment and the 3’ wing segment and wherein each modified nucleoside within each wing segment comprises a modified sugar. Further disclosed is a compound which comprises a modified oligonucleotide consisting of 12 - 30 linked nucleosides, at least a 12 nucleobase sequence portion of which is complementary to nucleotides within the region selected from nucleotides 1457-1689, 2120-2147,2267-2301,553-611,1469-1508 and 1559-1605 of SEQ ID NO: 9, wherein the modified oligonucleotide comprises (a) a gap segment consisting of linked deoxynucleosides; (b) a 5’ wing segment consisting of linked modified nucleosides; and (c) a 3’ wing segment consisting of linked modified nucleosides; wherein the gap segment is positioned between the 5’ wing segment and the 3’ wing segment and wherein each modified nucleoside within each wing segment comprises a modified sugar; and wherein the compound demonstrates at least 60% inhibition in a human connective tissue growth factor expression assay.

5. 发明专利

ZA201101549B ANTISENSE OLIGONUCLEOTIDES DIRECTED AGAINST CONNECTIVE TISSUE GROWTH FACTOR AND USES THEREOF 未知
公开(公告)号：ZA201101549B
公开(公告)日：2012-06-27
申请号：ZA201101549
申请日：2011-02-28
申请人： EXCALIARD PHARMACEUTICALS INC , ISIS PHARMACEUTICALS INC
发明人： DEAN NICHOLAS MARK , FOULKES J GORDON , O'DONNELL NIALL , BENNETT C FRANK , FREIER SUSAN M
IPC分类号： A61K20060101 , C12N15/113
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.

6. 发明专利

AU2010224447A1 Antisense oligonucleotides directed against connective tissue growth factor and uses thereof 未知
公开(公告)号：AU2010224447A1
公开(公告)日：2010-10-21
申请号：AU2010224447
申请日：2010-09-28
申请人： ISIS PHARMACEUTICALS INC , EXCALIARD PHARMACEUTICALS INC
发明人： BENNETT C FRANK , FOULKES J GORDON , O'DONNELL NIALL , DEAN NICHOLAS M , FRIER SUSAN M
IPC分类号： C12N15/113
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.

7. 发明专利

CA2733262C ANTISENSE OLIGONUCLEOTIDES DIRECTED AGAINST CONNECTIVE TISSUE GROWTH FACTOR AND USES THEREOF 未知
公开(公告)号：CA2733262C
公开(公告)日：2019-12-10
申请号：CA2733262
申请日：2009-08-25
申请人： EXCALIARD PHARMACEUTICALS INC , ISIS PHARMACEUTICALS INC
发明人： DEAN NICHOLAS M , FOULKES J GORDON , O'DONNELL NIALL , BENNETT C FRANK , FREIER SUSAN M
IPC分类号： C12N15/113 , A61K31/7088 , A61K31/7125 , A61K31/713 , A61P17/00 , A61P17/02 , A61P35/00 , C07H21/00
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue growth factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.

8. 发明专利

EA022207B1 АНТИСМЫСЛОВЫЕ ОЛИГОНУКЛЕОТИДЫ ПРОТИВ ФАКТОРА РОСТА СОЕДИНИТЕЛЬНОЙ ТКАНИ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ 未知
公开(公告)号：EA022207B1
公开(公告)日：2015-11-30
申请号：EA201170345
申请日：2009-08-25
申请人： EXCALIARD PHARMACEUTICALS INC , ISIS PHARMACEUTICALS INC
发明人： DEAN NICHOLAS M , FOULKES J GORDON , O'DONNELL NIALL , BENNETT C FRANK , FREIER SUSAN M
IPC分类号： A61K48/00 , C12N15/113 , A61P17/02 , A61P19/04 , A61P35/00 , C12N15/19
摘要： Настоящееизобретениеотноситсяк соединениям, включающиммодифицированныеолигонуклеотиды, способныеингибироватьэкспрессиюфактораростасоединительнойткани, ик композиции, содержащейуказанныесоединения, атакжек способамлечениягиперпролиферативныхнарушенийи фиброзныхзаболеванийи способамуменьшениярубцеванияв процессезаживленияраныс использованиемтакихсоединений.

9. 发明专利

CA2733262A1 ANTISENSE OLIGONUCLEOTIDES DIRECTED AGAINST CONNECTIVE TISSUE GROWTH FACTOR AND USES THEREOF 未知
公开(公告)号：CA2733262A1
公开(公告)日：2010-04-15
申请号：CA2733262
申请日：2009-08-25
申请人： EXCALIARD PHARMACEUTICALS INC , ISIS PHARMACEUTICALS INC
发明人： DEAN NICHOLAS M , FOULKES J GORDON , O'DONNELL NIALL , BENNETT C FRANK , FREIER SUSAN M
IPC分类号： C12N15/113 , A61K31/7088 , A61K31/7125 , A61K31/713 , A61P17/00 , A61P17/02 , A61P35/00 , C07H21/00
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue growth factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.

10. 发明专利

SG196769A1 ANTISENSE OLIGONUCLEOTIDES DIRECTED AGAINST CONNECTIVE TISSUE GROWTH FACTOR AND USES THEREOF 未知
公开(公告)号：SG196769A1
公开(公告)日：2014-02-13
申请号：SG2013087341
申请日：2009-08-25
申请人： EXCALIARD PHARMACEUTICALS INC , ISIS PHARMACEUTICALS INC
发明人： DEAN NICHOLAS M , FOULKES J GORDON , O DONNELL NIALL , BENNETT C FRANK , FREIER SUSAN M
IPC分类号： C12N15/113
摘要： -128- ANTISENSE OLIGONUCLEOTIDES DIRECTED AGAINST CONNECTIVE TISSUE GROWTHFACTOR AND USES THEREOF Abstract Thisinvention providescompounds whichcomprise modified oligonucleotides capable of inhibitory expression ofconnective tissue growth factor and composition containing same as well asmethods of treating hyperprolific disorders and fibrotic diseases, and ofreducing scarring resulting from wound healing using such compounds. No

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