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1. 发明申请

WO2010062127A2 NANOPARTICLE ASSEMBLY-BASED SWITCHING DEVICE 审中-公开
标题翻译：基于纳米装配的开关装置
公开(公告)号：WO2010062127A2
公开(公告)日：2010-06-03
申请号：PCT/KR2009/007026
申请日：2009-11-27
申请人： EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION , INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY , KIM, Tae Hee , CHEON, Jin Woo , JANG, Jung-Tak
发明人： KIM, Tae Hee , CHEON, Jin Woo , JANG, Jung-Tak
IPC分类号： B82B3/00 , H01H1/021 , B82B1/00 , H01L27/02
CPC分类号： H01L45/04 , B82Y30/00 , C01G23/0536 , C01G41/02 , C01G45/02 , C01G45/12 , C01G49/0018 , C01G49/0063 , C01G49/0072 , C01G51/40 , C01G53/40 , C01P2004/03 , C01P2004/04 , C01P2004/32 , C01P2004/64 , C01P2004/84 , C01P2006/40 , C04B35/26 , C04B35/265 , C04B35/2658 , C04B35/2666 , C04B35/62826 , C04B35/6325 , C04B2235/3262 , C04B2235/3272 , C04B2235/3274 , C04B2235/3275 , C04B2235/3279 , C04B2235/44 , C04B2235/5454 , H01L45/08 , H01L45/146 , H01L45/147 , H01L45/1608
摘要： The present invention relates to a switching device fabricated by using nanoparticles and a preparation method thereof. The present invention ensures the mass production of switching devices (e.g., memristor) by use of nanoparticles that exhibits reversible switching behavior at current of less than mA and at room temperature (25°C) 〧 250°C in a more convenient and economical manner. Predictions of the high potential of memristors based on nanoparticle assemblies are supported by the tremendous versatility to tune the electrical behavior of nanoparticles by controlling their nanoscale characteristics such as size, composition, dimension, surface area, and chemical potential.
摘要翻译：本发明涉及通过使用纳米粒子制造的开关器件及其制备方法。本发明通过使用在小于mA的电流和室温（25℃）下呈现可逆转换行为的纳米颗粒来确保开关器件（例如，忆阻器）的批量生产？ 250°C，更方便，经济。基于纳米颗粒组件的忆阻器的高潜力的预测由极大的多功能性来支持，以通过控制纳米尺度的纳米尺度特征如尺寸，组成，尺寸，表面积和化学势来调节纳米颗粒的电性能。

2. 发明申请

WO2009142438A2 HEAT GENERATING NANOMATERIALS 审中-公开
标题翻译：热发生纳米材料
公开(公告)号：WO2009142438A2
公开(公告)日：2009-11-26
申请号：PCT/KR2009/002661
申请日：2009-05-20
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY , CHEON, Jin Woo , JANG, Jung Tak
发明人： CHEON, Jin Woo , JANG, Jung Tak
IPC分类号： C09K5/14
CPC分类号： C09K5/14 , A61K9/5115 , A61K41/0052 , A61N1/406
摘要： The present invention relates to a heat-generating composition, comprising a hetero-structure nanomaterial which comprises (a) a first material comprising at least one component selected from the group consisting of a metal, a metal chalcogen, a metal pnicogen, an alloy and a multi-component hybrid structure thereof; and (b) a second material comprising at least one component selected from the group consisting of metal, metal chalcogen, metal pnicogen, alloy and the multi-component hybrid structure thereof; wherein the first material is enclosed in the second material; wherein at least one of the first material and the second material comprise a magnetic material. The specific loss power of the present nanomaterial is much higher than that of conventional nanomaterials ( e.g. , 40-fold higher than commercially accessible Feridex) and may be controlled by changing compositions or ratios of the first material and/or the second material. The heat-generating nanomaterial of the present invention may be used in a variety of application fields, for example cancer hyperthermia.
摘要翻译：本发明涉及一种发热组合物，其包含异质结构纳米材料，其包含（a）第一材料，其包含选自金属，金属硫族元素，金属原子，合金和其多组分杂化结构; 和（b）包含选自金属，金属硫属元素，金属致癌剂，合金及其多组分混合结构中的至少一种成分的第二材料; 其中所述第一材料被封闭在所述第二材料中; 其中所述第一材料和所述第二材料中的至少一个包括磁性材料。本纳米材料的特定损耗功率远高于常规纳米材料（例如，比商业上可接受的Feridex高40倍），并且可以通过改变第一材料和/或第二材料的组成或比例来控制。本发明的发热纳米材料可以用于各种应用领域，例如癌症高热。

3. 发明申请

WO2009142439A2 METHODS FOR CONTROLLING HEAT GENERATION OF MAGNETIC NANOPARTICLES AND HEAT GENERATING NANOMATERIALS 审中-公开
标题翻译：用于控制磁性纳米粒子的热生成和热生成纳米材料的方法
公开(公告)号：WO2009142439A2
公开(公告)日：2009-11-26
申请号：PCT/KR2009/002662
申请日：2009-05-20
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY , CHEON, Jin Woo , JANG, Jung Tak
发明人： CHEON, Jin Woo , JANG, Jung Tak
IPC分类号： B82B3/00
CPC分类号： A61K41/0052 , A61K9/5094
摘要： The present invention relates to a method for controlling heat generation of a magnetic nanomaterial, comprising the steps of: (a) mixing (i) a nanomaterial precursor comprising a metal precursor material and a predetermined amount of a zinc precursor with (ii) a reaction solvent; and (b) preparing a zinc-containing magnetic nanomaterial from the mixture of step (a) comprising a zinc doped metal oxide nanomaterial matrix; and wherein a specific loss power of the zinc-containing magnetic nanomaterial is varied depending an amount of zinc to be doped, whereby the heat generation of the magnetic nanomaterial is controlled. In addition, the present invention relates to a heat-generating nanoparticle and a composition for hyperthermia. The present invention suggests a novel approach to improve a heat generation of a magnetic nanomaterial. According to the present invention, the specific loss power can be controlled by changing a zinc-content to be introduced into nanomaterials and therefore a composition for hyperthermia showing controlled heat generation potential can be successfully provided.
摘要翻译：本发明涉及一种用于控制磁性纳米材料的发热的方法，包括以下步骤：（a）将（i）包含金属前体材料和预定量的锌前体的纳米材料前体与（ii）反应溶剂; 和（b）从包含锌掺杂金属氧化物纳米材料基质的步骤（a）的混合物制备含锌磁性纳米材料; 并且其中所述含锌磁性纳米材料的特定损耗功率随着待掺杂的锌的量而变化，由此控制所述磁性纳米材料的发热。另外，本发明涉及发热性纳米粒子和热疗用组合物。本发明提出了改进磁性纳米材料的发热的新方法。根据本发明，可以通过改变要引入纳米材料的锌含量来控制比损失功率，因此可以成功地提供显示受控制热势的热疗组合物。

4. 发明申请

WO2007097605A1 WATER-SOLUBLE MAGNETIC OR METAL OXIDE NANOPARTICLES COATED WITH LIGANDS, PREPARATION METHOD AND USAGE THEREOF 审中-公开
标题翻译：配有配体的水溶性磁性或金属氧化物纳米颗粒，其制备方法及其用途
公开(公告)号：WO2007097605A1
公开(公告)日：2007-08-30
申请号：PCT/KR2007/001001
申请日：2007-02-27
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY , CHEON, Jin Woo , JUN, Young Wook , CHOI, Jin Sil
发明人： CHEON, Jin Woo , JUN, Young Wook , CHOI, Jin Sil
IPC分类号： B82B3/00
CPC分类号： A61K41/0042 , A61K41/0052 , A61K49/1833 , A61K49/1836 , A61K49/1854 , A61K49/1857 , A61K49/186 , A61K49/1863 , A61K49/1866 , A61K49/1869 , A61K49/1875 , A61L2/238 , A61L27/50 , A61L2400/12 , A61L2400/18 , B82Y5/00 , Y10T428/2991 , Y10T428/2993 , Y10T436/143333
摘要： This invention provides water-soluble magnetic or water-soluble metal oxide nanoparticles, which are coated with phase transfer ligands having an adhesive region, an adhesive region-crosslinking region, or an adhesive region-reactive region, and also provides a method of preparing water-soluble magnetic or metal oxide nanoparticles, the method including (1) synthesizing water-insoluble magnetic or metal oxide nanoparticles in an organic solvent; (2) dissolving the water-insoluble magnetic or metal oxide nanoparticles in a first solvent and dissolving a phase transfer ligand in a second solvent; and (3) mixing the two solutions achieved in step (2) to thus exchange the surface of the water-insoluble magnetic or metal oxide nanoparticles with the phase transfer ligand. Further, the water-soluble magnetic and water-soluble metal oxide nanoparticles coated with the phase transfer ligand can be used in various fields, including the separation and detection of materials, the diagnosis and treatment of diseases, and the decomposition of microorganisms and contaminants.
摘要翻译：本发明提供水溶性磁性或水溶性金属氧化物纳米粒子，其被涂覆有具有粘合剂区域的相转移配体，粘合剂区域交联区域或粘合剂区域反应性区域，并且还提供了制备水的方法所述方法包括（1）在有机溶剂中合成水不溶性磁性或金属氧化物纳米颗粒; （2）将水不溶性磁性或金属氧化物纳米颗粒溶解在第一溶剂中并将相转移配体溶解在第二溶剂中; 和（3）混合在步骤（2）中实现的两种溶液，从而使相互转移配体交换水不溶性磁性或金属氧化物纳米颗粒的表面。此外，涂覆有相转移配体的水溶性磁性和水溶性金属氧化物纳米粒子可用于各种领域，包括物质的分离和检测，疾病的诊断和治疗以及微生物和污染物的分解。

5. 发明申请

WO2009136764A3 DUAL-MODALITY PET/MRI CONTRAST AGENTS 审中-公开
公开(公告)号：WO2009136764A3
公开(公告)日：2009-11-12
申请号：PCT/KR2009/002441
申请日：2009-05-08
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY , KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , CHEON, Jin Woo , CHOI, Jin-Sil , YOO, Jeongsoo , PARK, Jeong Chan , CHANG, Yongmin
发明人： CHEON, Jin Woo , CHOI, Jin-Sil , YOO, Jeongsoo , PARK, Jeong Chan , CHANG, Yongmin
IPC分类号： A61K49/06
摘要： The present invention relates a dual-modality PET (positron emission tomography)/MRI (magnetic resonance imaging) contrast agent, a hybrid nanoparticle comprising: (a) a magnetic signal generating core; (b) a water-soluble multi-functional ligand coated on the signal generating core; and (c) a positron emitting factor linked to the water-soluble multi-functional ligand. The contrast agent of the present invention is the dual-modality contrast agent enabling to perform PET and MR imaging and can effectively obtain images having the merits of PET (excellent sensitivity and high temporal resolution) and MR (high spatial resolution and anatomical information) imaging. The contrast agent of the present invention is very useful for non-invasive and highly sensitive real-time fault-free imaging of various biological events such as cell migration, diagnosis of various diseases (e. g., cancer diagnosis) and drug delivery.

6. 发明申请

WO2009136763A2 NANOPARTICLES FOR PENETRATION OF BLOOD-BRAIN BARRIER 审中-公开
标题翻译：用于血液透析的纳米颗粒
公开(公告)号：WO2009136763A2
公开(公告)日：2009-11-12
申请号：PCT/KR2009/002440
申请日：2009-05-08
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY , CHEON, Jin Woo , LEE, Jae-Hyun
发明人： CHEON, Jin Woo , LEE, Jae-Hyun
IPC分类号： B82B3/00
CPC分类号： A61K49/1863 , A61K49/1857 , A61K49/1869 , B82Y5/00
摘要： The present invention relates to (a) a nanoparticle for penetration of a blood-brain barrier (BBB) comprising an inorganic nanoparticle core and a water-soluble multi-functional organic ligand coated on the nanoparticle core, and (b) a composition for brain imaging and (c) a pharmaceutical composition for brain-targeting thereof. The basic strategy adopted in the present invention is based on the finding that the water-soluble multi-functional organic ligand coated on the nanoparticle core permits the nanoparticle to penetrate the blood-brain barrier. The nanoparticle of the present invention may be efficiently used as a brain-imaging agent and in a drug delivery system into brain since the inorganic nanoparticle core coated with the water-soluble multi-functional organic ligand ensures an effective penetration of the blood-brain barrier even with no use of conventional adjuvants.
摘要翻译：本发明涉及（a）包含无机纳米颗粒核心和涂覆在纳米颗粒核心上的水溶性多官能有机配体的血脑屏障（BBB）的渗透纳米颗粒，和（b）脑组合物成像和（c）用于脑靶向它的药物组合物。本发明中采用的基本策略是基于以下发现：涂覆在纳米颗粒核上的水溶性多官能有机配体允许纳米颗粒穿透血脑屏障。本发明的纳米颗粒可以有效地用作脑显像剂和药物递送系统进入脑部，因为涂覆有水溶性多功能有机配体的无机纳米颗粒核心确保了血脑屏障的有效穿透即使没有使用常规的佐剂。

7. 发明申请

WO2010021519A2 T1-T2 DUAL MODAL MRI CONTRAST AGENTS 审中-公开
标题翻译： T1-T2双模式MRI对比剂
公开(公告)号：WO2010021519A2
公开(公告)日：2010-02-25
申请号：PCT/KR2009/004683
申请日：2009-08-21
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY , CHEON, Jin Woo , CHOI, Jin-Sil
发明人： CHEON, Jin Woo , CHOI, Jin-Sil
IPC分类号： A61K49/06
CPC分类号： A61K49/1869 , A61K49/183 , A61K49/1836 , A61K49/1854 , A61K49/1857 , A61K49/1863 , B82Y5/00
摘要： The present invention relates a T1-T2 dual-modal MRI (magnetic resonance imaging) contrast agent, comprising (a) a first layer consisting of T1 contrast material; (b) a second layer consisting of T2 contrast material; and (c) a separating layer which is present in a space between the first layer and the second layer, and inhibits a reciprocal interference between T1 contrast material and T2 contrast material, and a heat-generating composition and a drug delivery composition having the same. The T1-T2 dual-modal contrast agent of the present invention may generate both T1 and T2 signal and thus observe the signal complementarily, resulting in accurate diagnosis through reduction of misdiagnosis. Further, T1 and T2 MR imaging may be simultaneously obtained by simple operation within the same MR imaging device, enabling to remarkably reduce a diagnosis time and diagnosis cost. In addition, the particle constituting the T1-T2 dual-modal contrast agent of the present invention may be applied to hyperthermia and drug delivery systems.
摘要翻译：本发明涉及一种T1-T2双模态MRI（磁共振成像）造影剂，其包括（a）由T1对比材料组成的第一层; （b）由T2造影材料组成的第二层; 和（c）分离层，其存在于第一层和第二层之间的空间中，并且抑制T1造影材料与T2造影剂材料之间的相互干涉，以及发热组合物和具有其的药物递送组合物。本发明的T1-T2双模造影剂可以产生T1和T2信号，从而互补地观察信号，从而通过减少误诊来进行准确的诊断。此外，可以通过在同一MR成像装置内的简单操作同时获得T1和T2 MR成像，从而显着地减少诊断时间和诊断成本。此外，构成本发明的T1-T2双模造影剂的颗粒可以应用于高热和药物输送系统。

8. 发明授权

EP1996508B1 Preparation method for water-soluble magnetic or metal oxide nanoparticles coated with ligands, and usage thereof 有权
标题翻译：生产过程为水溶性的，涂覆有配体的磁性或Metalloxidnanoteilchen，以及它们的使用
公开(公告)号：EP1996508B1
公开(公告)日：2016-07-13
申请号：EP07715412.8
申请日：2007-02-27
申请人： Industry-Academic Cooperation Foundation, Yonsei University
发明人： CHEON, Jin Woo , JUN, Young Wook , CHOI, Jin Sil
IPC分类号： B82B3/00 , A61K41/00 , A61K47/48 , A61L2/238 , A23L3/358 , A61F2/14 , A61L27/04
CPC分类号： A61K41/0042 , A61K41/0052 , A61K49/1833 , A61K49/1836 , A61K49/1854 , A61K49/1857 , A61K49/186 , A61K49/1863 , A61K49/1866 , A61K49/1869 , A61K49/1875 , A61L2/238 , A61L27/50 , A61L2400/12 , A61L2400/18 , B82Y5/00 , Y10T428/2991 , Y10T428/2993 , Y10T436/143333

9. 发明授权

EP2294157B1 HEAT GENERATING NANOMATERIALS 有权
公开(公告)号：EP2294157B1
公开(公告)日：2020-08-12
申请号：EP09750760.2
申请日：2009-05-20
申请人： Industry-Academic Cooperation Foundation, Yonsei University
发明人： CHEON, Jin Woo , JANG, Jung Tak
IPC分类号： C09K5/14 , A61N1/40

10. 发明公开

EP2294157A2 HEAT GENERATING NANOMATERIALS 有权
标题翻译：发热纳米材料
公开(公告)号：EP2294157A2
公开(公告)日：2011-03-16
申请号：EP09750760.2
申请日：2009-05-20
申请人： Industry-Academic Cooperation Foundation, Yonsei University
发明人： CHEON, Jin Woo , JANG, Jung Tak
IPC分类号： C09K5/14
摘要： The present invention relates to a heat-generating composition, comprising a hetero-structure nanomaterial which comprises (a) a first material comprising at least one component selected from the group consisting of a metal, a metal chalcogen, a metal pnicogen, an alloy and a multi-component hybrid structure thereof; and (b) a second material comprising at least one component selected from the group consisting of metal, metal chalcogen, metal pnicogen, alloy and the multi-component hybrid structure thereof; wherein the first material is enclosed in the second material; wherein at least one of the first material and the second material comprise a magnetic material. The specific loss power of the present nanomaterial is much higher than that of conventional nanomaterials (e.g., 40-fold higher than commercially accessible Feridex) and may be controlled by changing compositions or ratios of the first material and/or the second material. The heat-generating nanomaterial of the present invention may be used in a variety of application fields, for example cancer hyperthermia.

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