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1. 发明申请

WO2017005483A9 PROCESS FOR PREPARING POLY(GLYCOLIDE-CO-LACTIDE) COPOLYMER MICROPARTICLES 审中-公开
公开(公告)号：WO2017005483A9
公开(公告)日：2017-01-12
申请号：PCT/EP2016/064270
申请日：2016-06-21
申请人： EVONIK RÖHM GMBH , KIRCHNER, Andreas , LIZIO, Rosario , ROSSMEISSL, Markus Rolf , LULEY, Wolfgang , VORHOLZ, Johannes , GRIMM, Silko , SCHNEIDER, Marc
发明人： KIRCHNER, Andreas , LIZIO, Rosario , ROSSMEISSL, Markus Rolf , LULEY, Wolfgang , VORHOLZ, Johannes , GRIMM, Silko , SCHNEIDER, Marc
IPC分类号： C08G63/88 , C08J9/14 , C08J9/20
摘要： The invention refers to a process for preparing poly(lactide-co-glycolide) copolymer particles with an average particle size in the range of 50 - 800 nm comprising the steps: a) transfer of ethanol and a poly(lactide-co-glycolide) copolymer with a content of polymerized monomer units of 55 - 80 mol% lactide and 20 to 45 mol% of glycolide and a molecular weight M w of 1.000 - 25.000 into a first reactor with a stirring equipment, b) feeding carbon dioxide into the first reactor so that carbon dioxide is from 65 to 85 % by weight and the ethanol is 15 to 35 % by weight wherein carbon dioxide and ethanol add up to 100%, c) mixing the poly(lactide-co-glycolide) copolymer, the ethanol and the carbon dioxide by stirring and adjusting or maintaining the mixture in the first reactor to a temperature of at least 31 and up to 70 °C and a pressure of at least 7.38 and up to 50 MPa, d) stirring the mixture from step c) for 1 to 5 hours, whereby at least a part of the poly(lactide-co-glycolide) copolymer becomes dissolved in the mixture of carbon dioxide and ethanol, e) transfer of the mixture from step d) into a second reactor under rapid reduction of the pressure and expansion with phase separation into a gas phase, an aerosol and an ethanolic suspension containing poly(lactide-co-glycolide) copolymer particles, f) removing the carbondoxide gas and the ethanol aerosol from the reactor g) obtaining the poly(glycolide-co-lactide) copolymer particles with an average particle size in the range of 50 - 800 nm in the form of an ethanolic suspension or in dry form from the second reactor.

2. 发明申请

WO2017005483A1 PROCESS FOR PREPARING POLY(GLYCOLIDE-CO-LACTIDE) COPOLYMER MICROPARTICLES 审中-公开
标题翻译：制备聚（丙二醇共聚物）共聚物微球的方法
公开(公告)号：WO2017005483A1
公开(公告)日：2017-01-12
申请号：PCT/EP2016/064270
申请日：2016-06-21
申请人： EVONIK RÖHM GMBH , KIRCHNER, Andreas , LIZIO, Rosario , ROSSMEISSL, Markus Rolf , LULEY, Wolfgang , VORHOLZ, Johannes , GRIMM, Silko , SCHNEIDER, Marc
发明人： KIRCHNER, Andreas , LIZIO, Rosario , ROSSMEISSL, Markus Rolf , LULEY, Wolfgang , VORHOLZ, Johannes , GRIMM, Silko , SCHNEIDER, Marc
IPC分类号： C08G63/88 , C08J9/14 , C08J9/20
CPC分类号： C08J3/12 , A61K9/146 , A61K47/34 , C08G63/88 , C08J3/095 , C08J2367/04
摘要： The invention refers to a process for preparing poly(lactide-co-glycolide) copolymer particles with an average particle size in the range of 50 - 800 nm comprising the steps: a) transfer of ethanol and a poly(lactide-co-glycolide) copolymer with a content of polymerized monomer units of 55 - 80 mol% lactide and 20 to 45 mol% of glycolide and a molecular weight M w of 1.000 - 25.000 into a first reactor with a stirring equipment, b) feeding carbon dioxide into the first reactor so that carbon dioxide is from 65 to 85 % by weight and the ethanol is 15 to 35 % by weight wherein carbon dioxide and ethanol add up to 100%, c) mixing the poly(lactide-co-glycolide) copolymer, the ethanol and the carbon dioxide by stirring and adjusting or maintaining the mixture in the first reactor to a temperature of at least 31 and up to 70 °C and a pressure of at least 7.38 and up to 50 MPa, d) stirring the mixture from step c) for 1 to 5 hours, whereby at least a part of the poly(lactide-co-glycolide) copolymer becomes dissolved in the mixture of carbon dioxide and ethanol, e) transfer of the mixture from step d) into a second reactor under rapid reduction of the pressure and expansion with phase separation into a gas phase, an aerosol and an ethanolic suspension containing poly(lactide-co-glycolide) copolymer particles, f) removing the carbondoxide gas and the ethanol aerosol from the reactor g) obtaining the poly(glycolide-co-lactide) copolymer particles with an average particle size in the range of 50 - 800 nm in the form of an ethanolic suspension or in dry form from the second reactor.
摘要翻译：本发明涉及一种制备平均粒度在50-800nm范围内的聚（丙交酯 - 共 - 乙交酯）共聚物颗粒的方法，包括以下步骤：a）乙醇和聚（丙交酯 - 共 - 乙交酯）共聚物，其中具有55-80摩尔％丙交酯和20至45摩尔％乙交酯的聚合单体单元的含量，并且使用搅拌设备将第二反应器的分子量Mw为1.000-25.10000，b）将二氧化碳进料到第一反应器使得二氧化碳为65至85重量％，乙醇为15至35重量％，其中二氧化碳和乙醇加至100％，c）将聚（丙交酯 - 共 - 乙交酯）共聚物，乙醇和通过搅拌并将第一反应器中的混合物调节或维持至至少31℃至70℃的温度和至少7.38至高达50MPa的压力，d）搅拌并搅拌来自步骤c）的混合物， 1至5小时，由此至少一部分聚（丙交酯 - 共 - 乙交酯） olymer溶解在二氧化碳和乙醇的混合物中，e）将混合物从步骤d）转移到第二反应器中，在快速降低压力和膨胀的同时将相分离成气相，气溶胶和含有聚（丙交酯 - 共 - 乙交酯）共聚物颗粒，f）从反应器中除去碳氧烷气体和乙醇气溶胶g）获得平均粒度在50-800nm范围内的聚（乙交酯 - 共 - 丙交酯）共聚物颗粒以乙醇悬浮液的形式或来自第二反应器的干燥形式。

3. 发明申请

WO2015140057A1 VERFAHREN ZUR ABTRENNUNG VON AMMONIAK AUS ALKOHOLISCHER LÖSUNG IN GEGENWART VON KOHLENSÄUREVERBINDUNGEN 审中-公开
标题翻译：用于从乙醇溶液对二氧化碳的连接PRESENCE分离氨
公开(公告)号：WO2015140057A1
公开(公告)日：2015-09-24
申请号：PCT/EP2015/055252
申请日：2015-03-13
申请人： EVONIK RÖHM GMBH , MAY, Alexander , PLÖSSER, Willi , ROSSMEISSL, Markus Rolf , KRILL, Steffen , KÖSTNER, Martin
发明人： MAY, Alexander , PLÖSSER, Willi , ROSSMEISSL, Markus Rolf , KRILL, Steffen , KÖSTNER, Martin
IPC分类号： C01C1/12 , B01D3/14 , C01B21/12 , C07C231/06
CPC分类号： C01C1/10 , B01D3/42 , B01D5/0063 , C01C1/12 , C01P2006/80
摘要： Die vorliegende Erfindung beschreibt ein Verfahren zur Abtrennung von Ammoniak aus alkoholischer Lösung in Gegenwart von Kohlensäureverbindungen unter Vermeidung von Belagsbildung indem die zu trennende Lösung im oberen Teil einer Destillationskolonne aufgegeben wird und die Temperatur an der Aufgabestelle so eingestellt wird, dass die Löslichkeit der Ammoniumsalze der betreffenden Kohlensäureverbindung im betreffenden am Kopf der Destillationskolonne unter den Betriebsbedingungen gegeben ist.
摘要翻译：本发明描述了从在碳酸化合物的存在下的醇溶液中除去氨，而通过将溶液被分离在蒸馏塔和在馈电点的温度的上半部分被馈送避免沉积物的形成被调节的方法，使有关的铵盐的溶解度碳酸化合物在蒸馏塔的各个头的操作条件下加入。

4. 发明公开

EP3320019A1 PROCESS FOR PREPARING POLY(GLYCOLIDE-CO-LACTIDE) COPOLYMER MICROPARTICLES 有权转让
标题翻译：制备聚（羟乙酸共聚物）共聚物微粒的方法
公开(公告)号：EP3320019A1
公开(公告)日：2018-05-16
申请号：EP16745630.0
申请日：2016-06-21
申请人： Evonik Röhm GmbH
发明人： KIRCHNER, Andreas , LIZIO, Rosario , ROSSMEISSL, Markus Rolf , LULEY, Wolfgang , VORHOLZ, Johannes , GRIMM, Silko , SCHNEIDER, Marc
IPC分类号： C08G63/88 , C08J9/14 , C08J9/20
摘要： A process for preparing poly(lactide-co-glycolide) copolymer particles with an average particle size in the range of 50-800 nm includes transferring a mixture of poly(lactide-co-glycolide) copolymer, ethanol and carbon dioxide from a first reactor into a second reactor under rapid reduction of the pressure and expansion with phase separation into a gas phase, an ethanol aerosol and an ethanolic suspension containing poly(lactide-co-glycolide) copolymer particles, removing the carbon dioxide gas and the ethanol aerosol from the second reactor, and obtaining the poly(glycolide-co-lactide) copolymer particles in the form of an ethanolic suspension or in dry form from the second reactor.

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